LOCUS       NM_019502               1093 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus translocase of inner mitochondrial membrane 10B
            (Timm10b), transcript variant 6, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_019502
VERSION     NM_019502.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1093)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1093)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   4  (bases 1 to 1093)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1093)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
REFERENCE   6  (bases 1 to 1093)
  AUTHORS   Jin,H., Kendall,E., Freeman,T.C., Roberts,R.G. and Vetrie,D.L.
  TITLE     The human family of Deafness/Dystonia peptide (DDP) related
            mitochondrial import proteins
  JOURNAL   Genomics 61 (3), 259-267 (1999)
   PUBMED   10552927
REFERENCE   7  (bases 1 to 1093)
  AUTHORS   Hadjiargyrou,M., Halsey,M.F., Ahrens,W., Rightmire,E.P.,
            McLeod,K.J. and Rubin,C.T.
  TITLE     Cloning of a novel cDNA expressed during the early stages of
            fracture healing
  JOURNAL   Biochem Biophys Res Commun 249 (3), 879-884 (1998)
   PUBMED   9731230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125227.6.
            
            On Jan 26, 2018 this sequence version replaced NM_019502.2.
            
            Transcript Variant: This variant (6), as well as variants 4 and 5,
            encodes isoform d.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009158.1, AV456350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC125227.6         151743-151920
            179-274             AC125227.6         152060-152155
            275-1093            AC125227.6         152326-153144
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.93 cM"
     gene            1..1093
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /note="translocase of inner mitochondrial membrane 10B"
                     /db_xref="GeneID:14356"
                     /db_xref="MGI:MGI:1315196"
     exon            1..178
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..451
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /note="isoform d is encoded by transcript variant 6; small
                     zinc finger-like protein; fractured callus 1;
                     mitochondrial import inner membrane translocase subunit
                     Tim9 B; Fracture Callus 1; fractured callus expressed
                     transcript 1; mitochondrial import inner membrane
                     translocase subunit Tim10 B"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim10 B isoform d"
                     /protein_id="NP_062375.1"
                     /db_xref="CCDS:CCDS21657.1"
                     /db_xref="GeneID:14356"
                     /db_xref="MGI:MGI:1315196"
                     /translation="MEQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAEEEA
                     CLHSCAGKLIHSNHRLMAAYVHLMPALVQRRIADYEAASAAPGIPAEQTRDSPSGS"
     exon            179..274
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     exon            275..1093
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      575..580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /note="hexamer: AATAAA"
     polyA_site      597
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /note="major polyA site"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="Timm10b"
                     /gene_synonym="Fxc1; Tim10b; Tim9b"
ORIGIN      
        1 tacgccttca agctcttggg gagtagtgag agtttacttc cggggcgact ctgagagctc
       61 taacctcccc cctccgcccc cccaaccccg cgccaccctg ccaccccgcc acgggcggaa
      121 gtgactaggg ctgtgcgccc ttggcgtgat ggagcagcag cagcagcaac tgagaaactt
      181 gcgagacttc ctgttggtct acaatcggat gacagaactg tgtttccagc gctgtgtgcc
      241 cagcctgcac caccgagctc tggacgctga ggaggaggcc tgcctgcaca gctgtgctgg
      301 gaaactcatc cattctaacc accgcctcat ggccgcttac gtgcacctca tgcccgccct
      361 ggtccagcgc cgcatcgcgg actacgaggc tgcctcggcc gcgccaggta ttcctgcaga
      421 acagaccaga gactcgccat caggcagcta gccgtccctg gcccctggag agaaggtgct
      481 tggatgggct cctctatgga ccttgggctt atctaaatgt gtacagagag attgagcttg
      541 aaagctgggt gctgttgctc cttttcttgg agccaataaa cccgttttta cagtctggtt
      601 atttgtctat gggtaccagc ctttattctg tcatctagtg catgtgtact gcctttagcc
      661 ctggaggttg atgtagtgcc ttcttatgtg tagaaggaca aattcagcat tcccagcacc
      721 ccagcaaaag cagggattat gggtagagct ttaaggttag taatagcaat gggaaattgg
      781 ttccaaaagg agagctctca gtggctgtcc ttgggactaa ctcaaggacc tgaatataca
      841 ttgactcata actagttttt attttcagct gtcaaaaaga attgctgtga acctagggga
      901 agaaggtaaa accaaacaac aaaagcagga agaaaactct acccccttag gctttagcca
      961 ctgcttccta ggaggtcagt gacaacagaa caaagacaag cctctaagaa ttcaggaatg
     1021 ttgaccattt ccccaattta ctctcttagt acttcctgcc tttgtgaaat tagcaataaa
     1081 gactttaaac aaa
//
