LOCUS       NM_173394               3264 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus TIR domain containing adaptor molecule 2 (Ticam2),
            mRNA.
ACCESSION   NM_173394
VERSION     NM_173394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3264)
  AUTHORS   Caldwell,B.A., Ie,S., Lucas,A. and Li,L.
  TITLE     Ticam2 ablation facilitates monocyte exhaustion recovery after
            sepsis
  JOURNAL   Sci Rep 15 (1), 2059 (2025)
   PUBMED   39814939
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3264)
  AUTHORS   Li,J., Jiang,L., Zhao,K., Tang,Y., Yuan,X. and Xu,Y.
  TITLE     MYELOID-DERIVED TLR4-TRIF SIGNALING PATHWAY MEDIATES OXIDATIVE
            STRESS IN LPS/D-GALN-INDUCED ACUTE LIVER FAILURE
  JOURNAL   Shock 62 (4), 582-587 (2024)
   PUBMED   39158930
  REMARK    GeneRIF: MYELOID-DERIVED TLR4-TRIF SIGNALING PATHWAY MEDIATES
            OXIDATIVE STRESS IN LPS/D-GALN-INDUCED ACUTE LIVER FAILURE.
REFERENCE   3  (bases 1 to 3264)
  AUTHORS   Geng,S., Zhang,Y., Lu,R., Irimia,D. and Li,L.
  TITLE     Resolving neutrophils through genetic deletion of TRAM attenuate
            atherosclerosis pathogenesis
  JOURNAL   iScience 27 (6), 110097 (2024)
   PUBMED   38883832
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3264)
  AUTHORS   Solon,M., Ge,N., Hambro,S., Haller,S., Jiang,J., Baca,M.,
            Preston,J., Maltzman,A., Wickliffe,K.E., Liang,Y., Reja,R.,
            Nickles,D., Newton,K. and Webster,J.D.
  TITLE     ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8
            and TNFR1
  JOURNAL   Cell Death Differ 31 (5), 672-682 (2024)
   PUBMED   38548850
  REMARK    GeneRIF: ZBP1 and TRIF trigger lethal necroptosis in mice lacking
            caspase-8 and TNFR1.
REFERENCE   5  (bases 1 to 3264)
  AUTHORS   Zhuang,Z., Chen,Y., Zheng,J. and Chen,S.
  TITLE     The role of TRIF protein in regulating the proliferation and
            antigen presentation ability of myeloid dendritic cells through the
            ERK1/2 signaling pathway in chronic low-grade inflammation of
            intestinal mucosa mediated by flagellin-TLR5 complex signal
  JOURNAL   PeerJ 12, e16716 (2024)
   PUBMED   38188180
  REMARK    GeneRIF: The role of TRIF protein in regulating the proliferation
            and antigen presentation ability of myeloid dendritic cells through
            the ERK1/2 signaling pathway in chronic low-grade inflammation of
            intestinal mucosa mediated by flagellin-TLR5 complex signal.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3264)
  AUTHORS   Meylan,E., Burns,K., Hofmann,K., Blancheteau,V., Martinon,F.,
            Kelliher,M. and Tschopp,J.
  TITLE     RIP1 is an essential mediator of Toll-like receptor 3-induced
            NF-kappa B activation
  JOURNAL   Nat Immunol 5 (5), 503-507 (2004)
   PUBMED   15064760
REFERENCE   7  (bases 1 to 3264)
  AUTHORS   Oshiumi,H., Sasai,M., Shida,K., Fujita,T., Matsumoto,M. and Seya,T.
  TITLE     TIR-containing adapter molecule (TICAM)-2, a bridging adapter
            recruiting to toll-like receptor 4 TICAM-1 that induces
            interferon-beta
  JOURNAL   J Biol Chem 278 (50), 49751-49762 (2003)
   PUBMED   14519765
REFERENCE   8  (bases 1 to 3264)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Uematsu,S., Hoshino,K., Kaisho,T.,
            Takeuchi,O., Takeda,K. and Akira,S.
  TITLE     TRAM is specifically involved in the Toll-like receptor 4-mediated
            MyD88-independent signaling pathway
  JOURNAL   Nat Immunol 4 (11), 1144-1150 (2003)
   PUBMED   14556004
REFERENCE   9  (bases 1 to 3264)
  AUTHORS   Fitzgerald,K.A., Rowe,D.C., Barnes,B.J., Caffrey,D.R., Visintin,A.,
            Latz,E., Monks,B., Pitha,P.M. and Golenbock,D.T.
