LOCUS       NM_001417366            7139 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus tight junction protein 1 (Tjp1), transcript variant 3,
            mRNA.
ACCESSION   NM_001417366 XM_036152891
VERSION     NM_001417366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7139)
  AUTHORS   Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C.,
            Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y.,
            Kan,K.W., Huang,H.P. and Lee,M.S.
  TITLE     Spint1 disruption in mouse pancreas leads to glucose intolerance
            and impaired insulin production involving HEPSIN/MAFA
  JOURNAL   Nat Commun 15 (1), 10537 (2024)
   PUBMED   39627229
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7139)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7139)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7139)
  AUTHORS   Havrylov,S., Chrystal,P., van Baarle,S., French,C.R.,
            MacDonald,I.M., Avasarala,J., Rogers,R.C., Berry,F.B., Kume,T.,
            Waskiewicz,A.J. and Lehmann,O.J.
  TITLE     Pleiotropy in FOXC1-attributable phenotypes involves altered
            ciliation and cilia-dependent signaling
  JOURNAL   Sci Rep 14 (1), 20278 (2024)
   PUBMED   39217245
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7139)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7139)
  AUTHORS   Mohandas,T.K., Chen,X.N., Rowe,L.B., Birkenmeier,E.H.,
            Fanning,A.S., Anderson,J.M. and Korenberg,J.R.
  TITLE     Localization of the tight junction protein gene TJP1 to human
            chromosome 15q13, distal to the Prader-Willi/Angelman region, and
            to mouse chromosome 7
  JOURNAL   Genomics 30 (3), 594-597 (1995)
   PUBMED   8825647
REFERENCE   7  (bases 1 to 7139)
  AUTHORS   Miragall,F., Krause,D., de Vries,U. and Dermietzel,R.
  TITLE     Expression of the tight junction protein ZO-1 in the olfactory
            system: presence of ZO-1 on olfactory sensory neurons and glial
            cells
  JOURNAL   J Comp Neurol 341 (4), 433-448 (1994)
   PUBMED   8201022
REFERENCE   8  (bases 1 to 7139)
  AUTHORS   Woods,D.F. and Bryant,P.J.
  TITLE     ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate
            and synaptic cell junctions
  JOURNAL   Mech Dev 44 (2-3), 85-89 (1993)
   PUBMED   8155583
  REMARK    Review article
REFERENCE   9  (bases 1 to 7139)
  AUTHORS   Itoh,M., Nagafuchi,A., Yonemura,S., Kitani-Yasuda,T., Tsukita,S.
            and Tsukita,S.
  TITLE     The 220-kD protein colocalizing with cadherins in non-epithelial
            cells is identical to ZO-1, a tight junction-associated protein in
            epithelial cells: cDNA cloning and immunoelectron microscopy
  JOURNAL   J Cell Biol 121 (3), 491-502 (1993)
   PUBMED   8486731
REFERENCE   10 (bases 1 to 7139)
  AUTHORS   Fleming,T.P., Javed,Q. and Hay,M.
  TITLE     Epithelial differentiation and intercellular junction formation in
            the mouse early embryo
  JOURNAL   Dev Suppl, 105-112 (1992)
   PUBMED   1299356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122222.6 and AC131741.4.
