LOCUS       NM_029978               2348 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus TLC domain containing 3B (Tlcd3b), transcript variant
            1, mRNA.
ACCESSION   NM_029978 XM_001480258 XM_924242
VERSION     NM_029978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2348)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2348)
  AUTHORS   Qian,X., Srinivasan,T., He,J., Lu,J., Jin,Y., Gu,H. and Chen,R.
  TITLE     Ceramide compensation by ceramide synthases preserves retinal
            function and structure in a retinal dystrophy mouse model
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37466006
REFERENCE   3  (bases 1 to 2348)
  AUTHORS   Tuomainen,T., Naumenko,N., Mutikainen,M., Shakirzyanova,A.,
            Sczelecki,S., Estall,J.L., Ruas,J.L. and Tavi,P.
  TITLE     PGC-1alpha4 Interacts with REST to Upregulate Neuronal Genes and
            Augment Energy Consumption in Developing Cardiomyocytes
  JOURNAL   Cells 11 (19), 2944 (2022)
   PUBMED   36230906
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2348)
  AUTHORS   Qian,X., Liu,H., Fu,S., Lu,J., Hung,Y.T., Turner,C., Gu,H. and
            Chen,R.
  TITLE     AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype
            in a Tlcd3b Knockout Mouse Model
  JOURNAL   Invest Ophthalmol Vis Sci 63 (3), 11 (2022)
   PUBMED   35275174
REFERENCE   5  (bases 1 to 2348)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2348)
  AUTHORS   Bertrand,R.E., Wang,J., Xiong,K.H., Thangavel,C., Qian,X.,
            Ba-Abbad,R., Liang,Q., Simoes,R.T., Sampaio,S.A.M., Carss,K.J.,
            Lucy Raymond,F., Robson,A.G., Webster,A.R., Arno,G., Porto,F.B.O.
            and Chen,R.
  TITLE     Ceramide synthase TLCD3B is a novel gene associated with human
            recessive retinal dystrophy
  JOURNAL   Genet Med 23 (3), 488-497 (2021)
   PUBMED   33077892
REFERENCE   7  (bases 1 to 2348)
  AUTHORS   Martineau,C., Naja,R.P., Husseini,A., Hamade,B., Kaufmann,M.,
            Akhouayri,O., Arabian,A., Jones,G. and St-Arnaud,R.
  TITLE     Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3
            and its effector molecule FAM57B2
  JOURNAL   J Clin Invest 128 (8), 3546-3557 (2018)
   PUBMED   30010626
REFERENCE   8  (bases 1 to 2348)
  AUTHORS   Yamashita-Sugahara,Y., Tokuzawa,Y., Nakachi,Y.,
            Kanesaki-Yatsuka,Y., Matsumoto,M., Mizuno,Y. and Okazaki,Y.
  TITLE     Fam57b (family with sequence similarity 57, member B), a novel
            peroxisome proliferator-activated receptor gamma target gene that
            regulates adipogenesis through ceramide synthesis
  JOURNAL   J Biol Chem 288 (7), 4522-4537 (2013)
   PUBMED   23275342
  REMARK    GeneRIF: PPARgamma regulates Fam57b transcription during the
            adipogenesis of ST2 cells
            Erratum:[J Biol Chem. 2020 Apr 10;295(15):5176. doi:
            10.1074/jbc.AAC120.013475. PMID: 32277067]
REFERENCE   9  (bases 1 to 2348)
  AUTHORS   Thompson,P.J., Norton,K.A., Niri,F.H., Dawe,C.E. and McDermid,H.E.
  TITLE     CECR2 is involved in spermatogenesis and forms a complex with SNF2H
            in the testis
  JOURNAL   J Mol Biol 415 (5), 793-806 (2012)
   PUBMED   22154806
REFERENCE   10 (bases 1 to 2348)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131642.1, BM948380.1, BB796908.1 and BE984215.1.
