LOCUS       NM_011592               1798 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane 44
            (Timm44), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_011592
VERSION     NM_011592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Ma,Z.R., Li,H.P., Cai,S.Z., Du,S.Y., Chen,X., Yao,J., Cao,X.,
            Zhen,Y.F. and Wang,Q.
  TITLE     The mitochondrial protein TIMM44 is required for angiogenesis in
            vitro and in vivo
  JOURNAL   Cell Death Dis 14 (5), 307 (2023)
   PUBMED   37147302
  REMARK    GeneRIF: The mitochondrial protein TIMM44 is required for
            angiogenesis in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Guo,Y.Z., Chen,G., Huang,M., Wang,Y., Liu,Y.Y., Jiang,Q., Cao,C.
            and Liu,F.
  TITLE     TIMM44 is a potential therapeutic target of human glioma
  JOURNAL   Theranostics 12 (17), 7586-7602 (2022)
   PUBMED   36438483
  REMARK    GeneRIF: TIMM44 is a potential therapeutic target of human glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Hoshino,A., Wang,W.J., Wada,S., McDermott-Roe,C., Evans,C.S.,
            Gosis,B., Morley,M.P., Rathi,K.S., Li,J., Li,K., Yang,S.,
            McManus,M.J., Bowman,C., Potluri,P., Levin,M., Damrauer,S.,
            Wallace,D.C., Holzbaur,E.L.F. and Arany,Z.
  TITLE     The ADP/ATP translocase drives mitophagy independent of nucleotide
            exchange
  JOURNAL   Nature 575 (7782), 375-379 (2019)
   PUBMED   31618756
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Fakruddin,M., Wei,F.Y., Suzuki,T., Asano,K., Kaieda,T., Omori,A.,
            Izumi,R., Fujimura,A., Kaitsuka,T., Miyata,K., Araki,K., Oike,Y.,
            Scorrano,L., Suzuki,T. and Tomizawa,K.
  TITLE     Defective Mitochondrial tRNA Taurine Modification Activates Global
            Proteostress and Leads to Mitochondrial Disease
  JOURNAL   Cell Rep 22 (2), 482-496 (2018)
   PUBMED   29320742
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1798)
  AUTHORS   Wallner,E.I., Wada,J., Lin,S., Pan,X., Reddy,J.K., Chugh,S.S. and
            Kanwar,Y.S.
  TITLE     Renal gene expression in embryonic and newborn diabetic mice
  JOURNAL   Exp Nephrol 10 (2), 130-138 (2002)
   PUBMED   11937760
  REMARK    Review article
REFERENCE   9  (bases 1 to 1798)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   10 (bases 1 to 1798)
  AUTHORS   Wada,J. and Kanwar,Y.S.
  TITLE     Characterization of mammalian translocase of inner mitochondrial
            membrane (Tim44) isolated from diabetic newborn mouse kidney
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 144-149 (1998)
   PUBMED   9419343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA493459.1, BC117523.1 and BQ031430.1.
