LOCUS       NM_178892               4154 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TCDD-inducible poly(ADP-ribose) polymerase (Tiparp),
            mRNA.
ACCESSION   NM_178892
VERSION     NM_178892.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Rasmussen,M., Alvik,K., Kannen,V., Olafsen,N.E., Erlingsson,L.A.M.,
            Grimaldi,G., Takaoka,A., Grant,D.M. and Matthews,J.
  TITLE     Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast
            Cancer Cells and Prevents Mammary Tumor Growth by Increasing
            Antitumor Immunity
  JOURNAL   Cancers (Basel) 15 (14), 3689 (2023)
   PUBMED   37509350
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4154)
  AUTHORS   Shen,B., Wang,L., Xu,Y., Wang,H. and He,S.
  TITLE     Knockdown of lncRNA SNHG15 Ameliorates Oxygen and Glucose
            Deprivation (OGD)-Induced Neuronal Injury via Regulating the
            miR-9-5p/TIPARP Axis
  JOURNAL   Biochem Genet 60 (2), 755-769 (2022)
   PUBMED   34453220
  REMARK    GeneRIF: Knockdown of lncRNA SNHG15 Ameliorates Oxygen and Glucose
            Deprivation (OGD)-Induced Neuronal Injury via Regulating the
            miR-9-5p/TIPARP Axis.
REFERENCE   4  (bases 1 to 4154)
  AUTHORS   Hutin,D., Hagen,K.A., Shao,P., Sugamori,K., Grant,D.M. and
            Matthews,J.
  TITLE     Reduced Colonic Mucosal Injury in
            2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase
            (TIPARP/PARP7)-Deficient Mice
  JOURNAL   Int J Mol Sci 23 (2), 920 (2022)
   PUBMED   35055106
  REMARK    GeneRIF: Reduced Colonic Mucosal Injury in
            2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase
            (TIPARP/PARP7)-Deficient Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4154)
  AUTHORS   Rijo,M.P., Diani-Moore,S., Yang,C., Zhou,P. and Rifkind,A.B.
  TITLE     Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase
            TiPARP in TCDD-induced nuclear export and proteasomal degradation
            of the transcription factor AHR
  JOURNAL   J Biol Chem 297 (2), 100886 (2021)
   PUBMED   34146543
  REMARK    GeneRIF: Roles of the ubiquitin ligase CUL4B and
            ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and
            proteasomal degradation of the transcription factor AHR.
REFERENCE   6  (bases 1 to 4154)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   7  (bases 1 to 4154)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   8  (bases 1 to 4154)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4154)
  AUTHORS   Ma,Q.
  TITLE     Induction and superinduction of
            2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose)
            polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon
            receptor nuclear translocator transcription activation domains and
            a labile transcription repressor
  JOURNAL   Arch Biochem Biophys 404 (2), 309-316 (2002)
   PUBMED   12147270
  REMARK    Erratum:[Arch Biochem Biophys. 2003 Sep 1;417(1):129]
REFERENCE   10 (bases 1 to 4154)
  AUTHORS   Ma,Q., Baldwin,K.T., Renzelli,A.J., McDaniel,A. and Dong,L.
  TITLE     TCDD-inducible poly(ADP-ribose) polymerase: a novel response to
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   Biochem Biophys Res Commun 289 (2), 499-506 (2001)
   PUBMED   11716501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC113279.7.
