LOCUS       NM_001356430            1976 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus TRAF-interacting protein with forkhead-associated
            domain (Tifa), transcript variant 2, mRNA.
ACCESSION   NM_001356430 XM_006501239
VERSION     NM_001356430.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Guo,X., Qiao,G., Wang,J., Yang,C., Zhao,M., Zhang,Q. and Wan,Y.
  TITLE     TIFA contributes to periodontitis in diabetic mice via activating
            the NF-kappaB signaling pathway
  JOURNAL   Mol Med Rep 29 (2) (2024)
   PUBMED   38099344
  REMARK    GeneRIF: TIFA contributes to periodontitis in diabetic mice via
            activating the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Li,Y., Zhang,J., Zhai,P., Hu,C., Suo,J., Wang,J., Liu,C. and
            Peng,Z.
  TITLE     The potential biomarker TIFA regulates pyroptosis in sepsis-induced
            acute kidney injury
  JOURNAL   Int Immunopharmacol 115, 109580 (2023)
   PUBMED   36586274
  REMARK    GeneRIF: The potential biomarker TIFA regulates pyroptosis in
            sepsis-induced acute kidney injury.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Shen,W., Chang,A., Wang,J., Zhou,W., Gao,R., Li,J., Xu,Y., Luo,X.,
            Xiang,R., Luo,N. and Stupack,D.G.
  TITLE     TIFA, an inflammatory signaling adaptor, is tumor suppressive for
            liver cancer
  JOURNAL   Oncogenesis 4 (10), e173 (2015)
   PUBMED   26501855
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Ding,N., Zhang,Y., Loughran,P.A., Wang,Q., Tsung,A. and
            Billiar,T.R.
  TITLE     TIFA upregulation after hypoxia-reoxygenation is TLR4- and
            MyD88-dependent and associated with HMGB1 upregulation and release
  JOURNAL   Free Radic Biol Med 63, 361-367 (2013)
   PUBMED   23722163
  REMARK    GeneRIF: The increase in TIFA level appears to be a feed-forward
            mechanism involved in TLR4/MyD88-dependent signaling, leading to
            NF-kappaB activation and HMGB1 release
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Minoda,Y., Saeki,K., Aki,D., Takaki,H., Sanada,T., Koga,K.,
            Kobayashi,T., Takaesu,G. and Yoshimura,A.
  TITLE     A novel Zinc finger protein, ZCCHC11, interacts with TIFA and
            modulates TLR signaling
  JOURNAL   Biochem Biophys Res Commun 344 (3), 1023-1030 (2006)
   PUBMED   16643855
  REMARK    GeneRIF: We propose that ZCCHC11 is a unique TLR signal regulator,
            which interacts with TIFA after LPS treatment and suppresses the
            TRAF6-dependent activation of NF-kappaB.
            Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121]
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Takatsuna,H., Kato,H., Gohda,J., Akiyama,T., Moriya,A., Okamoto,Y.,
            Yamagata,Y., Otsuka,M., Umezawa,K., Semba,K. and Inoue,J.
  TITLE     Identification of TIFA as an adapter protein that links tumor
            necrosis factor receptor-associated factor 6 (TRAF6) to
            interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1
            receptor signaling
  JOURNAL   J Biol Chem 278 (14), 12144-12150 (2003)
   PUBMED   12566447
  REMARK    GeneRIF: TIFA is likely to mediate IRAK-1/TRAF6 interaction upon
            IL-1 stimulation
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Kanamori,M., Suzuki,H., Saito,R., Muramatsu,M. and Hayashizaki,Y.
  TITLE     T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and
            AP-1 without TNF stimulation
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1108-1113 (2002)
   PUBMED   11798190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149408.1, AK041891.1 and AC163391.4.
