LOCUS       NM_029835               7213 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus TOPBP1-interacting checkpoint and replication
            regulator (Ticrr), mRNA.
ACCESSION   NM_029835 XM_620515 XM_908178 XM_920750
VERSION     NM_029835.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7213)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7213)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7213)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 7213)
  AUTHORS   Pons,S., Martin,V., Portal,L., Zini,R., Morin,D., Berdeaux,A. and
            Ghaleh,B.
  TITLE     Regular treadmill exercise restores cardioprotective signaling
            pathways in obese mice independently from improvement in associated
            co-morbidities
  JOURNAL   J Mol Cell Cardiol 54, 82-89 (2013)
   PUBMED   23201226
REFERENCE   5  (bases 1 to 7213)
  AUTHORS   Sansam,C.L., Cruz,N.M., Danielian,P.S., Amsterdam,A., Lau,M.L.,
            Hopkins,N. and Lees,J.A.
  TITLE     A vertebrate gene, ticrr, is an essential checkpoint and
            replication regulator
  JOURNAL   Genes Dev 24 (2), 183-194 (2010)
   PUBMED   20080954
REFERENCE   6  (bases 1 to 7213)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7213)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY731867.1, AK041726.1, AK051639.1, CN537331.1, CF730550.1,
            AK033104.1, BC058634.1 and BC028450.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_620515.2, XM_920750.1, XM_908178.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               BY731867.1         1-601
            602-2688            AK041726.1         552-2638
            2689-3670           AK051639.1         2652-3633
            3671-4121           CN537331.1         209-659
            4122-4737           CF730550.1         119-734
            4738-5192           AK033104.1         284-738
            5193-7190           BC058634.1         405-2402
            7191-7213           BC028450.1         1397-1419
FEATURES             Location/Qualifiers
     source          1..7213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.09 cM"
     gene            1..7213
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /note="TOPBP1-interacting checkpoint and replication
                     regulator"
                     /db_xref="GeneID:77011"
                     /db_xref="MGI:MGI:1924261"
     exon            1..807
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1084
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1323
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1558
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1688
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1825
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2044
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2196
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2297
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2391
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2471
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2699
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2796
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2854
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3016
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3107