            
            On Mar 25, 2008 this sequence version replaced NM_011592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023454.1, BC110677.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CA493459.1         39-48
            11-1447             BC117523.1         1-1437
            1448-1798           BQ031430.1         1-351               c
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.99 cM"
     gene            1..1798
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /note="translocase of inner mitochondrial membrane 44"
                     /db_xref="GeneID:21856"
                     /db_xref="MGI:MGI:1343262"
     exon            1..63
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1377
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /note="translocator of inner mitochondrial membrane 44;
                     translocator of inner mitochondrial membrane 44; DNA
                     segment, Chr 8, ERATO Doi 118, expressed"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM44"
                     /protein_id="NP_035722.2"
                     /db_xref="CCDS:CCDS22083.1"
                     /db_xref="GeneID:21856"
                     /db_xref="MGI:MGI:1343262"
                     /translation="MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPHGSSYQISRPGRE
                     LTLTKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARR
                     KYKSIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSA
                     ESVSKSGEKLGKTAAFKAISQGVESVKKELDESVLGQTGPYRRPERLRKRTEFAGAKF
                     KESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRAS
                     RALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDHFLHQCETDIIPNILEAMISG
                     ELDILKDWCYEATYSQLAHPIQQAKALGFQFHSRILDISNVDLAMGKMMEQGPVLIVT
                     FQAQVVMVIKNSKGEVYDGDPDKVQRMLYVWALCRDQEELNPYAAWRLLDISASSTEQ
                     IL"
     exon            64..159
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            160..330
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            331..411
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            412..561
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            562..701
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            702..787
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            788..880
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1005
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1056
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1146
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1257
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1782
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="Timm44"
                     /gene_synonym="0710005E20Rik; D8Ertd118e; Mimt44; Tim44"
                     /note="major polyA site"
ORIGIN      
        1 cacacgggct cttccaacat ggcggcggca gctctgcggg gtggctggtg ccgctgtccg
       61 cggaggtgcc taggcagcgg aatccaattt ctctccagcc acaacctacc ccatggttca
      121 agctaccaga taagccggcc aggaagagag ctgacactga ccaaatctta ttcttctggg
      181 agcagaaaag ggtttttgtc aggcttgcta gataacatca aacaagaatt agccaaaaac
      241 aaagagatga aagaaagtat aaaaaagttc cgagatgagg ccaagaagct agaagagtcg
      301 gatgctctcc aggaagccag aaggaagtat aaatccatcg aatcagaaac tgtgcgtacc
      361 agtgaagcaa taaaaaagaa gcttggagaa ttaacaggga cagtgaagga gagtcttgat
      421 gaagtcagta agagtgacct tggccggaag atcaaggagg gggtagaaga ggccgccagg
      481 acagccaagc agtcagcgga gtcagtgtcc aagagcgggg agaagctggg caagacggca
      541 gccttcaaag ccatctccca gggtgtagag tcagtgaaga aggagcttga cgagagcgtg
      601 cttggacaga cggggcccta ccgccggccc gagcggctcc ggaaaaggac agagtttgct
      661 ggagcaaaat tcaaagaaag caaagtgttc gaggctaatg aggaagcatt aggggttgtg
      721 ctacacaagg actccaagtg gtaccagcag tggaaggact tcaaagataa caacgttgta
      781 ttcaaccgct tctttgagat gaagatgaag tatgatgaaa gtgacaatgt cctcatccgg
      841 gcgtcgcggg ccttaaccga caaggtcact gacttgctag gaggtctttt ctcaaagaca
      901 gaaatgtcag aggtgctaac ggagatcctg agagtggacc caacctttga caaggaccac
      961 tttcttcatc agtgtgagac tgacatcatc cccaacatcc tagaggccat gatttccggg
     1021 gagcttgaca ttctcaaaga ctggtgctat gaagctacct acagccagct ggcccaccct
     1081 atccagcagg ccaaggctct gggcttccag ttccactccc gaattctgga catcagcaat
     1141 gtggacctgg ccatgggcaa gatgatggag cagggcccag tgctgatcgt tacctttcag
     1201 gcccaggtgg tgatggtgat caagaactcc aaaggcgagg tgtatgatgg tgacccggac
     1261 aaggtgcagc gaatgctgta cgtgtgggca ctctgcagag accaggagga gctcaaccct
     1321 tatgctgcct ggcgccttct ggacatctca gcctccagca cagagcagat cctctgaggg
     1381 cagcaatgga gtctaggcag ctcgaggcta gaccatcatg ggacagacac acagagacac
     1441 tttgccacat ctgatacagc tgtgaacaag cttctgcccc aagttcttca gggcagctgt
     1501 gaaaccagct ggacaaggga agagcttggg gtgtctagca ggatggggac tgtctcccag
     1561 tgcgtccgtc acaggggttg ctggcagtgt cagaaggccc cagcccagga ctcctgtcgg
     1621 gtgaggcctg gcctgctgtt ctaagtagtc cactggcatt gccttccaag ccactttagg
     1681 tccttttgtt ttgttttgtt tttgttttta aatcagtgct cttacttcct gtacataagc
     1741 ctaagatctg gacctaataa aacaccaaag cgcagaagag caaaaaaaaa aaaaaaaa
//
