LOCUS       NM_013769               3043 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tight junction protein 3 (Tjp3), transcript variant 3,
            mRNA.
ACCESSION   NM_013769
VERSION     NM_013769.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Hinze,C., Ruffert,J., Walentin,K., Himmerkus,N., Nikpey,E.,
            Tenstad,O., Wiig,H., Mutig,K., Yurtdas,Z.Y., Klein,J.D.,
            Sands,J.M., Branchi,F., Schumann,M., Bachmann,S., Bleich,M. and
            Schmidt-Ott,K.M.
  TITLE     GRHL2 Is Required for Collecting Duct Epithelial Barrier Function
            and Renal Osmoregulation
  JOURNAL   J Am Soc Nephrol 29 (3), 857-868 (2018)
   PUBMED   29237740
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Qiao,X., Roth,I., Feraille,E. and Hasler,U.
  TITLE     Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney
            collecting duct principal cell proliferation and adhesion
  JOURNAL   Cell Cycle 13 (19), 3059-3075 (2014)
   PUBMED   25486565
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Capaldo,C.T., Koch,S., Kwon,M., Laur,O., Parkos,C.A. and Nusrat,A.
  TITLE     Tight function zonula occludens-3 regulates cyclin D1-dependent
            cell proliferation
  JOURNAL   Mol Biol Cell 22 (10), 1677-1685 (2011)
   PUBMED   21411630
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Tsukita,S., Katsuno,T., Yamazaki,Y., Umeda,K., Tamura,A. and
            Tsukita,S.
  TITLE     Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens
            and tight junctions with paracellular permselective barrier
            function
  JOURNAL   Ann N Y Acad Sci 1165, 44-52 (2009)
   PUBMED   19538286
  REMARK    GeneRIF: ZO-3 shows an epithelial-specific Tight junctions
            localization
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Franco,C.A., Mericskay,M., Parlakian,A., Gary-Bobo,G., Gao-Li,J.,
            Paulin,D., Gustafsson,E. and Li,Z.
  TITLE     Serum response factor is required for sprouting angiogenesis and
            vascular integrity
  JOURNAL   Dev Cell 15 (3), 448-461 (2008)
   PUBMED   18804439
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Adachi,M., Inoko,A., Hata,M., Furuse,K., Umeda,K., Itoh,M. and
            Tsukita,S.
  TITLE     Normal establishment of epithelial tight junctions in mice and
            cultured cells lacking expression of ZO-3, a tight-junction MAGUK
            protein
  JOURNAL   Mol Cell Biol 26 (23), 9003-9015 (2006)
   PUBMED   17000770
  REMARK    GeneRIF: ZO-3 (-/-) mice were viable and fertile and their tight
            junctions did not appear to be affected.
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Inoko,A., Itoh,M., Tamura,A., Matsuda,M., Furuse,M. and Tsukita,S.
  TITLE     Expression and distribution of ZO-3, a tight junction MAGUK
            protein, in mouse tissues
  JOURNAL   Genes Cells 8 (11), 837-845 (2003)
   PUBMED   14622136
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Unda,F.J., Perez-Nanclares,G., Le Morvan,V., Hernandez,C.,
            Vilaxa,A., De-la-Fuente,M. and Gorry,P.
  TITLE     Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2,
            ZO-3 and occludin during mouse tooth development
  JOURNAL   Histol Histopathol 18 (1), 27-38 (2003)
   PUBMED   12507281
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Kausalya,P.J., Reichert,M. and Hunziker,W.
  TITLE     Connexin45 directly binds to ZO-1 and localizes to the tight
            junction region in epithelial MDCK cells
  JOURNAL   FEBS Lett 505 (1), 92-96 (2001)
   PUBMED   11557048
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134100.1, AK029083.1 and AV236903.1.
