LOCUS       NM_001146325             963 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus T cell immunoreceptor with Ig and ITIM domains
            (Tigit), mRNA.
ACCESSION   NM_001146325 XM_001478513 XM_001479949
VERSION     NM_001146325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Zhong,X., Xie,H., Wang,S., Ren,T., Chen,J., Huang,Y. and Yang,N.
  TITLE     TIGIT regulates CD4+ T cell immunity against polymicrobial sepsis
  JOURNAL   Front Immunol 15, 1290564 (2024)
   PUBMED   38545097
  REMARK    GeneRIF: TIGIT regulates CD4[+] T cell immunity against
            polymicrobial sepsis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Trivedi,P., Jhala,G., De George,D.J., Chiu,C., Selck,C., Ge,T.,
            Catterall,T., Elkerbout,L., Boon,L., Joller,N., Kay,T.W.,
            Thomas,H.E. and Krishnamurthy,B.
  TITLE     TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling
            in autoimmune diabetes
  JOURNAL   Front Immunol 15, 1370907 (2024)
   PUBMED   38533515
  REMARK    GeneRIF: TIGIT acts as an immune checkpoint upon inhibition of PD1
            signaling in autoimmune diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Hasan,M.F., Campbell,A.R., Croom-Perez,T.J., Oyer,J.L.,
            Dieffenthaller,T.A., Robles-Carrillo,L.D., Cash,C.A.,
            Eloriaga,J.E., Kumar,S., Andersen,B.W., Naeimi Kararoudi,M.,
            Tullius,B.P., Lee,D.A. and Copik,A.J.
  TITLE     Knockout of the inhibitory receptor TIGIT enhances the antitumor
            response of ex vivo expanded NK cells and prevents fratricide with
            therapeutic Fc-active TIGIT antibodies
  JOURNAL   J Immunother Cancer 11 (12), e007502 (2023)
   PUBMED   38081778
  REMARK    GeneRIF: Knockout of the inhibitory receptor TIGIT enhances the
            antitumor response of ex vivo expanded NK cells and prevents
            fratricide with therapeutic Fc-active TIGIT antibodies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Tang,L., Li,Q., Chen,L., Li,X., Gu,S., He,W., Pan,Q., Wang,L.,
            Sun,J., Yi,X. and Li,Y.
  TITLE     IL-21 collaborates with anti-TIGIT to restore NK cell function in
            chronic HBV infection
  JOURNAL   J Med Virol 95 (10), e29142 (2023)
   PUBMED   37815034
  REMARK    GeneRIF: IL-21 collaborates with anti-TIGIT to restore NK cell
            function in chronic HBV infection.
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Stanietsky,N., Rovis,T.L., Glasner,A., Seidel,E., Tsukerman,P.,
            Yamin,R., Enk,J., Jonjic,S. and Mandelboim,O.
  TITLE     Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
  JOURNAL   Eur J Immunol 43 (8), 2138-2150 (2013)
   PUBMED   23677581
  REMARK    GeneRIF: findings show that TIGIT is expressed by NK cells, that it
            interacts specifically with PVR and possibly with an additional
            unknown ligand found on PBMCs and that these interactions lead to
            the inhibition of NK-cell activities
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Levin,S.D., Taft,D.W., Brandt,C.S., Bucher,C., Howard,E.D.,
            Chadwick,E.M., Johnston,J., Hammond,A., Bontadelli,K., Ardourel,D.,
            Hebb,L., Wolf,A., Bukowski,T.R., Rixon,M.W., Kuijper,J.L.,
            Ostrander,C.D., West,J.W., Bilsborough,J., Fox,B., Gao,Z., Xu,W.,
            Ramsdell,F., Blazar,B.R. and Lewis,K.E.
  TITLE     Vstm3 is a member of the CD28 family and an important modulator of
            T-cell function
  JOURNAL   Eur J Immunol 41 (4), 902-915 (2011)
   PUBMED   21416464
  REMARK    GeneRIF: animals deficient in Vstm3 are more sensitive to
            autoimmune challenges indicating that this new member of the CD28
            family is an important regulator of T-cell responses
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Joller,N., Hafler,J.P., Brynedal,B., Kassam,N., Spoerl,S.,
            Levin,S.D., Sharpe,A.H. and Kuchroo,V.K.
  TITLE     Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
  JOURNAL   J Immunol 186 (3), 1338-1342 (2011)
   PUBMED   21199897
  REMARK    GeneRIF: TIGIT can act directly on T cells by attenuating T cell
            receptor-driven activation signals; loss of TIGIT results in
            hyperproliferative T cell responses and increased susceptibility to
            autoimmunity.
