LOCUS       NM_001177845            4749 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus toll-interleukin 1 receptor (TIR) domain-containing
            adaptor protein (Tirap), transcript variant 1, mRNA.
ACCESSION   NM_001177845
VERSION     NM_001177845.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4749)
  AUTHORS   Xiao,Q., Liu,L., Qian,W., Kang,T., Ying,R. and Nie,J.
  TITLE     CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2,
            Boosts Coxsackievirus B3-Induced Myocardial Inflammation via
            Interacting with TIRAP
  JOURNAL   J Cardiovasc Transl Res 17 (3), 540-553 (2024)
   PUBMED   38229002
  REMARK    GeneRIF: CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader
            IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation
            via Interacting with TIRAP.
REFERENCE   2  (bases 1 to 4749)
  AUTHORS   Belhaouane,I., Pochet,A., Chatagnon,J., Hoffmann,E., Queval,C.J.,
            Deboosere,N., Boidin-Wichlacz,C., Majlessi,L., Sencio,V.,
            Heumel,S., Vandeputte,A., Werkmeister,E., Fievez,L., Bureau,F.,
            Rouille,Y., Trottein,F., Chamaillard,M., Brodin,P. and Machelart,A.
  TITLE     Tirap controls Mycobacterium tuberculosis phagosomal acidification
  JOURNAL   PLoS Pathog 19 (3), e1011192 (2023)
   PUBMED   36888688
  REMARK    GeneRIF: Tirap controls Mycobacterium tuberculosis phagosomal
            acidification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4749)
  AUTHORS   Chen,Y., Zhou,P., Deng,Y., Cai,X., Sun,M., Sun,Y. and Wu,D.
  TITLE     ALKBH5-mediated m6 A demethylation of TIRAP mRNA promotes
            radiation-induced liver fibrosis and decreases radiosensitivity of
            hepatocellular carcinoma
  JOURNAL   Clin Transl Med 13 (2), e1198 (2023)
   PUBMED   36792369
  REMARK    GeneRIF: ALKBH5-mediated m[6] A demethylation of TIRAP mRNA
            promotes radiation-induced liver fibrosis and decreases
            radiosensitivity of hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4749)
  AUTHORS   Gopal,A., Ibrahim,R., Fuller,M., Umlandt,P., Parker,J., Tran,J.,
            Chang,L., Wegrzyn-Woltosz,J., Lam,J., Li,J., Lu,M. and Karsan,A.
  TITLE     TIRAP drives myelosuppression through an Ifngamma-Hmgb1 axis that
            disrupts the endothelial niche in mice
  JOURNAL   J Exp Med 219 (3) (2022)
   PUBMED   35089323
  REMARK    GeneRIF: TIRAP drives myelosuppression through an Ifngamma-Hmgb1
            axis that disrupts the endothelial niche in mice.
REFERENCE   5  (bases 1 to 4749)
  AUTHORS   Evans,S., Weinheimer,C.J., Kovacs,A., Williams,J.W., Randolph,G.J.,
            Jiang,W., Barger,P.M. and Mann,D.L.
  TITLE     Ischemia reperfusion injury provokes adverse left ventricular
            remodeling in dysferlin-deficient hearts through a pathway that
            involves TIRAP dependent signaling
  JOURNAL   Sci Rep 10 (1), 14129 (2020)
   PUBMED   32839504
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4749)
  AUTHORS   Schilling,D., Thomas,K., Nixdorff,K., Vogel,S.N. and Fenton,M.J.
  TITLE     Toll-like receptor 4 and Toll-IL-1 receptor domain-containing
            adapter protein (TIRAP)/myeloid differentiation protein 88
            adapter-like (Mal) contribute to maximal IL-6 expression in
            macrophages
  JOURNAL   J Immunol 169 (10), 5874-5880 (2002)
   PUBMED   12421970
  REMARK    GeneRIF: The induction of IL-6 gene expression in macrophages via
            Tlr4 is TIRAP-dependent.
