LOCUS       NM_177003               3653 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Trp53 induced glycolysis regulatory phosphatase
            (Tigar), mRNA.
ACCESSION   NM_177003
VERSION     NM_177003.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Zhang,T., Linghu,K.G., Tan,J., Wang,M., Chen,D., Shen,Y., Wu,J.,
            Shi,M., Zhou,Y., Tang,L., Liu,L., Qin,Z.H. and Guo,B.
  TITLE     TIGAR exacerbates obesity by triggering LRRK2-mediated defects in
            macroautophagy and chaperone-mediated autophagy in adipocytes
  JOURNAL   Autophagy 20 (8), 1741-1761 (2024)
   PUBMED   38686804
  REMARK    GeneRIF: TIGAR exacerbates obesity by triggering LRRK2-mediated
            defects in macroautophagy and chaperone-mediated autophagy in
            adipocytes.
            Erratum:[Autophagy. 2024 Oct 23:1-3. doi:
            10.1080/15548627.2024.2416687.. PMID: 39440400]
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Wang,D., Li,Y., Yang,H., Shen,X., Shi,X., Li,C., Zhang,Y., Liu,X.,
            Jiang,B., Zhu,X., Zhang,H., Li,X., Bai,H., Yang,Q., Gao,W., Bai,F.,
            Ji,Y., Chen,Q. and Ben,J.
  TITLE     Disruption of TIGAR-TAK1 alleviates immunopathology in a murine
            model of sepsis
  JOURNAL   Nat Commun 15 (1), 4340 (2024)
   PUBMED   38773142
  REMARK    GeneRIF: Disruption of TIGAR-TAK1 alleviates immunopathology in a
            murine model of sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   He,X., Williams,Q.A., Cantrell,A.C., Besanson,J., Zeng,H. and
            Chen,J.X.
  TITLE     TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy
            in Mice
  JOURNAL   Int J Mol Sci 25 (4), 2433 (2024)
   PUBMED   38397106
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   He,X., Zeng,H., Cantrell,A.C., Williams,Q.A. and Chen,J.X.
  TITLE     Knockout of TIGAR enhances myocardial phosphofructokinase activity
            and preserves diastolic function in heart failure
  JOURNAL   J Cell Physiol 237 (8), 3317-3327 (2022)
   PUBMED   35621078
  REMARK    GeneRIF: Knockout of TIGAR enhances myocardial phosphofructokinase
            activity and preserves diastolic function in heart failure.
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Cheung,E.C., Athineos,D., Lee,P., Ridgway,R.A., Lambie,W.,
            Nixon,C., Strathdee,D., Blyth,K., Sansom,O.J. and Vousden,K.H.
  TITLE     TIGAR is required for efficient intestinal regeneration and
            tumorigenesis
  JOURNAL   Dev Cell 25 (5), 463-477 (2013)
   PUBMED   23726973
  REMARK    GeneRIF: TIGAR has roles in efficient intestinal regeneration and
            tumorigenesis
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Hoshino,A., Matoba,S., Iwai-Kanai,E., Nakamura,H., Kimata,M.,
            Nakaoka,M., Katamura,M., Okawa,Y., Ariyoshi,M., Mita,Y., Ikeda,K.,
            Ueyama,T., Okigaki,M. and Matsubara,H.
  TITLE     p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage
            after ischemia
  JOURNAL   J Mol Cell Cardiol 52 (1), 175-184 (2012)
   PUBMED   22044588
  REMARK    GeneRIF: p53/TIGAR-mediated inhibition of myocyte mitophagy is
            responsible for impairment of mitochondrial integrity and
            subsequent apoptosis.
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Kimata,M., Matoba,S., Iwai-Kanai,E., Nakamura,H., Hoshino,A.,
            Nakaoka,M., Katamura,M., Okawa,Y., Mita,Y., Okigaki,M., Ikeda,K.,
            Tatsumi,T. and Matsubara,H.
  TITLE     p53 and TIGAR regulate cardiac myocyte energy homeostasis under
            hypoxic stress
  JOURNAL   Am J Physiol Heart Circ Physiol 299 (6), H1908-H1916 (2010)
   PUBMED   20935145
  REMARK    GeneRIF: p53 and TIGAR inhibit glycolysis in hypoxic myocytes and
            that inhibition of glycolysis is closely involved in apoptosis,
            suggesting that p53 and TIGAR are significant mediators of cellular
            energy homeostasis and cell death under ischemic stress.
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Bensaad,K., Tsuruta,A., Selak,M.A., Vidal,M.N., Nakano,K.,
            Bartrons,R., Gottlieb,E. and Vousden,K.H.
