LOCUS       NM_027249               1424 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TLC domain containing 2 (Tlcd2), transcript variant 1,
            mRNA.
ACCESSION   NM_027249 XM_354627
VERSION     NM_027249.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV562896.1, AL591496.13, CO044816.1 and AI549721.1.
            
            On Mar 27, 2014 this sequence version replaced NM_027249.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021945.1, SRR5189682.91505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CV562896.1         1-6
            7-633               CV562896.1         8-634
            634-924             AL591496.13        114613-114903
            925-1416            CO044816.1         18-509              c
            1417-1424           AI549721.1         510-517
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.91 cM"
     gene            1..1424
                     /gene="Tlcd2"
                     /note="TLC domain containing 2"
                     /db_xref="GeneID:380712"
                     /db_xref="MGI:MGI:1917141"
     exon            1..328
                     /gene="Tlcd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1088
                     /gene="Tlcd2"
                     /note="isoform 1 is encoded by transcript variant 1; TLC
                     domain-containing protein 2"
                     /codon_start=1
                     /product="TLC domain-containing protein 2 isoform 1"
                     /protein_id="NP_081525.1"
                     /db_xref="CCDS:CCDS48850.1"
                     /db_xref="GeneID:380712"
                     /db_xref="MGI:MGI:1917141"
                     /translation="MASWGLLVAGASFTAFRGLHWGLQLLPTPKSVRDRWMWRNIFVS
                     LIHSLLSGVGALVGLWQFPQMVTDPINDHPPWARVLVAVSVGYFAADGVDMLWNQTLA
                     QAWDLLCHHLAVVSCLSTAVVSGHYVGFSMVSLLLELNSICLHLRKLLLLSHKAPSLA
                     FRVSSWASLATLVLFRLLPLGWMSLWLSRQHYQLSLALVLLCVAGLVTVGSISISTGI
                     RILTKDILQSQPYPFILMHKETKTREPVARNTSTLSLKGSRYLYSTAAAALGGHLMVL
                     ASPKRCMTPSVLGLQERRLEPGKVAHADNASTWE"
     exon            329..411
                     /gene="Tlcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..494
                     /gene="Tlcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..924
                     /gene="Tlcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1424
                     /gene="Tlcd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tlcd2"
                     /note="hexamer: AATAAA"
     polyA_site      1416
                     /gene="Tlcd2"
                     /note="major polyA site"
ORIGIN      
        1 cacgctggaa agataataca ggccaggaag ccccaggcac agcagggtgg aaaagctaga
       61 tcccgattct gccggagggg ggccccttcg aggtcccggg caccgggtgc caggatcaga
      121 gaaactgact gaaacctagc tgacctgccc agaccatggc atcctgggga ctccttgtgg
      181 ctggcgcttc cttcacggcg tttcggggac tgcactgggg gctgcagctg ctgcccaccc
      241 cgaaatctgt tcgggaccgc tggatgtggc ggaacatttt cgtttcgctg atacacagcc
      301 tactctctgg agtaggggcg ctggtcgggc tgtggcagtt tcctcaaatg gtcaccgacc
      361 caattaatga tcacccaccg tgggcacggg tcctagtagc agtgtcagtg ggttatttcg
      421 ctgcagatgg agttgatatg ctgtggaacc agacattggc ccaggcctgg gaccttctct
      481 gtcaccattt ggcggtagtg agctgcctca gcaccgctgt tgtgtctggc cactatgtgg
      541 gcttctctat ggtatccctg cttctggagc tgaactccat ctgtttgcat ctacggaagc
      601 tactgctgct ctcccataag gccccatcct tggccttcag agtaagcagt tgggccagcc
      661 tggccaccct ggtcctcttc cgccttctgc ctctgggatg gatgagtctg tggttgtccc
      721 ggcagcacta ccagctgtct cttgctctgg ttctgctttg tgtggctggg ctggtcaccg
      781 tgggcagcat aagcatctcc acagggatcc gaattctgac caaggatatc ttgcagtctc
      841 agccctaccc gtttatcctc atgcacaagg aaaccaagac acgtgagcct gttgccagga
      901 acacttccac tctcagtctg aaaggctcca gatacctgta ctccactgct gctgctgctc
      961 ttggtggtca tctcatggta ctggcatctc caaaacgctg catgacccct tcagtcctgg
     1021 gccttcaaga gagaagacta gagcctggca aagtggcaca tgctgataat gctagcactt
     1081 gggaatgaca agcagaagga tcagaagttc aaggccagcc tgggctacaa gagactctgt
     1141 ttcaacaaac aaacaaacaa acaaaccaaa gaagagaaag aaaaaactgg acatgacagc
     1201 cggaacatta tctgacattc ataaggtcct gagttcaatg ccaagttggc agtgcctagt
     1261 ttgataaggg tctagccact ctggtaatac catggctgac tgaacacctt acccagcaac
     1321 ttgctgatag actctgcctt ccagcaaaag ggaggagctt cgctgaggag agaacattga
     1381 accctattgt atatgaataa attgctgtgc aaatgatttc atca
//
