LOCUS       NM_011595               4681 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus tissue inhibitor of metalloproteinase 3 (Timp3), mRNA.
ACCESSION   NM_011595
VERSION     NM_011595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Grenell,A., Singh,C., Raju,M., Wolk,A., Dalvi,S., Jang,G.F.,
            Crabb,J.S., Hershberger,C.E., Manian,K.V., Hernandez,K.,
            Crabb,J.W., Singh,R., Du,J. and Anand-Apte,B.
  TITLE     Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase
            glycolytic activity and dysregulate glutamine metabolism in RPE
            cells
  JOURNAL   Mol Metab 88, 101995 (2024)
   PUBMED   39047907
  REMARK    GeneRIF: Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations
            increase glycolytic activity and dysregulate glutamine metabolism
            in RPE cells.
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Guo,P., Ru,X., Zhou,J., Chen,M., Li,Y., Duan,M., Li,Y., Li,W.,
            Chen,Y., Zuo,S. and Feng,H.
  TITLE     TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage
            in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
  JOURNAL   Cell Mol Neurobiol 44 (1), 33 (2024)
   PUBMED   38625414
  REMARK    GeneRIF: TIMP-3 Alleviates White Matter Injury After Subarachnoid
            Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell
            Maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Hung,J.H., Tsai,P.H., Aala,W.J.F., Chen,C.C., Chiou,S.H.,
            Wong,T.W., Tsai,K.J., Hsu,S.M. and Wu,L.W.
  TITLE     TIMP3/Wnt axis regulates gliosis of Muller glia
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167087 (2024)
   PUBMED   38369214
  REMARK    GeneRIF: TIMP3/Wnt axis regulates gliosis of Muller glia.
REFERENCE   4  (bases 1 to 4681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4681)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4681)
  AUTHORS   Sun,Y., Hegamyer,G., Kim,H., Sithanandam,K., Li,H., Watts,R. and
            Colburn,N.H.
  TITLE     Molecular cloning of mouse tissue inhibitor of metalloproteinases-3
            and its promoter. Specific lack of expression in neoplastic JB6
            cells may reflect altered gene methylation
  JOURNAL   J Biol Chem 270 (33), 19312-19319 (1995)
   PUBMED   7642607
REFERENCE   7  (bases 1 to 4681)
  AUTHORS   Apte,S.S., Olsen,B.R. and Murphy,G.
  TITLE     The gene structure of tissue inhibitor of metalloproteinases
            (TIMP)-3 and its inhibitory activities define the distinct TIMP
            gene family
  JOURNAL   J Biol Chem 270 (24), 14313-14318 (1995)
   PUBMED   7782289
  REMARK    Erratum:[J Biol Chem. 1996 Feb 2;271(5):2874.. PMID: 8576269]
REFERENCE   8  (bases 1 to 4681)
  AUTHORS   Harvey,M.B., Leco,K.J., Arcellana-Panlilio,M.Y., Zhang,X.,
            Edwards,D.R. and Schultz,G.A.
  TITLE     Proteinase expression in early mouse embryos is regulated by
            leukaemia inhibitory factor and epidermal growth factor
  JOURNAL   Development 121 (4), 1005-1014 (1995)
   PUBMED   7743917
REFERENCE   9  (bases 1 to 4681)
  AUTHORS   Reponen,P., Leivo,I., Sahlberg,C., Apte,S.S., Olsen,B.R.,
            Thesleff,I. and Tryggvason,K.
  TITLE     92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV
            collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse
            embryo implantation
  JOURNAL   Dev Dyn 202 (4), 388-396 (1995)
   PUBMED   7626795
REFERENCE   10 (bases 1 to 4681)
  AUTHORS   Apte,S.S., Hayashi,K., Seldin,M.F., Mattei,M.G., Hayashi,M. and
            Olsen,B.R.
  TITLE     Gene encoding a novel murine tissue inhibitor of metalloproteinases
            (TIMP), TIMP-3, is expressed in developing mouse epithelia,
            cartilage, and muscle, and is located on mouse chromosome 10
  JOURNAL   Dev Dyn 200 (3), 177-197 (1994)
   PUBMED   7949367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE651900.1, AK083905.1, AK147847.1 and BY439696.1.
