LOCUS       NM_001161355            3153 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus T cell immunoglobulin and mucin domain containing 2
            (Timd2), transcript variant 1, mRNA.
ACCESSION   NM_001161355
VERSION     NM_001161355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3153)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   2  (bases 1 to 3153)
  AUTHORS   Valenca,A., Mendes-Jorge,L., Bonet,A., Catita,J., Ramos,D.,
            Jose-Cunilleras,E., Garcia,M., Carretero,A., Nacher,V., Navarro,M.
            and Ruberte,J.
  TITLE     TIM2 modulates retinal iron levels and is involved in blood-retinal
            barrier breakdown
  JOURNAL   Exp Eye Res 202, 108292 (2021)
   PUBMED   33065090
REFERENCE   3  (bases 1 to 3153)
  AUTHORS   Dewitz,C., Moller-Hackbarth,K., Schweigert,O., Reiss,K.,
            Chalaris,A., Scheller,J. and Rose-John,S.
  TITLE     T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of
            ADAM10-mediated ectodomain shedding
  JOURNAL   FEBS J 281 (1), 157-174 (2014)
   PUBMED   24164679
REFERENCE   4  (bases 1 to 3153)
  AUTHORS   Qi,Y., Song,X.R., Shen,J.L., Xu,Y.H., Shen,Q., Luo,Q.L.,
            Zhong,Z.R., Wang,W., Chu,D.Y. and Song,W.J.
  TITLE     Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in
            Th2-biased response in Schistosoma japonicum infection in mice
  JOURNAL   Immunol Lett 144 (1-2), 60-66 (2012)
   PUBMED   22469568
  REMARK    GeneRIF: We concluded that pro-apoptotic effects on Th1 population
            through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on
            Th2 cells might be critical to Th2-biased response of host with
            schistosomiasis japonica.
REFERENCE   5  (bases 1 to 3153)
  AUTHORS   Han,J., Seaman,W.E., Di,X., Wang,W., Willingham,M., Torti,F.M. and
            Torti,S.V.
  TITLE     Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor
            in mouse cells
  JOURNAL   PLoS One 6 (8), e23800 (2011)
   PUBMED   21886823
  REMARK    GeneRIF: TIM-2 can function as an iron uptake pathway.
REFERENCE   6  (bases 1 to 3153)
  AUTHORS   Knickelbein,J.E., de Souza,A.J., Tosti,R., Narayan,P. and Kane,L.P.
  TITLE     Cutting edge: inhibition of T cell activation by TIM-2
  JOURNAL   J Immunol 177 (8), 4966-4970 (2006)
   PUBMED   17015678
  REMARK    GeneRIF: expression of TIM-2 significantly impairs the induction of
            NFAT and AP-1 transcriptional reporters
REFERENCE   7  (bases 1 to 3153)
  AUTHORS   Rennert,P.D., Ichimura,T., Sizing,I.D., Bailly,V., Li,Z.,
            Rennard,R., McCoon,P., Pablo,L., Miklasz,S., Tarilonte,L. and
            Bonventre,J.V.
  TITLE     T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a
            novel mechanism for the regulation of Th2 immune responses and
            airway inflammation
  JOURNAL   J Immunol 177 (7), 4311-4321 (2006)
   PUBMED   16982865
REFERENCE   8  (bases 1 to 3153)
  AUTHORS   Chen,T.T., Li,L., Chung,D.H., Allen,C.D., Torti,S.V., Torti,F.M.,
            Cyster,J.G., Chen,C.Y., Brodsky,F.M., Niemi,E.C., Nakamura,M.C.,
            Seaman,W.E. and Daws,M.R.
  TITLE     TIM-2 is expressed on B cells and in liver and kidney and is a
            receptor for H-ferritin endocytosis
  JOURNAL   J Exp Med 202 (7), 955-965 (2005)
   PUBMED   16203866
  REMARK    GeneRIF: TIM-2 is expressed on B cells and in liver and kidney and
            is a receptor for H-ferritin endocytosis.
REFERENCE   9  (bases 1 to 3153)
  AUTHORS   Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C.,
            Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and
            Kikutani,H.
