LOCUS       NM_011587               3883 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 (Tie1), mRNA.
ACCESSION   NM_011587
VERSION     NM_011587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3883)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 3883)
  AUTHORS   Brouillard,P., Murtomaki,A., Leppanen,V.M., Hyytiainen,M.,
            Mestre,S., Potier,L., Boon,L.M., Revencu,N., Greene,A.,
            Anisimov,A., Salo,M.H., Hinttala,R., Eklund,L., Quere,I.,
            Alitalo,K. and Vikkula,M.
  TITLE     Loss-of-function mutations of the TIE1 receptor tyrosine kinase
            cause late-onset primary lymphedema
  JOURNAL   J Clin Invest 134 (14), e173586 (2024)
   PUBMED   38820174
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3883)
  AUTHORS   Sato-Nishiuchi,R., Doiguchi,M., Morooka,N. and Sekiguchi,K.
  TITLE     Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic
            endothelial cells
  JOURNAL   J Cell Biol 222 (9) (2023)
   PUBMED   37338522
  REMARK    GeneRIF: Polydom/SVEP1 binds to Tie1 and promotes migration of
            lymphatic endothelial cells.
REFERENCE   4  (bases 1 to 3883)
  AUTHORS   Cao,X., Li,T., Xu,B., Ding,K., Li,W., Shen,B., Chu,M., Zhu,D.,
            Rui,L., Shang,Z., Li,X., Wang,Y., Zheng,S., Alitalo,K., Liu,G.,
            Tang,J., Kubota,Y. and He,Y.
  TITLE     Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein
            Assembly in Synergy With Its Homologue TIE2
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (8), e323-e338 (2023)
   PUBMED   37317851
REFERENCE   5  (bases 1 to 3883)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 3883)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   7  (bases 1 to 3883)
  AUTHORS   Fong,G.H., Rossant,J., Gertsenstein,M. and Breitman,M.L.
  TITLE     Role of the Flt-1 receptor tyrosine kinase in regulating the
            assembly of vascular endothelium
  JOURNAL   Nature 376 (6535), 66-70 (1995)
   PUBMED   7596436
REFERENCE   8  (bases 1 to 3883)
  AUTHORS   Shalaby,F., Rossant,J., Yamaguchi,T.P., Gertsenstein,M., Wu,X.F.,
            Breitman,M.L. and Schuh,A.C.
  TITLE     Failure of blood-island formation and vasculogenesis in
            Flk-1-deficient mice
  JOURNAL   Nature 376 (6535), 62-66 (1995)
   PUBMED   7596435
REFERENCE   9  (bases 1 to 3883)
  AUTHORS   Korhonen,J., Polvi,A., Partanen,J. and Alitalo,K.
  TITLE     The mouse tie receptor tyrosine kinase gene: expression during
            embryonic angiogenesis
  JOURNAL   Oncogene 9 (2), 395-403 (1994)
   PUBMED   7507228
  REMARK    Erratum:[Oncogene 1996 Feb 15;12(4):943]
REFERENCE   10 (bases 1 to 3883)
  AUTHORS   Korhonen,J., Partanen,J., Armstrong,E., Vaahtokari,A., Elenius,K.,
            Jalkanen,M. and Alitalo,K.
  TITLE     Enhanced expression of the tie receptor tyrosine kinase in
            endothelial cells during neovascularization
  JOURNAL   Blood 80 (10), 2548-2555 (1992)
   PUBMED   1384789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841681.1, AK052413.1, AK052192.1 and CR518034.1.