REFERENCE   7  (bases 1 to 4749)
  AUTHORS   O'Neill,L.A.
  TITLE     Toll-like receptor signal transduction and the tailoring of innate
            immunity: a role for Mal?
  JOURNAL   Trends Immunol 23 (6), 296-300 (2002)
   PUBMED   12072368
  REMARK    GeneRIF: The adapter MyD88-adapter-like (Mal) is recruited
            specifically by TLR-4. The set of genes being induced may be
            tailored for the subsequent elimination of the pathogen being
            recognized, due to differences in signal transduction pathways
            activated by TLRs.
            Review article
REFERENCE   8  (bases 1 to 4749)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   9  (bases 1 to 4749)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   10 (bases 1 to 4749)
  AUTHORS   Horng,T., Barton,G.M. and Medzhitov,R.
  TITLE     TIRAP: an adapter molecule in the Toll signaling pathway
  JOURNAL   Nat Immunol 2 (9), 835-841 (2001)
   PUBMED   11526399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080135.1, AK168494.1, AK081514.1 and BY507516.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080135.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1843              AK080135.1         2-1844
            1844-2355           AK168494.1         1764-2275
            2356-3339           AK081514.1         129-1112
            3340-4743           AK081514.1         1114-2517
            4744-4749           BY507516.1         395-400
FEATURES             Location/Qualifiers
     source          1..4749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 19.99 cM"
     gene            1..4749
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="toll-interleukin 1 receptor (TIR) domain-containing
                     adaptor protein"
                     /db_xref="GeneID:117149"
                     /db_xref="MGI:MGI:2152213"
     exon            1..127
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            128..226
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            227..349
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            350..411
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            412..570
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1229
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="Toll-like receptor 4 adaptor protein; TIR
                     domain-containing adapter protein; adaptor protein Wyatt;
                     myD88 adapter-like protein"
                     /codon_start=1
                     /product="toll/interleukin-1 receptor domain-containing
                     adapter protein"
                     /protein_id="NP_001171316.1"
                     /db_xref="CCDS:CCDS40575.2"
                     /db_xref="GeneID:117149"
                     /db_xref="MGI:MGI:2152213"
                     /translation="MVSLEACTMASSSSVPASSTPSKKPRDKIADWFRQALLKKPKKM
                     PISQESHLYDGSQTATQDGLSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHVDS
                     SSSSSGRWSKDYDVCVCHSEEDLEAAQELVSYLEGSQASLRCFLQLRDAAPGGAIVSE
                     LCQALSRSHCRVLLITPGFLRDPWCKYQMLQALTEAPASEGCTIPLLSGLSRAAYPPE
                     LRFMYYVDGRGKDGGFYQVKEAVIHYLETLS"
