LOCUS       NM_011594               3635 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus tissue inhibitor of metalloproteinase 2 (Timp2), mRNA.
ACCESSION   NM_011594
VERSION     NM_011594.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3635)
  AUTHORS   Xu,D., Jiang,J., Liu,Y., Pang,J., Suo,J., Li,Y. and Peng,Z.
  TITLE     TIMP2 protects against sepsis-associated acute kidney injury by
            cAMP/NLRP3 axis-mediated pyroptosis
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1353-C1366 (2024)
   PUBMED   38497110
  REMARK    GeneRIF: TIMP2 protects against sepsis-associated acute kidney
            injury by cAMP/NLRP3 axis-mediated pyroptosis.
REFERENCE   2  (bases 1 to 3635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3635)
  AUTHORS   Tang,J., Kang,Y., Zhou,Y., Shang,N., Li,X., Wang,H., Lan,J.,
            Wang,S., Wu,L. and Peng,Y.
  TITLE     TIMP2 ameliorates blood-brain barrier disruption in traumatic brain
            injury by inhibiting Src-dependent VE-cadherin internalization
  JOURNAL   J Clin Invest 134 (3), e164199 (2023)
   PUBMED   38015626
  REMARK    GeneRIF: TIMP2 ameliorates blood-brain barrier disruption in
            traumatic brain injury by inhibiting Src-dependent VE-cadherin
            internalization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3635)
  AUTHORS   Gupta,N., Soriano-Ubeda,C., Stein,P., Savy,V., Papas,B.N.,
            Ardestani,G., Carvacho,I., Alfandari,D., Williams,C.J. and
            Fissore,R.A.
  TITLE     Essential role of Mg2+ in mouse preimplantation embryo development
            revealed by TRPM7 chanzyme-deficient gametes
  JOURNAL   Cell Rep 42 (10), 113232 (2023)
   PUBMED   37824328
REFERENCE   5  (bases 1 to 3635)
  AUTHORS   Ferreira,A.C., Hemmer,B.M., Philippi,S.M., Grau-Perales,A.B.,
            Rosenstadt,J.L., Liu,H., Zhu,J.D., Kareva,T., Ahfeldt,T.,
            Varghese,M., Hof,P.R. and Castellano,J.M.
  TITLE     Neuronal TIMP2 regulates hippocampus-dependent plasticity and
            extracellular matrix complexity
  JOURNAL   Mol Psychiatry 28 (9), 3943-3954 (2023)
   PUBMED   37914840
REFERENCE   6  (bases 1 to 3635)
  AUTHORS   Stetler-Stevenson,W.G., Liotta,L.A. and Seldin,M.F.
  TITLE     Linkage analysis demonstrates that the Timp-2 locus is on mouse
            chromosome 11
  JOURNAL   Genomics 14 (3), 828-829 (1992)
   PUBMED   1427919
REFERENCE   7  (bases 1 to 3635)
  AUTHORS   De Clerck,Y., Szpirer,C., Aly,M.S., Cassiman,J.J., Eeckhout,Y. and
            Rousseau,G.
  TITLE     The gene for tissue inhibitor of metalloproteinases-2 is localized
            on human chromosome arm 17q25
  JOURNAL   Genomics 14 (3), 782-784 (1992)
   PUBMED   1427908
REFERENCE   8  (bases 1 to 3635)
  AUTHORS   Leco,K.J., Hayden,L.J., Sharma,R.R., Rocheleau,H., Greenberg,A.H.
            and Edwards,D.R.
  TITLE     Differential regulation of TIMP-1 and TIMP-2 mRNA expression in
            normal and Ha-ras-transformed murine fibroblasts
  JOURNAL   Gene 117 (2), 209-217 (1992)
   PUBMED   1639268
REFERENCE   9  (bases 1 to 3635)
  AUTHORS   Shimizu,S., Malik,K., Sejima,H., Kishi,J., Hayakawa,T. and
            Koiwai,O.
  TITLE     Cloning and sequencing of the cDNA encoding a mouse tissue
            inhibitor of metalloproteinase-2
  JOURNAL   Gene 114 (2), 291-292 (1992)
   PUBMED   1601312
REFERENCE   10 (bases 1 to 3635)
  AUTHORS   Kishi,J., Ogawa,K., Yamamoto,S. and Hayakawa,T.