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3166
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3298
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3456
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..5578
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5704
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            5705..7199
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7169..7174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /note="hexamer: ATTAAA"
     polyA_site      7199
                     /gene="Ticrr"
                     /gene_synonym="5730590G19Rik; Lrrk1"
                     /note="major polyA site"
ORIGIN      
        1 aatagctgca gctgtcggag agcgcgggag ccttcggagc agggcctcag agaagcgggc
       61 aatggcgctg gttctctgaa gagagtgctt tacctcagga agggccacgc gcggccgggc
      121 agagggagtc ccgtggcggc cgagatggcc tgctgtcaca aagtgatgct gctggtggac
      181 acagcgggcg tctctgctcc tcatagcccg gcccgacgcg ccgccctccg gctcctcact
      241 tacctgagct gccgcttcgg ccttgccagg gtccactgga ccttcaagtt cttcgactct
      301 cagggggcac ggagccggcc ctcccgcgtg tccgacttcc gcgagctggg gagccgctcc
      361 tgggaggact tcgaggagga gctggaggcc aggctggggg atcgccctcc cggagctcac
      421 ctgccgggcc cgacgcccag agccacccac acgcacggtg ccctgatgga gacgctgctc
      481 gactaccagt gggaccggcc ggagatcacg tcgcccacca agccgatcct gcggagtagc
      541 ggcaggaggc tgctggacgc cgacggcgag gccagggagg cccaggccgc gctcgggggc
      601 tttgggaacg ccgtcttcct cctggcgccc tgtcctcact cgcagaggga gctgcttcag
      661 ttcgtgtccg ggtgcgaggc acaggctcaa cgcgtgccgc tcacccccaa gcaggtgatg
      721 gagaaggtgt tgcccaagag agtccaagag gttatgatcg cccgaaatat caccttgtac
      781 tgggtggaca ccaccgagcg atctaagttg tgggcttccc cagaccatgt tggatactgg
      841 acagtgtgtg agctgctaca ccatggagga ggtaccatct tgccagctga aacttggagc
      901 ctgggattta ctaaagccag ggaaacagtg ctgccatgtg gtggcgagct gtcacacaaa
      961 cctcacccct ccccgtggat ctcagctctg ccaatagatg ccactgtaaa ctgtttgctg
     1021 tataattctg agtatgaagc ctcatttcca cgaattgaag gaacattatt tctccctgtt
     1081 caaggcaaag aaattgaaga aacatgggca atctccctgg agcctttagc catgcatcag
     1141 agacattttc aaaagccagt cagaattgtc ctaagaggct cagtggcaca gtggtctctc
     1201 ccagtgagta gtgctttagg cactgacagt tggatgctac aaagtccaga ggaacacagg
     1261 tcaactcaaa ggctgttgtt tcaggagctg gtaagcaggc tgactgctga agaattccat
     1321 ctggttgcca gtgtggatcc tggtgaaggc tggcccccca taacgggaat tatttcccca
     1381 ttctctgcca atgccatgat tctcacagtg ttccgagcca aagaagctga atttcaaagc
     1441 cattttctcc aaacagctgc gactgaaggt tcccaggata cagcttccct tttctcagat
     1501 gttgtagata gtgtcctgaa tcagagtcat aatttatttg aagaccctgc gtcttctgcc
     1561 ccctgtgttc cagagtgggt ccagcaggag cttagtcata ccagctcctg gagtccagct
     1621 cttgtcgaaa agtggtttcc tttctccaac gccagtggtg ctacttcaga cttgatggaa
     1681 tcattttggt tgttacacgc tgcctcacct gataatgatg aatcctccaa aaccgaaagt
     1741 gaactaacac gctgcctctc tgagctctac cagagatctc acgaagaatc tactgtagtc
     1801 aatcaagaac gcagcagaaa gaaacgtggt atccctcgaa ctccagtgag acagaagatg
     1861 aataccatgt cccgctcctt gaagatgttg aatgtggcaa ggctaaatgt aaaggctcag
     1921 aaattacatc cagatggtag tccagacacg gctgtagaga aagggctcca gaaagctgtc
     1981 attggcagaa cagcagacaa attggaagat agaggaagga tattaagaag ttctaaactt
