LOCUS       NM_016897               1162 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane 23
            (Timm23), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016897
VERSION     NM_016897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Pandey,J., Larson-Casey,J.L., Patil,M.H., Joshi,R., Jiang,C.S.,
            Zhou,Y., He,C. and Carter,A.B.
  TITLE     NOX4-TIM23 interaction regulates NOX4 mitochondrial import and
            metabolic reprogramming
  JOURNAL   J Biol Chem 299 (5), 104695 (2023)
   PUBMED   37044213
  REMARK    GeneRIF: NOX4-TIM23 interaction regulates NOX4 mitochondrial import
            and metabolic reprogramming.
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Jiao,H., Jiang,D., Hu,X., Du,W., Ji,L., Yang,Y., Li,X., Sho,T.,
            Wang,X., Li,Y., Wu,Y.T., Wei,Y.H., Hu,X. and Yu,L.
  TITLE     Mitocytosis, a migrasome-mediated mitochondrial quality-control
            process
  JOURNAL   Cell 184 (11), 2896-2910 (2021)
   PUBMED   34048705
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Hamilton,J., Brustovetsky,T., Khanna,R. and Brustovetsky,N.
  TITLE     Mutant huntingtin does not cross the mitochondrial outer membrane
  JOURNAL   Hum Mol Genet 29 (17), 2962-2975 (2020)
   PUBMED   32821928
  REMARK    GeneRIF: Mutant huntingtin does not cross the mitochondrial outer
            membrane.
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Chen,L., Gunji,A., Uemura,A., Fujihara,H., Nakamoto,K., Onodera,T.,
            Sasaki,Y., Imamichi,S., Isumi,M., Nozaki,T., Kamada,N.,
            Jishage,K.I. and Masutani,M.
  TITLE     Development of renal failure in PargParp-1 null and Timm23
            hypomorphic mice
  JOURNAL   Biochem Pharmacol 167, 116-124 (2019)
   PUBMED   31326434
  REMARK    GeneRIF: Combined Poly(ADP-ribose) glycohydrolase and Parp-1 loss
            with a hypomorphic state of Timm23 leads to the development of
            severe renal failure.
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   Murdoch,J.N., Doudney,K., Paternotte,C., Copp,A.J. and Stanier,P.
  TITLE     Severe neural tube defects in the loop-tail mouse result from
            mutation of Lpp1, a novel gene involved in floor plate
            specification
  JOURNAL   Hum Mol Genet 10 (22), 2593-2601 (2001)
   PUBMED   11709546
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Sun,Y., Kuraishi,T., Aoki,F. and Sakai,S.
  TITLE     Hormonal regulation of mitochondrial Tim23 gene expression in the
            mouse mammary gland
  JOURNAL   Mol Cell Endocrinol 172 (1-2), 177-184 (2001)
   PUBMED   11165051
REFERENCE   10 (bases 1 to 1162)
  AUTHORS   Underhill,D.A., Vogan,K.J., Kibar,Z., Morrison,J., Rommens,J. and
            Gros,P.
  TITLE     Transcription mapping and expression analysis of candidate genes in
            the vicinity of the mouse Loop-tail mutation
  JOURNAL   Mamm Genome 11 (8), 633-638 (2000)
   PUBMED   10920231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY767660.1, AK146516.1 and AV345749.1.
            
            On Jul 24, 2009 this sequence version replaced NM_016897.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB021122.1, SRR1660815.121980.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY767660.1         1-34
            35-1157             AK146516.1         1-1123
            1158-1162           AV345749.1         235-239
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..1162
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /note="translocase of inner mitochondrial membrane 23"
                     /db_xref="GeneID:53600"
                     /db_xref="MGI:MGI:1858317"
     exon            1..249
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..773
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /note="translocase of inner mitochondrial membrane 23
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim23"
                     /protein_id="NP_058593.2"
                     /db_xref="CCDS:CCDS36864.1"
                     /db_xref="GeneID:53600"
                     /db_xref="MGI:MGI:1858317"
                     /translation="MEGGGGSSNKSTSGLAGFFGAGGAGYSNADLAGVPLTGMNPLSP
                     YLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKE
                     TQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAA
                     GTMTGMLYKCTGGLRGIARGGLAGLTLTSLYALYNNWEHMKGSLLQQSL"
     exon            250..308
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     exon            309..402
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     exon            403..487
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     exon            488..546
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     exon            547..657
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1162
                     /gene="Timm23"
                     /gene_synonym="Tim23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccggcgc ccggaaggtc agcgtggtga aggtggcagg agcaacgcgg gtcttcccgc
       61 tgttgcttgt cgcggccacg gccgagcata cgtccccggc ctgaggtggt ggtggcgagc
      121 ccaccgccgt ttgctgcgac ctcatggaag gtggcggagg aagtagcaac aaatccacca
      181 gcgggttagc tggcttcttc ggagccggag gagcgggtta ctcgaacgct gatttggccg
      241 gcgtcccgct gactggtatg aaccccctgt ctccttattt aaatgtggat ccacgctatc
      301 tcgttcagga tactgatgaa tttattttgc caactggagc taataaaacc cgaggcagat
      361 ttgaactagc tttctttacc attggaggat gttgcatgac aggggccgca ttcggggcaa
      421 tgaacggtct tcgtttagga ttgaaggaaa cccagagcat ggcctggtcc aaaccaagaa
      481 atgtacagat tttgaatatg gtgactaggc aaggagcact ttgggctaat actctaggct
      541 ccctggcttt gctctatagt gcttttggtg ttatcattga gaaaacacgg ggtgcagaag
      601 atgacctcaa cacagtagca gctggaacca tgaccgggat gttgtataaa tgtacaggtg
      661 gtcttcgagg aatagcacgc ggtggcctgg caggactgac actcaccagt ctctatgcac
      721 tgtataacaa ctgggagcac atgaaaggtt ccctgctcca acagtcactc tgaagatttt
      781 tggcacctca ggaatggggg acacttcata gtcatccaga tcaattaata agccagtctg
      841 gagttgcttt ctgtcttgta cctacagtta ctttgaacaa ttggagactc tgatttgctg
      901 tgacaaagat catggatggt tagcctggac tgcactgctt gccctcagtg agtggaagcc
      961 aaccccttgg tggctcactg agtatgtgtt ctcttctcct ttggagatga tcttgcaccc
     1021 caaactggaa aaccacttac tctccaaatt caggccatac tttttattac catgttaatt
     1081 catttaaaaa atctaaaact taaatgttgc cctgttttcc aaataaaggg tgaaaacaga
     1141 accaaagtca taattccaac at
//
