LOCUS       NM_145513               4395 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TIP41, TOR signalling pathway regulator-like (S.
            cerevisiae) (Tiprl), transcript variant 1, mRNA.
ACCESSION   NM_145513
VERSION     NM_145513.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Wu,C.G., Zheng,A., Jiang,L., Rowse,M., Stanevich,V., Chen,H.,
            Li,Y., Satyshur,K.A., Johnson,B., Gu,T.J., Liu,Z. and Xing,Y.
  TITLE     Methylation-regulated decommissioning of multimeric PP2A complexes
  JOURNAL   Nat Commun 8 (1), 2272 (2017)
   PUBMED   29273778
  REMARK    GeneRIF: TIPRL (TOR signaling pathway regulator) makes highly
            integrative multibranching contacts with the PP2A catalytic
            subunit, selective for the unmethylated tail and
            perturbing/inactivating the phosphatase active site.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Rosales,K.R., Reid,M.A., Yang,Y., Tran,T.Q., Wang,W.I., Lowman,X.,
            Pan,M. and Kong,M.
  TITLE     TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX
            Phosphorylation in the DNA Damage Response
  JOURNAL   PLoS One 10 (12), e0145938 (2015)
   PUBMED   26717153
  REMARK    GeneRIF: overexpression of TIPRL promotes phosphorylation of H2AX,
            and increases gamma-H2AX positive foci in response to DNA damage,
            whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF531065.1 and AK049784.1.
            
            On May 16, 2009 this sequence version replaced NM_145513.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049784.1, SRR1660817.247804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CF531065.1         3-17
            16-3915             AK049784.1         2-3901
            3916-4395           AK049784.1         3903-4382
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.55 cM"
     gene            1..4395
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="TIP41, TOR signalling pathway regulator-like (S.
                     cerevisiae)"
                     /db_xref="GeneID:226591"
                     /db_xref="MGI:MGI:1915087"
     exon            1..229
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..941
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TIP41-like protein"
                     /codon_start=1
                     /product="TIP41-like protein isoform 1"
                     /protein_id="NP_663488.1"
                     /db_xref="CCDS:CCDS15441.1"
                     /db_xref="GeneID:226591"
                     /db_xref="MGI:MGI:1915087"
                     /translation="MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPS
                     LPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSK
                     EVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDEL
                     HDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRE
                     SKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSQSTPSE"
     exon            230..409
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..509
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..641
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            642..737
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            738..800
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            801..4395
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1067..1072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1099
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="major polyA site"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1759
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="hexamer: AATACA"
     polyA_site      2278
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="hexamer: AATATA"
     polyA_site      2825
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2908
                     /gene="Tiprl"
                     /gene_synonym="1810011K17Rik"
ORIGIN      
        1 gcggcggcag ggggcggggc cgagatggta acggacgcgc ccaggagccg cgctgcagag
       61 agggccatcg tgcgaccgct gccgcaggcg cttgctccga gtaaccctgc ggctccgctt
      121 ctgccatgat gatccacggc tttcagagca gccaccagga cttctccttc gggccttgga
      181 agctgacggc gtccaagacc cacatcatga agtctgcgga tgtggaaaag ttagctgacg
      241 agctgcacat gccatccctc cctgaaatga tgtttggaga caacgttcta aggatccagc
      301 atggctctgg ctttggaata gagttcaatg ctacggacgc actgagatgt gtgaacaact
      361 atcagggcat gctcaaagta gcttgtgctg aagagtggca ggaaagtagg acggagggcg
      421 aacactccaa agaagttatt aaaccatatg actggaccta tacaacagat tataaaggaa
      481 cgctgcttgg agaatctctt aagttaaagg ttgtacctac aacagatcat atagatacag
      541 aaaaattgaa agccagagaa cagattaaat tttttgaaga agttctcctg tttgaagatg
      601 aattgcatga tcatggtgtt tccagcctga gtgtgaaaat tagagtgatg ccttccagct