  TITLE     LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll
            adapters TRAM and TRIF
  JOURNAL   J Exp Med 198 (7), 1043-1055 (2003)
   PUBMED   14517278
  REMARK    GeneRIF: LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the
            toll adapters TRAM and TRIF.
            Erratum:[J Exp Med. 2003 Nov 3;198(9):following 1450]
REFERENCE   10 (bases 1 to 3264)
  AUTHORS   Bin,L.H., Xu,L.G. and Shu,H.B.
  TITLE     TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing
            adapter protein involved in TIR signaling
  JOURNAL   J Biol Chem 278 (27), 24526-24532 (2003)
   PUBMED   12721283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134103.1, BC099933.1 and AK080873.1.
            
            On Feb 5, 2010 this sequence version replaced NM_173394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY275837.1, BC099933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1298              AK134103.1         2-1299
            1299-2346           BC099933.1         1298-2345
            2347-3264           AK080873.1         2121-3038
FEATURES             Location/Qualifiers
     source          1..3264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.65 cM"
     gene            1..3264
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="TIR domain containing adaptor molecule 2"
                     /db_xref="GeneID:225471"
                     /db_xref="MGI:MGI:3040056"
     exon            1..319
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            320..422
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            423..3264
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1175
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="TRIF-related adapter molecule TRAM; TRIF-related
                     adaptor molecule; Toll-interleukin I receptor domain
                     (TIR)-containing adaptor molecule (TICAM) 2; TIR
                     domain-containing adapter protein; toll/interleukin-1
                     receptor domain-containing protein; toll-like receptor
                     adaptor molecule 2"
                     /codon_start=1
                     /product="TIR domain-containing adapter molecule 2"
                     /protein_id="NP_775570.1"
                     /db_xref="CCDS:CCDS29232.1"
                     /db_xref="GeneID:225471"
                     /db_xref="MGI:MGI:3040056"
                     /translation="MGVGKSKLDKCPLSWHKKDSVDADQDGHESDSKNSEEACLRGFV
                     EQSSGSEPPTGEQDQPEAKGAGPEEQDEEEFLKFVILHAEDDTDEALRVQDLLQNDFG
                     IRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVSR
                     QHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVFERQQSI
                     WKETRSVSQKQFIA"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="major polyA site"
     regulatory      3088..3093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="hexamer: AATAAA"
     polyA_site      3108
                     /gene="Ticam2"
                     /gene_synonym="B430113A10; TICAM-2; Tirp; TRAM; Trif"
                     /note="major polyA site"
ORIGIN      
        1 atctgcttcc tcctggggac agtgcatccc caccctgtag ttggtggccc agtctgccag
       61 agacccaggg ctccgcagag cacgcagagc acgacttcca aaggcaaaga ccattgcccg
      121 ggctccatgg ccagtcctgg acttccactc cgcgggctca gtgggcgtgg cgtgcagacc
      181 cacactggcc ttgggacaag atctacgaca gtcacatcct aactttcaga cttctgtggc
      241 aagctacttg tcaacaaggg tttgctcagt gcgagaggaa gatcgaagag cctcgtggtc
      301 aagcagtacc acttcccagc taactgaatt ctcctgtgct cccacccact ggaggctaag
      361 gcgtctcaat caccgaatgg taaggtgcca cagagcccag tgtcaaatga gttattttta
