LOCUS       NM_024273               2080 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane domain
            containing 1 (Timmdc1), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_024273 XM_622625
VERSION     NM_024273.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056343.1, AK081781.1, BY468650.1, BQ175474.1 and BX637624.1.
            
            On Mar 21, 2009 this sequence version replaced NM_024273.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081781.1, BC002243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               CJ056343.1         3-615
            614-1144            AK081781.1         557-1087
            1145-1147           BY468650.1         55-57
            1148-1561           AK081781.1         1089-1502
            1562-2073           BQ175474.1         18-529              c
            2074-2080           BX637624.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.86 cM"
     gene            1..2080
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /note="translocase of inner mitochondrial membrane domain
                     containing 1"
                     /db_xref="GeneID:76916"
                     /db_xref="MGI:MGI:1922139"
     exon            1..323
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..987
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /note="transmembrane protein C3orf1 homolog; translocase
                     of inner mitochondrial membrane domain-containing protein
                     1; TIMM domain containing-protein 1"
                     /codon_start=1
                     /product="complex I assembly factor TIMMDC1,
                     mitochondrial"
                     /protein_id="NP_077235.2"
                     /db_xref="CCDS:CCDS28169.1"
                     /db_xref="GeneID:76916"
                     /db_xref="MGI:MGI:1922139"
                     /translation="MGAPPPAPRSRLCGAWGPFPRVFAAGAVAADSPGFVEDREQRSG
                     VSDPGSLESGWDRLRQLFAKDEQQRFSKEIDYIYRAAVSAGIIGWAYGGIPAFIYAKK
                     RYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWSWRTAVFVTIFNTVNTGLTVYR
                     NKDAMSHFAIAGAVTGGLFRINLGVRGLVAGSIIGALLGAPMGSLLMALEKYSGETVQ
                     ERRQKEWKALHEQRLEEWRSSLQVTELLPMEIESGLEKIQPEGDAQRIEELLSLPRNP
                     SSPHQQSKH"
     exon            324..489
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            490..578
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..646
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..725
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            837..2077
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1567
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /note="major polyA site"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2077
                     /gene="Timmdc1"
                     /gene_synonym="2810021C21Rik; 4930455C21Rik"
ORIGIN      
        1 gagccggctg gggaccggat gtgaggttca gtgtccccca acgtgccgct agtgggctgt
       61 acaggtcacc ctctcccacg gtgcccgccg accctggggt gtctgtctct ctgcgggtag
      121 gagggcgcca tgggcgcgcc gccgcccgct ccccgcagcc gcctttgcgg agcctggggt
      181 cctttccccc gagtctttgc tgccggtgcg gtggctgcgg attccccagg ctttgtggag
      241 gatcgggagc agcgttcagg tgtctcagac cccggttccc tggaatccgg atgggaccgc
      301 ctccggcagc tgtttgccaa agatgaacaa cagagattct caaaggaaat tgactatatc
      361 tacagggcag cagtttcagc aggcatcatt ggctgggcat atggaggaat acctgctttt
      421 atttatgcta aaaaacgcta cattgaacag agccaagcgg agatttatca taaccgattt
      481 gatgctgtgc aaagtgcaca ccgtgctgcc acaaggggct tcatccggta tggctggcgc
      541 tggagttgga gaactgcagt tttcgtgacc atatttaaca cagtgaacac tggactaact
      601 gtgtatcgaa ataaagacgc catgagccat tttgccattg caggagctgt cacaggaggt
      661 cttttcagaa taaacttagg tgttcgaggc ctggtggctg gtagtataat tggagcgttg
      721 ttgggcgcgc ccatgggaag cttgctgatg gccctggaga agtactccgg tgagacggtt
      781 caggagagaa ggcagaagga atggaaggcc ttgcacgagc agaggctgga agagtggaga
      841 agcagtctgc aagtcactga gctcctcccg atggagattg aaagtggctt ggagaagatt
      901 cagcctgagg gagacgctca gaggattgag gagctgctaa gcctccctag gaacccttca
      961 tcgccacatc aacaaagcaa gcactgagga ccagggggct gtgtctggga acgccagtgc
     1021 caggctactc cgctactcct tgccagcccg ctgactgatg tgagggctgg aagctgtgct
     1081 agcggtcact tgtctctgat ctttttcttt ctttctttct tttttttttt tttttttttt
     1141 ttttttggtt tttcaagaca gggtttctct gtgtagccct ggctgtcctg gaactcactt
     1201 tgtagaccag gctagcctcg aactcagaaa tccacctgcc tctgctccga gtgctgggat
     1261 taaaggcacg catcaccaca tggcttccga tctttttatt acatccagaa ttaggcaccc
     1321 agtactcagg gtgccactga cctgtaaatc cagaagcttg ggaggctgag aaaggaagat
     1381 agtgtgatgc tagcctgagc tacttaatga gaacctggtt aaaaaatgtg cacccacaaa
     1441 aaaacccaaa caacagaacc aaaaagcaac ccaaatattc ttatttattc cgatcattga
     1501 tccatctaaa tatttcatat ttctctatca tgctagattt tgtacaagta aaattcttcc
     1561 caaaagattt aaattgtgtt gtctggatcg cctaatcatg cctcagtctt tgaagagtgt
     1621 tctcttggag gacctgaagg aactggagga ggagcatgtc cgcgagaccc tcttcctcgg
     1681 gccctcagac agtggatagt gtgagcctct acgtttagtt gtttggattt tttttttaaa
     1741 ataagaataa gaggtgattc cttgccattt aaacgtggtt taacaaactg gaagcaggtg
     1801 ggtatcagta aagaagcgat ccagcttagt ctccgccccc acactgccaa caaagcacct
     1861 gtgctgcagg acacagaaga tgcgacatgc tgtccccaca gtaaggagct ggctgcctga
     1921 gagaagccgt cctatagatt tcagctatgg acagaatggg agaaagtgca agaccgagtc
     1981 acaggcagca cttttctggc ctttgggtgt gttttttcaa ttttactaac atgcagttaa
     2041 tggtctgaaa acattaaatg gaagatccca ggactaaaaa
//