  TITLE     TIGAR, a p53-inducible regulator of glycolysis and apoptosis
  JOURNAL   Cell 126 (1), 107-120 (2006)
   PUBMED   16839880
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Forsthuber,T., Yip,H.C. and Lehmann,P.V.
  TITLE     Induction of TH1 and TH2 immunity in neonatal mice
  JOURNAL   Science 271 (5256), 1728-1730 (1996)
   PUBMED   8596934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163683.4 and AK145896.1.
            
            On Apr 10, 2010 this sequence version replaced NM_177003.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145896.1, AK165614.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC163683.4         182040-182055       c
            17-2292             AK145896.1         2-2277
            2293-3653           AC163683.4         157619-158979       c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..3653
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="Trp53 induced glycolysis regulatory phosphatase"
                     /db_xref="GeneID:319801"
                     /db_xref="MGI:MGI:2442752"
     exon            1..117
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..895
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /EC_number="3.1.3.46"
                     /note="probable fructose-2,6-bisphosphatase TIGAR;
                     TP53-induced glycolysis and apoptosis regulator;
                     TP53-induced glycolysis regulatory phosphatase; Trp53
                     induced glycolysis repulatory phosphatase"
                     /codon_start=1
                     /product="fructose-2,6-bisphosphatase TIGAR"
                     /protein_id="NP_795977.1"
                     /db_xref="CCDS:CCDS20563.1"
                     /db_xref="GeneID:319801"
                     /db_xref="MGI:MGI:2442752"
                     /translation="MPRFALTVIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAAAGQ
                     FLSNVQFTHAFSSDLTRTKQTIHGILEKSRFCKDMAVKYDSRLRERMYGVAEGKPLSE
                     LRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRESVLPGAPGS
                     GLESSLAEVFPVGKHGSLGANPKGGTLGLAASILVVSHGAYMRSLFGYFLSDLRCSLP
                     GARDKLELSSITPNTGISVFIIDCEEARQPSIQCVCMNLQEHLNGVTEKQH"
     exon            118..155
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            156..277
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..355
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..466
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            467..3653
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1276
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="major polyA site"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2685
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="major polyA site"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3653
                     /gene="Tigar"
                     /gene_synonym="9630033F20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgcagg caaagtggtc ccagagtcag gcgcagcgag gtgctgctgc agagccgggt
       61 cgtggctcac gcgtcttgtg ccaaaatgcc gcgcttcgcc ttgaccgtta tccgccatgg
      121 tgaaacaaga cttaataagg agaaaatcat tcaaggacaa ggcgtagatg cgcccctttc
      181 ggagactggg tttcggcaag cagcggccgc cgggcagttt ctgagcaatg tgcagtttac
      241 ccacgccttc tccagcgatc tcacgaggac taagcagacc atacatggca ttttggagaa
      301 aagcagattt tgtaaagaca tggcggtgaa gtacgactcc aggctccgag aaaggatgta
      361 cggagtcgcg gaaggcaagc cgctaagcga gcttcgggcc atggccaaag ccgctgggga
      421 agagtgcccc atgttcaccc cgcctggagg agagacagtt gagcaggtaa agatgcgcgg
      481 aaaggatttc tttgatttca tttgtcagct aatcctgggc aaggcagggc agagagaaag
      541 cgtcctgcct ggagcgccag gcagcggttt ggaaagctct ttggcagagg ttttccctgt
      601 tggaaaacat ggcagcttgg gggcgaatcc caaaggtggc accctgggct tagcagccag
