LOCUS       NM_012033               1708 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus tubulointerstitial nephritis antigen (Tinag),
            transcript variant 1, mRNA.
ACCESSION   NM_012033
VERSION     NM_012033.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Zhang MH, Niu H, Li Z, Huo RT, Wang JM and Liu J.
  TITLE     Activation of PI3K/AKT is involved in TINAG-mediated promotion of
            proliferation, invasion and migration of hepatocellular carcinoma
  JOURNAL   Cancer Biomark 23 (1), 33-43 (2018)
   PUBMED   29991125
  REMARK    GeneRIF: Collectively, our results underscore the significance of
            TINAG in Hepatocellular carcinoma (HCC)progression and prognosis,
            and TINAG might be a novel candidate oncogene in HCC. These results
            propose that targeting TINAG might offer future clinical utility in
            HCC.
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le
            Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen
            GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D and Gondin J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Naba A, Clauser KR, Hoersch S, Liu H, Carr SA and Hynes RO.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Xie P, Sun L, Nayak B, Haruna Y, Liu FY, Kashihara N and Kanwar YS.
  TITLE     C/EBP-beta modulates transcription of tubulointerstitial nephritis
            antigen in obstructive uropathy
  JOURNAL   J Am Soc Nephrol 20 (4), 807-819 (2009)
   PUBMED   19297554
  REMARK    GeneRIF: Altered interactions between C/EBP-beta and TINag play a
            critical role in the pathophysiology of renal injury after
            obstruction.
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Ikeda M, Takemura T, Hino S and Yoshioka K.
  TITLE     Molecular cloning, expression, and chromosomal localization of a
            human tubulointerstitial nephritis antigen
  JOURNAL   Biochem Biophys Res Commun 268 (1), 225-230 (2000)
   PUBMED   10652240
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Kanwar YS, Kumar A, Yang Q, Tian Y, Wada J, Kashihara N and Wallner
            EI.
  TITLE     Tubulointerstitial nephritis antigen: an extracellular matrix
            protein that selectively regulates tubulogenesis vs.
            glomerulogenesis during mammalian renal development
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11323-11328 (1999)
   PUBMED   10500175
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Kumar A, Ota K, Wada J, Wallner EI, Charonis AS, Carone FA and
            Kanwar YS.
  TITLE     Developmental regulation and partial-length cloning of
            tubulointerstitial nephritis antigen of murine metanephros
  JOURNAL   Kidney Int 52 (3), 620-627 (1997)
   PUBMED   9291180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140981.3.
            
            On Apr 25, 2009 this sequence version replaced NM_012033.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010745.1, AF153366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AC140981.3         150698-151130       c
            434-497             AC140981.3         137775-137838       c
            498-587             AC140981.3         137038-137127       c
            588-702             AC140981.3         132239-132353       c
            703-826             AC140981.3         114291-114414       c
            827-977             AC140981.3         110979-111129       c
            978-1158            AC140981.3         106930-107110       c
            1159-1204           AC140981.3         105178-105223       c
            1205-1328           AC140981.3         102242-102365       c
            1329-1374           AC140981.3         67558-67603         c
            1375-1708           AC140981.3         57047-57380         c
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.67 cM"
     gene            1..1708
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /note="tubulointerstitial nephritis antigen"
                     /db_xref="GeneID:26944"