            
            On Apr 10, 2007 this sequence version replaced NM_011587.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X80764.1, SRR1660821.62762.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BB841681.1         2-69
            69-1133             AK052413.1         2-1066
            1134-3879           AK052192.1         1054-3799
            3880-3883           CR518034.1         1-4                 c
FEATURES             Location/Qualifiers
     source          1..3883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.67 cM"
     gene            1..3883
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /note="tyrosine kinase with immunoglobulin-like and
                     EGF-like domains 1"
                     /db_xref="GeneID:21846"
                     /db_xref="MGI:MGI:99906"
     exon            1..202
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..3549
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase receptor Tie-1; tyrosine
                     kinase receptor 1"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor Tie-1
                     precursor"
                     /protein_id="NP_035717.2"
                     /db_xref="CCDS:CCDS18553.1"
                     /db_xref="GeneID:21846"
                     /db_xref="MGI:MGI:99906"
                     /translation="MVWWGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCV
                     SGEAGAGRSSDPPLLLEKDDRIVRTFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFS
                     CVGGAGARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNG
                     SYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRW
                     GPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGC
                     RGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCP
                     SGWHGVHCEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTM
                     LLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTA
                     PRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLK
                     PKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSL
                     PSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLL
                     GPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGG
                     SGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSE
                     GPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSG
                     SGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKK
                     DGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIE
                     YAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFI
                     HRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKS
                     DVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD
                     RPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA"
     exon            203..511
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..622
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..778
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..910
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1051
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1180
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1326
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1471
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1630
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1768
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2059
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2350
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2541
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2752
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2863
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..3054
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3168
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3239
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3280
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3377
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3477
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3879
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3861..3866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /note="hexamer: AATAAA"
     polyA_site      3879
                     /gene="Tie1"
                     /gene_synonym="D430008P04Rik; TIE; tie-1"
                     /note="major polyA site"
ORIGIN      
        1 ctgccacccc tcctacccta accatcattt cctcttcctc cccagcaccg aggtgcactg
       61 agctggacag gctgaacact cagacccaca gcaactgacc ccgggcccag ctggccttgg
      121 ctggcccagg gcagcttcca gagtatggtc tggtggggat cctctttgct gctccccact
