LOCUS       NM_178759               2175 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus T cell immunoglobulin and mucin domain containing 4
            (Timd4), mRNA.
ACCESSION   NM_178759
VERSION     NM_178759.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Wang,Y., Wang,Y., Ge,Y., Wu,Z., Yue,X., Li,C., Liang,X., Ma,C.,
            Wang,P. and Gao,L.
  TITLE     Tim-4 alleviates acute hepatic injury by modulating homeostasis and
            function of NKT cells
  JOURNAL   Clin Exp Immunol 218 (1), 101-110 (2024)
   PUBMED   39036980
  REMARK    GeneRIF: Tim-4 alleviates acute hepatic injury by modulating
            homeostasis and function of NKT cells.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Joshi,S., Lopez,L., Morosi,L.G., Amadio,R., Pachauri,M.,
            Bestagno,M., Ogar,I.P., Giacca,M., Piperno,G.M., Vorselen,D. and
            Benvenuti,F.
  TITLE     Tim4 enables large peritoneal macrophages to cross-present tumor
            antigens at early stages of tumorigenesis
  JOURNAL   Cell Rep 43 (4), 114096 (2024)
   PUBMED   38607919
  REMARK    GeneRIF: Tim4 enables large peritoneal macrophages to cross-present
            tumor antigens at early stages of tumorigenesis.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Hori,A., Toyoura,S., Fujiwara,M., Taniguchi,R., Kano,Y., Yamano,T.,
            Hanayama,R. and Nakayama,M.
  TITLE     MHC class I-dressing is mediated via phosphatidylserine recognition
            and is enhanced by polyI:C
  JOURNAL   iScience 27 (5), 109704 (2024)
   PUBMED   38680663
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Wang,Z., Zeng,H., Wang,C., Wang,J., Zhang,J., Qu,S., Han,Y.,
            Yang,L., Ni,Y., Peng,W., Liu,H., Tang,H., Zhao,Q. and Zhang,Y.
  TITLE     Tim4 deficiency reduces CD301b+ macrophage and aggravates
            periodontitis bone loss
  JOURNAL   Int J Oral Sci 16 (1), 20 (2024)
   PUBMED   38418808
  REMARK    GeneRIF: Tim4 deficiency reduces CD301b[+] macrophage and
            aggravates periodontitis bone loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Hirao,H., Kageyama,S., Nakamura,K., Kadono,K., Kojima,H.,
            Siyuan,Y., Farmer,D.G., Kaldas,F.M., Dery,K.J. and
            Kupiec-Weglinski,J.W.
  TITLE     Recipient TIM4 signaling regulates ischemia reperfusion-induced ER
            stress and metabolic responses in liver transplantation: from
            mouse-to-human
  JOURNAL   Front Transplant 2, 1176384 (2023)
   PUBMED   38993869
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Nakae,S., Iikura,M., Suto,H., Akiba,H., Umetsu,D.T., Dekruyff,R.H.,
            Saito,H. and Galli,S.J.
  TITLE     TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast
            cells
  JOURNAL   Blood 110 (7), 2565-2568 (2007)
   PUBMED   17620455
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Wilker,P.R., Sedy,J.R., Grigura,V., Murphy,T.L. and Murphy,K.M.
  TITLE     Evidence for carbohydrate recognition and homotypic and heterotypic
            binding by the TIM family
  JOURNAL   Int Immunol 19 (6), 763-773 (2007)
   PUBMED   17513880
  REMARK    GeneRIF: The Ig domains of murine TIM1, 3 and 4 display
            calcium-dependent binding to carbohydrate ligands expressed by
            murine splenocytes and non-murine cell lines. Both homo- and
            heterotypic interactions were observed for binding between the TIM
            proteins.
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Meyers,J.H., Chakravarti,S., Schlesinger,D., Illes,Z., Waldner,H.,
            Umetsu,S.E., Kenny,J., Zheng,X.X., Umetsu,D.T., DeKruyff,R.H.,
            Strom,T.B. and Kuchroo,V.K.
  TITLE     TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction
            regulates T cell proliferation
  JOURNAL   Nat Immunol 6 (5), 455-464 (2005)
   PUBMED   15793576
  REMARK    GeneRIF: TIM-1-TIM-4 interaction is involved in regulating T cell
            proliferation.
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Shakhov,A.N., Rybtsov,S., Tumanov,A.V., Shulenin,S., Dean,M.,
            Kuprash,D.V. and Nedospasov,S.A.
  TITLE     SMUCKLER/TIM4 is a distinct member of TIM family expressed by
            stromal cells of secondary lymphoid tissues and associated with
            lymphotoxin signaling
  JOURNAL   Eur J Immunol 34 (2), 494-503 (2004)
   PUBMED   14768054
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   DICKIES,M.M.
  TITLE     A new viable yellow mutation in the house mouse
  JOURNAL   J Hered 53, 84-86 (1962)
   PUBMED   13886198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080212.1, AK046560.1 and AY376716.1.