REFERENCE   9  (bases 1 to 963)
  AUTHORS   Yu,X., Harden,K., Gonzalez,L.C., Francesco,M., Chiang,E.,
            Irving,B., Tom,I., Ivelja,S., Refino,C.J., Clark,H., Eaton,D. and
            Grogan,J.L.
  TITLE     The surface protein TIGIT suppresses T cell activation by promoting
            the generation of mature immunoregulatory dendritic cells
  JOURNAL   Nat Immunol 10 (1), 48-57 (2009)
   PUBMED   19011627
REFERENCE   10 (bases 1 to 963)
  AUTHORS   Dike,S., Balija,V.S., Nascimento,L.U., Xuan,Z., Ou,J., Zutavern,T.,
            Palmer,L.E., Hannon,G., Zhang,M.Q. and McCombie,W.R.
  TITLE     The mouse genome: experimental examination of gene predictions and
            transcriptional start sites
  JOURNAL   Genome Res 14 (12), 2424-2429 (2004)
   PUBMED   15574821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV307751.1, EU675311.1 and AC120871.12.
            
            [WARNING] On May 24, 2024 this sequence was replaced by
            NM_001146325.2.
            
            On or before Apr 8, 2009 this sequence version replaced
            XM_001478513.1, XM_001479949.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU675311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CV307751.1         1-38
            39-843              EU675311.1         1-805
            844-963             AC120871.12        10173-10292
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..963
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /note="T cell immunoreceptor with Ig and ITIM domains"
                     /db_xref="GeneID:100043314"
                     /db_xref="MGI:MGI:3642260"
     exon            1..161
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..823
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /note="V-set and transmembrane domain-containing protein
                     3; V-set and transmembrane domain containing 3"
                     /codon_start=1
                     /product="T-cell immunoreceptor with Ig and ITIM domains
                     precursor"
                     /protein_id="NP_001139797.1"
                     /db_xref="CCDS:CCDS49852.1"
                     /db_xref="GeneID:100043314"
                     /db_xref="MGI:MGI:3642260"
                     /translation="MHGWLLLVWVQGLIQAAFLATGATAGTIDTKRNISAEEGGSVIL
                     QCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMN
                     DTGEYFCTYHTYPGGIYKGRIFLKVQESSVAQFQTAPLGGTMAAVLGLICLMVTGVTV
                     LARKKSIRMHSIESGLGRTEAEPQEWNLRSLSSPGSPVQTQTAPAGPCGEQAEDDYAD
                     PQEYFNVLSYRSLESFIAVSKTG"
     exon            162..491
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..589
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..963
                     /gene="Tigit"
                     /gene_synonym="Vstm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttcacca gcttggtttc accttacagc tgcagtgagc cagtttcagt tggaggagag
       61 gccacatcca ctttgctgta ggcctctggt tagaagcatg catggctggc tgctcctggt
      121 ctgggtccag gggctgatac aggctgcctt cctcgctaca ggagccacag caggcacgat
      181 agatacaaag aggaacatct ctgcagagga aggtggctct gtcatcttac agtgtcactt
      241 ctcctctgac acagctgaag tgacccaagt cgactggaag cagcaggacc agcttctggc
      301 catttatagt gttgacctgg ggtggcatgt cgcttcagtc ttcagtgatc gggtggtccc
      361 aggccccagc ctaggcctca ccttccagtc tctgacaatg aatgacacgg gagagtactt
      421 ctgtacctat catacgtatc ctggtgggat ttacaagggg agaatattcc tgaaggtcca
      481 agaaagctca gtggctcagt tccagactgc cccgcttgga ggaaccatgg ctgctgtgct
      541 gggactcatt tgcttaatgg tcacaggagt gactgtactg gctagaaaga agtctattag
      601 aatgcattct atagaaagtg gccttgggag aacagaagcg gagccacagg aatggaacct
      661 gaggagtctc tcatcccctg gaagccctgt ccagacacaa actgcccctg ctggtccctg
      721 tggagagcag gcagaagatg actatgctga cccacaggaa tactttaatg tcctgagcta
      781 cagaagccta gagagcttca ttgctgtatc gaagactggc taacgacagc tctctatccc
      841 tctccctatg tctctctctc tctgtctctc tctgtctctc tctgtctctc tctgtctctg
      901 tctctgtctc tgtctctctc tctctctctc tctctctctc tctgtgtgtg tgtgtgtgtg
      961 tgt
//