      421 atattgaaaa gaaaaatact caaataaagc tccctcgtct gccccaccac tctgtcatgg
      481 gtgttgggaa gtctaaacta gataagtgcc ccctttcttg gcataaaaaa gacagtgtgg
      541 atgccgatca agacggccat gagtcagact ccaagaattc tgaggaagcc tgcttgcgtg
      601 gttttgtgga gcagagcagt ggatcagagc caccaacagg agagcaggac caacctgagg
      661 caaagggggc ggggcctgag gagcaagatg aagaagagtt cctcaaattt gtgatacttc
      721 atgcagaaga tgacaccgac gaggccctca gagtccagga tctactgcaa aacgactttg
      781 gtatcaggcc ggggatcgtt ttcgccgaga tgccgtgcgg aagactgcat ttgcagaatc
      841 tagacgatgc ggtcaatggg tcggcctgga ccatcttgtt actgactgag aacttcctaa
      901 gagacacctg gtgtaacttc cagttctaca cttccctgat gaattctgtg agcaggcagc
      961 acaagtacaa ctccgtcata cccatgcggc ccctgaacag ccctcttccc cgggaacgga
     1021 ctcccttggc gctgcaaacc atcaatgcct tagaggaaga aagtcaaggc ttttccacac
     1081 aagtggagag aattttccgg gagtctgtat ttgagaggca acaaagtata tggaaagaga
     1141 cacgaagtgt gtcgcagaaa cagttcattg cctgaaaccg agcacacacc gggccggctc
     1201 ctgttttgta aacaaaatga tccatcttca cttgagagag tagtttctaa gaaatgctta
     1261 gacgtgagtc tgcttccaag aaatctgtgg cacacaagaa aggtacactt ctgcagccct
     1321 aggattgggc tactttcgaa tgacaaactc aagactgtca gagcttctga cacttttctt
     1381 aaagttttca tagttcatga atattcttaa ctcatttctt gtgttgagcc ataaacaggc
     1441 acatgtggca aaatacgata ttgaaaattc tcaaaagact tgagggaaat ggctctggcc
     1501 aggacaggtc tgaccacttc ccttcctgct tctttcatga attttagtta ccacaaagca
     1561 tcctggtgct gtcacacaga aacatgcaga atggggcacg tgcagtactg acatagtaag
     1621 ttggagatca gaagtagagg tcagggtcag ggtcaccgtt agtcccagca ctagggaggc
     1681 agaggcagga agatctctct gagttcatag gccagcctgg cttacagagt gagttccagc
     1741 atatccaggg ctacacaaag aaactgtctc ggggggaaaa aatgtcagaa cagtcaggct
     1801 tttggaaata atccagccat gtgtggtttt atttctgctg gaatttggaa ctagttccta
     1861 ccacaaatta gcaatccttt cgagagtgtg atagtgaggg actctgtaga gatgggccct
     1921 catcttgtag gtgtcttctg tgaccagggc tttaattcac agagcttgtg aaaaatatgt
     1981 gactcgccag ctgtttgcct ttaaaatcaa taacctctcg tgttagcttt tagaaatgtc
     2041 ccttacacac agtgtttaac tcggggaata tttcttatct agggctatgg gggtggaggg
     2101 gggagcgcgc aagcaaaacc agggacctac acagacctgt acctttccgc tcatagaact
     2161 tcgacccatt tgagactgaa gcggtttaaa caagcacaga cagggcttgt ggctagggga
     2221 aagtgcctgc tgggaatcag aagaccgact tgcagtccaa gctctgcccc tgcggatgaa
     2281 tgtgccagtg ggcagctatt ctcctttgtc tgcgaaataa aagggttgga ttgatgggtc
     2341 tctaaaggct tttgtcctct ctctcccagg atgggaaaaa ccgaagccag aaagcaataa
     2401 gcaaagcctg aaacttttat gaggtgaaac ataattgtaa tcattgcaga aggcatgacg
     2461 catgcttaca acaaacagat agatatttct gtatatttgc atcatcatcg atatttactg
     2521 cagtcacagg aaagaattac tatgtatgcc tatacttggt tctttgggtt tggctttgta
     2581 cagggtctca ttatctagcc ctggctggcc tgaaatttgc tatgtagacg agattggctt
     2641 caaactcatg gagatccacc tgcctctgac cctgacagtg ctaagattaa agatgggcac
     2701 tgccacaccc tgctactcgg gtttttaaaa gatacatatt tttataggaa ttcatgaata
     2761 ccttctccct agtttgcctg tctcctaatc ctcccttctc taaatcccca ggggccactg
     2821 tttacttctt tatagttgca agctactgtg ccccacagtc agacctggtg ttgggttctc
     2881 agagaaggtg actgctttca tagcattttc tcaatcctct ttgtcatggt aacttactac
     2941 ttagccttga gtttattgtt attattatta attattatta ctaccataat cctctctatg
     3001 tctcaagtgt caggtactca taaaacatga accacccacc cttcacacgc ctgccaagct
     3061 agaactgatg ctcaatggca cttcttcaat aaaccttttt attctttatg gttgactatt
     3121 ggtctcatct ccagtgaaga ctgtggaaaa gtattctgag aaataccatc ctgggcttgt
     3181 cagagaacat ggtgtaatgt cccaggcaac ctggagttca gcaatttttt tttatgatga
     3241 agaaataaat tttaagtgca gagt
//
