LOCUS       NM_001164081            4479 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus timeless circadian clock 1 (Timeless), transcript
            variant 4, mRNA.
ACCESSION   NM_001164081
VERSION     NM_001164081.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4479)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4479)
  AUTHORS   Barrio-Alonso,E., Lituma,P.J., Notaras,M.J., Albero,R.,
            Bouchekioua,Y., Wayland,N., Stankovic,I.N., Jain,T., Gao,S.,
            Calderon,D.P., Castillo,P.E. and Colak,D.
  TITLE     Circadian protein TIMELESS regulates synaptic function and memory
            by modulating cAMP signaling
  JOURNAL   Cell Rep 42 (4), 112375 (2023)
   PUBMED   37043347
  REMARK    GeneRIF: Circadian protein TIMELESS regulates synaptic function and
            memory by modulating cAMP signaling.
REFERENCE   3  (bases 1 to 4479)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4479)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4479)
  AUTHORS   Kurien,P., Hsu,P.K., Leon,J., Wu,D., McMahon,T., Shi,G., Xu,Y.,
            Lipzen,A., Pennacchio,L.A., Jones,C.R., Fu,Y.H. and Ptacek,L.J.
  TITLE     TIMELESS mutation alters phase responsiveness and causes advanced
            sleep phase
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 12045-12053 (2019)
   PUBMED   31138685
  REMARK    GeneRIF: The mutation prevents TIM accumulation in the nucleus and
            has altered affinity for CRY2.
REFERENCE   6  (bases 1 to 4479)
  AUTHORS   Dunlap,J.C.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (bases 1 to 4479)
  AUTHORS   Jin,X., Shearman,L.P., Weaver,D.R., Zylka,M.J., de Vries,G.J. and
            Reppert,S.M.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   8  (bases 1 to 4479)
  AUTHORS   Koike,N., Hida,A., Numano,R., Hirose,M., Sakaki,Y. and Tei,H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (bases 1 to 4479)
  AUTHORS   Zylka,M.J., Shearman,L.P., Levine,J.D., Jin,X., Weaver,D.R. and
            Reppert,S.M.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (bases 1 to 4479)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052884.1, BC082770.1 and CJ088470.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (2). Both variants 2 and
            4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071506.1, AB019001.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BC052884.1         11-81
            72-2815             BC082770.1         1-2744
            2816-3121           CJ088470.1         119-424
            3122-4479           BC082770.1         3048-4405
FEATURES             Location/Qualifiers
     source          1..4479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     gene            1..4479
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /note="timeless circadian clock 1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
     exon            1..113
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            114..277
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3774
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein timeless homolog; mTim"
                     /codon_start=1
                     /product="protein timeless homolog isoform 2"
                     /protein_id="NP_001157553.1"
                     /db_xref="CCDS:CCDS24266.1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
                     /translation="MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRH
                     EDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVPK
                     DSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERIL
                     LLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHV
                     LEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHS
                     RFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRS
                     VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAA
                     TFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATV
                     NEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHL
                     FLKMLERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGELEAMWPALAEQLLQC
                     AQDPELSVDPVVPFDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPE
                     GNAFGSPVISPGEEMQLLKQILSTPLPRQQEPEEGDAEEEEEEEEEEELQVVQVSEKE
                     FNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLS
                     LFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQKAFVELLFWKNTAVVREMT
                     QGYGSLDSGSSSHRAPLWSPEEEAQLQELYLAHKDVEGQDVVETILAHLKVVPRTRKQ
                     VIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNIT
                     AKRSRARVVDKLLALGLVSERRQLYKKRRKKLAPSCMQNGEKSPRDPWQEDPEEEDEH
                     LPEDESEDEESEEGLPSGQGQGSSSLSAENLGESLRQEGLSAPLLWLQSSLIRAANDR
                     EEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAKLSSTQL
                     RRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALRALLSARKRKAGLGPTEEE
                     ATGEEEWNSAPKKRQLLDSDEEEDDEGRRQAVSGTPRVHRKKRFQIEDEDD"
     exon            278..431
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            432..546
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            547..609
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            610..711
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            712..867
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1001
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1089
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1266
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1484
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1588
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1758
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1884
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2036
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2134
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2252
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2454
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2600
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2686
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2807
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2890
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3033
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3211
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3280
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3399
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3613
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3709
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..4459
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4439..4444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /note="hexamer: AATATA"
     polyA_site      4457
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /note="major polyA site"
ORIGIN      
        1 cccgcccgcg caggcgcaga ctggtcgctc tcagccgagt ggcgggaaag gctgcgaccc
       61 cgcacctcag ggcctcaggc tctgcgaggc ttcagaggac tcgcggagag cggtcccgta
      121 ggcctcaccc tctccgtcca ccatctctac tgcccgctct gctggttggg cctctggtgt
      181 atggacttgt acatgatgaa ctgtgaactt ctagccacgt gtagcgccct tgggtacttg
      241 gaaggaggga cttaccacaa ggagccggat tgcctggaga gtgtgaagga tttgatccga
      301 tacctgaggc acgaggatga gacccgagat gtgcggcagc agctgggagc tgcacagatc
      361 ctgcagagcg acctcctgcc aatcctcacg cagcatcgcc aggacaagcc tctcttcgat
      421 gccgtgatca ggctgatggt aaatttgaca cagccagcct tgctctgttt tggcagcgtg
      481 cctaaggact ccagtgtacg gcaccatttt ctgcaggttc taacgtacct gcaagcctac
      541 aaagaggcct ttgccagtga gaaggcattt ggagtcctca gcgagacctt gtatgaattg
      601 ctacagctgg gctgggagga tcggcaagaa gaagacaact tgctgatcga gcggatcctt
      661 ctgctggtca gaaatattct ccatgtcccg gccaaccttg agcaggagaa gagtatcgat
      721 gatgatgcca gcatccacga ccgtctcctt tgggcaattc acctcagtgg catggacgac
      781 ttgctcctct tcctgtccag ctcatccgcc gagcagcagt ggagcctcca tgtgctggag
      841 atcatctccc tcatgttccg agaccagacc cctgagcagc tagcgggagt agggcaggga
      901 cgcttggctc aggagcgaag cacggatgtg gcagaattgg aggtgctgcg ccaacgggag
      961 atggcggaga agagagctcg ggccctccag cgaggaaaca ggcactctcg atttgggggc
     1021 tcctacattg tccaggggtt gaaatctatt ggggagaagg atgtcgtctt tcacaaaggc
     1081 cttcacaatc tccagaacta cagctcagat ctgggaaagc agcccaggag ggtgcccaag