     exon            571..1209
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..4749
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="hexamer: ATTAAA"
     polyA_site      4741
                     /gene="Tirap"
                     /gene_synonym="C130027E04Rik; Mal; Tlr4ap; Wyatt"
                     /note="major polyA site"
ORIGIN      
        1 aaccttaatg ggacccatat cccagtaaaa gaacggacct cccaggggct agccggcttc
       61 tttgtccact taacctacct tacttaaggg gatgaaagtc tcattttccc caaccgtgcg
      121 aaagaagact ttaagaaaca atatcaacca gcataccgaa acacagatcc cgagtcctac
      181 caagccactt ttcacaggct ttcttgtgta acctgcatcc agaacaatgg agacaccaag
      241 acctaggaag actgttgaag gccatggtca gcaggaggtg caaacccatg caatctacct
      301 ggaatcggct gtcttcacca ttttatgact ttgtttgcct agctgacgga tctcaaatgc
      361 cctcctggcc aggtgaagcg gagaacaatc gctctaccaa gttcatacct tgatggctga
      421 tccatgaagt tcagactgga tctcttctct cccgccgttc ccccaatgcc tgctctttca
      481 tggttagttt ggaggcctgc actatggctt catcctcctc cgtcccagcc tcctccactc
      541 cgtccaagaa gcctcgagac aagatagctg actggttcag gcaggctctg ttgaagaagc
      601 ccaagaagat gccgatctcc caggaaagcc acctctatga tggttcacag acagccacac
      661 aggatggtct ctcaccctcg agctgcagct cacccccgag tcacagttca ccggagagcc
      721 gtagctcacc ctcgagctgc agttcaggaa tgtcacctac ctcgccacca acacacgtgg
      781 acagcagcag cagcagcagt ggccgctgga gcaaagacta cgatgtctgc gtgtgccaca
      841 gtgaggagga cttggaggcg gcccaggagc tggtctccta cttggagggt agccaggcca
      901 gtctacgctg cttcctgcag cttcgggatg cagccccggg tggcgccatt gtttcggagc
      961 tatgccaggc actgagtcgt agtcactgcc gtgtgctgct catcactcca ggcttccttc
     1021 gggacccctg gtgcaagtac cagatgctgc aggccctgac ggaggccccg gcgtcggagg
     1081 gttgcaccat acccctgctg tccggcctgt ccagagccgc ctatccgccg gaactccgat
     1141 tcatgtacta tgtggatggc agaggcaagg acggaggctt ttaccaagtc aaggaggctg
     1201 ttatacacta tctggagaca ctaagctgac acttgggctt tcataagaaa agctgggaat
     1261 agctcacagc agtcattaat ccagtatata cagcagagcc agagccagct gcaccctgtt
     1321 tatgacacag gatcagatcg tcaccagctt ccattatcgt gggcccacaa gatggccagg
     1381 ctgaagatgg gaaccacccc cgcaaggaga ccaggaagaa gatggggact ccccaagaag
     1441 ggcaggagga agccagggac tcccccagga agacaacgag gaagtcagaa attcgagttg
     1501 tcaagggact gtgctatcgg gaaggtcagc agtgtcccct ctgcgctgaa ctggatagga
     1561 agctgataca tggctgtctt cttcctctgg catcaggcac gggggaaatg gataccactc
     1621 ctcaagaggg gtgaacccga ttgatgagcc agaagttgcc tagggaagct gagaagaggt
     1681 ggcaagtatc cagtccttca cacacacaca cactactgaa actcttcccc agagatgtca
     1741 actcacctca caaaactgga agacacgttc atccccatac tgaatttcac cttttgaaaa
     1801 aaaatgtcat taaaaatgca ccccgagggg ctggggagac agtggttcag cggttaagaa
     1861 ctcttgttgc ttttccagag gatccaggtt caattcccag gatccacatg gtgactccca
     1921 accttatcta taactctgct tccaggggat ctgatgtctt ctctgaccaa gacctccttg
     1981 agcaccaggt acacacgtga acacctccat agatgcaggc aaaacaatca tacacataaa
     2041 gaaatcttcc tttttacatc agaagtgcaa acctaggact ctagatggag tccgtggtag
     2101 gcttgcttag catacctgag ggcttggatt ctacctccag caccaccaaa acaaaggaga
     2161 aaacacaaac ctggcagctg ctctgtatcc agaaacaggt aagaagaagg aaagccaggg
