LOCUS       NM_001404599            2382 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus Terf1 (TRF1)-interacting nuclear factor 2 (Tinf2),
            transcript variant 1, mRNA.
ACCESSION   NM_001404599
VERSION     NM_001404599.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Zhang,S., Chen,S., Sun,D., Li,S., Sun,J., Gu,Q., Liu,P., Wang,X.,
            Zhu,H., Xu,X., Li,H. and Wei,F.
  TITLE     TIN2-mediated reduction of mitophagy induces RPE senescence under
            high glucose
  JOURNAL   Cell Signal 119, 111188 (2024)
   PUBMED   38657846
  REMARK    GeneRIF: TIN2-mediated reduction of mitophagy induces RPE
            senescence under high glucose.
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Yin,S., Zhang,F., Lin,S., Chen,W., Weng,K., Liu,D., Wang,C., He,Z.,
            Chen,Y., Ma,W., Huang,J., Huang,Y. and Songyang,Z.
  TITLE     TIN2 deficiency leads to ALT-associated phenotypes and
            differentiation defects in embryonic stem cells
  JOURNAL   Stem Cell Reports 17 (5), 1183-1197 (2022)
   PUBMED   35395177
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Kaur,P., Barnes,R., Pan,H., Detwiler,A.C., Liu,M., Mahn,C.,
            Hall,J., Messenger,Z., You,C., Piehler,J., Smart,R.C., Riehn,R.,
            Opresko,P.L. and Wang,H.
  TITLE     TIN2 is an architectural protein that facilitates TRF2-mediated
            trans- and cis-interactions on telomeric DNA
  JOURNAL   Nucleic Acids Res 49 (22), 13000-13018 (2021)
   PUBMED   34883513
  REMARK    GeneRIF: TIN2 is an architectural protein that facilitates
            TRF2-mediated trans- and cis-interactions on telomeric DNA.
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   6  (bases 1 to 2382)
  AUTHORS   de Lange,T.
  TITLE     How shelterin solves the telomere end-protection problem
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 167-177 (2010)
   PUBMED   21209389
  REMARK    GeneRIF: Mouse gene deletion experiments revealed
            DNA-damage-response pathways that threaten chromosome ends and how
            the components of the telomeric shelterin complex prevent
            activation of these pathways.[Shelterin]
REFERENCE   7  (bases 1 to 2382)
  AUTHORS   Liu,D., O'Connor,M.S., Qin,J. and Songyang,Z.
  TITLE     Telosome, a mammalian telomere-associated complex formed by
            multiple telomeric proteins
  JOURNAL   J Biol Chem 279 (49), 51338-51342 (2004)
   PUBMED   15383534
REFERENCE   8  (bases 1 to 2382)
  AUTHORS   Chiang,Y.J., Kim,S.H., Tessarollo,L., Campisi,J. and Hodes,R.J.
  TITLE     Telomere-associated protein TIN2 is essential for early embryonic
            development through a telomerase-independent pathway
  JOURNAL   Mol Cell Biol 24 (15), 6631-6634 (2004)
   PUBMED   15254230
  REMARK    GeneRIF: TIN2 has a role independent of telomere length regulation
            that is essential for embryonic development and cell viability
REFERENCE   9  (bases 1 to 2382)
  AUTHORS   Kim,S.H., Parrinello,S., Kim,J. and Campisi,J.
  TITLE     Mus musculus and Mus spretus homologues of the human
            telomere-associated protein TIN2
  JOURNAL   Genomics 81 (4), 422-432 (2003)
   PUBMED   12676566
REFERENCE   10 (bases 1 to 2382)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025679.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.249556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               CT025679.5         115186-115604       c
            420-506             CT025679.5         115021-115107       c
            507-596             CT025679.5         114796-114885       c
            597-704             CT025679.5         114591-114698       c
            705-801             CT025679.5         114407-114503       c
            802-1243            CT025679.5         113811-114252       c
            1244-1308           CT025679.5         113662-113726       c
            1309-2382           CT025679.5         110004-111077       c
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2382
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /note="Terf1 (TRF1)-interacting nuclear factor 2"
                     /db_xref="GeneID:28113"
                     /db_xref="MGI:MGI:107246"
     exon            1..419
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1583
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRF1-interacting nuclear factor 2; TERF1-interacting
                     nuclear factor 2; TRF1-interacting nuclear protein 2"