            
            On Mar 4, 2023 this sequence version replaced XM_036152891.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.9521.1,
                                           SRR17253012.1514303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AC122222.6         105697-106156       c
            461-517             AC122222.6         89719-89775         c
            518-642             AC122222.6         78502-78626         c
            643-745             AC122222.6         77504-77606         c
            746-1022            AC122222.6         75037-75313         c
            1023-1126           AC122222.6         71930-72033         c
            1127-1295           AC122222.6         71384-71552         c
            1296-1443           AC122222.6         70919-71066         c
            1444-1583           AC122222.6         64513-64652         c
            1584-1689           AC122222.6         63811-63916         c
            1690-1840           AC131741.4         191498-191648       c
            1841-1949           AC131741.4         189225-189333       c
            1950-2169           AC131741.4         188191-188410       c
            2170-2354           AC131741.4         187730-187914       c
            2355-2450           AC131741.4         187516-187611       c
            2451-2533           AC131741.4         184486-184568       c
            2534-2744           AC131741.4         183600-183810       c
            2745-2845           AC131741.4         183223-183323       c
            2846-3196           AC131741.4         179895-180245       c
            3197-3436           AC131741.4         179329-179568       c
            3437-4306           AC131741.4         177791-178660       c
            4307-4404           AC131741.4         177570-177667       c
            4405-4632           AC131741.4         176240-176467       c
            4633-4799           AC131741.4         171606-171772       c
            4800-5274           AC131741.4         167980-168454       c
            5275-5492           AC131741.4         166302-166519       c
            5493-5636           AC131741.4         164906-165049       c
            5637-7139           AC131741.4         161401-162903       c
FEATURES             Location/Qualifiers
     source          1..7139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 35.02 cM"
     gene            1..7139
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:21872"
                     /db_xref="MGI:MGI:98759"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..5731
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /note="isoform 3 is encoded by transcript variant 3; tight
                     junction protein ZO-1; zona occludens protein 1; zonula
                     occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein 1 isoform 3"
                     /protein_id="NP_001404295.1"
                     /db_xref="GeneID:21872"
                     /db_xref="MGI:MGI:98759"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPEPVSDNEDDSYDEEVHDPRAGRGALANRRSEKSWARDRS
                     ASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSGRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAISTPVKHVDDHPPKAVEEVTVEKNEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGALPNSAHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKPASQQKAEASSPVPYLSPETTPASSASAVNHNVSVTNVSLEEPAPAPPTSHASQPG
                     CLGAPSAEAAHVVLRGEGPPLPPHADPAKVYRKEPYSEEMMRQNHILKQPALGHPGQR
                     PDKEPNLAYEPQLPYIEKQASRDLEQPSYRYEVSSYTDQFSRNYDHRLRFEDRIPTYE
                     DQWSYYDDKQPYQPRPFENQHPRDLDSRQHPEEASERGYFQRFEEPAPLSYDSRTRYE
                     QLPRTSTLRHEEQPAPAYEVHNRYRPEAQPYSSTGPKSSEPKQYFDQYPRSYEQVPPP
                     GFTSKTGHYEPLHGAAVVPPLIPSSQQKPEVLPSATKPQPPPPTLTEEEEDPAMKPQS
                     VLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPGASLAGPKPVPQSQFSEHDK
                     TLYRLPEPQKPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPSAHLPAGH
                     HSEPAKPVHSQSQPNFSSYSSKGKPETDAVDRSFSEKRYDPAQATPPPPPLPSQYSQP
                     APPLSSSSLHIHSKGAQGEGNSVSLDFQNSYMSKPDPPPSQSKPATFRPPTREDPPQT
                     FYPQKSFPDKAPVNGAEQTQKTITPVYNRFTPKPYTSSARPFERKFESPKFNHNLLPS
                     ETVHKPELSSKTPTSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQMNNISTMPKA
                     VPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEI
                     YFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFA
                     LKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3436
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..4306
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4404
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4632
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4799
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..5274
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5492
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5636
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     exon            5637..7139
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7119..7124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /note="hexamer: AATAAA"
     polyA_site      7139
                     /gene="Tjp1"
                     /gene_synonym="ZO1"
                     /note="major polyA site"
ORIGIN      
        1 agtggcccgg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggccgcgcgt tccggggaag ttacgtgcgg gagcaggctt
      121 tggaggagac gcccgagggt gtaggggaca gccggaggcc cgggtactgc ggagcggcga
      181 gccggcggag ggcggcggag gccgagcagg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctc gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatctct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ttaaaaggag ggccagctga aggacagcta caggaaaatg accgagttgc
      661 aatggttaac ggagtttcaa tggataacgt tgaacatgct tttgctgttc agcagctaag
      721 gaagagtggg aaaaacgcaa aaattactat ccgaaggaag aagaaagttc agatccctgt
      781 aagtcaccca gatcctgagc cggtgtctga taatgaagac gatagttatg acgaagaagt
      841 gcatgaccca agagctggcc gcggtgcttt agcgaacaga aggagcgaga agagctgggc
      901 aagggatagg agtgcaagca gggagaggag cctgtcccct cgctcggaca ggcggtccgt
      961 ggcctccagt cagcccgcaa agcccaccaa ggtcacactg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ttgaagataa atggtactgt
     1141 gacagaaaat atgtcattga cagatgcaaa aacactgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttactg aacgtccctg acctttcgga
     1261 tagtatccat tctgctaatg cctcggaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcaggtcgct cgcatgacag gccaccccgc cgcagccagt cacgatctcc
     1381 tgaccaacgt tcagagccct ccgatcattc cacgcagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgaat gtctaaacct ggggccatct caactcctgt
     1501 aaaacatgta gacgatcatc cacccaaagc agtggaagaa gttacagttg agaaaaatga
     1561 gaagcagacg cccactcttc cagaaccgaa acctgtgtat gctcaagttg gacaaccaga
     1621 tgtggattta cccgtcagcc cttctgatgg tgctctgcct aattcagctc atgaagacgg
     1681 gatacttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agggaagagg ccgtcctttt cctccttgac ctccctaaag gtgaagaagt
     1921 gaccatactg gctcagaaga agaaggacgt ttatcgccgc attgtagaat cagatgtagg
     1981 agattcattc tatattagaa cgcattttga atatgaaaaa gaatctcctt acggacttag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggatacttta tacaatggaa agctgggctc
     2101 ttggcttgcc attcgaattg gcaaaaatca taaggaggta gaacgaggca tcatccctaa
     2161 taagaacaga gctgaacagt tagccagtgt acagtacaca cttccaaaga cagcgggtgg
     2221 tgatcgggca gacttctgga ggtttcgagg tcttcgcagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacttgtcag ctcagccagt tcaaactaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccaa tagctgatgt
     2401 tgccagagaa aagttggcaa gagaggagcc agatatctat cagattgcaa aaagtgaacc
     2461 acgagatgct gggactgacc atcgtagctc tggcatcatt cgccttcata caataaagca
     2521 aatcatagat caggataaac atgctttatt agatgtaacg ccaaatgcgg ttgatcgtct
     2581 taattatgcg cagtggtatc caattgttgt gttccttaac cctgactcta agcaaggtgt
     2641 aaaaacaatg aggatgaggt tgtgtccgga gtctcggaaa agcgccagga agctatatga
     2701 acgctctcat aagcttcgta agaacaatca ccatctcttc acaactacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt acggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgacgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactccc ccggagtctg ccattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc agacataccc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gccagcctct caacagaaag cagaagcctc atctccagtc ccttaccttt cgcctgaaac
     3241 aaccccagca tcatcagcct ctgcagttaa tcataatgtc agtgtaacta atgtcagcct
     3301 ggaggagcct gccccagccc ctcccacctc gcacgcatca cagcctggtt gtttaggagc
     3361 accaagtgct gaggcagctc acgtagtgct cagaggtgaa ggaccaccat tgccgccgca
     3421 tgcagaccca gcaaaggtgt acaggaagga gccgtattct gaagaaatga tgagacaaaa
     3481 ccatatttta aaacaaccag ctcttggtca cccagggcag aggccagata aagagccaaa
     3541 tctagcctat gaaccccaac ttccatatat agaaaaacaa gccagcagag accttgagca