  TITLE     Purification and characterization of a new tissue inhibitor of
            metalloproteinases (TIMP-2) from mouse colon 26 tumor cells
  JOURNAL   Matrix 11 (1), 10-16 (1991)
   PUBMED   1851244
  REMARK    Erratum:[Matrix. 1991 Nov;11(5):373.. PMID: 1667327]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK081522.1, AK032818.1 and BQ030835.1.
            
            On Mar 25, 2005 this sequence version replaced NM_011594.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081522.1, AK032818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AK081522.1         96-181
            87-87               AK032818.1         1-1
            88-261              AK081522.1         183-356
            262-264             AK032818.1         176-178
            265-732             AK081522.1         361-828
            733-3618            AK032818.1         647-3532
            3619-3635           BQ030835.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.09 cM"
     gene            1..3635
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /note="tissue inhibitor of metalloproteinase 2"
                     /db_xref="GeneID:21858"
                     /db_xref="MGI:MGI:98753"
     exon            1..451
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..552
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..661
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..786
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..3622
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /note="hexamer: AATAAA"
     polyA_site      1094
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /note="major polyA site"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
                     /note="hexamer: AATAAA"
     polyA_site      3622
                     /gene="Timp2"
                     /gene_synonym="D11Bwg1104e; Timp-2"
ORIGIN      
        1 ccggcctgca ctggccgcca gccaccgaga ggaggagcag aggatcctcg gagcgcaata
       61 aaacggcggc tcggcccgag cccgcagcaa acacagccat agaaggcagc ggaggagccg
      121 agccgggctg cgctcgctcg ccgcccccca gcctctttct tctccgccgg gtgcactgcc
      181 ctgcgccgtc ccctcgccgc tgcgcccctt gacaaagagg acagaaagtt tgcgcggggg
      241 agcgggccag gtgaggaggg gcgtgcccgg cgccccagtc cgcgccccag cagccggacc
      301 caggccccca gcgcgcccgc catgggcgcc gcggcccgca gcctccggct ggcgctcggc
      361 ctcctgctgc tagccacgct gctgcgcccg gccgacgcct gcagctgctc cccggtgcac
      421 ccgcaacagg cgttttgcaa tgcagacgta gtgatcagag ccaaagcagt gagcgagaag
      481 gaggtggatt ccgggaatga catctatggc aaccccatca agaggattca gtatgagatc
      541 aagcagataa agatgttcaa aggacctgac aaagacatcg agtttatcta cacggccccc
      601 tcttcagcag tgtgcggggt ctcgctggac gttggaggaa agaaggagta tctaattgca
      661 ggaaaggcag aaggagatgg caagatgcac attaccctct gtgacttcat tgtgccctgg
      721 gacacgctta gcatcaccca gaagaagagc ctgaaccaca ggtaccagat gggctgtgag
      781 tgcaagatca ctcgctgtcc catgatccct tgctacatct cctccccgga tgagtgcctc
      841 tggatggact gggtcacaga gaagagcatc aatgggcacc aggccaagtt cttcgcctgc
      901 atcaagagaa gtgatggttc ttgcgcgtgg taccgcgggg cggcaccccc caagcaagag
      961 tttcttgaca tcgaggaccc gtaagaaggc tgacagagcc cctgtggcca attgaaaagc
     1021 ctctgagggt ttagactggt ccagctttga catcccttcc tggaaacagc atgaataaaa
