LOCUS       NM_054096               4741 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus toll-interleukin 1 receptor (TIR) domain-containing
            adaptor protein (Tirap), transcript variant 2, mRNA.
ACCESSION   NM_054096
VERSION     NM_054096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Xiao,Q., Liu,L., Qian,W., Kang,T., Ying,R. and Nie,J.
  TITLE     CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2,
            Boosts Coxsackievirus B3-Induced Myocardial Inflammation via
            Interacting with TIRAP
  JOURNAL   J Cardiovasc Transl Res 17 (3), 540-553 (2024)
   PUBMED   38229002
  REMARK    GeneRIF: CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader
            IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation
            via Interacting with TIRAP.
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Belhaouane,I., Pochet,A., Chatagnon,J., Hoffmann,E., Queval,C.J.,
            Deboosere,N., Boidin-Wichlacz,C., Majlessi,L., Sencio,V.,
            Heumel,S., Vandeputte,A., Werkmeister,E., Fievez,L., Bureau,F.,
            Rouille,Y., Trottein,F., Chamaillard,M., Brodin,P. and Machelart,A.
  TITLE     Tirap controls Mycobacterium tuberculosis phagosomal acidification
  JOURNAL   PLoS Pathog 19 (3), e1011192 (2023)
   PUBMED   36888688
  REMARK    GeneRIF: Tirap controls Mycobacterium tuberculosis phagosomal
            acidification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Chen,Y., Zhou,P., Deng,Y., Cai,X., Sun,M., Sun,Y. and Wu,D.
  TITLE     ALKBH5-mediated m6 A demethylation of TIRAP mRNA promotes
            radiation-induced liver fibrosis and decreases radiosensitivity of
            hepatocellular carcinoma
  JOURNAL   Clin Transl Med 13 (2), e1198 (2023)
   PUBMED   36792369
  REMARK    GeneRIF: ALKBH5-mediated m[6] A demethylation of TIRAP mRNA
            promotes radiation-induced liver fibrosis and decreases
            radiosensitivity of hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Gopal,A., Ibrahim,R., Fuller,M., Umlandt,P., Parker,J., Tran,J.,
            Chang,L., Wegrzyn-Woltosz,J., Lam,J., Li,J., Lu,M. and Karsan,A.
  TITLE     TIRAP drives myelosuppression through an Ifngamma-Hmgb1 axis that
            disrupts the endothelial niche in mice
  JOURNAL   J Exp Med 219 (3) (2022)
   PUBMED   35089323
  REMARK    GeneRIF: TIRAP drives myelosuppression through an Ifngamma-Hmgb1
            axis that disrupts the endothelial niche in mice.
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Evans,S., Weinheimer,C.J., Kovacs,A., Williams,J.W., Randolph,G.J.,
            Jiang,W., Barger,P.M. and Mann,D.L.
  TITLE     Ischemia reperfusion injury provokes adverse left ventricular
            remodeling in dysferlin-deficient hearts through a pathway that
            involves TIRAP dependent signaling
  JOURNAL   Sci Rep 10 (1), 14129 (2020)
   PUBMED   32839504
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Schilling,D., Thomas,K., Nixdorff,K., Vogel,S.N. and Fenton,M.J.
  TITLE     Toll-like receptor 4 and Toll-IL-1 receptor domain-containing
            adapter protein (TIRAP)/myeloid differentiation protein 88
            adapter-like (Mal) contribute to maximal IL-6 expression in
            macrophages
  JOURNAL   J Immunol 169 (10), 5874-5880 (2002)
   PUBMED   12421970
  REMARK    GeneRIF: The induction of IL-6 gene expression in macrophages via
            Tlr4 is TIRAP-dependent.
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   O'Neill,L.A.
  TITLE     Toll-like receptor signal transduction and the tailoring of innate
            immunity: a role for Mal?