            
            On May 2, 2007 this sequence version replaced NM_178892.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028529.1, BC068173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC113279.7         157797-157982
            187-1147            AC113279.7         160574-161534
            1148-1316           AC113279.7         175557-175725
            1317-1477           AC113279.7         176875-177035
            1478-1753           AC113279.7         181886-182161
            1754-4154           AC113279.7         182468-184868
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.2 cM"
     gene            1..4154
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /note="TCDD-inducible poly(ADP-ribose) polymerase"
                     /db_xref="GeneID:99929"
                     /db_xref="MGI:MGI:2159210"
     exon            1..186
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     exon            187..1147
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2201
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase diphtheria toxin-like 14"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase TIPARP"
                     /protein_id="NP_849223.2"
                     /db_xref="CCDS:CCDS17388.1"
                     /db_xref="GeneID:99929"
                     /db_xref="MGI:MGI:2159210"
                     /translation="MEVETTEPEPDCVVQPPSPSDDFSCQMRISEKISPLKTCFKKKQ
                     EQKRLGTGTLRSLRPILNTLLESGSLDGVFRARDQNRDESSLHEHIVKKPLEINPSCP
                     PAENSMPVLIPDGTNVEGQLPEAHPSTDAPEQGVPIQDHSFPPETISGTVADSTTGHF
                     QTDLLHPVSGDVPTSPDCVDKVMDYVPGAFQDNSFTIQYILDTSDKLSTELFQDKSEE
                     ASLELVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTT
                     QKWQSVSNDSQEHLERFYCNPENDRMRMKYGGQDFWADLNAMTVFETTEFDQLRRLST
                     PPCSNSNSIYHTFWKFFCRDHFGWREYPESVVRLIEEANSRGLKEVRFMMWNNHYILH
                     NSFFRREIKRRPLFRSCFILIPYLQTLGGVPTQASLPLEATSSQIICPDGVTSANFYP
                     ETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYK
                     RKKEYMNRKMSGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFA
                     KKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVD
                     NFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI"
     exon            1148..1316
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1477
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1753
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..4154
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="Tiparp"
                     /gene_synonym="ARTD14; PARP7"
                     /note="major polyA site"
ORIGIN      
        1 gagctggagc ctcgagagca gttgcggctt tcagcgctca ggtccgcgga atggcccgcg
       61 cgccgctcgc cgcgtcggcc gcccacgacc cctagacacc ggccctcgtc ctcggctcgg
      121 accgctggcg cagaggcggc cctccacgcc gcgcctgggc tgcgttcgaa gggcggcttg
      181 cctgaggatt tgtagatact gaggcacagt tgggagttaa tcacatcatg gaagtggaaa
      241 ccactgaacc tgagccagac tgtgtagtac agcctccttc tccttctgat gacttttcat
      301 gccaaatgag aatttctgag aagatctctc cattgaaaac gtgttttaag aaaaaacagg
      361 aacaaaaaag attgggaact ggaaccctga gatccttgag gccaatatta aatactttgc
      421 tagaatctgg ctcacttgat ggagttttta gagctagaga ccaaaacaga gatgagagca
      481 gcttacatga acatatagtg aaaaaacccc tggaaatcaa cccatcgtgt ccaccagcag
      541 aaaacagtat gcctgtcctg attcctgatg ggacaaatgt tgagggccaa ttaccagaag
      601 cgcatccttc tacagatgct ccagaacagg gggttccaat ccaagaccac agttttccac
      661 cagaaaccat cagtgggaca gtggcagatt ctacaacagg acacttccaa actgaccttt
      721 tgcatcctgt ttcaggtgat gttcctacaa gtcctgactg cgtagataaa gttatggatt
      781 atgtaccagg agctttccaa gacaatagtt ttacaatcca gtacattttg gataccagtg
      841 ataagttgag tactgagctc ttccaagaca aaagtgagga agcttccctt gagcttgtgt
      901 ttgaacttgt aaaccagcta cagtaccata ctcaccaaga gaatggaatt gaaatttgta
      961 tggactttct gcaaggcact tgcatttatg gcagggattg tttgaaacat cacaccgtat
