LOCUS       NM_001396442            1983 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TINCR ubiquitin domain containing (Tincr), transcript
            variant 1, mRNA.
ACCESSION   NM_001396442
VERSION     NM_001396442.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Morgado-Palacin,L., Brown,J.A., Martinez,T.F., Garcia-Pedrero,J.M.,
            Forouhar,F., Quinn,S.A., Reglero,C., Vaughan,J., Heydary,Y.H.,
            Donaldson,C., Rodriguez-Perales,S., Allonca,E., Granda-Diaz,R.,
            Fernandez,A.F., Fraga,M.F., Kim,A.L., Santos-Juanes,J., Owens,D.M.,
            Rodrigo,J.P., Saghatelian,A. and Ferrando,A.A.
  TITLE     The TINCR ubiquitin-like microprotein is a tumor suppressor in
            squamous cell carcinoma
  JOURNAL   Nat Commun 14 (1), 1328 (2023)
   PUBMED   36899004
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Nita,A., Matsumoto,A., Tang,R., Shiraishi,C., Ichihara,K.,
            Saito,D., Suyama,M., Yasuda,T., Tsuji,G., Furue,M., Katayama,B.,
            Ozawa,T., Murata,T., Dainichi,T., Kabashima,K., Hatano,A.,
            Matsumoto,M. and Nakayama,K.I.
  TITLE     A ubiquitin-like protein encoded by the 'noncoding' RNA TINCR
            promotes keratinocyte proliferation and wound healing
  JOURNAL   PLoS Genet 17 (8), e1009686 (2021)
   PUBMED   34351912
  REMARK    GeneRIF: A ubiquitin-like protein encoded by the ''noncoding'' RNA
            TINCR promotes keratinocyte proliferation and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Li,H., Shi,H., Zhang,F., Xue,H., Wang,L., Tian,J., Xu,J. and Han,Q.
  TITLE     LncRNA Tincr regulates PKCvarepsilon expression in a
            miR-31-5p-dependent manner in cardiomyocyte hypertrophy
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 393 (12), 2495-2506 (2020)
   PUBMED   32157348
  REMARK    GeneRIF: LncRNA Tincr regulates PKCvarepsilon expression in a
            miR-31-5p-dependent manner in cardiomyocyte hypertrophy.
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Eckhart,L., Lachner,J., Tschachler,E. and Rice,R.H.
  TITLE     TINCR is not a non-coding RNA but encodes a protein component of
            cornified epidermal keratinocytes
  JOURNAL   Exp Dermatol 29 (4), 376-379 (2020)
   PUBMED   32012357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485788.18.
            
            Summary: This gene encodes a spliced long non-coding RNA. A similar
            gene in human is associated with epidermal tissue differentiation.
            [provided by RefSeq, Dec 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.106343.1,
                                           SRR5189676.116801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 32012357, 34351912
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               CT485788.18        48142-48427         c
            287-400             CT485788.18        47473-47586         c
            401-1983            CT485788.18        45438-47020         c
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.39 cM"
     gene            1..1983
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="TINCR ubiquitin domain containing"
                     /db_xref="GeneID:100504425"
                     /db_xref="MGI:MGI:5012404"
     exon            1..286
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..290
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="tissue differentiation-inducing non-protein coding
                     RNA-like"
                     /codon_start=1
                     /product="TINCR ubiquitin domain containing"
                     /protein_id="NP_001383371.1"
                     /db_xref="GeneID:100504425"
                     /db_xref="MGI:MGI:5012404"
                     /translation="MAMEELRRGLSRWKRYHIKVHLADEALLLPLTVRPRDTLSDLRA
                     QLVGQGVSSWRRTFYYNSRPLPDHQTVREARLQDGSVLLLLSDTR"
     exon            287..400
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     exon            401..1983
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="hexamer: AATAAA"
     polyA_site      1983
                     /gene="Tincr"
                     /gene_synonym="Gm20219"
                     /note="major polyA site"
ORIGIN      
        1 gagagagtct caggctggca atggccatgg aggagctgcg gcgagggctg tcccgctgga
       61 agcgctacca catcaaggta cacctagccg acgaggcatt gctactgcca ctgaccgtgc
      121 ggccccgaga cacactgagt gacctgcgcg cacagctagt gggccagggt gtaagctctt
      181 ggcgcagaac cttctactac aactctaggc ctctgcctga ccatcagaca gttcgcgaag
      241 ctcgcctgca ggacggctca gtattacttc tgctcagcga caccaggtag gaaatggagg
      301 agatggagcg atgattttag ggacacaaga tgctggctga aggagcaaac tggcccaggc
      361 accacatctc tctcttcctg ggagtccagt cgtacttcag gtgctgggct tccagagaga
      421 tgccaactcc ccagccctgc tgatgcccac tgcctctggt gttcctgatg gtgacttctg
      481 acattgtcgt ccagccctcc atccccccaa ccccggcaag gaaccttctg gttgctctgt
      541 ggccttagga ccctcccttg ggagcctctg ctgcctggat cgacctctgt ccatccccag
      601 agcacagcct cctcggggaa gctcaacagg cacacttcct tctttggagg acccacgggg
      661 ctccagctac gaacagaaca ggaggacact ctgatccagg ggggtcttgg tgagcccata
      721 ggtgtgcaaa gtggtctgag tatttcagca cgtgctgtgg gggctctact ccacagctcc
      781 agtgttgggt gctatgtgac cctgcccccc attgtccctg tttcccccca ccccttcatg
      841 tgctggggga ctacactgtg agcccagaag gaaataatgt tttaattaag agttgtacag
      901 gctgcaggag gcagagcagg gcagctggga actgaaccat ggtctttgga atcagggttg
      961 ctagacattc gcaactatgc aggccttggg ggtgtgggtc cctctctgcc tccccagtct
     1021 ccttctagat ccaccaggct gttgttcagc tgtgggggaa gctgctggcc ctctgggaga
     1081 gctgctgggg agtggagggg aggctggtat tgaggggcga gagaaagcat tttgacattt
     1141 aacaaacctt atgcaaattg catgcaaatt acatgcaaat cactattcat ttcttcaggc
     1201 ggacagcctt agcgtgttca gaaataataa tgtagggcct gttccttggt cccagtcctg
     1261 gcggtcttcc ctccctgccc tcctccctct ctccctccct ccctccctct ctctttccct
     1321 cctacccttc ccatctttga tccaaggccg cctagccctg aagtggatgt aaacagccca
     1381 attggctgcc ttcattctgt tttctagatc agagaaccaa ggcctgaggt cccaaagcca
     1441 caatgtggag agcatgtgac ctctctccaa cagtcatcag aagccaacat gaacagaacc
     1501 tgtgacccac aaagaaaagg tgacatgagg aggctccagg cctgtgatag cttgcaacag
     1561 cacaggggaa ttgtggtgct gaaggccagg ctgctgagtg tgagcccccc acaagctcac
     1621 cctgttcctt atgtcctgag atctccctga attcctgcca caggaccatc agtttttttt
     1681 ttttcccact ccaccttctt tttgtttttt atagactcct atttattcta ccttcagtgc
     1741 cccatttata cacagccatt cctgatactc cagtgatagc ctccagtgtc ctccgggtcc
     1801 ctgctatgcc agcactatgc tcctgtccta ggcctgagtc atgagcccag gttaggtagg
     1861 aggctcattc catctctgtg aactcacttc aggagaccca aggtcatgtt cctactccgg
     1921 gctctaggtg cagaggtgcc attttgaatg tgttatcaaa taaagactga caacaaagca
     1981 gga
//