  TITLE     Class IV semaphorin Sema4A enhances T-cell activation and interacts
            with Tim-2
  JOURNAL   Nature 419 (6907), 629-633 (2002)
   PUBMED   12374982
REFERENCE   10 (bases 1 to 3153)
  AUTHORS   McIntire,J.J., Umetsu,S.E., Akbari,O., Potter,M., Kuchroo,V.K.,
            Barsh,G.S., Freeman,G.J., Umetsu,D.T. and DeKruyff,R.H.
  TITLE     Identification of Tapr (an airway hyperreactivity regulatory locus)
            and the linked Tim gene family
  JOURNAL   Nat Immunol 2 (12), 1109-1116 (2001)
   PUBMED   11725301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB953226.1, AK163225.1, AK145630.1 and AK166877.1.
            
            Transcript Variant: This variant (1), variant 2 and variant 3
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166877.1, AK145630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               CB953226.1         4-242
            240-2097            AK163225.1         1-1858
            2098-3084           AK145630.1         1860-2846
            3085-3153           AK166877.1         2839-2907
FEATURES             Location/Qualifiers
     source          1..3153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.05 cM"
     gene            1..3153
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="T cell immunoglobulin and mucin domain containing
                     2"
                     /db_xref="GeneID:171284"
                     /db_xref="MGI:MGI:2159681"
     exon            1..288
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..346
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1215
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="T-cell immunoglobulin and mucin domain-containing
                     protein 2; TIMD-2; T-cell membrane protein 2; T-cell
                     immunoglobulin mucin receptor 2"
                     /codon_start=1
                     /product="T-cell immunoglobulin and mucin
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001154827.1"
                     /db_xref="CCDS:CCDS24582.1"
                     /db_xref="GeneID:171284"
                     /db_xref="MGI:MGI:2159681"
                     /translation="MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLG
                     GIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVVG
                     DGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRV
                     STSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPSTPADWHNTVTSSDDPWDDNTEV
                     IPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIG
                     ASPKKVVERTRCEDQVYIIEDTPYPEEES"
     exon            347..682
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..826
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..895
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..945
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1057
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1094
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..3153
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="hexamer: ATTAAA"
     polyA_site      1265
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="major polyA site"
     polyA_site      1377
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="major polyA site"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
                     /note="hexamer: AATAAA"
     polyA_site      2099
                     /gene="Timd2"
                     /gene_synonym="G9D3; TIM-2; Tim2"
ORIGIN      
        1 actatgtaaa cggagttggt cttgaactca gaagatccac ttgcctctgc tttcctgagt
       61 gctagtcttt taagtatttt tttataatct ctttaagttg aacatataca atcaggcaaa
      121 aggatggtag aactagagag actcagtttt caaacaaaat attgaaggtg tggccaggag