     1081 catcaatcat ccaagtgggt tcacgctagt gtgattctgc cccctcccct attttcccta
     1141 gacatggtag tgggtctgga gggacaggcg ggccaggttc cctgccatac cccttccctc
     1201 tgccagcctg agcactgtgt gtctcagtct ttgatccttg ctacaggcag gagtggagca
     1261 cagacttgtt accaggtctc tctggcactg tcacatgcag cagacaggca gcattaaggg
     1321 taccctagct ctgttagggc agagcctggg aatgtgcatt ttgcagaaac tcttgaaggt
     1381 tgttgtaaga ctgtgtagcc ggcctaccag gtccttttca tcctgagagt gacatgtccc
     1441 tcgttttctg cagtggccac ctctctctct ggcccttgca aatgcttccc atccctcctg
     1501 catctggtat ggactttcag gaccctggtc tccctcgggt ctaagaatca ccctccaacc
     1561 agtggttcat ttttctagga gtcccagtca gccccatgaa tccacagact tcagcgaatg
     1621 gaagccctcc ctgagccgtg tttctggctt caaccaagtc attgctgcct tcctctcccc
     1681 tgtctctaca cacaccctca gtggggtctg tgaggtctca tgctgggggc agggatctgt
     1741 ggtgaggggt gcttggcagt ccttgttgcc actctcaagc ttcccaagcc attcttcacc
     1801 cctttccaag caagcttcaa gcatccaggc tgagcagcac ggctcggttt ggctctctgt
     1861 cgcatcaggc cctgccgctg ttggggggcg ctaccagcac tccctctttt gcacaaactg
     1921 atgatataaa aggccagtcc taggcaccta ggaaaagtct agtgaactct ccctgctaga
     1981 tcagcggtca ttatgaccct gttgatttct gtgtcagtaa ctaagcacgc agcaggggag
     2041 actttgcggt gggcagttct tcgtaccaag cccccccccc caaggatgct gtggcttgtt
     2101 ttcagatcca tctcattttc ctaaaggtga attctcatgc atggctgaga gacatgtgta
     2161 tgcagctctg cttctgtctc ttaatgtcgc ttaaggccct tatagggaac tggtatatct
     2221 acttgctcct taaagcaatt ttctttctga tgccaatagg atgggggtta agacaggcag
     2281 agctttatca ctaacaatat agacagccac tcttccttct gcctgcgtct taaaaaataa
     2341 gctgtcccaa ggacacaaat gtatattatc catacatgca cgcatatgct cacacacaaa
     2401 ctcagactct gaagtctggt agcctgtgaa tgttcctttt gtaaaatgct tccaaaagcc
     2461 tctttgctcc aaccctgtcc taaccatcag aaaccccaaa gaaacggtta aggactcccc
     2521 ctcagactct ccctacccaa gcccctacac caggacctgg ccagtccttt taagacagac
     2581 tgggaggaca cacaggagtc agcctgcccc ttctgagggc attttcgtgt tgtgcagtga
     2641 tgttcttcct tggatgctgg cctggaccag ccaacgagac cctgcagtct atcccgccct
     2701 gcctgtttgc ttcctgtgcg gtggtatcaa tatgtaacag tgcctgtttc tgctgatttc
     2761 atgacatgtt ctggtttgtt tctgatgttc gccgtgagcg ttcttgtgcc gtgttgatgc
     2821 ctttcgtagc attagacttt gcacttttaa aaaaaaaaaa aacaaaaatg ttgaagcatc
     2881 gaggaagcat cgaacccaga gtggaatgca tggtatggta gctggcctgg gacagaggga
     2941 ccctttctca tcttcctttg agttctttga ctatctgctt ttccagcctc tcccgtcttt
     3001 tgtatctggt tcaaattatt ataaaggaaa gaccctctga gtataccggt tctgaaagac
     3061 ggcctttctg ttttccactc atgctggggt ttctagccac accaggcaga tgagaggaaa
     3121 ccgagcgagc aaacgaacct ttgggacaaa gtgccagatg gcagctgagc aacagccact
     3181 caaatgcctt cccagcaaac caattgcaat atatagttta aggtgttgtt ttacttctgt
     3241 tatattctaa gccctgggcc tccctccctt actcccgtca tgccagcaac tcgcaatatt
     3301 tcagatgacg tttacatggt agcaatttcc aaatcgctgc ctgatgcgta ttaagacata
     3361 tccgtgggct tgctgcataa ctcaacgctt tgttgatttt gtttctgttt gaactcttgg
     3421 ttgtaggggg ggaggggtgg aaccccatgt gcgtgctgga atatgaagtc tgagatgtac
     3481 cccccaacac cccacgctgg cgatacgtga gagttgttga aagtcagcaa gccgagcgcg
     3541 cctgatgctc tgtatcagtc tctactttta tttttatgag tttgctctgt caatggacaa
     3601 taaaccatat tatcaaagag aaaaaaaaaa aaaaa
//