      181 cttttcttgg cctctcatgt tggtgcgtct gttgacttaa cattgctggc caacctgcgc
      241 atcacagacc cccagcgttt cttcctgacc tgcgtgtctg gtgaggccgg agcagggagg
      301 agctcggacc cgcccctgct gctggagaag gatgatcgca tcgtgcgcac cttcccgcct
      361 gggcagcccc tgtacctggc acgcaacggt tctcaccagg tcacgctgag gggcttctcc
      421 aagccctcgg atttggtagg cgtcttctcc tgtgtgggtg gtgctggcgc gcggcgcact
      481 cgagttctct atgtgcacaa cagcccaggg gcacacctgt ttccagacaa ggtcacacac
      541 acggtgaaca aaggtgacac tgctgtgctt tctgcccatg tgcacaagga aaagcagact
      601 gacgtgatct ggaagaacaa cggatcctac ttcaataccc tagactggca agaggccgat
      661 gacgggcgtt ttcaactgca gctccaaaat gtacagccac catcaagtgg catctacagt
      721 gccacctacc tagaggccag ccccctgggc agtgccttct ttcggctcat cgtgcgaggc
      781 tgtggggctg gacgctgggg gccaggatgt gtcaaggatt gcccaggctg cctgcatgga
      841 ggtgtctgtc atgaccatga tggcgaatgt gtgtgtcccc caggattcac tggcacccgc
      901 tgtgagcagg cctgcaggga gggtcgtttt ggacagagct gtcaggaaca gtgcccaggc
      961 acagcaggtt gtagaggtct caccttctgc ctcccggatc cctatggctg ttcctgtgga
     1021 tctggctgga gaggaagcca gtgccaggaa gcatgtgcac ctggtcattt tggggctgat
     1081 tgtcgcctcc agtgccagtg tcaaaatggt ggcacttgtg accggttcag cggctgcgtc
     1141 tgcccctctg ggtggcatgg agtccactgt gaaaagtcag accggatccc ccagatcctc
     1201 agtatggcca cagaggtgga gttcaacata gggacgatgc cccggatcaa ctgtgcagct
     1261 gccgggaatc ccttcccagt gcggggcagc atgaaacttc gcaagccaga tggcaccatg
     1321 cttttgtcta ccaaagtcat tgtggagcca gacaggacca cagcagagtt tgaagtgccc
     1381 agtttgactc ttggggacag tgggttctgg gaatgccgcg tatcgacttc tggtggccaa
     1441 gacagccggc gcttcaaggt caatgtcaaa gtacccccag tgcctttgac tgcacctcga
     1501 ctcctggcca agcagagccg tcagcttgtg gtctccccac tggtctcctt tagtggggat
     1561 ggacccatct cctctgtccg cctgcactac cggccccagg acagcacgat tgcctggtct
     1621 gccattgtgg tggatcccag tgagaatgtg acattaatga acctgaagcc aaagacagga
     1681 tacaatgtcc gagtgcagct gagccggcca ggggaaggag gagaaggagg ctggggacct
     1741 tctgccctta tgactactga ctgtcctgag cctttgctgc agccctggct agagagctgg
     1801 cacgtggagg gtcctgacag gctccgtgtg agctggtctc taccctcggt gccactgtcc
     1861 ggtgatggtt tcctgctgcg cctgtgggat ggggcccggg gacaggagag gcgggagaac
     1921 atctcattcc cccaggcccg cactgccctc ctgactggac tcacgccggg cacccactac
     1981 cagctggatg tgcgactgta tcactgtacc ctcctgggcc ctgcctcacc ccctgcgcat
     2041 gtgcacctgc cccccagcgg gcctccagct ccccgccacc tccatgccca ggccctctca
     2101 gactctgaga ttcaactcat gtggcagcat cccgaggctc cgtctgggcc tatatccaag
     2161 tacatcgtgg agattcaggt ggccgggggc tcaggagacc cacagtggat ggatgtagac
     2221 aggcccgagg agacaagcat cattgttcgt ggcctcaatg ctagcacacg atatcttttc
     2281 cgtgtgcggg ccagtgtgca gggtcttggc gactggagca atacagtaga agaggccact
     2341 ctgggcaatg ggctgcagag tgagggccca gtccgagaaa gccgggcagc tgaagaaggc
     2401 ctggatcagc agctggtcct ggctgtggta ggttccgtct ctgccacctg cctcaccatc
     2461 ctggctgccc ttttagcctt ggtgtgtatc cgaagaagct gcctacatcg gagacgcacc
     2521 ttcacttacc agtcaggatc gggtgaagag accatcctgc agttcagctc agggaccttg
     2581 accttgaccc ggcgaccgaa gccacagcct gagcccttga gttaccccgt gctggagtgg
     2641 gaggacatca cctttgagga cctcataggg gagggcaact ttggccaagt gatccgggcc
     2701 atgatcaaga aggacgggct caagatgaac gcagccatca agatgctaaa agagtatgcg
     2761 tctgaaaatg accatcgaga ctttgcaggt gaactagaag ttctgtgcaa actaggacac
     2821 caccccaata ttatcaacct cttgggggcc tgtgagaacc gaggctactt gtatattgct
     2881 atcgaatacg ccccctatgg aaacctactg gacttcctga gaaagagcag ggtcctggag
     2941 actgatccag cttttgctcg agagcatggg acggcctcca cactcagctc tcggcagctg
     3001 ctgcgctttg ccagtgatgc agccaacggc atgcagtacc ttagtgagaa gcagttcatt
     3061 cacagggacc tggctgcccg aaatgtgctg gtcggagaga acctggcctc caagattgca
     3121 gactttggcc tttctcgagg ggaggaggtg tatgtgaaga agacaatggg ccgtctccct
     3181 gtgcgttgga tggccattga gtccctcaac tacagcgtct ataccaccaa gagtgatgtc
     3241 tggtcctttg gggtcctcct ctgggagata gtgagccttg gaggcacgcc ctactgtggc
     3301 atgacctgtg ctgagctcta cgagaagctg cctcaaggct atcgcatgga gcagcctcga
     3361 aactgcgatg acgaagtgta cgagctgatg cggcagtgct ggcgggatcg gccctatgag
     3421 cgccccccct ttgctcagat cgcactacag ttgggccgca tgctggaagc caggaaggcc
     3481 tacgtgaaca tgtcgctgtt tgagaacttc acctatgcgg gcatcgatgc cacagctgag
     3541 gaggcctagg ctgcccccca ccagcccctg gctctgctgg ccggagcaaa ttgcttccac
     3601 ctgtgacttt ggacccttct cacctctgac ccaagctgtc tcaagaaagt ctttaattta
     3661 aaggaggaaa gaaaagatcc aggaaaaggg ggggaggggg gagggaaaca ggcatcccct
     3721 ttcttgccag ctgttcccat agctaccctt cctctctgcg gctccccaaa cccaaacccc
     3781 acttctgatc ctccacctaa agcagcatgc atgttactaa caccctgttt agcccccgac
     3841 tctctgctta tactcagaaa aataaatgct cggaacagca aaa
//