     2041 aaagaattta aaaccgagga ggagcttctg gcttacatac atgacaacta ccaaaaggct
     2101 gtggctacgg aagaaatcac attgtattca tgtgcacaaa atatggtctc aaccattaaa
     2161 atgttcctaa aatcaaagga catcaaggaa ttagaagtgg cctgcctgag tcatgtgaac
     2221 agtaacctct taaaaaccag caagaccctt agacagaacc tagccggaaa gatggataca
     2281 gaggacaaag tcggagagtg ccagcttcag gtatttcttc gtctggagat gtgtgagcag
     2341 tgcccctcag tcctggaccg cccagatgag gtggagcgca tagtggagga ggtgacagat
     2401 ttgctgcgtc tggtgtgtct cactaaggac tcagcgtacc tgtcagagtt tctggaggag
     2461 atcttgagat tgtatattgg ctccatcccc gggacaattg gacaactcta ccacagcctg
     2521 gggttaaaaa ttcctcagaa gctggctgga gtccttccta cagggttttt cagtgatgat
     2581 tctatgtctc aagagagcat gtcaccacct ccctcatcaa gtactcacag atcagtgtcg
     2641 gccattactg agtctgagca gctggaggag cttcggacca gatcagccaa gaagagaagg
     2701 aaaaatgcac taataagaca taaaagtatt gcagagattt cccagactct tcgacaaatt
     2761 gaagttccca aagtgtccaa gagagctaca agaaatgaga actcccactc tgcttccata
     2821 cagctgccag tcccgaggaa agacacaata caggaagtaa caaaagttcg aagaaacctc
     2881 ttcaaccagg aaatgctttc tccttcaaag agggggctaa agaaggggct gcctcgcagc
     2941 cattctgtat ctgctttgga atgtctccac cataaacagg acaagttcaa gaagaccaaa
     3001 agcagcacat ttcagggtta ttgcaaactg ctgactaaga gtgtggctga gaccccagtc
     3061 cacaagcaaa tctccaggag gctgctccat agacaaatca agggcaggtc ttctgatcct
     3121 ggtcctgata ttcatgtagt tgaagagtct cctgaaaaag aggatgaaat gactttgaga
     3181 agaagtcctc gaatcaagca gctgtcattt agcagaacga actctggctc cttctattct
     3241 gtatctcagc cgaaatctcg aagtgtgcaa agaatccact cgtcccagca ggagtcagaa
     3301 caaagagaaa attttccagt tcaaagtatt cagtctccta aaacacttct ttttggggca
     3361 ttgtctgaga ttcccagctc ctctaagaag ggttcagccc aaattaagag atccttaaga
     3421 agcatgttgg attctgagat atctacatct tacgagactc ccaaaaagag taaccagaaa
     3481 tctccaagct tttctaaaac tacaccaaga agattccctc gtacagcaca gaccttacta
     3541 tacactccag aaagactaca aaactcccct acagaaatga catcagctga agggaccatt
     3601 tctgaagcaa ccataaaaac cccctcctca cacggttaca actcaccatt tgcatcaaaa
     3661 gtcacttctc aaaagacagt ctccccagca aaagaagaga cctctcctcc cctcacaaag
     3721 ctacccagca cacccagaga gtctgatgtc cagccacctc aatgttcgtc agactgcaca
     3781 tggccacact cagtgaattc cagtccagaa ggtccttatt acccagcgtc cccacctcct
     3841 atggctggcc aggccaggag tcagtgtctg acccctataa gatactcctt cagaacccct
     3901 ccacgtacag cccttgctgg cacgtctaag cagcaggagc accaagagct ccctctcccc
     3961 agggcctctc agacacaaga acctccacag ggactggaga agaaagctct caaaatccca
     4021 aagaaaccag cacacacaag tacttcacct ctttctccag aggaacatta ttctggatgt
     4081 gatgtctccc cacatcaacc taggaactct ttgtcagcct cccctcctcc tggagaactg
     4141 aattggaaag aacaccagac atcacccagt gtaacttcat ctgtctcttg tcctgttcct
     4201 tcaactcctc ctagaacccc acagagaatg acctgcccca taccaccttc tccaccatcc
     4261 aagcttcgga gatcatgtag aaagaagtcc tgtcctcctc aggacttccc agagtgccat
     4321 cctggaccct ctgctgctcc cgtgcttagc tcagccacca gcccaggagc tgtcacaggc
     4381 tctagagagg agcagtctca gttttctgaa ggacagagtt acctaggcac tggtttcaga
     4441 agtgactgtc atgtgtcctc tcctgtgctc actgcaagtg acacaaagtg cttgccactg
     4501 attgatgaag cccaactcca tgggcttaaa aaccaagagg taaaaagtgg catcttgcca
     4561 ggggaagaag gtgaggaacc agagagcact attgccgacg agcttccctc tgtgtctgac