     1141 cgtcgtcagg ctgcccagga gctgtctgtc catcgccgct ctgtcctgaa tgtgagactc
     1201 ttcctcagag acttctgctc tgagttcctg gagaactgct acaacccgct catgggcgcg
     1261 gtcaaggatc atctgcttcg ggagagagcg cagcagcatg acgagactta ctacatgtgg
     1321 gcaatggctt tcttcatggc cttcaaccga gctgccacct tccgccccgg ccttgtttct
     1381 gagaccctca gtatccgtac ctttcacttt gtggagcaga acctcaccaa ctactacgag
     1441 atgatgctga cagaccgcaa ggaggccgcc tcctgggcgc gcaggatgca cctggccctg
     1501 aaggcctacc aggagctgct ggccacggtg aacgagatgg acatgtgccc agatgaggct
     1561 gttagggaga gcagtcgtat catcaaaaac aacattttct atatgatgga gtaccgagaa
     1621 ctattcctgg cgctctttcg aaagtttgat gagagatacc atccacgctc attccttcga
     1681 gacctggtgg aaaccaccca cctcttcctc aaaatgttgg agcgcttttg ccggagccgc
     1741 gggaacctga tggtgcagaa caaaagaaaa aagaggaaaa agaaaaagaa ggttcaggac
     1801 cagggtgttg ctttctcaca aagccccggg gagctggagg ccatgtggcc agccctggca
     1861 gagcagctgc tgcagtgtgc ccaggaccct gagctcagtg tggaccccgt cgttcccttt
     1921 gatgcggcct cagaggtgcc agtggaggag cagcgggtag aagccatggt gaggatccaa
     1981 gactgcctta cggctggcca ggccccgcaa gccctggccc tcctgcggtc tgcccgggaa
     2041 gtgtggcctg aaggaaatgc gtttggctct ccagtcattt ccccagggga agaaatgcag
     2101 ttgctgaaac aaatcctctc cacgcccctt ccccggcagc aggagccaga agaaggagat
     2161 gcagaggagg aagaggaaga ggaggaggaa gaggagttac aggtggtcca ggtgtcagag
     2221 aaggagttta actttctgga atacctgaaa cgcttcgcat cctcaaccat cgtgcgggcc
     2281 tacgtgcttc tcctgcggag ctacaggcag aacagtgctc acaccaacca ctgcatcgcc
     2341 aagatgctgc accggctggc ccatggcctg gggatggaag ccctgctttt ccagctgtcc
     2401 ctgttctgcc tcttcaatcg gctgcttagt gacccagctg ctgcggccta caaagagcta
     2461 gtgacttttg ccaaatacat cattggcaag ttctttgcgt tggctgccgt gaaccagaaa
     2521 gcgtttgtgg agctgctgtt ctggaagaac accgcagtgg ttcgggaaat gacccaggga
     2581 tatggctccc tcgacagtgg gtcttccagc cacagagctc ctctgtggag ccctgaggaa
     2641 gaggcccagc ttcaggaact atacctcgcc cacaaggatg tggaaggtca agatgtagtg
     2701 gaaaccatat tggcgcacct gaaagtcgtt cctcgaacac gcaagcaggt catccaccac
     2761 ctggtccgga tgggcctggc cgacagcgtc aaggagttcc agaagaggaa agggacccag
     2821 attgtcttgt ggacggagga ccaggagctg gagttacagc ggctctttga ggagttccgg
     2881 gactctgatg atgttcttgg tcaaatcatg aagaatatca cagccaaacg ttcacgggct
     2941 cgagtagtgg acaaactgtt ggccctgggg ttggtgtctg agcggaggca gctatacaag
     3001 aaacggagaa agaagctggc gccttcttgc atgcagaatg gagaaaagtc cccgagagac
     3061 ccctggcagg aagatccgga agaggaagac gaacacttgc cagaggacga aagtgaagat
     3121 gaggagagtg aggaaggctt gccatcagga cagggtcagg gcagctcatc tctctctgct
     3181 gaaaacctcg gtgagagcct tcgtcaggaa ggcctctctg ctcccctcct gtggctccag
     3241 agctccctga tccgagcagc aaatgaccga gaagaggatg gctgctccca ggcaatccct
     3301 ctggtgcctc tgacagagga aaatgaggaa gcaatggaga acgaacagtt tcagcatctg
     3361 ctacgcaagc tagggatccg gccgcccagc tcagggcagg aaaccttctg gagaattcca
     3421 gccaaactga gctccaccca gcttcggagg gtggctgctt ctttgagtca gcaagaaaac
     3481 gaggaggaaa gggaagagga gccagagcca ggagtccccg gagagcaggg tcccagtgag
     3541 gagcaccgga cagaagccct gagagccctt ctgtcagccc gtaagaggaa agcaggcctg
     3601 gggcctacag aagaggaggc cactggggag gaagaatgga actcagcgcc caagaagcgg
     3661 caactgctgg acagcgacga agaggaagat gatgagggga ggaggcaagc agtgtcggga
     3721 acgccaagag tccacaggaa gaaacggttt cagattgagg atgaggatga ctgaaagcca
     3781 gatgtgtttg accgatgtga gttggaggca caaaagctac ttttgcctgc gttggaagca
     3841 atcttctcta cattgacagc ccaggaattt taggcagcag tgttgggtgg agtctttgcg
     3901 gtcagtcctt gccccaggtt catcagcgtg cacagccggt ctctgggtcc gtctcgtagc
     3961 aaatgaagag tggcgaaagg ttcaaggtgg cttgtcctcc tctaaggact gcgtcttggc
     4021 ttctgacggg gagctttata acccagcacg gttgttcatt ctgtcctcac aaagcactgg
     4081 attgctccca ttttctttct ttcatcccag gacacatgat tgaacccgtt tctacagttg
     4141 agggagagct gggatgcacc actctcaagc tgacaagcat ccctgatttg tgtttcatat
     4201 taaatgtgta caattaacag ttgctcatct cagagcggcc agccagccat ctgttgtgtc
     4261 ttcggaagaa cttttaagag taaaattaaa agacatgtcc tgaactgagc ttggtagtgt
     4321 gagctaatcc catcgtgtgg gagacagagg caagagaatt gccatgaggg agaggaaaga
     4381 gtcatatagc cctacgcgtg ggccaataaa tgtaatttaa aaaatcagct tgataataaa
     4441 tataattttt aaaaaaagaa aaaaaaaaaa aaaaaaaaa
//
