LOCUS       NM_001396444            1285 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TINCR ubiquitin domain containing (Tincr), transcript
            variant 3, mRNA.
ACCESSION   NM_001396444 NR_130128 XR_105857 XR_397558
VERSION     NM_001396444.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1285)
  AUTHORS   Morgado-Palacin,L., Brown,J.A., Martinez,T.F., Garcia-Pedrero,J.M.,
            Forouhar,F., Quinn,S.A., Reglero,C., Vaughan,J., Heydary,Y.H.,
            Donaldson,C., Rodriguez-Perales,S., Allonca,E., Granda-Diaz,R.,
            Fernandez,A.F., Fraga,M.F., Kim,A.L., Santos-Juanes,J., Owens,D.M.,
            Rodrigo,J.P., Saghatelian,A. and Ferrando,A.A.
  TITLE     The TINCR ubiquitin-like microprotein is a tumor suppressor in
            squamous cell carcinoma
  JOURNAL   Nat Commun 14 (1), 1328 (2023)
   PUBMED   36899004
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1285)
  AUTHORS   Nita,A., Matsumoto,A., Tang,R., Shiraishi,C., Ichihara,K.,
            Saito,D., Suyama,M., Yasuda,T., Tsuji,G., Furue,M., Katayama,B.,
            Ozawa,T., Murata,T., Dainichi,T., Kabashima,K., Hatano,A.,
            Matsumoto,M. and Nakayama,K.I.
  TITLE     A ubiquitin-like protein encoded by the 'noncoding' RNA TINCR
            promotes keratinocyte proliferation and wound healing
  JOURNAL   PLoS Genet 17 (8), e1009686 (2021)
   PUBMED   34351912
  REMARK    GeneRIF: A ubiquitin-like protein encoded by the ''noncoding'' RNA
            TINCR promotes keratinocyte proliferation and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1285)
  AUTHORS   Li,H., Shi,H., Zhang,F., Xue,H., Wang,L., Tian,J., Xu,J. and Han,Q.
  TITLE     LncRNA Tincr regulates PKCvarepsilon expression in a
            miR-31-5p-dependent manner in cardiomyocyte hypertrophy
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 393 (12), 2495-2506 (2020)
   PUBMED   32157348
  REMARK    GeneRIF: LncRNA Tincr regulates PKCvarepsilon expression in a
            miR-31-5p-dependent manner in cardiomyocyte hypertrophy.
REFERENCE   5  (bases 1 to 1285)
  AUTHORS   Eckhart,L., Lachner,J., Tschachler,E. and Rice,R.H.
  TITLE     TINCR is not a non-coding RNA but encodes a protein component of
            cornified epidermal keratinocytes
  JOURNAL   Exp Dermatol 29 (4), 376-379 (2020)
   PUBMED   32012357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485788.18.
            
            On Oct 17, 2021 this sequence version replaced NR_130128.2.
            
            Summary: This gene encodes a spliced long non-coding RNA. A similar
            gene in human is associated with epidermal tissue differentiation.
            [provided by RefSeq, Dec 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927932.2479319.1,
                                           SRR1660817.246060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 32012357, 34351912
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               CT485788.18        48142-48427         c
            287-400             CT485788.18        47473-47586         c
            401-709             CT485788.18        46712-47020         c
            710-1285            CT485788.18        45438-46013         c
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.39 cM"
     gene            1..1285
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="TINCR ubiquitin domain containing"
                     /db_xref="GeneID:100504425"
                     /db_xref="MGI:MGI:5012404"
     exon            1..286
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..290
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="tissue differentiation-inducing non-protein coding
                     RNA-like"
                     /codon_start=1
                     /product="TINCR ubiquitin domain containing"
                     /protein_id="NP_001383373.1"
                     /db_xref="GeneID:100504425"
                     /db_xref="MGI:MGI:5012404"
                     /translation="MAMEELRRGLSRWKRYHIKVHLADEALLLPLTVRPRDTLSDLRA
                     QLVGQGVSSWRRTFYYNSRPLPDHQTVREARLQDGSVLLLLSDTR"
     exon            287..400
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     exon            401..709
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1285
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="hexamer: AATAAA"
     polyA_site      1285
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="major polyA site"
ORIGIN      
        1 gagagagtct caggctggca atggccatgg aggagctgcg gcgagggctg tcccgctgga
       61 agcgctacca catcaaggta cacctagccg acgaggcatt gctactgcca ctgaccgtgc
      121 ggccccgaga cacactgagt gacctgcgcg cacagctagt gggccagggt gtaagctctt
      181 ggcgcagaac cttctactac aactctaggc ctctgcctga ccatcagaca gttcgcgaag
      241 ctcgcctgca ggacggctca gtattacttc tgctcagcga caccaggtag gaaatggagg
      301 agatggagcg atgattttag ggacacaaga tgctggctga aggagcaaac tggcccaggc
      361 accacatctc tctcttcctg ggagtccagt cgtacttcag gtgctgggct tccagagaga
      421 tgccaactcc ccagccctgc tgatgcccac tgcctctggt gttcctgatg gtgacttctg
      481 acattgtcgt ccagccctcc atccccccaa ccccggcaag gaaccttctg gttgctctgt
      541 ggccttagga ccctcccttg ggagcctctg ctgcctggat cgacctctgt ccatccccag
      601 agcacagcct cctcggggaa gctcaacagg cacacttcct tctttggagg acccacgggg
      661 ctccagctac gaacagaaca ggaggacact ctgatccagg ggggtcttga tcagagaacc
      721 aaggcctgag gtcccaaagc cacaatgtgg agagcatgtg acctctctcc aacagtcatc
      781 agaagccaac atgaacagaa cctgtgaccc acaaagaaaa ggtgacatga ggaggctcca
      841 ggcctgtgat agcttgcaac agcacagggg aattgtggtg ctgaaggcca ggctgctgag
      901 tgtgagcccc ccacaagctc accctgttcc ttatgtcctg agatctccct gaattcctgc
      961 cacaggacca tcagtttttt ttttttccca ctccaccttc tttttgtttt ttatagactc
     1021 ctatttattc taccttcagt gccccattta tacacagcca ttcctgatac tccagtgata
     1081 gcctccagtg tcctccgggt ccctgctatg ccagcactat gctcctgtcc taggcctgag
     1141 tcatgagccc aggttaggta ggaggctcat tccatctctg tgaactcact tcaggagacc
     1201 caaggtcatg ttcctactcc gggctctagg tgcagaggtg ccattttgaa tgtgttatca
     1261 aataaagact gacaacaaag cagga
//