     2221 tgagccaggc ggtggtggca cacgccttta atcccagcac tcgggaggca ttggcaggcg
     2281 gatttctgag ttcgaggcca gcctggtcta cagagttcca ggacagccag ggctacacag
     2341 agaaaccctg tctcgaaaaa ccaaaaaaaa aaaaaaaaaa aaaaaaaagc caagaaagcc
     2401 agggtgtggc tccttcacct ggatcaaagc ccacagatca tgtgacccag gggcctcctc
     2461 agacatctga aagagcccaa gagcccatgc ttcaagagag cctgtgcttc acggcatctg
     2521 gctttgtgtt gaactgtgag gaaccggttc tcaatctagc accagagtat atccccaggg
     2581 agagacaagg ggccacctgt gttcgaataa gaacagaaac atggccagct gaatgtcctt
     2641 gtctcccctg gtatgtacct tgagcctctt ccttttgaca tatcttttta ctgaaaaaaa
     2701 atttttttaa ttatgttttc tttgttacat acaaagtatt taaaggatac tataccatac
     2761 tcacatacct accacctaac ttaagaaaac cttattacca acactcatgt ttcctttgtg
     2821 ttctgacttt cagccccttc aagtttccta acaaaaataa ccaacattct gaatcttgaa
     2881 ttattttgaa gtgtctatat gtgtgcaccc tagaaacatt atttgatttt atgactttat
     2941 cttctatgca gattgcatca caatgtgcat ttcctttgtt tgacatgttt acaaggtgtg
     3001 tcgccgttgc tgtgtcactc gcggattttc ttttgtttgt gtcggtcagc agttctccac
     3061 cctttacggt ggaatgaccc tttcacaagg gcgcatgtca gatagcctcc atatcagata
     3121 tttacattaa gattcataac agtagggggc tggcaagatg gttcagcggg taagaacact
     3181 gactgctttt ccaaaggtcc tgagttcaaa taccagcaac cacatacatg gtggctcaca
     3241 accacccata atgagatctg acgccctctt ctggtgcatt tgaagtcagc tacagtgtac
     3301 ttatgtgtaa taataaataa atctttgggc cggagcgagc agggactgag tgagcggggc
     3361 tgaccagagt gagcagaggt cctacaattc aatttccatc aagaaggctc acaaccatct
     3421 gtacagctac agtgtactca tatacataaa ataaataaat ctttaaaaaa ttcataacta
     3481 gcagaattac agttatgaag tatcaatgga agtaacttta tggttggggg tcaccacatg
     3541 aggatctgta ctaaagggtc gcagtattag gaaggttgag aaccactgct ctaagatcac
     3601 cttaaagcaa attccagggg cttcctcact aaatttctag ttacaaacct ctaaatcatg
     3661 agtttttttt tttaagtgtg agcataatat cttttaaagc tacgttttta tcataacata
     3721 aaatactacc catgaagctg tcatcagtgt tttctgtctt acaaaggtct tcctgtgtta
     3781 gtccacattt tcttctacat ttaatcctga aaagaagttg atcttatttt ctgtcacagt
     3841 gtttctagtc acatctagac ctgtgctcca cttggggttc ttgctgtctg ttgatttttt
     3901 taaaaatggt ctgtagccca gactgacccc aaacttgacg tccttctcat tcagcttgcc
     3961 ggatgctggg ctttaggcat tataagctat cgtgcctggc tgattatcaa gtcagaaatc
     4021 taattctttt ctctcaattt ctactaggta ctcagtagtc cagcctatcc tcactggtat
     4081 ctgtttgtta ttttttctgt ttgtttgtga taggatctca ctatgtatcc ctagctgtcc
     4141 aagaattcac tatgcaaacc agactggtca caaactcaga gatttgtctg cctctgccac
     4201 cccagcacag agctggggtt agaggtgggc accagcgcag ccatctactg ctgtcatgtg
     4261 tacgtgtcta ttgctgggtc tctagtctct ttcaagtata ccctgtgtta gtgccaaggc
     4321 atcttttata aagctttaat gccctgtgag ccagttctcc ccactcttct tgttcattga
     4381 aatcactgtc gtaattctta ctttttcaag ttgtttttat tcatacactg tcaggtttca
     4441 ggagaaagta tatttttatt ggagttgtat tcagtttatt gatttgacta gagaaaagag
     4501 gtactttcat gataaagtct tcctatccat aacgggacat caccacttat gtccttaaat
     4561 gtatttcaat aaatttgtct aatacttttc atgttgtttc atcttttaat agatttattc
     4621 ttatttactt catattttgg ctgctactat aaagagttta aaattatata tacatatgtc
     4681 tatcagtggc ataaaagatt atttaatatg ttggcctacc attaaatagt gtgctgaatt
     4741 atctattgt
//
