LOCUS       NM_001168615            3498 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TRAF-interacting protein with forkhead-associated
            domain, family member B (Tifab), transcript variant 1, mRNA.
ACCESSION   NM_001168615
VERSION     NM_001168615.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Niederkorn,M., Hueneman,K., Choi,K., Varney,M.E., Romano,L.,
            Pujato,M.A., Greis,K.D., Inoue,J.I., Meetei,R. and
            Starczynowski,D.T.
  TITLE     TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and
            Malignant Hematopoiesis
  JOURNAL   Cell Rep 30 (8), 2776-2790 (2020)
   PUBMED   32101751
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Varney,M.E., Choi,K., Bolanos,L., Christie,S., Fang,J.,
            Grimes,H.L., Maciejewski,J.P., Inoue,J.I. and Starczynowski,D.T.
  TITLE     Epistasis between TIFAB and miR-146a: neighboring genes in del(5q)
            myelodysplastic syndrome
  JOURNAL   Leukemia 31 (2), 491-495 (2017)
   PUBMED   27733775
  REMARK    Erratum:[Leukemia. 2017 Jul;31(7):1659. doi: 10.1038/leu.2017.95..
            PMID: 28386122]
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Stoddart,A., Qian,Z., Fernald,A.A., Bergerson,R.J., Wang,J.,
            Karrison,T., Anastasi,J., Bartom,E.T., Sarver,A.L., McNerney,M.E.,
            Largaespada,D.A. and Le Beau,M.M.
  TITLE     Retroviral insertional mutagenesis identifies the del(5q) genes,
            CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential
            targets in del(5q) myeloid neoplasms
  JOURNAL   Haematologica 101 (6), e232-e236 (2016)
   PUBMED   26944478
  REMARK    GeneRIF: Retroviral insertional mutagenesis identifies the del(5q)
            genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as
            potential targets in del(5q) myeloid neoplasms
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Varney,M.E., Niederkorn,M., Konno,H., Matsumura,T., Gohda,J.,
            Yoshida,N., Akiyama,T., Christie,S., Fang,J., Miller,D., Jerez,A.,
            Karsan,A., Maciejewski,J.P., Meetei,R.A., Inoue,J. and
            Starczynowski,D.T.
  TITLE     Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through
            derepression of Toll-like receptor-TRAF6 signaling
  JOURNAL   J Exp Med 212 (11), 1967-1985 (2015)
   PUBMED   26458771
  REMARK    GeneRIF: TIFAB loss increases TRAF6 protein and the dynamic range
            of TLR4 signaling
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Matsumura,T., Kawamura-Tsuzuku,J., Yamamoto,T., Semba,K. and
            Inoue,J.
  TITLE     TRAF-interacting protein with a forkhead-associated domain B
            (TIFAB) is a negative regulator of the TRAF6-induced cellular
            functions
  JOURNAL   J Biochem 146 (3), 375-381 (2009)
   PUBMED   19470519
  REMARK    GeneRIF: study shows TIFAB is mainly expressed in B cells rather
            than T cells in the spleen; results suggest TIFAB could act as a
            negative regulator of TRAF6-induced cellular function such as B
            cell proliferation and maturation of dendritic cellss & macrophages
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Matsumura,T., Semba,K., Azuma,S., Ikawa,S., Gohda,J., Akiyama,T.
            and Inoue,J.