            
            On Jul 22, 2006 this sequence version replaced NM_178759.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY376716.1, AK080042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1361              AK080212.1         2-1362
            1362-1808           AK046560.1         1361-1807
            1809-2175           AY376716.1         1807-2173
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.09 cM"
     gene            1..2175
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /note="T cell immunoglobulin and mucin domain containing
                     4"
                     /db_xref="GeneID:276891"
                     /db_xref="MGI:MGI:2445125"
     exon            1..71
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1045
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /note="smuckler; T-cell immunoglobulin and mucin
                     domain-containing protein 4; TIMD-4; T-cell membrane
                     protein 4; T-cell immunoglobulin mucin receptor 4; spleen,
                     mucin-containing, knockout of lymphotoxin protein"
                     /codon_start=1
                     /product="T-cell immunoglobulin and mucin
                     domain-containing protein 4 precursor"
                     /protein_id="NP_848874.3"
                     /db_xref="CCDS:CCDS36137.1"
                     /db_xref="GeneID:276891"
                     /db_xref="MGI:MGI:2445125"
                     /translation="MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLS
                     WSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNT
                     NRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELL
                     PTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPA
                     SNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINS
                     RQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNTEDSDSVLNDMSHGR
                     DDEDGIFTL"
     exon            72..413
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..647
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            648..731
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..785
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            786..832
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            833..920
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            921..960
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     exon            961..2175
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="Timd4"
                     /gene_synonym="B430010N18Rik; TIM-4; Tim4"
                     /note="major polyA site"
ORIGIN      
        1 agatcctatc aaaatgtcca aggggcttct cctcctctgg ctggtgacgg agctctggtg
       61 gctttatctg acaccagctg cctcagagga tacaataata gggtttttgg gccagccggt
      121 gactttgcct tgtcattacc tctcgtggtc ccagagccgc aacagtatgt gctggggcaa
      181 aggttcatgt cccaattcca agtgcaatgc agagcttctc cgtacagatg gaacaagaat
      241 catctccagg aagtcaacaa aatatacact tttggggaag gtccagtttg gtgaagtgtc
      301 cttgaccatc tcaaacacca atcgaggtga cagtggggtg tactgctgcc gtatagaggt
      361 gcctggctgg ttcaatgatg tcaagaagaa tgtgcgcttg gagctgagga gagccacaac
      421 aaccaaaaaa ccaacaacaa ccacccggcc aaccaccacc ccttatgtga ccaccaccac
      481 cccagagctg cttccaacaa cagtcatgac cacatctgtt ctcccaacca ccacaccacc
      541 ccagacacta gccaccactg ccttcagtac agcagtgacc acgtgcccct caacaacacc
      601 tggctccttc tcacaagaaa ccacaaaagg gtccgccttc actacagaat cagaaactct
      661 gcctgcatcc aatcactctc aaagaagcat gatgaccata tctacagaca tagccgtact
      721 caggcccaca ggctctaacc ctgggattct cccatccact tcacagctga cgacacagaa
      781 aacaacatta acaacaagtg agtctttgca gaagacaact aaatcacatc agatcaacag
      841 cagacagacc atcttgatca ttgcctgctg tgtgggattt gtgctaatgg tgttattgtt
      901 tctggcgttt ctccttcgag ggaaagtcac aggagccaac tgtttgcaga gacacaagag
      961 gccagacaac actgaagata gtgacagcgt cctcaatgac atgtcacacg ggagggatga
     1021 tgaagacggg atcttcactc tctgactcac catctttatt taggattaag gatagggaat
     1081 ggcacttgaa ttgtcaaaat aagtttgggg acattgtaat ttccgtttaa agtctcactc
     1141 tgtttactga tgctgtgggt cctgtctggt tgtatcttcc cacatgaagg tgctttagag
     1201 acacattttc cctgcctcgt gccttagtcc tctttgttgt tttgtggcta ggtgactttt
     1261 cacactgggc ttgaacactg tcagtgatgg tgaaatcctt gccacagctt tgggagtctc
     1321 ttgcagtctc ccagcagtag agggagttag aaatatccag aggggaaaaa aaaatctctc
     1381 ttttcagaca gtatctgctt tattggtggt agctgaactt catttataca gagctccttt
     1441 aacctgtctg tcttcttctt ggtatctaag ctgccttttg tttttgtttt tgtttttgtt
     1501 tttatgatat taacttcttt tcacattcaa gtttctttaa agttgactat agtgccttct
     1561 gaactcttgc agagagtttg gattttggaa gctgccaggt acccatcaca gcaggggtgc
     1621 cagtgacaag gatggtgtac aaatgaaaca ctgaagctat ccaaataaat tcctctaagt
     1681 gtaattcatt ttactgcagc acaggaagaa caaatttgtc ttacaacttt aataattagt
     1741 accattatga accctaggag agaaataaga gcaaatacct gttgaataaa tgaatgtaag
     1801 aaaatgtgtg tctgagcaag aatactctgt ctggctacta tgggaagcta gctagatctg
     1861 aaagacattc tcagactatc ctcatgttca aggcattaaa ggaataagcc tccagcccct
     1921 aaccttagga gaattctgca gtcaagtgag gagtttttaa aacaggaatc tctaggttcc
     1981 agtcctctag ctattctttt atgcttagtc caggtaatga gttgaacatc caagtatttt
     2041 ttaaggaccc aaagaaatgc aaccagagct attaccagaa ttttggagtg gtcctcctag
     2101 agttgccgca tgttgctggg aaaattgggg tcttagagtt cttagtctac ttaataaaag
     2161 aattttaaaa aatgg
//