     4621 cctgggattc ttgtacctgc gccttcctct gtgtctagct cctctgagct gctgccctac
     4681 cccctgtgct gtacagcaga cggaaagcag aggcaagatg ctgctcagca ggggagtcca
     4741 cgagcttccg aggccaccag cagccctcag acctacgaag ttgagctgga gatgcaagct
     4801 tctggccttc ccaagctccg gattaaaaaa atagaccctg gagttctttt ggaagctgag
     4861 gccctaggaa aggaagcccc cctgggagag gagggtgccc tccctgctct ctgtatgccc
     4921 aaggccagca agtcctccgg gagaactgag cacccttact tgtcaccccc ttgtctccgc
     4981 ccctcacaca gcacacctgg caagaatgga ggtcaaacct tcatctgcca atcttgtact
     5041 ccctctcgct gtccccccag taccccctct ccatttcaag cagatgctgg ggtttcttgg
     5101 acaccatccc ctaagcaaag tgggaagacc actcctgaaa ttatcaaaga ctggccccgc
     5161 aggaagaggg cagtggattg cagtgctgga ccctctgctg ggagaggcga ggccagtatg
     5221 gaccttcctg ggtccttgtc actgcttgag cctgagcctg agggaaagga gcgaagcctt
     5281 gaacaagacc tctctaaggt tctcatctca gaggagtttg aactagaggg ggtgtgtcag
     5341 ttgccagacc agtcacctcc caaagacagt gcctctgtga cagaggaaac ctcctgggga
     5401 cagtttggat taggcagaaa gagattcctg tccgccaagg aagaatctga atacaaagtc
     5461 aaaagggtct gtgattccct gagtgaggat ccccaagcta gcaagcagaa agagtgctct
     5521 ccacgctgga gtgcactacc actccactca gtaggggacg acgaggtgtt tgtttctggc
     5581 tccaccccac cctctggttg catggttcga agctgtctct ctgccagtgg tctgcaggcc
     5641 ttgacccagt ctccactgct gttccaagga agaacgccct cctctcatag cacggacacc
     5701 agagatgagg aagtggatgt gttcccctct actgctgaag agtctccgtt cagccacacc
     5761 ctctcccgga aacggccttt cagaacctac acgagaaaga agcttattag ctagccctgc
     5821 ttgagcattg cgctggagga ctcaaaatga ggaacgctgt gagcctggct agaccccttg
     5881 cactcaggag atgtactcta gagcagcttt ctctgggtac agtaacaatg ccagactcat
     5941 gccagcaatc tagcattgtg cccagaacac gagtggccag gacttcatgg gactgagaaa
     6001 gttcacaagt aaagatgaca gcagcaaagt ccctgtggac ttaaagaaat tgaagattct
     6061 gcagggtatg gtagtaagcc tatagtccta gcacttggga gacggagaca gaagattctg
     6121 actacatagc atgtacaagg gcagcctggg ctacatgaga ccctgtctca aaaacaacaa
     6181 aagacattaa agaccttaag cctttttccc atggtcatct gaagattacc actggaatgc
     6241 ctcatggtct gaaaattcct ctctaggtct tcatatgagg ccaggccctg actctttagg
     6301 gggaaggttg gaagtctggt gggcagctag tactatatat aactcagaca gcccaaagat
     6361 cccattccag atcttggtaa ttcagaggac tactgccaca ctgtgaaatg gaaaaaaagg
     6421 aggtgtttac caagcctttt ctctgggtac agtaacaatg ccagagttct tttacacaat
     6481 tggtacttca taaagtaaga cccataagtg aaagacgtca gcaagaagca agctaacaat
     6541 aaagtcatcc tggcaactta gcatttggca tttctgcctg ggagtaactg gctatggtcc
     6601 agagcaatca tactgcaggg tctaccctga aaagcagcca ccgcatgaca gtcttagcca
     6661 ggtatgtgct tgacacctgt gttgccctat aatcaaccta accaacttgc tatggagtgt
     6721 tggcaggagc ctcatttgca gtgagggctg atttggaacc ttctcagtct ccccagaaga
     6781 ttcaaccctg ttgtggtccc agggctcttt ctgttgtcag atgccaggtg aaaactccca
     6841 tgtctccttt cagagaaaga aaaggcagcc ctggaatgct tgcatgggtt caattgccag
     6901 taacactgat gagtagagaa ggaagggttt caagctggct ctaactaagt tcatagttat
     6961 ttgtcctgag ttgggagcct gtgcacaggc agtaggaggg gagaggcagg actccaatat
     7021 gcccttcaag gatactctcc aataacctca ccaccaccac accccagctc tgataggctc
     7081 cactgcctct cagctgagga ccagccttca ggaattcttg ggggacatat ttaagatgta
     7141 agccataatg agattactcc tgtttattat taaatggtat tttttaaaaa ttctaaaaaa
     7201 aaaaaaaaaa aaa
//
