LOCUS       NM_009388               3242 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus transketolase (Tkt), mRNA.
ACCESSION   NM_009388
VERSION     NM_009388.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3242)
  AUTHORS   Liu,M.J., Zhao,Y., Li,Q.T., Lei,X.Y., He,K.Y., Guo,J.R., Yang,J.Y.,
            Yan,Z.H., Wu,D.H., Zhang,L., Jian,Y.P. and Xu,Z.X.
  TITLE     HMGA1 promotes the progression of esophageal squamous cell
            carcinoma by elevating TKT-mediated upregulation of pentose
            phosphate pathway
  JOURNAL   Cell Death Dis 15 (7), 541 (2024)
   PUBMED   39080260
  REMARK    GeneRIF: HMGA1 promotes the progression of esophageal squamous cell
            carcinoma by elevating TKT-mediated upregulation of pentose
            phosphate pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3242)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3242)
  AUTHORS   Liu,Q., Zhu,F., Liu,X., Lu,Y., Yao,K., Tian,N., Tong,L.,
            Figge,D.A., Wang,X., Han,Y., Li,Y., Zhu,Y., Hu,L., Ji,Y., Xu,N.,
            Li,D., Gu,X., Liang,R., Gan,G., Wu,L., Zhang,P., Xu,T., Hu,H.,
            Hu,Z., Xu,H., Ye,D., Yang,H., Li,B. and Tong,X.
  TITLE     Non-oxidative pentose phosphate pathway controls regulatory T cell
            function by integrating metabolism and epigenetics
  JOURNAL   Nat Metab 4 (5), 559-574 (2022)
   PUBMED   35606596
  REMARK    GeneRIF: Non-oxidative pentose phosphate pathway controls
            regulatory T cell function by integrating metabolism and
            epigenetics.
REFERENCE   4  (bases 1 to 3242)
  AUTHORS   Wang,Z., Qiu,Z., Hua,S., Yang,W., Chen,Y., Huang,F., Fan,Y.,
            Tong,L., Xu,T., Tong,X., Yang,K. and Jin,W.
  TITLE     Nuclear Tkt promotes ischemic heart failure via the cleaved
            Parp1/Aif axis
  JOURNAL   Basic Res Cardiol 117 (1), 18 (2022)
   PUBMED   35380314
  REMARK    GeneRIF: Nuclear Tkt promotes ischemic heart failure via the
            cleaved Parp1/Aif axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3242)
  AUTHORS   Tian,N., Hu,L., Lu,Y., Tong,L., Feng,M., Liu,Q., Li,Y., Zhu,Y.,
            Wu,L., Ji,Y., Zhang,P., Xu,T. and Tong,X.
  TITLE     TKT maintains intestinal ATP production and inhibits
            apoptosis-induced colitis
  JOURNAL   Cell Death Dis 12 (10), 853 (2021)
   PUBMED   34535624
  REMARK    GeneRIF: TKT maintains intestinal ATP production and inhibits
            apoptosis-induced colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3242)
  AUTHORS   Salamon,C., Chervenak,M., Piatigorsky,J. and Sax,C.M.
  TITLE     The mouse transketolase (TKT) gene: cloning, characterization, and
            functional promoter analysis
  JOURNAL   Genomics 48 (2), 209-220 (1998)
   PUBMED   9521875
REFERENCE   7  (bases 1 to 3242)
  AUTHORS   James,H.M., Williams,S.G., Bais,R., Rofe,A.M., Edwards,J.B. and
            Conyers,R.A.
  TITLE     The metabolic production of oxalate from xylitol: activities of
            transketolase, transaldolase, fructokinase and aldolase in liver,
            kidney, brain, heart and muscle in the rat, mouse, guinea pig,
            rabbit and human
  JOURNAL   Int J Vitam Nutr Res Suppl 28, 29-46 (1985)
   PUBMED   3009653
REFERENCE   8  (bases 1 to 3242)
  AUTHORS   Trebukhina,R.V., Ostrovsky,Y.M., Mikhaltsevich,G.N., Velichko,M.G.
            and Tumanov,V.N.
  TITLE     Transketolase, pyruvate and oxoglutarate dehydrogenase activities
            and [14C]thiamin turnover in tissues of mice fed thiamin-deficient
            diet
  JOURNAL   J Nutr 113 (7), 1285-1291 (1983)
   PUBMED   6864328
REFERENCE   9  (bases 1 to 3242)
  AUTHORS   Blass,J.P., Piacentini,S., Boldizsar,E. and Baker,A.
