LOCUS       NM_001044384             905 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus tissue inhibitor of metalloproteinase 1 (Timp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001044384
VERSION     NM_001044384.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Song T, Yao Y, Papoin J, Sherry B, Diamond B, Gu H, Blanc L and Zou
            YR.
  TITLE     Host factor TIMP1 sustains long-lasting myeloid-biased
            hematopoiesis after severe infection
  JOURNAL   J Exp Med 220 (12) (2023)
   PUBMED   37851372
  REMARK    GeneRIF: Host factor TIMP1 sustains long-lasting myeloid-biased
            hematopoiesis after severe infection.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Davis FM, Melvin WJ, Mangum K, Tsoi LC, Joshi AD, Cai Q, Henke PK,
            Gudjonsson JE and Gallagher KA.
  TITLE     The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of
            Metalloproteinase-Matrix Metalloproteinase Activity During
            Abdominal Aortic Aneurysm Development
  JOURNAL   Ann Surg 278 (3), 426-440 (2023)
   PUBMED   37325923
  REMARK    GeneRIF: The Histone Methyltransferase SETDB2 Modulates Tissue
            Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity
            During Abdominal Aortic Aneurysm Development.
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Cordoba-Jover B, Ribera J, Portoles I, Lecue E, Rodriguez-Vita J,
            Perez-Sisques L, Mannara F, Solsona-Vilarrasa E, Garcia-Ruiz C,
            Fernandez-Checa JC, Casals G, Rodriguez-Revenga L, Alvarez-Mora MI,
            Arteche-Lopez A, Diaz de Bustamante A, Calvo R, Pujol A, Azkargorta
            M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J,
            Melgar-Lesmes P, Jimenez W and Morales-Ruiz M.
  TITLE     Tcf20 deficiency is associated with increased liver fibrogenesis
            and alterations in mitochondrial metabolism in mice and humans
  JOURNAL   Liver Int 43 (8), 1822-1836 (2023)
   PUBMED   37312667
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Zhu H, Li Q, Huang Q, Yang H, Zheng J, Xie R, Han D and Wei Q.
  TITLE     RIG-I contributes to keratinocyte proliferation and wound repair by
            inducing TIMP-1 expression through NF-kappaB signaling pathway
  JOURNAL   J Cell Physiol 238 (8), 1876-1890 (2023)
   PUBMED   37269543
  REMARK    GeneRIF: RIG-I contributes to keratinocyte proliferation and wound
            repair by inducing TIMP-1 expression through NF-kappaB signaling
            pathway.
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Paredes A, Justo-Mendez R, Jimenez-Blasco D, Nunez V, Calero I,
            Villalba-Orero M, Alegre-Marti A, Fischer T, Gradillas A, Sant'Anna
            VAR, Were F, Huang Z, Hernansanz-Agustin P, Contreras C, Martinez
            F, Camafeita E, Vazquez J, Ruiz-Cabello J, Area-Gomez E,
            Sanchez-Cabo F, Treuter E, Bolanos JP, Estebanez-Perpina E, Ruperez
            FJ, Barbas C, Enriquez JA and Ricote M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. PMID: 37322272]
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Edwards DR, Rocheleau H, Sharma RR, Wills AJ, Cowie A, Hassell JA
            and Heath JK.
  TITLE     Involvement of AP1 and PEA3 binding sites in the regulation of
            murine tissue inhibitor of metalloproteinases-1 (TIMP-1)
            transcription
  JOURNAL   Biochim Biophys Acta 1171 (1), 41-55 (1992)
   PUBMED   1420363
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Andria ML, Barsh GS and Levy S.
  TITLE     Expression of TAPA-1 in preimplantation mouse embryos
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1201-1206 (1992)
   PUBMED   1380797
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Cocuzzi ET, Walther SE, Rajan S and Denhardt DT.
  TITLE     Expression and purification of mouse TIMP-1 from E. coli
  JOURNAL   FEBS Lett 307 (3), 375-378 (1992)
   PUBMED   1322839
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Coulombe B, Ponton A, Kerbel RS and Skup D.