                     /db_xref="MGI:MGI:1349477"
     exon            1..433
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1509
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /codon_start=1
                     /product="tubulointerstitial nephritis antigen precursor"
                     /protein_id="NP_036163.3"
                     /db_xref="CCDS:CCDS23351.1"
                     /db_xref="GeneID:26944"
                     /db_xref="MGI:MGI:1349477"
                     /translation="MWTGYKILIFFSLTTDICTETHFSQGEAEPGPRFTRNHTIFEGS
                     RHKRAIFQGEYCRRFGCCEARDDTCVTQFYEANALCYCDSFCERDTSDCCPDYKSFCH
                     EEKEEPPFQQPSDPEGCFRDSQHYEEGSVVKENCNSCTCSGQQWKCSQHVCLVHPELI
                     DHINKGDYGWTAQNYSQFWGMTLEEGFKFRLGTLPPSPMLLSMNEMTASFPPRADLPE
                     IFIASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCC
                     AKNRHGCNSGSIDRAWWFLRKRGLVSHACYPLFKDQNTTNNICAMASRSDGRGKRHAT
                     KPCPNSFEKSNRIYQCSPPYRVSSNETEIMREIIQNGPVQAIMQVHEDFFYYKTGIYR
                     HVVSTNEEPEKYKKLRTHAVKLTGWGTLRGARGKKEKFWIAANSWGKSWGENGYFRIL
                     RGVNESDIEKLIIAAWGQLTSSDDP"
     exon            434..497
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            498..587
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            588..702
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            703..826
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            827..977
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1158
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1204
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1328
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1374
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1708
                     /gene="Tinag"
                     /gene_synonym="TIN-ag"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaggctt caaagaaaaa aatccccaag actaaaagaa tcaggtgcag ttgaaagagg
       61 aagctgaacc aacaaacaat aatgtggact ggatataaga tcttaatctt cttctctctg
      121 acgacagaca tctgcactga gactcatttc tctcaaggag aagcagaacc agggccaaga
      181 ttcactagaa atcacaccat ttttgaaggt tctcggcaca aaagggccat tttccaaggg
      241 gaatactgta ggcgctttgg ctgttgtgaa gctagagatg acacctgtgt cactcagttc
      301 tatgaggcca atgcactgtg ttactgtgac agcttctgtg agcgggacac ctctgattgc
      361 tgtcctgatt acaagtcatt ctgccacgaa gaaaaagaag agcctccttt ccaacagcct
      421 tcagacccag aaggttgctt cagagatagc cagcattatg aagaaggatc agtagttaaa
      481 gaaaactgca actcctgtac atgttcagga cagcagtgga aatgttccca acatgtgtgc
      541 cttgttcatc cagaattaat tgaccacatc aataaaggag actatggatg gacagcacag
      601 aattatagcc aattctgggg aatgacctta gaagaaggat tcaaattccg cctcggcacc
      661 ttgccaccta gccccatgct tctcagcatg aatgaaatga cagcttcttt tcctcccaga
      721 gctgatcttc ctgagatctt cattgcttct tataagtggc ctggatggac tcatggtcca
      781 ctggatcaaa aaaactgtgc tgcatcctgg gctttttcca ccgcaagtgt ggcagctgac
      841 cgaattgcaa ttcagtccaa gggtcgatac acagccaatc tctcgcctca gaatttgatc
      901 tcttgttgtg ccaagaatcg tcacggatgc aacagtggaa gcatagatag ggcctggtgg
      961 ttcctgagaa aacgtggact ggtatctcat gcatgctacc cacttttcaa ggaccaaaac
     1021 actaccaata atatctgtgc tatggcaagt agatcagatg ggcggggaaa acggcatgcc
     1081 acaaagccat gtcccaacag cttcgagaaa tccaacagga tttaccaatg ttctcctcca
     1141 tacagagtct cttccaatga aactgaaatt atgagagaaa tcatacaaaa tggaccagtt
     1201 caagccataa tgcaagtcca tgaagacttc ttttattata agacaggaat atacagacat
     1261 gttgtcagca caaatgaaga accagaaaag tataaaaaac ttcggacaca tgcagttaaa
     1321 ctcactggat ggggcacact gagaggagca cgaggaaaaa aagaaaaatt ttggattgct
     1381 gccaattcct ggggaaagtc atggggagag aatggctatt ttaggattct tcgaggagta
     1441 aatgaatctg acattgagaa attgattatc gcagcgtggg gccaactgac aagttcagat
     1501 gatccatagc tatcacattt ccataaggtc atgcattcaa gtaactcatt aaatcgaatt
     1561 ttagcaatcc aaggttccct gagccagagg aagggtgcat ttttgctatg tgcgtaggac
     1621 attcctcctt tcttgtttta ctccagactc taatccgttc tctttatatt attaaaatac
     1681 taataaaaga aagaatggct aaatgtca
//
