LOCUS       NM_001360858             921 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane 17a
            (Timm17a), transcript variant 4, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001360858
VERSION     NM_001360858.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 921)
  AUTHORS   Ishihara,N., Nomura,M., Jofuku,A., Kato,H., Suzuki,S.O., Masuda,K.,
            Otera,H., Nakanishi,Y., Nonaka,I., Goto,Y., Taguchi,N.,
            Morinaga,H., Maeda,M., Takayanagi,R., Yokota,S. and Mihara,K.
  TITLE     Mitochondrial fission factor Drp1 is essential for embryonic
            development and synapse formation in mice
  JOURNAL   Nat Cell Biol 11 (8), 958-966 (2009)
   PUBMED   19578372
REFERENCE   2  (bases 1 to 921)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130277.6.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (4) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB843067.2, SRR5189673.204759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC130277.6         52-95
            45-148              AC130277.6         3919-4022
            149-212             AC130277.6         4591-4654
            213-341             AC130277.6         7572-7700
            342-452             AC130277.6         9249-9359
            453-921             AC130277.6         11786-12254
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.48 cM"
     gene            1..921
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="translocase of inner mitochondrial membrane 17a"
                     /db_xref="GeneID:21854"
                     /db_xref="MGI:MGI:1343131"
     exon            1..44
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            45..148
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            149..212
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            213..341
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..538
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="isoform 4 is encoded by transcript variant 4;
                     translocator of inner mitochondrial membrane 17a;
                     mitochondrial import inner membrane translocase subunit
                     Tim17-A; inner membrane preprotein translocase Tim17a;
                     translocator of inner mitochondrial membrane 17 kDa, a"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim17-A isoform 4"
                     /protein_id="NP_001347787.1"
                     /db_xref="GeneID:21854"
                     /db_xref="MGI:MGI:1343131"
                     /translation="MVQIRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILL
                     ALIEGAGILLTRFASAQFPNGPQFTEDHSQLPSSQLPSSPFGDYRQYQ"
     exon            342..452
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     exon            453..921
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: AATAAA"
     polyA_site      776
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
     regulatory      797..802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: GATAAA"
     polyA_site      839
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="hexamer: AATAAA"
     polyA_site      910
                     /gene="Timm17a"
                     /gene_synonym="mTim17a; Tim17a"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggttg gagccaagat ggaggaatac gcgagagagc cgtgcccctg gcgaattgta
       61 gatgactgtg gcggtgcgtt taccatgggc accataggtg gtggcatctt ccaggccttc
      121 aaaggttttc gaaattctcc agtggtgagg aataaaccac agactccgag gaagtttgac
      181 agctattaaa accagggctc cacagttggg aggtagcttt gcagtttggg gaggactgtt
      241 ttccacgatt gactgcagta tggttcaaat acgaggcaaa gaagacccct ggaactccat
      301 cactagcggt gccttaacag gagccatcct ggcagcaaga aatggaccgg tagccatggt
      361 tgggtccgct gcgatgggcg gcattctcct agctttaatt gaaggagctg gtatcttgct
      421 gacaagattt gcctctgcac agtttcccaa tggccctcag ttcactgaag atcactccca
      481 gttgccttcc agccagttgc catcctcgcc gtttggagac taccgacagt atcagtagga
      541 cttggttccc aggattcctg gaaccgggtg gactgtagtt cggtaggatt tcagaagatc
      601 aagttacagt ctgtttaaag ccttaggtgg gacatcagcg gccaagcggg ccataaagag
      661 acatttagca catttttcta tttaaaagag actcagaggg tgaaaaatat attgagttta
      721 tttattcttg cttggattgc atctgtgatc aaaataaatg tctaatacca tttaaagaat
      781 gtatatgagc ttagaagata aaggaccaaa ggccaaataa cagtgacact ccaccatcat
      841 tccttcggga cttctctgcc tggtgttttg tgtacagtta ttcagacaat aaaaggcttc
      901 tgggacttaa cctttccttt g
//
