LOCUS       NM_001324557            1858 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus timeless interacting protein (Tipin), transcript
            variant 3, mRNA.
ACCESSION   NM_001324557
VERSION     NM_001324557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Dorval,V., Mandemakers,W., Jolivette,F., Coudert,L., Mazroui,R., De
            Strooper,B. and Hebert,S.S.
  TITLE     Gene and MicroRNA transcriptome analysis of Parkinson's related
            LRRK2 mouse models
  JOURNAL   PLoS One 9 (1), e85510 (2014)
   PUBMED   24427314
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Howden,R., Cho,H.Y., Miller-DeGraff,L., Walker,C., Clark,J.A.,
            Myers,P.H., Rouse,D.C. and Kleeberger,S.R.
  TITLE     Cardiac physiologic and genetic predictors of hyperoxia-induced
            acute lung injury in mice
  JOURNAL   Am J Respir Cell Mol Biol 46 (4), 470-478 (2012)
   PUBMED   22052878
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Smith,K.D., Fu,M.A. and Brown,E.J.
  TITLE     Tim-Tipin dysfunction creates an indispensible reliance on the
            ATR-Chk1 pathway for continued DNA synthesis
  JOURNAL   J Cell Biol 187 (1), 15-23 (2009)
   PUBMED   19805627
  REMARK    GeneRIF: The tim-Tipin dysfunction creates an indispensible
            reliance on the ATR-Chk1 pathway for continued DNA synthesis.
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Gotter,A.L., Suppa,C. and Emanuel,B.S.
  TITLE     Mammalian TIMELESS and Tipin are evolutionarily conserved
            replication fork-associated factors
  JOURNAL   J Mol Biol 366 (1), 36-52 (2007)
   PUBMED   17141802
  REMARK    GeneRIF: TIM and Tipin are functional orthologs of their
            replisome-associated yeast counterparts capable of coordinating
            replication with genotoxic stress responses, and distinguishes
            mammalian TIM from the circadian-specific paralogs.
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Gotter,A.L.
  TITLE     Tipin, a novel timeless-interacting protein, is developmentally
            co-expressed with timeless and disrupts its self-association
  JOURNAL   J Mol Biol 331 (1), 167-176 (2003)
   PUBMED   12875843
  REMARK    GeneRIF: mTIM promotes the nuclear localization of TIPIN, and TIPIN
            is capable of regulating mTIM activity by disrupting the ability of
            mTIM to form homo-multimeric complexes
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082457.1, AK011357.1 and AK038111.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by
            NM_001324557.2.
            
            Summary: The protein encoded by this gene is part of the replisome
            complex, a group of proteins that support DNA replication. It binds
            TIM and aids in protecting cells against DNA damage and stress.
            [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011357.1, BY710649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ082457.1         2-23
            23-1053             AK011357.1         1-1031
            1054-1858           AK038111.1         1036-1840
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.6 cM"
     gene            1..1858
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /note="timeless interacting protein"
                     /db_xref="GeneID:66131"
                     /db_xref="MGI:MGI:1921571"
     exon            1..63
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            64..199
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..906
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /codon_start=1
                     /product="TIMELESS-interacting protein"
                     /protein_id="NP_001311486.1"
                     /db_xref="CCDS:CCDS23279.1"
                     /db_xref="GeneID:66131"
                     /db_xref="MGI:MGI:1921571"
                     /translation="MLEQEENGLFEIPDYEHVEDETFPPFPPPASPERDPADAEPEEG
                     SGSGVPVPPKRTVKRNLPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIR
                     HMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVGE
                     ANGPDVSATGFDPFLTSSSDSRKFASEPTRSLTEEQQQRIERNKQLALERRQAKLLSN
                     SQSLENDVTVEENSTGEDQEESNGLNIDTADGPHDVPFASTHEEEQCKAEETQLDHTN
                     LD"
     exon            200..272
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            273..348
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            349..471
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            472..535
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            536..742
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1858
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1230
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /note="major polyA site"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1750
                     /gene="Tipin"
                     /gene_synonym="1110005A05Rik; 1110018P21Rik"
ORIGIN      
        1 gtctcgcgga gccgagtctc gcgagaagcg gtgttggcgc gcttggcggc ggccgctgtc
       61 taggaaaaga tgttagagca agaagaaaat ggcttgtttg aaataccaga ttatgaacat
      121 gtagaggatg aaacttttcc tcccttccca cctccggcct cgccagagag agatcctgca
      181 gacgctgaac ctgaggaagg atcagggagt ggagtacctg ttccgccaaa gagaacagtt
      241 aaaaggaatc tacctaagct agatgctacg agattgactt cagagagagg gcttccagcc
      301 ttaaggcatg tgtttgataa gacgaaattc aaggggaagg gtcatgaggc tgaagacttg
      361 aaaacgctaa tcagacacat ggagcactgg gcacataggc tattccccaa gctgcaattt
      421 gaagatttta ttgacagagt cgaaaaccta ggaaataaaa aggaggttca gacctgttta
      481 aaacgaattc gacttgatct gcctattgta catgaagatt ttgttaacaa taatgatgaa
      541 gttggagaag ctaatggccc agatgtatct gctactggat ttgatccctt cttgacaagt
      601 tcttctgaca gcaggaagtt tgcttctgaa ccaactagaa gcctaacaga agagcagcaa
      661 cagagaattg agagaaataa acagctggcc ttggaaagaa ggcaggcaaa gctactgagt
      721 aatagccagt ccctagaaaa tgatgtgaca gttgaagaga acagtactgg tgaggatcaa
      781 gaagagtcaa atggattaaa catagacact gctgatggtc cacatgatgt tcctttcgcc
      841 agtacacatg aagaggaaca gtgcaaagca gaggagacac aactggacca tactaactta
      901 gactaatcta gaaatgctat aagtagccaa ctctacaaca gaatcctgca agcttggggt
      961 tacttgtagt gttttctacc ttgtataaat ccttaagtct taagacttat gtggattcct
     1021 gcttaaaata cagtgactat ttaaattgtt tcctacttat tttagtaagt ctgtttatta
     1081 tttttggtgt cctgtataag tctgccttta taagctattt tgtagtttgc attgaattgt
     1141 ttctcgctaa attgggtaat gatttaaaat gtaaatatgc actcactatt aggtcagttt
     1201 ttataaagaa ataaattatt ttgtaagcaa ctctcaggat ttgagtttct caccatgatt
     1261 tagttataca atttaaactt tttgctgaag cagttaagaa ttttgacttt ttaaaatctc
     1321 actcattaca gcatcctggc tggtctgaaa ttagaggtca atgtcctgct ttttctgcct
     1381 tcaaatgctc tgtgtgacag ctgtgtacat catctggtct tttctttcat atcattattg
     1441 gaacagtctg tctcactgca atctcagctg gtttgaaggc tgctttgtgt tggggttaaa
     1501 ggtctgtgcc acaacactca tcttgctaca gagtcacttt aatgtttaaa agatcacata
     1561 aaaggttgat actgggactg gcaagatggc tcagtggata agagcactga tggctcttcc
     1621 aaaggtcctg agttccacag ggtggctcac aaccacccgt aatgagatct gacgcttttt
     1681 ctggtgcgcc tgaagacagc tacagtgtac ttatttacaa taataaatca atctttgggt
     1741 tgaagtgagc ggaattgacc ggagctagcc aaagtcctaa attcaaatcc caacaaccat
     1801 atgaaggctc acagccatct gtacagctac agtgtactca tatacataaa ataaatct
//