  TITLE     Kinetic studies of mouse brain transketolase
  JOURNAL   J Neurochem 39 (3), 729-733 (1982)
   PUBMED   7097279
REFERENCE   10 (bases 1 to 3242)
  AUTHORS   Gumaa,K.A. and McLean,P.
  TITLE     The pentose phosphate pathway of glucose metabolism. Enzyme
            profiles and transient and steady-state content of intermediates of
            alternative pathways of glucose metabolism in Krebs ascites cells
  JOURNAL   Biochem J 115 (5), 1009-1029 (1969)
   PUBMED   5360673
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY276711.1, AK166763.1,
            AK030446.1, AC154646.2 and AI837706.1.
            
            On Dec 18, 2013 this sequence version replaced NM_009388.5.
            
            Summary: This gene encodes an enzyme that binds magnesium and
            thiamine pyrophosphate and catalyzes the transfer of sugar
            phosphates to an aldose acceptor. This enzyme is a key component of
            the pentose phosphate pathway during glycolysis. It is
            significantly expressed in the cornea and may be involved in the
            cellular response against oxidative stress. Haploinsufficiency of
            this gene leads to decreased growth and reduction of adipose
            tissue. [provided by RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030446.1, AK167084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY276711.1         2-14
            14-1686             AK166763.1         1-1673
            1687-2114           AK166763.1         1675-2102
            2115-2147           AK030446.1         2098-2130
            2148-2148           AC154646.2         107418-107418       c
            2149-3223           AK030446.1         2131-3205
            3224-3242           AI837706.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 18.79 cM"
     gene            1..3242
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /note="transketolase"
                     /db_xref="GeneID:21881"
                     /db_xref="MGI:MGI:105992"
     exon            1..250
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2015
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /EC_number="2.2.1.1"
                     /note="TK"
                     /codon_start=1
                     /product="transketolase"
                     /protein_id="NP_033414.1"
                     /db_xref="CCDS:CCDS26894.1"
                     /db_xref="GeneID:21881"
                     /db_xref="MGI:MGI:105992"
                     /translation="MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSA
                     AEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRK
                     ISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSE
                     GSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDIYQKRCEAFGWHTIIVDG
                     HSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYS
                     QVQSKKKILATPPQEDAPSVDIANIRMPTPPSYKVGDKIATRKAYGLALAKLGHASDR
                     IIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAF
                     FTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSD
                     GVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGA
                     GVTLHEALAAAESLKKDKISIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEG
                     GIGEAVSAAVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTKG"
     exon            251..368
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            369..482
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            483..580
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            581..772
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            773..891
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1085
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1250
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1407
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1538
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1622
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1716
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1839
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..3227
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /note="hexamer: AATATA"
     polyA_site      2123
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /note="major polyA site"
     regulatory      3208..3213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tkt"
