LOCUS       NM_001168333            1954 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus tubulointerstitial nephritis antigen-like 1 (Tinagl1),
            transcript variant 2, mRNA.
ACCESSION   NM_001168333
VERSION     NM_001168333.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Teng,Y., Xie,R., Xu,J., Wang,P., Chen,W., Shan,Z., Yan,Z., Mao,F.,
            Cheng,P., Peng,L., Zhang,J., Tian,W., Yang,S., Zhao,Y., Chen,W.,
            Zou,Q. and Zhuang,Y.
  TITLE     Tubulointerstitial nephritis antigen-like 1 is a novel
            matricellular protein that promotes gastric bacterial colonization
            and gastritis in the setting of Helicobacter pylori infection
  JOURNAL   Cell Mol Immunol 20 (8), 924-940 (2023)
   PUBMED   37336990
  REMARK    GeneRIF: Tubulointerstitial nephritis antigen-like 1 is a novel
            matricellular protein that promotes gastric bacterial colonization
            and gastritis in the setting of Helicobacter pylori infection.
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Sato,Y., Kawashima,K., Fukui,E., Matsumoto,H., Yoshizawa,F. and
            Sato,Y.
  TITLE     Functional analysis reveals that Tinagl1 is required for normal
            muscle development in mice through the activation of ERK signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (9), 119294 (2022)
   PUBMED   35597451
  REMARK    GeneRIF: Functional analysis reveals that Tinagl1 is required for
            normal muscle development in mice through the activation of ERK
            signaling.
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Tian,W.Q., Chen,S.Y., Chuan,F.N., Zhao,W.R. and Zhou,B.
  TITLE     Down-regulated TINAGL1 in fibroblasts impairs wound healing in
            diabetes
  JOURNAL   FASEB J 36 (3), e22235 (2022)
   PUBMED   35199864
  REMARK    GeneRIF: Down-regulated TINAGL1 in fibroblasts impairs wound
            healing in diabetes.
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Braitsch,C.M., Azizoglu,D.B., Htike,Y., Barlow,H.R., Schnell,U.,
            Chaney,C.P., Carroll,T.J., Stanger,B.Z. and Cleaver,O.
  TITLE     LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit
            pancreatic progenitor differentiation
  JOURNAL   PLoS Biol 17 (7), e3000382 (2019)
   PUBMED   31323030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Shen,M., Jiang,Y.Z., Wei,Y., Ell,B., Sheng,X., Esposito,M.,
            Kang,J., Hang,X., Zheng,H., Rowicki,M., Zhang,L., Shih,W.J.,
            Celia-Terrassa,T., Liu,Y., Cristea,I., Shao,Z.M. and Kang,Y.
  TITLE     Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and
            Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR
            Signaling
  JOURNAL   Cancer Cell 35 (1), 64-80 (2019)
   PUBMED   30612941
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Igarashi,T., Tajiri,Y., Sakurai,M., Sato,E., Li,D., Mukai,K.,
            Suematsu,M., Fukui,E., Yoshizawa,M. and Matsumoto,H.
  TITLE     Tubulointerstitial nephritis antigen-like 1 is expressed in
            extraembryonic tissues and interacts with laminin 1 in the Reichert
            membrane at postimplantation in the mouse
  JOURNAL   Biol Reprod 81 (5), 948-955 (2009)
   PUBMED   19587330
  REMARK    GeneRIF: In mouse embryos, the expression of both Tinagl1 mRNA and
            TINAGL1 protein was increased just prior to implantation. During
            postimplantation, TINAGL1 expression was restricted to
            extraembryonic regions.
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Li,D., Mukai,K., Suzuki,T., Suzuki,R., Yamashita,S., Mitani,F. and
            Suematsu,M.
  TITLE     Adrenocortical zonation factor 1 is a novel matricellular protein
            promoting integrin-mediated adhesion of adrenocortical and vascular
            smooth muscle cells
  JOURNAL   FEBS J 274 (10), 2506-2522 (2007)
   PUBMED   17425658
  REMARK    GeneRIF: Collectively with the putative role of AZ-1 in the
            adrenocortical zonation, we propose that AZ-1 potentially regulates
            functions of adrenocortical and VSM cells by modulating cell-matrix
            interactions
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Mukai,K., Mitani,F., Nagasawa,H., Suzuki,R., Suzuki,T., Suematsu,M.
            and Ishimura,Y.
  TITLE     An inverse correlation between expression of a preprocathepsin
            B-related protein with cysteine-rich sequences and steroid 11beta
            -hydroxylase in adrenocortical cells
  JOURNAL   J Biol Chem 278 (19), 17084-17092 (2003)
   PUBMED   12600995
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Kobayashi,M., Kinouchi,T., Hakamata,Y., Kamiakito,T., Kuriki,K.,
            Suzuki,K., Tokue,A., Fukayama,M. and Tanaka,A.