      661 catcttagtt gtgagccatg gcgcttacat gagaagcctc tttggttatt ttctgagtga
      721 cctcagatgc tcgttgccag gagcgagaga caaattggaa ctttcctcca tcactcccaa
      781 cactgggatc agtgtcttca tcatagactg tgaggaagca cgccagccat cgattcagtg
      841 cgtttgtatg aacctccagg agcacctgaa cggagtgact gagaagcagc actgagtgtg
      901 gagcccgtgc agtggagcct ctgaagggag ggacttggcc tctgctgctg ccattttaga
      961 agcagcggag aattcatgtg ttgaagcccc actggggttg tggctgtgtc agacgttagt
     1021 ggggaatcca ctcacagcca gcctggcttt tcctgtcatt ttctacactg atttttgtca
     1081 ctctgtccca ttatgtctct gatctgttaa cttatgagga cattgaggct tgcacatccg
     1141 gggatgagca gccttctttc cacacacttc cttttccttg gcccttgtga tgtctaggtg
     1201 gtgttggctt ttgaagataa ttgtatgatt tcacactcgc tcaccaagtg cttgcaagaa
     1261 agaatggttt cagtaatacg ctgcgtattt gcagtgatcc aaagtgttca gagtgaagct
     1321 tcagatcagt gttcaaggta aagtgaccga acactctagt gtcctggaga aactagctct
     1381 tgggatttat tattattatt attattatta ttattattat tattattatt gcctcagaat
     1441 acagcagagg gactgaaggg gtgggtgggc agttaagagt acttcctgtt actcagaact
     1501 ccagttcaga tcccgttacc catgttgggg agctcacagc tgcctggaac tccagcattg
     1561 gagagccagt gccccctctg tgcctctgca gacacttggc acacatacac acaaataaaa
     1621 gtgatgaaag cagcctcggg ggaagaaagg aatgcaccac ttgatcaaaa cacactaaga
     1681 atcccctgag cagaaggaaa aaggagctct ccaggcaaac agggtgggtg aggggttgct
     1741 caaattgtcc tctgctttgt atctggcttg ccagttgatc taaagaagag gtgctgaaaa
     1801 ctgctatcta gaaggcacag atgaagaacc ttccctctag gtggccctgt aggaaaggga
     1861 ttttgattgc tgctcgggag tccttaattg ggaaaccgga ttgaactgct gaaatgccag
     1921 ctcacaccac agcctcaggg aaaggaatta catggggaaa ctgtaatcat aacagcgggc
     1981 ccagataggc atcaaacaaa cttaaaccta gaaaaaggaa ggaatatgtc gaggctcaca
     2041 gctgctagct tgccacagct gtaaagcact gctaggtcct tcccctgtct agacactgcg
     2101 gagctggtgt caacactggg tactggtggc cccagactag ggatttcctt gagattccat
     2161 atgcatatgt accttgcaca aaaacatcac tagtgtgcac ccaaagtgtg gccatcttcc
     2221 gagaaaccca aagacgtgat taagggggcc gcagaaaagt tgccctatgg gtgacagcaa
     2281 acttcagccc aaaagtggcg ccagcatcgg agccagtggt ggatgcgtga atttgagagg
     2341 gaagcccgag gggtctggag gtggtcttca gtgggccctg ggttccatcc ttggtattag
     2401 gggggaaaaa caagaaggct gtgggtttgg ttctcttcct acttctgtgg aggcccccca
     2461 ccccgacccg gcaagccttc aggtgtcaac agtgtggtcc agggaacagt tgtgacaaag
     2521 tttggtgggc tggcttcgtc tccagttgga ctcttgtctg gcctgagtct ctgctgctcc
     2581 cctgagagtg atttctcttc ctccttatca ggctgtattt tcccatccct aagagtagat
     2641 gataaaatgt tacattttga acacattaaa agaaatttaa aaatacacaa tggttaggct
     2701 gcctcaaagc agtgtccaag tgttattttg atctaaagtc aggtaagaag aaatggcagc
     2761 tttgcctaac aacagtataa cctcagacct catccttctc ctcttccccc ccccactccc
     2821 caagctccca gggatgcctt gatacccgtc ttggtacttg cggagctgca tcctaccacc
     2881 ccccaccccc accccctccg tggcctccag tcagacccgc tcacgttcca ctaggtggat
     2941 ttgttacaaa agattatttt ttttttagca acttcaggtt tatggaaaag tcaaacaagg
     3001 agaagttccc ctacacaccc tccccccccc ccatttattc tgttggcaaa atctcgccac
     3061 agcgttgaag tctgtatctg aacgaagtgt gccgtttgtc agttttgtgt taccacgtta
     3121 atggagtgaa tgtcgccttc ctgtgagctc agcgtttcct ctggctgtca tctccattgt
     3181 atagaaagtc cagcatccac accattctta gtgtgccccg cactaccttt ttctgccggt
     3241 gatggatacg tgaatttgag aggaaagtta taaaaaacct gaagggtctg gaggtgttgc
     3301 tcattgggcc ctgggttcca tcctcagtat tgggggaaag aaacacaaaa ggagaacaaa
     3361 acaaaaacct acttttaaag aagagaaatc cagtgttagt gaggaaatgc agggtgagct
     3421 aggggtctag tgtagaccag gtgcagagca tcatgggaag tcctctggtt ctttaccagg
     3481 agcatctgag cagcagtgtt gttccaatgc ctttcacgtg tacagaaata cccagctatc
     3541 tgtagtcttt gttttaccca tattgtttga ggcactattt atttgggaat gtatggatct
     3601 acttaattgt aaccagtatt ctactgaata aagcatcttt tgtttataaa gga
//