  JOURNAL   Trends Immunol 23 (6), 296-300 (2002)
   PUBMED   12072368
  REMARK    GeneRIF: The adapter MyD88-adapter-like (Mal) is recruited
            specifically by TLR-4. The set of genes being induced may be
            tailored for the subsequent elimination of the pathogen being
            recognized, due to differences in signal transduction pathways
            activated by TLRs.
            Review article
REFERENCE   8  (bases 1 to 4741)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   9  (bases 1 to 4741)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   10 (bases 1 to 4741)
  AUTHORS   Horng,T., Barton,G.M. and Medzhitov,R.
  TITLE     TIRAP: an adapter molecule in the Toll signaling pathway
  JOURNAL   Nat Immunol 2 (9), 835-841 (2001)
   PUBMED   11526399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740695.1, AF378130.1, AK168494.1, AK081514.1 and BY507516.1.
            
            On Apr 29, 2010 this sequence version replaced NM_054096.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378130.1, AK168494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                BY740695.1         7-97
            92-704              AF378130.1         1-613
            705-2347            AK168494.1         633-2275
            2348-3331           AK081514.1         129-1112
            3332-4735           AK081514.1         1114-2517
            4736-4741           BY507516.1         395-400
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 19.99 cM"
     gene            1..4741
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="toll-interleukin 1 receptor (TIR) domain-containing
                     adaptor protein"
                     /db_xref="GeneID:117149"
                     /db_xref="MGI:MGI:2152213"
     exon            1..109
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            110..218
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            219..341
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            342..403
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            404..562
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1221
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="Toll-like receptor 4 adaptor protein; TIR
                     domain-containing adapter protein; adaptor protein Wyatt;
                     myD88 adapter-like protein"
                     /codon_start=1
                     /product="toll/interleukin-1 receptor domain-containing
                     adapter protein"
                     /protein_id="NP_473437.2"
                     /db_xref="CCDS:CCDS40575.2"
                     /db_xref="GeneID:117149"
                     /db_xref="MGI:MGI:2152213"
                     /translation="MVSLEACTMASSSSVPASSTPSKKPRDKIADWFRQALLKKPKKM
                     PISQESHLYDGSQTATQDGLSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHVDS
                     SSSSSGRWSKDYDVCVCHSEEDLEAAQELVSYLEGSQASLRCFLQLRDAAPGGAIVSE
                     LCQALSRSHCRVLLITPGFLRDPWCKYQMLQALTEAPASEGCTIPLLSGLSRAAYPPE
                     LRFMYYVDGRGKDGGFYQVKEAVIHYLETLS"
     exon            563..1201