      661 tctttctgct gctgcggttt ttcctgagaa ttgatggggt gctcatcaga atgaatgaca
      721 cgaggcttta ccatgaggct gacaagacct acatgttacg agaatataca tccagagaga
      781 gcaaaattgc taatttaatg catgttccac cttccctctt cacggaacct aatgaaatat
      841 cacaatattt accaattaag gaagcagttt gtgagaagct cgtatttcca gaaagaattg
      901 atcctaaccc agtggactca caaagtacgc cctcagaata aaatgtggta cagcagactc
      961 tctccatgtg gaacctgact ggaaaccttg gctatttgta ggggtatttt tattatgaga
     1021 attaatttcc ttgcttatgc gcagattttc tgtagcctta aaggaaaata aaagattgct
     1081 gcaggcaggt tccacacaac tcctgtttat cctgtctgtt ttcaagttcc tgctccagag
     1141 agagatgtgc tctggagctt acgtcagcag tgatgtgtgt gggtctcatg aggggacatg
     1201 gtctgcatcc ggcctgaagc atcgtcttca ctgtgaggag gctgactgta aggctgtcac
     1261 tgagccccga tgcctgggac ctgccggccg ccataggatg ctgactgcat gctgatgtgc
     1321 tactctggct cttggctgtg ggctttctgg tgtttgttcg cacttacgga gagttgtgac
     1381 atgtcaccta caaaattaat cttgtattag tcattagttg gagtttctgg gcaacatatt
     1441 gtgtgtgttt gtacacacaa gtatttttta aatcttttca tttaaatgtc tttgtctctg
     1501 agtagtgtta gattacttat tttgataatt cattgttaaa aattgtggag aattaaaata
     1561 aaataattga ctttttaaaa aaaattaaag aggtgggcgg tggggaggag gagtgtgcat
     1621 ctgaagattg tattagtgta tccctgtgag gagtacccag gtgtgtcctt ggccatttct
     1681 aaatatgaca tatgccattt tatatttatt tgtccaagtg tcttttgtaa gaggagaata
     1741 aataataagg aattatgtat tcatagtttg ctgtttattt cagcttttct tagacttact
     1801 tgaagattgg attaggatgt atcgttctca tttattttgt tctgaacccg ttcagtattg
     1861 cagacacatt tcccacgcag attacaaatg gaaactgcta ggtatgaacg cgatccccta
     1921 gtttgttcgc ctttaagcgc ctgtctctct tctccctctg ctccttacac tcctgagggc
     1981 acttttaagt agtcagaaca catgggtaca tgtcatgcat agcatcccct tcagttctga
     2041 gtaccgtgtt ctctgatgtg gtataaggga ttacataatg aagcgataga atgtggttgg
     2101 tcctttatac ggcgagtgct gtgtatgtgg agtcatccgg ctcctcatca aacagttgaa
     2161 aacatcccag cgattatgac cacgcacaga ctttctgttg tcattccctg actgtcagtt
     2221 ttagctattt gccttgtatt aggtattatg agtgaaatac agggtaattt atagtgtatg
     2281 agaggatctg atggcttatt ttttattttg gtatttatgt gaatgtgaac caaatctcct
     2341 atggtgaccg agacaacttt ttgtggggtt aaggtccgcc agagaatgca gaagcatcta
     2401 cacgtggtgt cagatgtgat ggcagaaata acaacttgag aaagatggga ggagcgactt
     2461 tggtattcct ctctgctttt gaagaagctg tcgcaggcct tgagattgtc attaccataa
     2521 ccagggaaaa agccaggcag tcaaaaaaat taccatgcct tgaacaactg aaagtgggat
     2581 tacaaaacaa actgaatctc aaagaatggg aagctccaag gagaaaaagg acagagactg
     2641 cctcctcttc agagcacaag agaaaggtgg ctaatatcac cacagccaac atcttacttc
     2701 aagataatca catcatttag tcttcccttc cgtcctctca gcctgtcata tgctcctccc
     2761 tgctcttttc aaattcatat atgcatgact gtctagcttc taaatatata agtacaacct
     2821 gcccacactg tataatgtta cttgcatgta tgttttcagg gctgaccatt tgaagttaga
     2881 taactaaatt atgctgttcc ctggggaaga gtgtttgcac ctgtctcgac attccttaat
     2941 ttactgtagt tcattgtgta ggatcatttt acaagttctt ttttttttaa aaaaaaagat
     3001 ctattctgta tatttgagta cactgttgca gtcttcagac ataccataag agagcatcag
     3061 atcccatttc agatggttgt gagccgccat gtggttgctg ggaatcgaac tcaaaacctc
     3121 tggaagagca atcagtgctc ttaacagctg agccatctct ccagccccat tttataaatt
     3181 cttaaaggct gtgtgaggac tagtgtgtca tttttggaat agctacaagt ctcatttaag
     3241 gggacttact aactttctca gttaaggatt tgcctcttag atccaaaggt ctgtgcctgg
     3301 aaaagaacca agcggagctc acgaaagtcc tggtaaggag gccaggcaag caggaagtaa
     3361 ctggggacag gggtaaagcc ctgcccacct accctaggtt ccgagctctg aagggtttaa
     3421 atgccttagg gtgttgtggg gaaagctgca aaaacctgtt ttcatcccta ttgcatctga
     3481 caaagcctac ttgcccctgg aggaggagtg gagggagagt cctggacagg caaaggacaa
     3541 ttcctaccaa agaaggaatg gaagccaaac ttggctgact tgatgaggaa ctggaaagca
     3601 gcgtggacca tagttgcata tgcagaatac tgaggactgc tgcctctggt gggagggtgc
     3661 tggtgacgtt cttcacttgg gaccattgat ttaaggttgg gtttcccccg attgctgaat
     3721 gaggtgcaag tgtcgagaag gccacatcct gaaaaccaga tacggctgcc cacagcaggc
     3781 tagccaaggt caacagagaa aactttcctg taccccaaag tgagcctggg ggccactagg
     3841 taagaaggaa accagtctat gtcaaaggaa gaacaaagtg ttgctcccta tctcctaatg
     3901 gagtaggcat tggggaccta aagctgagga taagcagtac tttaaaacac acagactgct
     3961 gggaagcgtg gaattccagc tttagtttga actacatggt gagacttttt ctaagaaaac
     4021 caaaggctgg agatgctgct ctgcggttaa gggtgaatat gcttaagagc acaggttcaa
     4081 ttcccagtag tgcagaaaca aaaacagcct gttagctggg gtttatgggg acagtcatac
     4141 ctatgggaat acctagtaat catttggtga ttggatgatg agggaagcta tgcaatgggc
     4201 acatttactt acataacgag gcaagctttc tgttactcat ttctcacaat tataaaatgt
     4261 attatgaata acaaaacatc ataactgata atgcttgttg tagaaactag agatgctctg
     4321 atttcttctt ccttcttatg gaattctttt tcatttgttt gaaatactct gagaatctaa
     4381 tacatataca atgtg
//