            
            On Aug 18, 2013 this sequence version replaced NM_013769.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding region, compared to variant 1. The encoded isoform (2) has a
            shorter and distinct N-terminus, compared to isoform 1. Both
            variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134100.1, BC012518.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AK134100.1         2-55
            55-3024             AK029083.1         2-2971
            3025-3043           AV236903.1         223-241
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3043
                     /gene="Tjp3"
                     /note="tight junction protein 3"
                     /db_xref="GeneID:27375"
                     /db_xref="MGI:MGI:1351650"
     exon            1..220
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..277
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..2944
                     /gene="Tjp3"
                     /note="isoform 2 is encoded by transcript variant 3; tight
                     junction protein ZO-3; zona occludens protein 3; zonula
                     occludens protein 3"
                     /codon_start=1
                     /product="tight junction protein ZO-3 isoform 2"
                     /protein_id="NP_038797.2"
                     /db_xref="CCDS:CCDS24051.1"
                     /db_xref="GeneID:27375"
                     /db_xref="MGI:MGI:1351650"
                     /translation="MEELTIWEQHTATLYKDPRRGFGIAVSGGHDRASGSVVVSDVVP
                     GGPAEGRLRTGDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKA
                     SPASGHQLSDQEEADHGRGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGG
                     SEANGLDLVSGYKRLPKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESGLAA
                     RNHGLQEGDLILQINGVSSANLSLSDTRRLIEKSEGELTLLVLRDSGQFLVNIPPAVS
                     DSDSSLMEDISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRRERSVN
                     SRAIAEPESPGESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGASIGLRLAGGNDVGI
                     FVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDMELVTQSK
                     QDIFKKMVQSRVGDSFYIRTHFELEPSPPYGLGFTRGDVFHVVDTLYPGSGPGHGHSS
                     HGGLWLAARMGRDLREQERGVIPNQSRAEQLASLEAAQRAAGVGPGASVGSNPRAEFW
                     RLRGLRRGTKKASTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAM
                     KKLTTEMPEEFEIAESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQ
                     YYPIVIFCAPESRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGT
                     SDSWYQEVKAVIQQQQARPIWTAEDQLNSSSEDLDLPGHGLAASSGDLSCDSRTNSDY
                     EDTDGEGAYTDREGGPQDVDEEVAPTALARSSEPVWVDDHQGLMGHGTTITDKWETQA
                     DSHYTQDQRRQDSMRTYKHEALRKKFTRARDVESSDDEGYDWGPATDL"
     exon            278..387
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..490
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..818
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            819..922
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1082
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1191
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1253
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1320
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1477
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1586
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1833
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2048
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2144
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2215
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2426
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2527
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2794
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2841
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3043