  TITLE     TIFAB inhibits TIFA, TRAF-interacting protein with a
            forkhead-associated domain
  JOURNAL   Biochem Biophys Res Commun 317 (1), 230-234 (2004)
   PUBMED   15047173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY209244.1, AK153654.1 and AC124395.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031130.1, AK153654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               BY209244.1         1-269
            270-2714            AK153654.1         2-2446
            2715-3498           AC124395.5         138815-139598
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..3498
                     /gene="Tifab"
                     /note="TRAF-interacting protein with forkhead-associated
                     domain, family member B"
                     /db_xref="GeneID:212937"
                     /db_xref="MGI:MGI:2385852"
     exon            1..339
                     /gene="Tifab"
                     /inference="alignment:Splign:2.1.0"
     exon            340..567
                     /gene="Tifab"
                     /inference="alignment:Splign:2.1.0"
     exon            568..3498
                     /gene="Tifab"
                     /inference="alignment:Splign:2.1.0"
     CDS             573..1016
                     /gene="Tifab"
                     /note="TIFA related protein TIFAB; TIFA like protein"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein B"
                     /protein_id="NP_001162086.1"
                     /db_xref="CCDS:CCDS26558.1"
                     /db_xref="GeneID:212937"
                     /db_xref="MGI:MGI:2385852"
                     /translation="MERPLTVLQVSLYHPTQGPVAFAHVPQQLQHDASRLLVGRGQNT
                     HLQLQLPQLSRYHLSLEPYLEKGSSLLAFCLKVLTRKSCVWVNGLPLRYLEQVPLGTI
                     NRISFSGIQMLVRKEGGASLETFVCYFHLSPSPLIYRPKAQETDE"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tifab"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="Tifab"
                     /note="major polyA site"
ORIGIN      
        1 tctgccctca gaggacagaa gaagctgata ctctgtggtc tctgaggctg aaataataga
       61 ggctggagca ccgagaccca ggaaagcgta ccatccggag gcccctccta gagaggcacc
      121 cgtttcacaa ctcaagcaag cggttccact tctgcaagag aaaataatac ttcaatttca
      181 ttcctagagg aaaaaggaag agcggcagag ctgacgtgct ctctgacaca gtgcacgccc
      241 gaaccacgga cgcgcttgcc tgcccaggtc ttcctccagc ccaggtcctg cctgatcaca
      301 cagctgcaga gttagtgcca ggtgtacccc ggaggtaagc tggaggcacc atatctttcc
      361 cttcaagagc ggtgctccca agagcaaagg cctatctcca cagcacctgg attgacacct
      421 ggctcgaaga agactctgca agagtttgtt tgttgcatgc ctgccagatt caagaaagcc
      481 tgtcctgtct gctcatctgt tcctataaag caaggacaaa ctgtctccaa atggcctgtg
      541 gactatcagg cgccaccctg taagctggat ctatggagag gcccctcaca gtcctgcagg
      601 tgagcctgta ccaccctaca cagggcccgg tcgcctttgc ccacgtccca cagcagctgc
      661 aacatgacgc cagccggctg ttggttgggc gaggacagaa cacccatctc cagctgcagc
      721 tgccacagtt gtctcgctac catttgtccc tggaacccta cctggagaaa ggcagcagtc
      781 tgctggcctt ctgcctcaag gtgctgaccc gcaagagctg tgtgtgggtc aacgggctgc
      841 cactgaggta cctggagcag gttcccttgg gcaccatcaa cagaatctcc ttctctggca
      901 tccagatgct agtccgcaaa gaggggggag cctcccttga gacctttgtc tgctacttcc