                     /gene_synonym="p68"
                     /note="hexamer: AATAAA"
     polyA_site      3214
                     /gene="Tkt"
                     /gene_synonym="p68"
     polyA_site      3227
                     /gene="Tkt"
                     /gene_synonym="p68"
ORIGIN      
        1 atgggcgggt cctaaggagt cttaacgcgc ccgcccgcag cacccgtcct cggtcactgc
       61 tggtcgcttc ctgagccgct gctggctctg tgtctctgtc ctcagcgttc tcgtcctcgt
      121 cctcgtcctc gtcctaccac gccatggaag gttaccataa gccagatcag cagaagctcc
      181 aggccctgaa ggacacagcc aatcgcctgc gcatcagctc catccaggcc accaccgcgg
      241 caggctcagg ccaccccaca tcatgctgca gcgctgccga gatcatggct gtcctgtttt
      301 tccataccat gcgttacaag gccctggatc cccgaaaccc tcacaatgat cgatttgtgc
      361 tctctaaggg ccatgcagct cccattttat atgcagtctg ggctgaagct ggcttcctac
      421 ccgaggccga gctgctgaac ctgaggaaga tcagctctga cttggacggg catcctgtcc
      481 cgaaacaagc cttcaccgat gtggccactg gctccctggg ccagggcctg ggagctgctt
      541 gcgggatggc atacacaggc aaatactttg acaaagccag ctaccgagtc tattgcatgc
      601 tgggagacgg ggaggtctcc gagggctccg tctgggaggc catggccttt gctggaattt
      661 acaagctgga caacctcgtt gccatttttg acatcaaccg cctgggccag agcgacccag
      721 ccccgctgca gcaccaggtg gacatctacc agaagcgctg tgaggccttt ggctggcaca
      781 ccatcatcgt ggacggacac agcgtggagg agctgtgcaa ggcctttggt caggccaagc
      841 accaaccaac agccatcatt gccaagacct tcaagggccg agggatcaca gggattgaag
      901 acaaggaggc gtggcacggg aagcccctcc ccaaaaacat ggccgagcag attatccagg
      961 agatttacag ccaggttcag agcaaaaaga agatcctggc cacgccccct caggaggatg
     1021 ccccatccgt ggacattgct aacatccgaa tgcctacgcc acccagctac aaagtggggg
     1081 acaagatagc cacccggaag gcctatggac tggccctcgc taagctgggc cacgccagtg
     1141 accgtatcat tgccctggat ggagacacca agaattccac cttctcggag ctcttcaaaa
     1201 aggagcaccc agaccggttc attgagtgct acattgccga gcaaaacatg gtgagcattg
     1261 ccgtgggctg tgccacacgt gaccggacag tgcccttctg cagtactttc gcggccttct
     1321 tcacacgggc cttcgaccag attcgcatgg ccgccatctc tgagagcaac atcaacctct
     1381 gtggctccca ctgtggtgtg tccattgggg aagacgggcc ctctcagatg gccctcgaag
     1441 acctggccat gttccggtca gtccccatgt ccaccgtctt ttacccaagc gatggagttg
     1501 caacagagaa ggcagtggag ttagcagcca acacaaaggg catttgcttc atccggacca
     1561 gccgcccaga gaatgccatt atttatagca acaatgagga tttccaggtc ggccaagcca
     1621 aggtggtcct gaagagcaag gatgaccaag tgacagtgat cggggctggt gtaactctgc
     1681 atgaggcctt ggctgctgca gagagtctaa agaaagataa gatcagcatc cgggtgctgg
     1741 atcccttcac tatcaagccc ctggacagga aactcatcct agactctgcc cgagcaacca
     1801 aaggcaggat cctcaccgtg gaggaccact actacgaagg tggcatagga gaggcagtgt
     1861 ctgctgccgt agtgggtgaa cctggagtga cggtcactcg cctggctgtc agccaagtac
     1921 cacgaagtgg caagccagct gagctactga agatgttcgg tattgacaag gacgccattg
     1981 tgcaagctgt gaaaggcctt gtcaccaagg gctagggagg gcatgggatg ctgggtgggt
     2041 gaactacaca ttccagggag gttctggcag aggtggcgaa ggtgtactga gtggggaggt
     2101 aaatatatgt tttgagaaaa aaattaatcc tcagactctt ttttttttcc tgtgatataa
     2161 acatatccag tgccagtatg agaaggagac tggggagaga gggagagagc tggctctcta
     2221 ggcttggggt caggatctag gtgtcccctg gatctaggtg tcccctggaa tccccttctc
     2281 cagttcagcc tctgcaaagc cacaactgct cccaccaagt cataactggg gacactcatt
     2341 gcagcctgcc ttttagccaa actaggatcc agccccttcc tttgccagtg taccctaaat
     2401 gacaccatgg agttccctcc tgccttataa aaccttcctg ggccctccat agctgcacca
     2461 tggcccccaa ggtcccacaa ctcctccttt tatgggtggt cactgctgtt tcctaggaat
     2521 tccgcagtgc ccttagggag gatggggccc atttgttgag ctatgtgcat gtttgccctt
     2581 tgtcgacaaa ctgctcagct agcgagttgc ctggcccgat ccttccatgc cagggaactg
     2641 tatggtacca actccagaaa cagcagagca ggtaggttgt ctcagggaga tgacagagac
     2701 tcctcagtgg gtgatcttag ggcacaccct gggaggcctt gagctccgca tgtcaggaac
     2761 tctccttcac tgagaaaaga aggcaagcca tctccctgtc aggacaattg aggaacttct
     2821 cagccacgag ttttgagtct ggacataact acaatatgtt atgtagttct gaacaaaaac
     2881 agtaaagctt gggtgcttgg tcaccacctg gtggccattt atggtactac agtgctaagc
     2941 acacccctac agaggaatct gaggaaggag actagggatg gtgttttctg aactctgtaa
     3001 agctcacagc aggtggaggt gacagtgaca ttactgaact ttgtatgcat tttacttaat
     3061 ccttactaca agaaaccact ttagaaggca ttccacttgg ctgagtgcta aggattggtc
     3121 tatgtattgc aatgctaaat tctgtaccca aaagtctaca ggcttttatt gtgcaaacct
     3181 tcttccttaa tttaaaacta ttgtttaaat aaaatggcta cagtcaaaaa aaaaaaaaaa
     3241 aa
//