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgcact cacaattgcg cacaacctgc acagtcctgc cggttccacc cggcaaaggg
       61 actcgcccac cgttccttcc actccgcttt cgctgagcaa acaggttgcc cggcccgagc
      121 agccagctcg ggtctcctcc ctgccaccca tgcctgacag ctatccagga cccagcttcc
      181 acctcccacc ctgcgtccat tcactcagcc ttccagaccg gtggcagaca tggaagagct
      241 gaccatctgg gaacaacaca cagccacact gtacaaggac ccccgccgcg gcttcggcat
      301 agctgtctct ggaggccatg accgagctag tggatccgtg gtggtgtctg atgtggtacc
      361 aggaggcccc gctgagggcc ggctccggac cggggaccac atcgtcatgg tgaatggtgt
      421 ctctgtggag aacgtcacat ctgcctttgc catccagatc cttaagacct gcaccaaaac
      481 agccaacgtt acagtgaagc gtccccgcag ggtccagctg cctgccacca aggctagccc
      541 agcttctggc caccagctct cagaccagga agaagctgac catggccggg gctatgaggg
      601 ggactcctcc agtggctcag gtcgatcatg gggtgagcgt tctcgccggt ccagggcagg
      661 tcgccgcggc agggtaggca gccatgggcg ccggagttcg ggtggcggat ctgaagccaa
      721 cggtctggac ctggtgtctg gctataagcg cttgccgaag caggatgtgc taatgaggcc
      781 actaaagtcc gtgctggtga aacgaagaaa cagcgaagag tttggggtga agctaggcag
      841 tcagatcttt ataaaacaca tcacggaatc tggccttgct gctcggaacc atgggctgca
      901 ggagggagac cttatcttac agatcaacgg ggtgtccagt gctaatctgt ccctgagtga
      961 cacacgaagg ctcattgaga agtcggaggg ggagctgacg ttgctggtgc taagagacag
     1021 tgggcagttc ctggtgaaca tccctcccgc agtgagcgac agcgacagct ccctaatgga
     1081 agacatctca gacctgacct cagaattgtc ccaggcgccc ccttcccacg ttcctccgcc
     1141 acctctgaag ggtcagagga gccctgagga cagccagaca gactccccag tggagacccc
     1201 gcagccccgg aggcgggaac ggtcagtgaa ttcaagagcc atcgctgaac cagagtctcc
     1261 tggagaaagc cgctatgaca tttacagggt tcctagccgg cagagcctgg aggaccgtgg
     1321 ctacagcccc gacactcgtg tcgtgagctt ccccaagggc gcgagtattg gcttgcggct
     1381 ggccggcggc aacgacgtgg gcatcttcgt atccggggtg caggcaggca gcccggccga
     1441 cgggcaaggc atccaggaag gggatgagat cttgcaggtg aatggtatgc catttcggaa
     1501 cctgactcgg gaggaggccg tgcagtttct gttggggctg cctccagggg aagacatgga
     1561 gctggtaaca cagagcaaac aggacatctt taagaagatg gtccagtctc gcgtgggtga
     1621 ctccttctac atccgcacac actttgagct ggagccgagc ccaccctatg gcctgggctt
     1681 cacccgcggt gatgtcttcc acgtagtgga cacgttgtac ccgggctccg ggccaggcca
     1741 tgggcacagc agccatgggg gcctctggct ggccgcccgc atgggcagag atctgcgaga
     1801 gcaagaacgc ggcgtcatcc ccaaccagag cagggccgag cagctggcca gtctggaggc
     1861 tgcgcagcgg gccgcgggcg tggggccagg cgcctcagtg ggttccaacc cacgggcgga
     1921 gttttggcga ctccgaggtc tccgccgagg gaccaagaag gcgtcgaccc agcggagccg
     1981 cgaggaccta tcagcgctga ccaggcaggg acactacccg ccctatgagc gtgtggtgct
     2041 cagagaagcc agttttaagc gccccgtggt gatcctagga ccagtggcag acattgccat
     2101 gaagaaactg accacagaga tgccagaaga gtttgagatt gcagaaagca tgtcccggac
     2161 tgacagccca tccaagatca tcaaactgga cacagtgcgg gtgatcgcag agagggataa
     2221 gcacgcactc ctggatgtca ccccctctgc catcgagcgc ctcaactacg tgcagtacta
     2281 ccccatcgtc atcttttgtg ccccagagag ccggccggcc ctcaaggccc tccgggagtg
     2341 gctggccccg gcctctcgcc gcagcagccg ccgcctgtat gcgcaggccc agaaactgca
     2401 gaaacacagt ggccacctct tcaccgccac catccccctg catggcacta gtgactcctg
     2461 gtaccaggaa gtcaaggctg taatacagca acagcaggcg cgaccgatct ggaccgcgga
     2521 ggaccagctg aacagctcat ccgaggacct tgacctgccg ggccatggtc tggccgccag
     2581 ctctggagac ctcagctgtg acagtcggac caacagcgac tatgaggaca ccgacggcga
     2641 gggcgcctat acggacagag agggcggacc ccaggatgtc gatgaggagg tcgcacccac
     2701 agccctggcc cggtcctcag agcccgtatg ggtagatgat caccaggggc tgatgggtca
     2761 tgggacaact atcacagaca aatgggagac acaggctgac agccactaca cccaggacca
     2821 gcggcgccag gacagcatgc ggacctacaa gcacgaggcc ctgaggaaga agttcacaag
     2881 agcccgggat gtggaatcct ctgatgacga gggctatgac tggggcccag ccaccgacct
     2941 gtgacctatg cagtcaccag cgtgccacaa gccctcaagc ttctgaccac ttaataaatc
     3001 tttaaaaaaa attttttata ttagaaaata atacaagact gag
//