            
            On or before Apr 9, 2009 this sequence version replaced
            XM_924242.3, XM_001480258.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131642.1, SRR1660819.316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AK131642.1         2-528
            528-570             BM948380.1         143-185
            571-2328            AK131642.1         570-2327
            2329-2331           BB796908.1         425-427
            2332-2348           BE984215.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..2348
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /note="TLC domain containing 3B"
                     /db_xref="GeneID:68952"
                     /db_xref="MGI:MGI:1916202"
     exon            1..910
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /inference="alignment:Splign:2.1.0"
     exon            911..994
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1229
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1325
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..2333
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="Tlcd3b"
                     /gene_synonym="1500016O10Rik; A330104J06Rik; Fam57b"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgtgg ctcagagctg catgggagac aacgctgctg caggtccggt ttcttggtgt
       61 ctggtcggtg ccatcatttc cctccccctc tcccaccctc cccaagctgg tggcttcccc
      121 tccccctccc cctcctcaca gagggggcag ggggctgggc accaactcta taatgccatg
      181 tgcggtgtct gcacagggca gcggggctct agcggcagca gcaggaggag gtggtagcct
      241 gtggtggcgg gagagcggtg ttgactggtg accgcttgcc cagctgcgcc tccgctccgc
      301 tccgctccgt cctttcctcc ctcccttttt tcagggctgg caccaccgtc ccccaccccg
      361 cctccttggg ccctcccagc ctctccacgt aagccccccc cccacctgcc gcggttctcc
      421 ctcccctccc ccactgcatc ttcctcctcc tgtcccctct ccctcttggt cctctcatca
      481 agtcctccct tggtagtctc tccccatcct ctcaccagcg ctctgtcgtc cccccccccc
      541 ccccgccacc tagctagccc tttctttctg tgtccccaat ctcattgaag tccctttctc
      601 ccttgccctg aactggtcct cttgtcccat cctgtccccg ccctggcccc tttgtgcctc
      661 cccctccctc tttctctctc cctttctggc ttggcaatcc cttcttcacc tccaactccc
      721 tccctcaatt tggccttcct gtcccttctg gaccctctgg tctccctgcc cgggttcaag
      781 tcaccatgct taccccaatg gtggctgggg gggtggtgtt ccccggactc ttcctcctat
      841 ccaagaacac gctccagagg ctgccccagc tgcgctggga ggaggccgac gcagtcattg
      901 tctccgccag gttggtgtcc tctgtccaag ccatcatggc ctccacagct ggctacatag
      961 tctccacttc ctgcaagcac atcatagatg accagcactg gctgtcctcg gcctatacac
     1021 agtttgcagt tccctacttc atctatgaca tctatgccat gttcctctgc cactggcaca
     1081 agcaccaggt taaagggcac ggaggggaag acgggacgcc cagagccctg ggcagcacct
     1141 gggctgtggt acgcggctac ctgcacaagg agttcctcat ggtgctccac cacgcggcca
     1201 tggtactggt gtgcttccca ctctcagtgg tgtggcgaca aggcaaggga gatttctttc
     1261 taggctgcat gttgatggcc gaggtcagca ctcctttcgt ctgcctgggc aagatcctca
     1321 ttcagtacaa gcagcagcac acgttgctgc acaaggtgaa cggagccctg atgctactca
     1381 gcttcctgtg ctgccgggtg ctgctcttcc cctacctgta ctgggcctac gggcgccacg
     1441 ctggcctgcc cctgctctca gtgcccatgg ccatcccggc ccacgtcaac ctgggcgccg
     1501 cactgctcct cgcaccccag ctctactggt tcttcctcat ttgccgcggg gcctgccgcc
     1561 tcttccgacc ccgaggctcc ccaccaccct ctccttgtca gacccaggac tgaggctagg
     1621 ccctggaaac cctccccccc ctccagcccc tgtggagaca gtgcattggg gtaatcagtg
     1681 tgtgagttgg gggggggggg acgagagcca gaagtccctt tccttgacag ccccaagaca
     1741 gatggactta gaataaggag aagctatatt ccctcgggag ctgaggtcag attggcaggc
     1801 aggaagagag gggaccgggg taacgaaccc cttcttgcct ctgtgttaac aaaatgaaag
     1861 gggaagggag gagatggggc tcacttggac caaggagtca agggacataa gggtggcccc
     1921 gctgccaagg acatcctagc cctgctgctg caaatccttc tctgctcccc atcacccggg
     1981 agagagaaga catcctaact ccccccacct gggccctgac agggcagtta cccccacagc
     2041 cccttcctgt ggagaccagt ccgaggaacc attttattta ttcacccata tcaaactaat
     2101 ttgttggggt gaggggagga aggcagttgc tcccctacaa cctttccagc gctgagcagc
     2161 cctggggaca ggcgccaggc cagtcccttc tgtcaggggc acatttagcc ctcggccccg
     2221 gcttgtccct ggtgctacag gccaatcgcg gcttcctcca gtctgggggc cacagacccc
     2281 gggaggtgct tttacagacc gctaataaag acgatcttcc tgaacgccag caaaaaaaaa
     2341 aaaaaaaa
//