  TITLE     Structure and function of murine TIMP gene
  JOURNAL   Matrix Suppl 1, 269-274 (1992)
   PUBMED   1480036
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Waterhouse P, Khokha R and Denhardt DT.
  TITLE     Modulation of translation by the 5' leader sequence of the mRNA
            encoding murine tissue inhibitor of metalloproteinases
  JOURNAL   J Biol Chem 265 (10), 5585-5589 (1990)
   PUBMED   2180930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671885.13, CJ055052.1 and BU756519.1.
            
            [WARNING] On Dec 4, 2023 this sequence was replaced by
            NM_001044384.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008107.1, BE311337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 2180930
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL671885.13        110970-111057
            89-531              CJ055052.1         1-443
            532-905             BU756519.1         1-374               c
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.38 cM"
     gene            1..905
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /note="tissue inhibitor of metalloproteinase 1"
                     /db_xref="GeneID:21857"
                     /db_xref="MGI:MGI:98752"
     exon            1..159
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      86..235
                     /regulatory_class="uORF"
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2180930]"
                     /note="this uORF is predicted to encode a 49 aa peptide
                     (PMID:2180930)"
     exon            160..291
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..785
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; metalloproteinase inhibitor 1; TPA-induced
                     protein; erythroid-potentiating activity; collagenase
                     inhibitor 16C8 fibroblast; tissue inhibitor of
                     metalloproteinases 1"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 1 isoform a
                     precursor"
                     /protein_id="NP_001037849.1"
                     /db_xref="CCDS:CCDS30046.1"
                     /db_xref="GeneID:21857"
                     /db_xref="MGI:MGI:98752"
                     /translation="MMAPFASLASGILLLLSLIASSKACSCAPPHPQTAFCNSDLVIR
                     AKFMGSPEINETTLYQRYKIKMTKMLKGFKAVGNAADIRYAYTPVMESLCGYAHKSQN
                     RSEEFLITGRLRNGNLHISACSFLVPWRTLSPAQQRAFSKTYSAGCGVCTVFPCLSIP
                     CKLESDTHCLWTDQVLVGSEDYQSRHFACLPRNPGLCTWRSLGAR"
     exon            292..371
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..498
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..623
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..890
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
     polyA_site      890
                     /gene="Timp1"
                     /gene_synonym="Clgi; EPA; Timp; TIMP-1; TPA-S1"
ORIGIN      
        1 aggctttgac tccagcggtg ggtggatgag taatgcgtcc aggaagcctg gaggcagtga
       61 tttccccgcc aactccgccc ttcgcatgga catttattct ccactgtgca gcccctgccg
      121 ccatcatcgc agatcggggc tcctagagac acaccagagc agataccatg atggccccct
      181 ttgcatctct ggcatctggc atcctcttgt tgctatcact gatagcttcc agtaaggcct
      241 gtagctgtgc cccaccccac ccacagacag ccttctgcaa ctcggacctg gtcataaggg
      301 ctaaattcat gggttcccca gaaatcaacg agaccacctt ataccagcgt tataagatca
      361 agatgactaa gatgctaaaa ggattcaagg ctgtgggaaa tgccgcagat atccggtacg
      421 cctacacccc agtcatggaa agcctctgtg gatatgccca caagtcccag aaccgcagtg
      481 aagagtttct catcacgggc cgcctaagga acggaaattt gcacatcagt gcctgcagct
      541 tcttggttcc ctggcgtact ctgagccctg ctcagcaaag agctttctca aagacctata
      601 gtgctggctg tggggtgtgc acagtgtttc cctgtttatc tatcccttgc aaactggaga
      661 gtgacactca ctgtttgtgg acggatcagg tcctcgtggg ctctgaggac taccagagcc
      721 gtcactttgc ttgcctgcca cggaatccag gcttgtgcac ctggagatcc cttggggccc
      781 gatgacctga agccttcccc caggaaaaac tgaagcctga acactgtcta cttttcctcc
      841 atctttcttt ctcttagatg gtgaaataaa gaactatcag acagcagcaa aaaaaaaaaa
      901 aaaaa
//
