LOCUS       NM_145133               2183 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus TRAF-interacting protein with forkhead-associated
            domain (Tifa), transcript variant 1, mRNA.
ACCESSION   NM_145133
VERSION     NM_145133.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Guo,X., Qiao,G., Wang,J., Yang,C., Zhao,M., Zhang,Q. and Wan,Y.
  TITLE     TIFA contributes to periodontitis in diabetic mice via activating
            the NF-kappaB signaling pathway
  JOURNAL   Mol Med Rep 29 (2) (2024)
   PUBMED   38099344
  REMARK    GeneRIF: TIFA contributes to periodontitis in diabetic mice via
            activating the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Li,Y., Zhang,J., Zhai,P., Hu,C., Suo,J., Wang,J., Liu,C. and
            Peng,Z.
  TITLE     The potential biomarker TIFA regulates pyroptosis in sepsis-induced
            acute kidney injury
  JOURNAL   Int Immunopharmacol 115, 109580 (2023)
   PUBMED   36586274
  REMARK    GeneRIF: The potential biomarker TIFA regulates pyroptosis in
            sepsis-induced acute kidney injury.
REFERENCE   4  (bases 1 to 2183)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2183)
  AUTHORS   Shen,W., Chang,A., Wang,J., Zhou,W., Gao,R., Li,J., Xu,Y., Luo,X.,
            Xiang,R., Luo,N. and Stupack,D.G.
  TITLE     TIFA, an inflammatory signaling adaptor, is tumor suppressive for
            liver cancer
  JOURNAL   Oncogenesis 4 (10), e173 (2015)
   PUBMED   26501855
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2183)
  AUTHORS   Ding,N., Zhang,Y., Loughran,P.A., Wang,Q., Tsung,A. and
            Billiar,T.R.
  TITLE     TIFA upregulation after hypoxia-reoxygenation is TLR4- and
            MyD88-dependent and associated with HMGB1 upregulation and release
  JOURNAL   Free Radic Biol Med 63, 361-367 (2013)
   PUBMED   23722163
  REMARK    GeneRIF: The increase in TIFA level appears to be a feed-forward
            mechanism involved in TLR4/MyD88-dependent signaling, leading to
            NF-kappaB activation and HMGB1 release
REFERENCE   7  (bases 1 to 2183)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 2183)
  AUTHORS   Minoda,Y., Saeki,K., Aki,D., Takaki,H., Sanada,T., Koga,K.,
            Kobayashi,T., Takaesu,G. and Yoshimura,A.
  TITLE     A novel Zinc finger protein, ZCCHC11, interacts with TIFA and
            modulates TLR signaling
  JOURNAL   Biochem Biophys Res Commun 344 (3), 1023-1030 (2006)
   PUBMED   16643855
  REMARK    GeneRIF: We propose that ZCCHC11 is a unique TLR signal regulator,
            which interacts with TIFA after LPS treatment and suppresses the
            TRAF6-dependent activation of NF-kappaB.
            Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121]
REFERENCE   9  (bases 1 to 2183)
  AUTHORS   Takatsuna,H., Kato,H., Gohda,J., Akiyama,T., Moriya,A., Okamoto,Y.,
            Yamagata,Y., Otsuka,M., Umezawa,K., Semba,K. and Inoue,J.
  TITLE     Identification of TIFA as an adapter protein that links tumor
            necrosis factor receptor-associated factor 6 (TRAF6) to
            interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1
            receptor signaling
  JOURNAL   J Biol Chem 278 (14), 12144-12150 (2003)
   PUBMED   12566447
  REMARK    GeneRIF: TIFA is likely to mediate IRAK-1/TRAF6 interaction upon
            IL-1 stimulation
REFERENCE   10 (bases 1 to 2183)
  AUTHORS   Kanamori,M., Suzuki,H., Saito,R., Muramatsu,M. and Hayashizaki,Y.
  TITLE     T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and
            AP-1 without TNF stimulation
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1108-1113 (2002)
   PUBMED   11798190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163391.4, BY168652.1 and AB062111.1.