            
            On Oct 4, 2017 this sequence version replaced XM_006501239.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149408.1, BY742552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1531              AK149408.1         3-1533
            1532-1970           AK041891.1         1532-1970
            1971-1976           AC163391.4         101875-101880       c
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 56.54 cM"
     gene            1..1976
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="TRAF-interacting protein with forkhead-associated
                     domain"
                     /db_xref="GeneID:211550"
                     /db_xref="MGI:MGI:2182965"
     exon            1..93
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            94..150
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     exon            151..1976
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..718
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="Traf2 binding protein"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein A"
                     /protein_id="NP_001343359.1"
                     /db_xref="CCDS:CCDS38628.1"
                     /db_xref="GeneID:211550"
                     /db_xref="MGI:MGI:2182965"
                     /translation="MSTFEDADTEETVTCLQMTIYHPGQQSGIFKSIRFCSKEKFPSI
                     EVVKFGRNSNMCQYTFQDKQVSRIQFVLQPFKQFNSSVLSFEIKNMSKKTSLMVDNQE
                     LGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFIMSSRPLLQENNWPTQNPI
                     PEDGMYSSYFTHRSSPSEMDENEL"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="hexamer: AATAAA"
     polyA_site      1971
                     /gene="Tifa"
                     /gene_synonym="T2bp"
                     /note="major polyA site"
ORIGIN      
        1 gggtcacagg aaagcccagc gtcgttgtga tccgggattt tccaattttc ccagaggatt
       61 cgcatccggt tgctgggaga ggctccgtgg ggggagagga gacaaggctc aggagtcctg
      121 atctagctgt ggccactgga agactctcag gccggggagc gtcatgtcca cctttgaaga
      181 cgctgataca gaggagacgg tcacttgtct ccagatgacc atttaccatc ctggccaaca
      241 aagtgggata tttaaatcaa taaggttttg cagcaaagag aagtttcctt ccattgaagt
      301 ggtgaaattt ggacgcaatt ccaacatgtg ccagtatacg tttcaggaca aacaggtgtc
      361 ccgaattcag tttgttttac agccgtttaa acagttcaac agctccgttc tctcgtttga
      421 aataaaaaac atgagcaaga aaaccagttt gatggtagac aaccaggagc tcggctacct
      481 caataaaatg gacctgcctt acaagtgtat gctcaggttc ggagagtatc agttcctgtt
      541 gcagaaggaa gacggagagt cggtggaatc ttttgagact caatttatca tgtcttcaag
      601 acctctcttg caagaaaaca actggccaac acagaatccc ataccagagg atgggatgta
      661 ttcttcatac ttcacccaca gaagttctcc ttcagaaatg gatgaaaacg aactgtgaag
      721 agggtccaac tggagacaca ttgaaggatg aggacacatg ggtcggatgt caagagacat
      781 cctacttccg agtttgtgag tgtagcgtag cgcggctgtc ctcatgctga ctttcgtttt
      841 ggtaatagca tttggaagtc tctagactgt gttaatcatc aacttagtca actgagtttc
      901 ggctctacaa agaattaagt gtacatctgt aagggttggt gcatcagaca cgtcttctgg
      961 gtaatgaggt cacccttgtt gcttttctgc atgatgttac ccccatgctt tgtcttggtg
     1021 gcagccatct cttggcccgg tcacatcatt tcgtagcagc ctttgttttt caggtttaga
     1081 gctcgggcag attgctcact ggtgtctgtg gcgtgctagc gcttgtagaa ctagagtcct
     1141 ggaataagtt ctagagtgct gagtcactga gtcaccatgg cttccttatg gaaagacttg
     1201 ggaaatagct ccttgatttt ctttctgtgg aacggtagtg tcgctttcct atatgtagga
     1261 cctacaacaa acatttaaag aacactgaga tgaagatggt tttcttacaa tattgaaagt
     1321 gaattttatg tatctcacag atttaaaaat ggcagaaatc aaaactttta acagcctctt
     1381 tgcacatgat aaagccggag cccagttcct tagttgcttc tttggaactt cttaaaggaa
     1441 aacatgtatt cttaaaggaa aacatctatt cttaggctgc cctatagaag tcagtacctg
     1501 tgaatattta tattaaatgc ttaattattt ctaaaatttt agtttcacat aaagttgtat
     1561 ttatttaaaa gattctcatt cacttcattt tggctagatt aagatgaatg ttagtgaaca
     1621 ttatgtaaaa gaggatgaaa gccattaagt taagataaat tctagcatta ctagtaagta
     1681 aggcaccctg tatagcttcc tctgtaaatg aaatttaatg ctgtaacagg tacaggattt
     1741 tgggtagggg aggaggtcag gtgggggaag ttagccacat tcatattttg tttttgtttt
     1801 tgtttttgtt tttgtttttg ttttccaaca atagcttgct ttgaagctca ggctggcttg
     1861 gaactcttga tcctcataca tcggccccct gaatgctgtg cctagcttaa tgtaactgta
     1921 tttctgcaac agccctttga aattatttct aataaactgt ttggcctagt accatg
//