      961 atctcagccc ttcacccctg atttacagac ccaaggctca ggagacagat gaatgaaccg
     1021 ggaaaactct gttaagaaag agactccccc tgttttgggg gaggcaactc atgaactctc
     1081 gaggtctctc cacagcccct cccagtctca gacagctgct tccctgccaa gcccggaaga
     1141 agcaatagaa acaaagttgc agaaggggcc ctcagacaat gcaccccact agccctgctg
     1201 cttgagagca aacctgacaa aaatagggtt tgagatggta gagctatatc ctgtgaggtt
     1261 gacacacaga gttcacatgt aaagcctgct ggccgccatg ttcacaggga actgattctg
     1321 taaactttga gcagcccatg gggtggagaa atgccctccg tagctctgtg taatgggaac
     1381 ttcatatacg tttagaggcc cccaggggtt ctggaagcct ctcccagcat tctgtgcccc
     1441 cccccatttc ctccattgtc tggcgaggag ttactttatg ttcttctgcc gaagggcagg
     1501 aacatggggt tgaaacagga atgcaaggac acagggagaa attacgtttg aggtagctcc
     1561 gggttccctt cagttttcaa atacccacag gcgctcaggg cttaggaaag cctgtgttta
     1621 ataaactaaa agtatttcat tatgctggca tgcccagtag gatcccctga ggcccagatg
     1681 ggccacatgt ataccatgtt gtcatgtggc tttgggggcg ggaaacctgg atgaggtgtg
     1741 agaggaaatt gggaaggtag gtaggcgtac gtttctggga aggttgcaag tagaactcgg
     1801 ggcttttggt gggggtaagg ggggctagaa gctaggactg tttggacatt tcttttcctc
     1861 ctcctcctct ctcttcctcc tctctgccct cttcttgttc cctctcctct cctcccatcc
     1921 tctatccctt ctggaccaga gccttggttg gccagaggtc aaaggtctat ggttttctag
     1981 agaagtgggc tctttcagaa ctaattctat ggttgggatg caaggttgta taagaagtca
     2041 acctagcagt tacctcactc agagtaaatc atatgccagc aagaaggggg agcaggggac
     2101 gaggggggta cctatccttc ctgaacggac aatgggggtg atggtggatt gttaaggagc
     2161 taagtaggca aggatgggag aattttctca gaagggagca gaaggctagc aggggggggg
     2221 ggtgtttact catgtgagag aaggagagtc ccacagactc tgctaaacac cataccacca
     2281 gatcctacac tagagtaccc caaacactca ggggacagtg ctgccagcag actgatccat
     2341 atcctcaaca cctggaacac cactgccata taccaccccg tacccctttg tgcccaaatc
     2401 ctaggtcata tgatcattac tgttccccag ctgagcatgt cttccccata aggaaactaa
     2461 cactagacaa gatacatgcg ggcttgggaa gcccctcctc ctacagaata cagactgtgt
     2521 gcactcagct cacagacaca agacgtgtgt ctacctacct gcgacagtgc tggctatact
     2581 gtgagtggcg tgtccccctc cccccaagac tcccaaagta ctttctccct catttgtcaa
     2641 tgaacttgca ccaagtgccc acctcacacc caatatgtcc aaagtctcag gatccaggaa
     2701 taaacaaagc cgggagaatc tgcgtgccat cagcttgcct gcctcaggag ggagaagcgt
     2761 tcggggacag acagcttaat tatttatcat ggctgttgct atcttccctc tcctctgttc
     2821 acttggagtt aagccctatc atcgagtggg tctgatgtta acacttctat atgttcatcc
     2881 ctctcctggt cgagtcacag tgtaataggc catcgagtgc tggagccagc tgtcactgcc
     2941 tagtcactcc ttgcagtccc ctagatagac actggtctca agcatagtcc acaggtaagg
     3001 acagtaaaat tcagaaggtc agtagccggg gccatctcat ctgtgagttg ggtgacctca
     3061 ggcaagtgag ttagcccacc gtgacctaga tgtctccctc tggaaagcca ggacgatgag
     3121 tattccaacc tgcaggaaca gcagagagta tcttaggaag tgggacctgg aaaacaccta
     3181 gtgccagaag gaattaaaaa aaaagggggg ggggctgcta tcctgagacc aaagacaggg
     3241 aagctaaaat atatactcct taagcttatt acaaacttgg atcttggggc gacttgaacc
     3301 ccagtgatct ggctccagag ctcaagggct ttcgacactc tgtgactctc taaggatttt
     3361 attttcattt ggggcctgga gggaggaaaa gggtttggtt tttggttttt ggttgttttg
     3421 ttttgttttg ttttgttttt tttgttttgt tttgttttag ctgcctttgt attaaaagac
     3481 ctgggtttgt agaacaag
//