            
            On Oct 4, 2017 this sequence version replaced NM_145133.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166239.1, AK151651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC163391.4         110357-110397       c
            42-245              BY168652.1         1-204
            246-2178            AB062111.1         2-1934
            2179-2183           AC163391.4         101875-101879       c
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 56.54 cM"
     gene            1..2183
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="TRAF-interacting protein with forkhead-associated
                     domain"
                     /db_xref="GeneID:211550"
                     /db_xref="MGI:MGI:2182965"
     exon            1..300
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            301..357
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            358..2183
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..925
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="Traf2 binding protein"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein A"
                     /protein_id="NP_660115.1"
                     /db_xref="CCDS:CCDS38628.1"
                     /db_xref="GeneID:211550"
                     /db_xref="MGI:MGI:2182965"
                     /translation="MSTFEDADTEETVTCLQMTIYHPGQQSGIFKSIRFCSKEKFPSI
                     EVVKFGRNSNMCQYTFQDKQVSRIQFVLQPFKQFNSSVLSFEIKNMSKKTSLMVDNQE
                     LGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFIMSSRPLLQENNWPTQNPI
                     PEDGMYSSYFTHRSSPSEMDENEL"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="major polyA site"
ORIGIN      
        1 agtcaggaga cctcagagag gcgacagggg gcagggcttc ctgtggaaaa gggctggacg
       61 gcggcggcag cctcttgcct ggctctgcgg ggctttcctc ccggcaaggg ctttgccgag
      121 gtcactcgcg cgaggccgct cttggcgcgc ccgtgggagg ctcggtggcg tgggaggacc
      181 agcgacctgc ggattcctcg agctcccacg gcgctggcag cgacggtccc ccacccccac
      241 ccctatcccc aggcttccac cagaaggctc cgcaagactc acggacctcc aagtccccag
      301 gagaggagac aaggctcagg agtcctgatc tagctgtggc cactggaaga ctctcaggcc
      361 ggggagcgtc atgtccacct ttgaagacgc tgatacagag gagacggtca cttgtctcca
      421 gatgaccatt taccatcctg gccaacaaag tgggatattt aaatcaataa ggttttgcag
      481 caaagagaag tttccttcca ttgaagtggt gaaatttgga cgcaattcca acatgtgcca
      541 gtatacgttt caggacaaac aggtgtcccg aattcagttt gttttacagc cgtttaaaca
      601 gttcaacagc tccgttctct cgtttgaaat aaaaaacatg agcaagaaaa ccagtttgat
      661 ggtagacaac caggagctcg gctacctcaa taaaatggac ctgccttaca agtgtatgct
      721 caggttcgga gagtatcagt tcctgttgca gaaggaagac ggagagtcgg tggaatcttt
      781 tgagactcaa tttatcatgt cttcaagacc tctcttgcaa gaaaacaact ggccaacaca
      841 gaatcccata ccagaggatg ggatgtattc ttcatacttc acccacagaa gttctccttc
      901 agaaatggat gaaaacgaac tgtgaagagg gtccaactgg agacacattg aaggatgagg
      961 acacatgggt cggatgtcaa gagacatcct acttccgagt ttgtgagtgt agcgtagcgc
     1021 ggctgtcctc atgctgactt tcgttttggt aatagcattt ggaagtctct agactgtgtt
     1081 aatcatcaac ttagtcaact gagtttcggc tctacaaaga attaagtgta catctgtaag
     1141 ggttggtgca tcagacacgt cttctgggta atgaggtcac ccttgttgct tttctgcatg
     1201 atgttacccc catgctttgt cttggtggca gccatctctt ggcccggtca catcatttcg
     1261 tagcagcctt tgtttttcag gtttagagct cgggcagatt gctcactggt gtctgtggcg
     1321 tgctagcgct tgtagaacta gagtcctgga ataagttcta gagtgctgag tcactgagtc
     1381 accatggctt ccttatggaa agacttggga aatagctcct tgattttctt tctgtggaac
     1441 ggtagtgtcg ctttcctata tgtaggacct acaacaaaca tttaaagaac actgagatga
     1501 agatggtttt cttacaatat tgaaagtgaa ttttatgtat ctcacagatt taaaaatggc
     1561 agaaatcaaa acttttaaca gcctctttgc acatgataaa gccggagccc agttccttag
     1621 ttgcttcttt ggaacttctt aaaggaaaac atgtattctt aaaggaaaac atctattctt
     1681 aggctgccct atagaagtca gtacctgtga atatttatat taaatgctta attatttcta
     1741 aaattttagt ttcacataaa gttgtattta tttaaaagat tctcattcac ttcattttgg
     1801 ctagattaag atgaatgtta gtgaacatta tgtaaaagag gatgaaagcc attaagttaa
     1861 gataaattct agcattacta gtaagtaagg caccctgtat agcttcctct gtaaatgaaa
     1921 tttaatgctg taacaggtac aggattttgg gtaggggagg aggtcaggtg ggggaagtta
     1981 gccacattca tattttgttt ttgtttttgt ttttgttttt gtttttgttt tccaacaata
     2041 gcttgctttg aagctcaggc tggcttggaa ctcttgatcc tcatacatcg gccccctgaa
     2101 tgctgtgcct agcttaatgt aactgtattt ctgcaacagc cctttgaaat tatttctaat
     2161 aaactgtttg gcctagtacc atg
//