  TITLE     Isolation of an androgen-inducible novel lipocalin gene, Arg1, from
            androgen-dependent mouse mammary Shionogi carcinoma cells
  JOURNAL   J Steroid Biochem Mol Biol 77 (2-3), 109-115 (2001)
   PUBMED   11377975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606925.16 and AB050626.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available conservation
            data. The CDS extension adds 51 aa to the N-terminus of the protein
            and includes a predicted signal peptide. The length of the
            extension and the signal peptide are supported by orthologs.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050626.1, BC018539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL606925.16        140175-140196       c
            23-1950             AB050626.1         1-1928
            1951-1954           AL606925.16        130994-130997       c
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..1954
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /note="tubulointerstitial nephritis antigen-like 1"
                     /db_xref="GeneID:94242"
                     /db_xref="MGI:MGI:2137617"
     exon            1..80
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            81..395
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1489
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /note="adrenocortical zonation factor 1;
                     androgen-regulated gene 1 protein; tubulointerstitial
                     nephritis antigen-related protein"
                     /codon_start=1
                     /product="tubulointerstitial nephritis antigen-like
                     precursor"
                     /protein_id="NP_001161805.1"
                     /db_xref="CCDS:CCDS18708.2"
                     /db_xref="GeneID:94242"
                     /db_xref="MGI:MGI:2137617"
                     /translation="MWGCWLGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGG
                     RYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQ
                     GCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGN
                     HSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHE
                     PLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDG
                     AWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSN
                     DIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQ
                     YRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETF
                     VLGVWGRVGMEDMGHH"
     exon            396..459
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            460..552
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            553..667
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            668..791
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            792..942
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1132
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1178
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1302
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1348
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1954
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /note="hexamer: AATAAA"
     polyA_site      1950
                     /gene="Tinagl1"
                     /gene_synonym="1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP;
                     Tinagl"
                     /note="major polyA site"
ORIGIN      
        1 acttgactcg gtctggcagt ctcgagcttg gaggcggagg cgcgcagggc agcctgggtc
       61 cagcccacac ccctcaccag gaggcaccat gtggggatgt tggctggggc tgctcttgct
      121 gctgctggct ggccaggctg ccctggaggc ccggcggagt cgttggcgca gggagctggc
      181 gccagggctg cacctgcggg gcatccggga cgccggtggc agatactgcc aagagcagga
      241 catgtgctgt cgaggccgtg ctgacgagtg tgccctgccc tacctgggag ccacctgtta
      301 ctgtgacctc ttctgcaacc gcaccgtctc tgactgctgc cccgacttct gggacttctg
      361 cctcgggatt ccacccccct tccctcccgt ccaagggtgc atgcatgggg gccggatcta
      421 cccagtcttc ggaacctact gggacaactg caatcgatgc acctgccatg agggagggca
      481 ttgggagtgc gaccaggagc cgtgtctagt ggacccagac atgattaaag ccatcaaccg
      541 aggcaactac gggtggcagg ctgggaacca cagtgccttc tggggcatga ccctggatga
      601 gggcattcgc taccgcctgg gcacaatccg cccatcctcc actgtcatga atatgaatga
      661 gatttatacg gtgctgggcc aaggggaagt gctacccact gcctttgaag cttcagagaa
      721 gtggcccaac ctgatccacg agccattgga ccagggcaat tgtgcaggtt cctgggcttt
      781 ctccacagca gctgtcgcat ctgatcgcgt ctctatccat tctttgggac acatgacacc
      841 catcctatca ccgcaaaacc tgctgtcctg tgatacccac caccagcagg gctgccgagg
      901 tgggcgtctt gatggcgctt ggtggttcct gcggcgccgc ggggtggtgt ctgacaactg
      961 ttacccattc tccggccgtg agcagaacga ggccagcccc actcctcgtt gtatgatgca
     1021 cagccgcgcc atggggcggg gcaagcgcca agccacttcc cgctgcccca atggtcaggt
     1081 tgattccaac gacatctacc aggtcacgcc tgcctaccgc ctgggctctg atgagaagga
     1141 gatcatgaag gagctaatgg aaaacggccc tgttcaagca ctcatggaag tacacgagga
     1201 cttcttcttg taccagcgtg gcatctacag ccacacacct gtaagccagg ggaggccgga
     1261 gcagtaccgc agacatggga ctcactcagt caagatcact gggtggggag aagagacgct
     1321 gccagacgga aggaccatta agtactggac tgctgccaac tcgtggggcc catggtgggg
     1381 tgaaaggggc cacttccgga tcgtgcgtgg caccaacgag tgcgacatcg agaccttcgt
     1441 gctgggcgtc tggggtcgcg tgggaatgga ggacatgggg caccactgag tctcagccac
     1501 taggcgaggt gggatccaca gccacagaag aggccttggg ggccatgccc gatgaagcct
     1561 tgtgtgcact tcgggaccag gtgctaatct ctacagactc agatccgcgc gtgcgcgcta
     1621 aggcagaatc ccacctagga gacaaagatg caccaggctg gcggaagccc ccagatatca
     1681 cagccggaac tgggaagggc cctgtttgga aactgcaggg agtatagaca gattccaggt
     1741 ccctggtcag ccaggccaag accacaggag ctaagacacc ccaacctcat caccctccta
     1801 cccaccctct ctctcatctt ctttttgatg aattctgtcc atctccctag cctccatttt
     1861 ggttgtacct ttccattctc agtactgctt tcttattctt taaagatatt tatttttctt
     1921 ttcattaaaa taaaaccaaa gtattgataa ttac
//