            
            On Dec 19, 2006 this sequence version replaced NM_011595.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z30970.1, AK083905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               BE651900.1         1-143
            144-294             AK083905.1         2-152
            295-1922            AK147847.1         153-1780
            1923-4279           AK083905.1         1781-4137
            4280-4681           BY439696.1         11-412
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 42.83 cM"
     gene            1..4681
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /note="tissue inhibitor of metalloproteinase 3"
                     /db_xref="GeneID:21859"
                     /db_xref="MGI:MGI:98754"
     exon            1..563
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..646
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            647..758
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..880
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
     exon            881..4681
                     /gene="Timp3"
                     /gene_synonym="Timp-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccccccg gccccgcccc ctttttggag ggccgatgag gtaatgcggc gctgccattg
       61 gtcggagggg gcggaccccg agctcccgag gggctgggtc ccctcgcgcc cctatatcac
      121 tctgcagccc tggactctcg ctcacagtgg gcagcgggca gccgccagcg ccaagaatct
      181 tcttctcccg cttctccgct tcccgatcct tctccgggag gccactcgtt ggctccgcgg
      241 actcgtgttc cagcgaccct tggccactta gtcctgtccc gccgggctac ttggaaggca
      301 cttccccgga gctcatcgtt gcccaccgtg cacagtgccc ggttaaaccc agcgagtgag
      361 ctcggactgt agcatcagcg ctagcgctcg gcaactttga agaaaagagc ggcagtcccc
      421 gcagcggacc acaacagcta ccatgactcc ctggcttggg cttgtcgtgc tcctgagctg
      481 ctggagcctt gggcactggg gcgcggaagc gtgcacatgc tctcccagcc atccccagga
      541 tgccttctgc aactccgaca tcgtgatccg ggccaaagtg gtgggaaaga agctggtgaa
      601 ggaggggccc tttggcactc tggtctacac tattaagcag atgaagatgt accgaggctt
      661 cagtaagatg ccccacgtgc agtacattca cacggaagcc tctgaaagtc tttgtggcct
      721 caagctagaa gtcaacaaat accagtacct gctgacaggg cgcgtgtatg aaggcaagat
      781 gtacacagga ctgtgcaact ttgtggagag gtgggaccac ctcacactgt cccagcgcaa
      841 gggcctcaat taccgctacc acctgggttg caattgcaag atcaagtcct gctactactt
      901 gccttgtttt gtgacctcca agaatgagtg tctctggacc gacatgctct ccaattttgg
      961 gtaccctggc tatcagtcca aacactacgc ctgcatccgg cagaagggtg gctactgcag
     1021 ctggtaccga ggatgggctc ccccagacaa gagcatcagc aacgccacag acccctgaac
     1081 ccagaccttc cccacctcac ctccttccca tcccgccgag cgtcccagac actaactctt
     1141 cccagatgat gacaatgaaa ttagtgcctg ttttcttgca aatttagcac tggggacact
     1201 taaagtctct gctgtctatg gagttgattt ggaaatacct tcctggcccc gcccctaccc
     1261 cttctttttg gttttgacat cacccatttc caactgggga tctctggtgc caagccagaa
     1321 agaacgaggc atgtatacac ctcttcttca tgatatataa tctatatttt tttaggaaaa
     1381 cagaaattga aaaatttatc ccattggggc atttaaagct actcttcttt cttcttcctc
     1441 tcttgaccac atcctagacc cagttccata tacacttctt catcccaata cacaggaaac
     1501 atggataagg aagttggcag aagtccaact gtttcccaat cagtcaaagg cagcaagcag
     1561 acagacgcca ggtatttgaa aggtcttcta cacagaggat atacaactgt atgtctgggt
     1621 cagacagtct gtctatgtgt gcatgtcaga gggagagaag agacagactg taggagtggg
     1681 tctcacagtt atccagccct gtgatacttg ggttgacccc atgtttcaga tcctggaaca
     1741 agcatccaag agtaacagaa ctttctgagc tggcaaaggc ttaaacatct gcctgggttc
     1801 agcaggcaac ctgcccgtct gtacaaaaaa ctcaaagggc tgagatgaac gtctttcctc