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..4741
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4713..4718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="hexamer: ATTAAA"
     polyA_site      4733
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="major polyA site"
ORIGIN      
        1 caggagagtg gctagtgcgg gcgggagggc cgtggccgag gagcttccgg gagccggggc
       61 gcgggcactt cccggacgag tctgcaaccc gcagcgtgga gccgcgtaga ctttaagaaa
      121 caatatcaac cagcataccg aaacacagat cccgagtcct accaagccac ttttcacagg
      181 ctttcttgtg taacctgcat ccagaacagt aagtctatat ggagacacca agacctagga
      241 agactgttga aggccatggt cagcaggagg tgcaaaccca tgcaatctac ctggaatcgg
      301 ctgtcttcac cattttatga ctttgtttgc ctagctgacg gatctcaaat gccctcctgg
      361 ccaggtgaag cggagaacaa tcgctctacc aagttcatac cttgatggct gatccatgaa
      421 gttcagactg gatctcttct ctcccgccgt tcccccaatg cctgctcttt catggttagt
      481 ttggaggcct gcactatggc ttcatcctcc tccgtcccag cctcctccac tccgtccaag
      541 aagcctcgag acaagatagc tgactggttc aggcaggctc tgttgaagaa gcccaagaag
      601 atgccgatct cccaggaaag ccacctctat gatggttcac agacagccac acaggatggt
      661 ctctcaccct cgagctgcag ctcacccccg agtcacagtt caccggagag ccgtagctca
      721 ccctcgagct gcagttcagg aatgtcacct acctcgccac caacacacgt ggacagcagc
      781 agcagcagca gtggccgctg gagcaaagac tacgatgtct gcgtgtgcca cagtgaggag
      841 gacttggagg cggcccagga gctggtctcc tacttggagg gtagccaggc cagtctacgc
      901 tgcttcctgc agcttcggga tgcagccccg ggtggcgcca ttgtttcgga gctatgccag
      961 gcactgagtc gtagtcactg ccgtgtgctg ctcatcactc caggcttcct tcgggacccc
     1021 tggtgcaagt accagatgct gcaggccctg acggaggccc cggcgtcgga gggttgcacc
     1081 atacccctgc tgtccggcct gtccagagcc gcctatccgc cggaactccg attcatgtac
     1141 tatgtggatg gcagaggcaa ggacggaggc ttttaccaag tcaaggaggc tgttatacac
     1201 tatctggaga cactaagctg acacttgggc tttcataaga aaagctggga atagctcaca
     1261 gcagtcatta atccagtata tacagcagag ccagagccag ctgcaccctg tttatgacac
     1321 aggatcagat cgtcaccagc ttccattatc gtgggcccac aagatggcca ggctgaagat
     1381 gggaaccacc cccgcaagga gaccaggaag aagatgggga ctccccaaga agggcaggag
     1441 gaagccaggg actcccccag gaagacaacg aggaagtcag aaattcgagt tgtcaaggga
     1501 ctgtgctatc gggaaggtca gcagtgtccc ctctgcgctg aactggatag gaagctgata
     1561 catggctgtc ttcttcctct ggcatcaggc acgggggaaa tggataccac tcctcaagag
     1621 gggtgaaccc gattgatgag ccagaagttg cctagggaag ctgagaagag gtggcaagta
     1681 tccagtcctt cacacacaca cacactactg aaactcttcc ccagagatgt caactcacct
     1741 cacaaaactg gaagacacgt tcatccccat actgaatttc accttttgaa aaaaaatgtc
     1801 attaaaaatg caccccgagg ggctggggag acagtggttc agcggttaag aactcttgtt
     1861 gcttttccag aggatccagg ttcaattccc aggatccaca tggtgactcc caaccttatc
     1921 tataactctg cttccagggg atctgatgtc ttctctgacc aagacctcct tgagcaccag
     1981 gtacacacgt gaacacctcc atagatgcag gcaaaacaat catacacata aagaaatctt
     2041 cctttttaca tcagaagtgc aaacctagga ctctagatgg agtccgtggt aggcttgctt
     2101 agcatacctg agggcttgga ttctacctcc agcaccacca aaacaaagga gaaaacacaa
     2161 acctggcagc tgctctgtat ccagaaacag gtaagaagaa ggaaagccag ggtgagccag
     2221 gcggtggtgg cacacgcctt taatcccagc actcgggagg cattggcagg cggatttctg