      181 ataaggatgg aattctggga cagattcctc tttatctatc agcagctcca tcagcagcag
      241 aggattagaa ggagacacta accagaagct acggctctct cctaactggt cagtaccatg
      301 aatcagattc aagtcttcat ttcaggcctc atactgcttc tcccaggtgc cgtggagtct
      361 catacagcag tgcaggggct ggcgggtcac cctgtcacac ttccatgtat ttattcgaca
      421 caccttggtg gaatcgttcc tatgtgttgg ggcctagggg aatgccgcca ttcttattgt
      481 atacggtcac ttatctggac caatggatat acggtcacac atcagaggaa cagtcgatac
      541 cagctaaagg ggaatatttc agaaggaaat gtgtccttga ccatagagaa cactgttgtg
      601 ggtgatggtg gtccctattg ctgtgtagtg gagatacctg gagcgttcca ttttgtggac
      661 tatatgttgg aagttaaacc agaaatttcc acgagtccac caacaaggcc cacagctaca
      721 ggaagaccca caactatttc aacaagatcc acacatgtac caacatcaac cagagtctct
      781 acctctactt ctccaacacc agcacacaca gagacctaca aaccagaggc cactacattt
      841 tatccagatc agactacagc tgaggtgaca gaaaccttac cctctactcc tgcagactgg
      901 cataacactg tgacatcctc agatgaccct tgggatgata acactgaagt aatccctcca
      961 cagaagccac agaaaaacct gaataagggc ttctatgttg gcatctccat tgcagccctg
     1021 ctgatattga tgcttctgag caccatggtt atcaccaggt acgtggttat gaaaaggaag
     1081 tcagaatctc tgagcttcgt tgccttccct atctctaaga ttggagcttc ccccaaaaaa
     1141 gtggtcgaac ggaccagatg tgaagaccag gtctacatta ttgaagacac tccttacccc
     1201 gaagaagagt cctagtggcc ctctgaggca ccttctgcct gagattaaag agactgtcag
     1261 tgatatcaca gcgtccagag caattttctg tgttggttct tccagctgta gtggagaggg
     1321 taaccctcta ctgtgtacac tcaactcaag tttaacatca tcctaattct tgtatcagca
     1381 ccgcctcagt gtctccattc actgcagcga ttttctcaaa tgtgaacatt tcagagggtt
     1441 gatttttttt ctgagtcaac acaattactg ataatacaga aatagtcttg gttatttaaa
     1501 ccattaagag agaaataata tttaaaagtt taaaaaaatg tgtgggtggg agggaagttc
     1561 tgaattcaga agaatttcat aatcatgttt tatctatttt atcatacttt gaaatgtcac
     1621 ttcccccatc ttgcccaaag ggcttcaata atgagagcat ggaggtttta aggaaatcta
     1681 atgtcgcttt tagaggtggc aaatttctca tacttctgga aataagatca tttattatgc
     1741 cgttggtctt aggataaggg tgggtgttca ttattaggag aggttatcat ggtgactatg
     1801 gaccaggcac acatcagggg aagaaaataa tggatcaagg gattcagttc attggtgcta
     1861 tttctactcc acttctgtct tggtgcttac tgttcctaaa cttacccact gagctctgaa
     1921 ttaggtgcta ggaggagata gtgaagaaat gaaaggggaa ggaaaggcaa gagagaaggg
     1981 cacaggctct ctgctgagag aagccttatg gcaggtgtga cagtatttgg gactatctac
     2041 ttttcataat gaagcaattt gtcacaatca ataaaatatt tggttttgct aagaactaac
     2101 aaaagttgtt gcagtttggt tgttgaaaag agcagattgg ctagagtttg ttaatgtcta
     2161 tatcagtctg catgattctt gacaccggat cagagacatt caacccatag ccaaggagag
     2221 cagggtgctg gatcttagta cagactccca gtgctgtact atggagttct aggaaatgaa
     2281 tgtgtgtctg cttcgggttt gtttggctgt ttggttgatt ggttgggtgg ttgattggtg
     2341 agtaggtttt ggtttggttt ggtttggttt ggattggttt ttaatatttg cttgtttgtt
     2401 tgtttttgtt tttgaaaagt cagatagtga gtggaaagtt gcattctgtc tgggtttgcc
     2461 aatggagcct ccttcatctg ctgtaaaaat aattatgctt aaagtacatt gttttatttt
     2521 tcttaaatat gcagcgatta tacatcaaag aatgttttta gccatgacag ccctgatttg
     2581 tagcttccct agaaatacta tggatggtga aagtacagga gttatagtct acagcttgat
     2641 tttaaaagag gttttaagaa gctaaaccta ttgcatctta agaccagcct ccatcttaaa
     2701 gaaaaaaagc ctaggaaaat gacctacagc tgaactcatg ctacacccaa gtgccaggaa
     2761 ggaccccatg tccttggccc ataacccaga gttactccct agctacttcc tagcaacagt
     2821 caatcaaaga ttagtctgac tgtttcagat gtactttccg accatttgtg attgccatgg
     2881 tcttgcttca gagcatgcac ctgagagctg acagtactca ttctgttaga tgctcgtcag
     2941 actagacacc cctcacttgc tcctattcta ctgtaaaact ctttccaaat gagggttcag
     3001 agttgcttca ccaaaccgtc ctatgcttag cagtaaggcc aaactccagt gtaaaataaa
     3061 gagaccctaa ggggatcgta ttgttatttg gctccttggt ggtcttttga ggttcataaa
     3121 tgcttccaag cacaatatta gaagttaaac ttt
//
