LOCUS       NM_011590                917 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane 17a
            (Timm17a), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_011590
VERSION     NM_011590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 917)
  AUTHORS   Ishihara,N., Nomura,M., Jofuku,A., Kato,H., Suzuki,S.O., Masuda,K.,
            Otera,H., Nakanishi,Y., Nonaka,I., Goto,Y., Taguchi,N.,
            Morinaga,H., Maeda,M., Takayanagi,R., Yokota,S. and Mihara,K.
  TITLE     Mitochondrial fission factor Drp1 is essential for embryonic
            development and synapse formation in mice
  JOURNAL   Nat Cell Biol 11 (8), 958-966 (2009)
   PUBMED   19578372
REFERENCE   2  (bases 1 to 917)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003129.1.
            
            On Apr 6, 2007 this sequence version replaced NM_011590.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003129.1, SRR1660817.596188.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-917               AK003129.1         2-918
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.48 cM"
     gene            1..917
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="translocase of inner mitochondrial membrane 17a"
                     /db_xref="GeneID:21854"
                     /db_xref="MGI:MGI:1343131"
     exon            1..44
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..534
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="isoform 2 is encoded by transcript variant 2;
                     translocator of inner mitochondrial membrane 17a;
                     mitochondrial import inner membrane translocase subunit
                     Tim17-A; inner membrane preprotein translocase Tim17a;
                     translocator of inner mitochondrial membrane 17 kDa, a"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim17-A isoform 2"
                     /protein_id="NP_035720.1"
                     /db_xref="CCDS:CCDS15318.1"
                     /db_xref="GeneID:21854"
                     /db_xref="MGI:MGI:1343131"
                     /translation="MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGI
                     NHRLRGSLTAIKTRAPQLGGSFAVWGGLFSTIDCSMVQIRGKEDPWNSITSGALTGAI
                     LAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFTEDHSQLPSSQLP
                     SSPFGDYRQYQ"
     exon            45..144
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            145..208
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            209..337
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            338..448
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            449..917
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      749..754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: AATAAA"
     polyA_site      772
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: GATAAA"
     polyA_site      835
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: AATAAA"
     polyA_site      906
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggttg gagccaagat ggaggaatac gcgagagagc cgtgcccctg gcgaattgta
       61 gatgactgtg gcggtgcgtt taccatgggc accataggtg gtggcatctt ccaggccttc
      121 aaaggttttc gaaattctcc agtgggaata aaccacagac tccgaggaag tttgacagct
      181 attaaaacca gggctccaca gttgggaggt agctttgcag tttggggagg actgttttcc
      241 acgattgact gcagtatggt tcaaatacga ggcaaagaag acccctggaa ctccatcact
      301 agcggtgcct taacaggagc catcctggca gcaagaaatg gaccggtagc catggttggg
      361 tccgctgcga tgggcggcat tctcctagct ttaattgaag gagctggtat cttgctgaca
      421 agatttgcct ctgcacagtt tcccaatggc cctcagttca ctgaagatca ctcccagttg
      481 ccttccagcc agttgccatc ctcgccgttt ggagactacc gacagtatca gtaggacttg
      541 gttcccagga ttcctggaac cgggtggact gtagttcggt aggatttcag aagatcaagt
      601 tacagtctgt ttaaagcctt aggtgggaca tcagcggcca agcgggccat aaagagacat
      661 ttagcacatt tttctattta aaagagactc agagggtgaa aaatatattg agtttattta
      721 ttcttgcttg gattgcatct gtgatcaaaa taaatgtcta ataccattta aagaatgtat
      781 atgagcttag aagataaagg accaaaggcc aaataacagt gacactccac catcattcct
      841 tcgggacttc tctgcctggt gttttgtgta cagttattca gacaataaaa ggcttctggg
      901 acttaacctt tcctttg
//