     2281 agttcgaggc cagcctggtc tacagagttc caggacagcc agggctacac agagaaaccc
     2341 tgtctcgaaa aaccaaaaaa aaaaaaaaaa aaaaaaaaaa gccaagaaag ccagggtgtg
     2401 gctccttcac ctggatcaaa gcccacagat catgtgaccc aggggcctcc tcagacatct
     2461 gaaagagccc aagagcccat gcttcaagag agcctgtgct tcacggcatc tggctttgtg
     2521 ttgaactgtg aggaaccggt tctcaatcta gcaccagagt atatccccag ggagagacaa
     2581 ggggccacct gtgttcgaat aagaacagaa acatggccag ctgaatgtcc ttgtctcccc
     2641 tggtatgtac cttgagcctc ttccttttga catatctttt tactgaaaaa aaattttttt
     2701 aattatgttt tctttgttac atacaaagta tttaaaggat actataccat actcacatac
     2761 ctaccaccta acttaagaaa accttattac caacactcat gtttcctttg tgttctgact
     2821 ttcagcccct tcaagtttcc taacaaaaat aaccaacatt ctgaatcttg aattattttg
     2881 aagtgtctat atgtgtgcac cctagaaaca ttatttgatt ttatgacttt atcttctatg
     2941 cagattgcat cacaatgtgc atttcctttg tttgacatgt ttacaaggtg tgtcgccgtt
     3001 gctgtgtcac tcgcggattt tcttttgttt gtgtcggtca gcagttctcc accctttacg
     3061 gtggaatgac cctttcacaa gggcgcatgt cagatagcct ccatatcaga tatttacatt
     3121 aagattcata acagtagggg gctggcaaga tggttcagcg ggtaagaaca ctgactgctt
     3181 ttccaaaggt cctgagttca aataccagca accacataca tggtggctca caaccaccca
     3241 taatgagatc tgacgccctc ttctggtgca tttgaagtca gctacagtgt acttatgtgt
     3301 aataataaat aaatctttgg gccggagcga gcagggactg agtgagcggg gctgaccaga
     3361 gtgagcagag gtcctacaat tcaatttcca tcaagaaggc tcacaaccat ctgtacagct
     3421 acagtgtact catatacata aaataaataa atctttaaaa aattcataac tagcagaatt
     3481 acagttatga agtatcaatg gaagtaactt tatggttggg ggtcaccaca tgaggatctg
     3541 tactaaaggg tcgcagtatt aggaaggttg agaaccactg ctctaagatc accttaaagc
     3601 aaattccagg ggcttcctca ctaaatttct agttacaaac ctctaaatca tgagtttttt
     3661 tttttaagtg tgagcataat atcttttaaa gctacgtttt tatcataaca taaaatacta
     3721 cccatgaagc tgtcatcagt gttttctgtc ttacaaaggt cttcctgtgt tagtccacat
     3781 tttcttctac atttaatcct gaaaagaagt tgatcttatt ttctgtcaca gtgtttctag
     3841 tcacatctag acctgtgctc cacttggggt tcttgctgtc tgttgatttt tttaaaaatg
     3901 gtctgtagcc cagactgacc ccaaacttga cgtccttctc attcagcttg ccggatgctg
     3961 ggctttaggc attataagct atcgtgcctg gctgattatc aagtcagaaa tctaattctt
     4021 ttctctcaat ttctactagg tactcagtag tccagcctat cctcactggt atctgtttgt
     4081 tattttttct gtttgtttgt gataggatct cactatgtat ccctagctgt ccaagaattc
     4141 actatgcaaa ccagactggt cacaaactca gagatttgtc tgcctctgcc accccagcac
     4201 agagctgggg ttagaggtgg gcaccagcgc agccatctac tgctgtcatg tgtacgtgtc
     4261 tattgctggg tctctagtct ctttcaagta taccctgtgt tagtgccaag gcatctttta
     4321 taaagcttta atgccctgtg agccagttct ccccactctt cttgttcatt gaaatcactg
     4381 tcgtaattct tactttttca agttgttttt attcatacac tgtcaggttt caggagaaag
     4441 tatattttta ttggagttgt attcagttta ttgatttgac tagagaaaag aggtactttc
     4501 atgataaagt cttcctatcc ataacgggac atcaccactt atgtccttaa atgtatttca
     4561 ataaatttgt ctaatacttt tcatgttgtt tcatctttta atagatttat tcttatttac
     4621 ttcatatttt ggctgctact ataaagagtt taaaattata tatacatatg tctatcagtg
     4681 gcataaaaga ttatttaata tgttggccta ccattaaata gtgtgctgaa ttatctattg
     4741 t
//