                     /codon_start=1
                     /product="TERF1-interacting nuclear factor 2 isoform 1"
                     /protein_id="NP_001391528.1"
                     /db_xref="GeneID:28113"
                     /db_xref="MGI:MGI:107246"
                     /translation="MAPPPGVGPASLRFAAAASWLVVRRRRVEHFPKVVEFLQSLRAA
                     APGLVCYRHHERLCMSLKAKVVVELILQARPWDQVLNALKHHFPAESRTTKEDRKLLE
                     ARENFCLLVKHLSEDPPSSLQELEQDYGESFLVAMEKLLFEYLCQLEKALPPVRAQEL
                     QDALSWSQPGSFITSSVALHQYGMDMGWTFPESSTSGSGNLIEPMEESPHQQTRPAFH
                     SPLPKAKLGPHQPASLEHPEHLAGHRFNLAPLGKRKSRSHWTSAKACHKERPTVMLLP
                     FRNMGLPAQDLSNPKSREEPGAASAASVGTEPVCTEEAKTPSRPLGKRALEETPPDSP
                     AAEQENSVNCVDPLRHSSPPLTVKKPGSSCRALPVSLPKAFATSPGQLQPPSYKVRNA
                     VRDSIDFSRLLNCPCQRTRTNVLTRTSPEPHPTENSGCWAATNPLQVLSLTEMIWPLR
                     P"
     exon            420..506
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..596
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..801
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1243
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1308
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..2382
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /note="hexamer: AATAAA"
     polyA_site      2382
                     /gene="Tinf2"
                     /gene_synonym="D14Wsu146e; Tin2"
                     /note="major polyA site"
ORIGIN      
        1 gtactcctgc gtttccctca gtggcggcat tttaagttta gtgatctgga caggttgata
       61 cacttaagtc accgcctgag aggagactgc ggggttcccg tggctccgcg aaatgggccc
      121 agctggtccg ccgaccttcc ggtgcagatg agagaagcgg ggctccgcct acgggagcgt
      181 ccgggaagcc tgggttgaac gaaaggagga aagggcgccc gcgggccatg gccccacctc
      241 caggggtagg tcccgcgtct ctgcggtttg ctgccgccgc cagctggctg gtagtccgcc
      301 gtcgccgcgt agagcacttc ccgaaagtgg tggagtttct gcagtccttg cgcgctgctg
      361 cccccggctt ggtttgctac cggcaccatg aacgcctgtg tatgagccta aaggccaagg
      421 tggtggtgga gctgatcctg caggcgcgac cctgggacca ggtcctgaat gccctgaagc
      481 atcacttccc agcagagtcc agaacaacaa aagaagacag gaagcttttg gaggcacggg
      541 aaaatttttg cttgcttgtg aagcacctgt cagaggaccc gccttcgagc ctgcaggaac
      601 tagaacaaga ctatggggaa tcctttctag ttgccatgga aaagctgttg tttgaatact
      661 tgtgtcagct agagaaagca ctgcctccag tcagagcaca agagcttcag gatgctctaa
      721 gttggagtca gccgggctcg ttcatcactt cttcggttgc tttgcaccag tatggtatgg
      781 acatggggtg gacatttcca gagagctcta cttctggctc agggaatctg atagagccca
      841 tggaagagag tcctcatcag caaaccaggc cagcattcca cagtcctctg cctaaagcta
      901 agcttggccc tcaccagcca gcttcactgg agcacccaga acacttagct ggccaccgct
      961 ttaatctggc ccctttggga aagcgaaaat cccgatcaca ttggacatcg gcaaaggcgt
     1021 gccataaaga gcggcccaca gtcatgctac tcccatttag gaacatgggc ttaccagctc
     1081 aagacttatc taaccctaaa agcagggaag aacccggtgc ggcctcagca gcttctgtgg
     1141 gaacagagcc agtctgcacg gaggaggcta agactccatc tcggcctttg gggaaaaggg
     1201 cattagagga gaccccacct gactcaccgg ctgcagagca ggagaacagt gtgaattgcg
     1261 tggatcctct aagacactca tcaccgcctc ttacagtcaa gaaaccagga tcttcctgcc
     1321 gtgccctccc agtctcctta ccaaaagcct ttgccacatc cccaggacag ctgcagcctc
     1381 catcctacaa agtaaggaat gctgtgagag acagcataga tttctcaaga cttctcaact
     1441 gcccatgtca aaggactaga actaatgtcc tgaccaggac ttcaccagag ccccacccta
     1501 cagaaaacag tggctgctgg gcagccacaa accctctcca ggtcttgagt cttactgaga
     1561 tgatatggcc tttgaggcca tgagcagcat ctgcacactc catcactgca ctgagctgtg
     1621 gataccccac tccagttttc ttccgagttg tacagacaga gcctgggaag agggacagag
     1681 gtgagagtaa actggcctat ggttttgcct ccaacgggac agatgagacg atggtcccaa
     1741 ggaaccagct taccaggacc aattcccact ttgatgatgt cagccccaga aaggattaac
     1801 tcttctacca tctctcctgt taccacattt cctgcctgag acaataatca aaacagagca
     1861 ctcttagggt cggtggtgga gagcagcttt tgtgctttca tataatccat gcctcaactg
     1921 tgaccttcct attataaata aagggtacct agagccctca ggactttcca ccaactccaa
     1981 aggacctaga ttcccagtta cccttcccat cccacataca tactttgact tagtgtgaag
     2041 gatagaggaa acaacattgt ctagggtaaa aacaggacca gaatgacctt taaggcagca
     2101 aggtgggcaa caagatataa agtggcatta aagagcagtt gttgagtcag aaaccccact
     2161 cagatcgaca gtagtgccct ttcattacta ggggactgct gcccagtcct gaagctctct
     2221 accttgaaaa acatggacag tcacaggaat gtgggttaaa atatccatct gcccaacaga
     2281 atgtggacag tgcgacaccc cccttcaatg ctgtgaagaa aatgaagcct tggattttat
     2341 ctctaataag cttctaaaaa ataaaacaat agttttatat ga
//