     1021 tgccctatca ttggcagatc aaaaggacaa ccactcagaa gtggcagagt gtttccaatg
     1081 attctcagga gcacttggaa agattttatt gtaatccaga aaatgataga atgagaatga
     1141 agtatggagg acaagacttt tgggcagatt tgaatgccat gactgtattt gaaacaactg
     1201 aatttgacca actacgaagg ctgtctacac caccctgtag taattcaaac tctatttacc
     1261 acacattttg gaaattcttc tgtagagacc actttggatg gagagagtat cctgagtctg
     1321 ttgttcgact aattgaagaa gccaactctc ggggtctgaa agaagttaga tttatgatgt
     1381 ggaacaacca ttatattctc cacaactcat tcttccggag agaaataaaa cggagacccc
     1441 ttttccgttc ctgtttcata ctgattccat atttacagac acttggtggg gttcccactc
     1501 aggcttctct gcctcttgaa gcaacttcat cacaaatcat ctgcccagat ggagtaactt
     1561 cagccaactt ttaccctgaa acgtgggttt atatgcatcc atctcaggac ttcatccaag
     1621 tgcctgtttc tgcagaagat aaaagttatc gaatcattta caaccttttt cataaaactg
     1681 tacctgaatt taaatacaga attttacaaa tattgagagt ccaaaaccaa tttctttggg
     1741 agaaatataa aaggaaaaaa gaatatatga acagaaaaat gtctggccgt gacagaataa
     1801 taaatgagag acacttattt catggaacat cccaagatgt agtagatgga atttgcaagc
     1861 acaactttga tccccgtgtc tgtggaaagc atgctacaat gtttggacaa ggcagttatt
     1921 tcgcaaagaa ggcaagctac tctcataact tttctaagaa gtcctccaaa ggagtccatt
     1981 tcatgttttt ggccaaagtg ttaactggca gatacacaat gggcagtcat ggcatgagaa
     2041 ggccccctcc ggtcaaccct ggcagtgtca ccagtgactt atatgactct tgtgtggata
     2101 atttttttga gcctcagatt tttgtcattt ttaatgatga ccagagttac ccttattttg
     2161 ttatccaata tgaagaagtc agtaacactg tttccatttg aaaatcttgg tactactaag
     2221 ttatttgata tgaactcaat ccagcatttg tagcaggttt gggtgggact gggaaggaaa
     2281 cagcatttga cagaaatagg atacttttca gacccaattt tttaataagt gctagaaagt
     2341 aattttttta aacaaacaaa aaaagggggt tttaaaattg ccacttatta tttaattgtt
     2401 tactaattgt tagtgtactt ggtgtggaaa agactaaagt gcatattctt cattcacact
     2461 tgtacatata gacagcagca atattagtag aagtatttgg aaaaaaaaca aaaaaaaaac
     2521 caaaaaactg actaggctaa tttaaacgtt gcttgggtct ggtagaagtt tggtcaaaac
     2581 aaagaggcta tgagcaaagt gagggttctg tttacttaac attgataaac cacctggaac
     2641 tgatactatc gtgcttatta cctagccaaa gcattttgta tggtacttcg gggtagtata
     2701 cgttcatgta agtctaatag gtggtaagaa attttcattc tgtgaccagg actgaaatat
     2761 atcacccact cagaactcca gaattttcct gagaactcag gatctattca gaggaagtaa
     2821 aataataata aagagcccat ttgaaaaaaa aattgtcacc agcaaaattc cctgattgtt
     2881 acgtgtgata catgtgttaa cattcagcca tggaaaaccc agcctctttc actgttgcct
     2941 accttagttt cagagttggg caactaggtt ggttaaagcc agtcgtaagg gttaaaagta
     3001 tttcttttgg aatccagacc taccctgggc tggtattaga tcctagaaga tatctacaac
     3061 caaggtggaa aggttgcgtc ctgtgcttca cacaagacag actcttagcc atatctgctg
     3121 agttgaattg ttcaagacaa caagctcacc ccatgcctgc tttgccagat gcactggatt
     3181 tcgtggctga ctgtacctta cactacttac tttaatagaa acacaaactt ggaaacggtg
     3241 ccactggccc agcaagagca ctgttaggtg aatgtgctgt tgcctcagtt cagagcggta
     3301 tagtaagtac ttctaagcaa agcagaaacc tgagtgaagt gaaaagtggt tgttgataaa
     3361 atataccaca gaagtccttc cgataccaag ctctccttgt atgtttgtgg ttatctcatt
     3421 tacccaaact ttatgggaac ttctttgtta tttaaagcaa gatagagctg tacagatgtc
     3481 tcagtgaatc agtctgttta agcacttatc agggcttcca cacaattatt tattttgccc
     3541 tagttgatcc tgttgtttgc tgccattggc aggaggaaat gggcaactgt ggcagtcatt
     3601 cattcagtta taacttgtaa accagtgacc ccagttgttt tcaagttaag acatgttacc
     3661 attgcttgtt tgattttatg gaacttgttc cttttttttc tccctaaagg aaacaaaagc
     3721 tttatgacat atttattttt ttaataaaac taagcaaaaa taaaagttaa ttcttaaaaa
     3781 cttctgtttt gttctatttc tatttaaata acaaaacact aaatagttga tctgtgtgtt
     3841 gggcggttga ctgattggct gggtgagtgg gttgatttag tttggtttgt tcactagaag
     3901 actgtaggat tgaatctgaa cagatctatt cagaatatgt tgcttatcct cttctgcttg
     3961 ggaatggagg aagtatatta cctagttttc aactgtaagt cacaagaaaa gaatgactgt
     4021 ttattttgca gacaatttat ttgggggtaa ggaacaagtc ttacatcagc aaaaagctat
     4081 aaagaaaaca agctaattga aaatgctact ttcaagtgta tggaaaaaaa aacattaaaa
     4141 ggaattgtaa actc
//