     3601 gccgtcatac aggtatgagg tctcaagcta cacagaccag ttttctcgga actatgacca
     3661 tcgcctacgg tttgaagatc gaatccctac ctatgaagac cagtggtcat attatgatga
     3721 caaacagccc taccaacctc ggccttttga gaatcagcat ccccgagacc tggactccag
     3781 acaacatccc gaagaggctt cagaacgagg ttatttccag cgttttgaag agccagcccc
     3841 tctgtcgtac gacagtagaa cacgctatga gcagctgcct cgaacctcta ctctacgaca
     3901 tgaagagcag ccagcccctg catatgaggt gcacaacagg tacaggccag aggcacagcc
     3961 ctattcttca acaggcccta agtcatctga gcccaagcag tactttgacc agtacccgcg
     4021 aagttatgag caagttccac caccaggctt tacctccaaa acaggccatt acgagcctct
     4081 ccatggtgct gcagttgtcc ctcctctgat accttcctct caacaaaagc cagaagtcct
     4141 gccctcggct accaaaccac agcctccacc cccaacccta actgaggagg aggaggatcc
     4201 agcaatgaaa ccacagtctg tgctcaccag agtcaaaatg tttgaaaaca aaagatctgc
     4261 gtctttggag aacaagaaag atgtgaatga cactgccagc tttaagcctc cggaagtagc
     4321 atctaaacct ccaggtgctt ctcttgctgg ccctaaacct gtccctcaga gtcagtttag
     4381 tgagcacgac aaaacgctct acaggctccc agagcctcag aaacctcaag tgaagccacc
     4441 cgaagatatt gttcgatcaa atcattacga ccctgaagag gatgaagaat attaccggaa
     4501 acagctctcc tactttgacc gaagaagttt tgagagcaag ccttctgcac atcttcctgc
     4561 tggccatcac tcagagcctg ctaagccagt ccattctcag agccagccca acttctctag
     4621 ttactcttca aagggaaaac ccgaaactga tgctgtggat agatcattca gtgagaaacg
     4681 ttatgatcca gcccaggcca cgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4741 agctccacct ctgtccagct cttctctcca catacattcc aagggcgccc agggtgaagg
     4801 caactcagta tcattggatt ttcagaactc atatatgtcc aaaccagacc cacccccatc
     4861 tcagagtaaa ccagcaactt tcagaccacc aactcgagaa gacccccctc agactttcta
     4921 tccgcagaaa agtttcccag acaaagctcc agttaacgga gctgagcaga ctcagaaaac
     4981 catcactccg gtgtacaatc gattcacacc aaagccgtac acaagttctg cccggccatt
     5041 tgaacgcaaa tttgaaagtc cgaagttcaa ccataatctt ctgccaagtg aaactgtaca
     5101 taaacctgaa ttgtcttcaa aaactcccac ttccccaaaa actcttatga aagctcatag
     5161 ttcaacacag cctccagagt ttgacagtgg agttgaaact ttctctgttc acacagataa
     5221 gcctaaatat caaatgaata atatcagcac catgcctaaa gctgtccctg tgagtccttc
     5281 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag ctcgtggcat
     5341 ttttaacagc aatggtggtg tgttgagttc catagaaacc ggtgttagta taattatccc
     5401 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5461 tagcattctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5521 gtgtgggccc catggcctca agttcctgaa gcccgtggag ctacgcttgc cacactgtgc
     5581 gtccatgact cctgacggtt ggtcttttgc tctaaaatca tccgactcct cgtcgggtga
     5641 ccctaaaacc tggcaaaaca agtgtcttcc tggagatccg aattaccttg ttggagccaa
     5701 ctgtgtttct gtcctgattg accactttta attcttagtg tataggaact ggactaagca
     5761 atgtgaacgt ggattgaact tactaaatct aaatggaacc actctaatga gtattatatt
     5821 ttcttagaat ttatactgca attggtagta ttaagcattt gttggaactg atgaaggtta
     5881 gcgagcatgc ccctgagcca cggtcagaaa acatgctaca agctatgtgt tattgagtga
     5941 agaactgtca ggcattggct agaggttcaa agatattttt gctttgtaat gatttttgta
     6001 cttttttatg gtcactgctt aacttcacat actgatttcc gttaaaaata ccagccagta
     6061 aatgggggtg catttgagtt ctgttctttc caaagtacac tcaaagttta ttatggcctt
     6121 ggcctagcat acacatttta ttttattatg catgaggtaa tgtgcacaca ttttttacaa
     6181 atgcacctgg aatatataac cagtatagtg gatttaacag aaatgtacag cagggggatt
     6241 tataacttgg ggagggaggg tcaaatgaag acaattactt attgtatatg aaaacacatt
     6301 tcttttaggg aaggacacca aagcatgtga gcccggttca tggcctctga atctataaat
     6361 taacatatca ccacagacat gtaaccagca ggaatgcctt accctagtgg gtttaattct
     6421 tccatcattt cgctgtgtat tactaagttt ttatgagttc tgtgcatatc tagatactgt
     6481 accatggaaa agactgagta gattgtggac ttgatggttt cagaaatgtg caaattacct
     6541 ggaagaaaat aatggtgtga cttaaaatat ttttttgaca gggggagtgg cagtcttctg
     6601 ttctttgggc tgtgcatctg agatgtttga tgctttcagg acgcatgtac ataatgcgtg
     6661 cataccactt ttgttcttgg tttgtaaatt aacttttata aactttacct ttttatacat
     6721 aaacagaacc aagtttctaa ggctaccttt gtattctctc ctgtacctct tgagccttga
     6781 actttgacct ctgcagcaat aaagcagcat ttctacacat acaaggtcat ttttctaaga
     6841 aaaagaatgc acagagttgt tacattttta agtgctgcat ttaaaagata cagttactct
     6901 agtttgatta aattcttgca aagtatccct tctgtaaaat ttgtgataca atactgtgcc
     6961 ctaaagtgta tttttttact aatagacagt ttattatggc acatcagcac gatttctgtt
     7021 tagataatac accactacat tctgttaata atcagtaggt gtgaaaggat ttcttttgtg
     7081 gttattaaaa aaaaatctca aatttctaaa tctgcaagaa taaaactttt taaaataca
//