     1861 tcctgcctcc catgagacag tctcctagga attcttgggg aagtttggct ggaagcttgc
     1921 caactgtaag ttggagaaac acacacctga cactatccac agatatagtc aagtagattt
     1981 ggatagagaa tactatttcc aaagtagtgt ttagctcatc tagggggatg tgtttatata
     2041 tacatttgca tatacccacg ggggattatg agctaatttt ttttatagga cacagaattc
     2101 tattcaatgc tgttaaatat gcaaatagtt taatcttttt ttcttttgtt gtttgatggg
     2161 aaattgtgac attccaagtt gacttttttt tattatctga attaaaattt gaaactctga
     2221 ccacactcag taccctactg tccctataac tggggttatc tgaccatcca tctcccttct
     2281 ttgttctgct ttctgttcgg ggtgcccttc acttaattgc cttactggct ggctgacggc
     2341 aggggagtgt gagtgttagg ttagggcctt ctcatgaaag gggcagttgc acagtggaat
     2401 gactcctctc ctggatctgg ggacagcata cacttcttcc ccagctcagt aatgggtgaa
     2461 gtcacttccg gaggtggtca cctcatagaa tgaacatgat tggttactga gggagccagg
     2521 ctctgccgtc caaatgtagg ccttttgttg tgttgtattt ttgtttttaa ataaaagtac
     2581 agtataaatt ttcctattaa ataagattat tttaagtttt agtgtcaaca ttgcaatgcc
     2641 aatagtaggt gagagtgtat tgcacagagt tggagatagt aaggtggtga catttaacac
     2701 agttactctg tcttttttca gattatgggt atttatcctc tattagtatc atatcgtttt
     2761 cattccactt tagaaacaca gttaccagtt gagagagaga gagagagaga gagagagaga
     2821 gagagagaga gagagagaga acaagttcta gtctgtcccc accccacaca taccactgct
     2881 ttgtccaggt gtttgataga agagcagggc aggaagacag ttcaggagat gggtgtcaag
     2941 ttttctcttg gttgatttca ttcccttgca tctttcccct gtgctgacag ggggcagaag
     3001 gcacaaccat ttccatggtg tgccgagaga aggagctgag gtcagcaagc cagtggttct
     3061 taagagctga acctctggct ttactgttgg aagttgtcta tttcaacctc agagtttcct
     3121 aatatggcgc tcctgatcta tcttactcaa gtgccctccc atatgtatac cccaacatct
     3181 tttccatctt aatccagcat cgggccattc tcaatccctg gtaatcacct cccttttaca
     3241 tggacagact tgaggtgagg cctaagtatg aggcacctga agataaaacc aatgggcaga
     3301 accaatggcc ccagtcggct tttgaggtct tggtgagaag tactggccac gaaagggtct
     3361 tgtgtaaagt tacatcatcg gagagcggtt tttgagcttt caataagcta tagctttgtt
     3421 tatttcacct gttcacttac tgtataattt aaaatcattt atgtagctga gacactttga
     3481 tacttcaatt atatcgtgaa tgttttattt tgctaaatca tgtgccatgt gtaggctgtt
     3541 gtgtgtacac tgtgtctaag agaagaagaa aagaaaaaaa aaagaaagaa acccacatgc
     3601 catttttttt ttctgattca aattctacag tagaatggag ggcagaatta ctgggacaca
     3661 atcaccactc agctagaatg gagattcaag gaaatggaag gtactagaaa cagactcctc
     3721 cagcctcctc cccatagaat cctaagggtg ggaagaagaa gaagaaaaaa agcaaaagca
     3781 aaacaaaaca gaaatcaaaa gtacactcaa gttcttgtcc tgtatcaaat atccctaggt
     3841 catctgccac ccactttcca agacctttct cctactcaac caggaagtca tggtttctgc
     3901 agtccagagc catggcaact gagattctaa gctctctttg tctcatccag gcaacttttc
     3961 tgtctcccaa ccaaggaatt cctctgctca ggctcctgtt gcccaggata gctctcttct
     4021 atagccagga tgtggagctt aaggagactc caatgtttac tttctccagt cctagctctg
     4081 ccatataaac actgtctcat gttgtgcttc ttaaacgaca aagaacatag tgacttttgg
     4141 ggatagatct gtctgggaga taatgtgagt ccaggaggca ttactcttcc ctgcctcaca
     4201 tcaaggtgcc attcaggtag ttggctccca gctacttaac gataaaaata tcactttcgt
     4261 atttgtatca gagaaactta aaaaaaaaat aaagtctgat ggtagaaatc caatgaaatg
     4321 ggagaaggca ggagagagag gtctcagtag atctaagtcg gctgtttggg ttgaggagga
     4381 gagaacccga ggaaatgacc atgctctggg gacaggggta ccttagattc tctgtctatt
     4441 tttcctctag caagccagct gtgctgaagc ccagtagaga tgaagagaca ccagccagag
     4501 aaaaccccct ctagaaggaa tgtatttgtt gctaaatttt gtagcactgt ttacagtttt
     4561 cctccatgtt atttatgaat tttatattcc gtgaatgtat attgtcttgt aatgttgcat
     4621 agtgttcact ttttatagct gtcctttatt ctaaacagta aagtggtttt atttctatca
     4681 c
//
