LOCUS       NM_174989               2830 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TIR domain containing adaptor molecule 1 (Ticam1),
            mRNA.
ACCESSION   NM_174989
VERSION     NM_174989.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Ashby,K.M., Voboril,M., Salgado,O.C., Lee,S.T., Martinez,R.J.,
            O'Connor,C.H., Breed,E.R., Xuan,S., Roll,C.R., Bachigari,S.,
            Heiland,H., Stetson,D.B., Kotenko,S.V. and Hogquist,K.A.
  TITLE     Sterile production of interferons in the thymus affects T cell
            repertoire selection
  JOURNAL   Sci Immunol 9 (97), eadp1139 (2024)
   PUBMED   39058762
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Yow,S.J., Rosli,S.N., Hutchinson,P.E. and Chen,K.W.
  TITLE     Differential signalling requirements for RIPK1-dependent pyroptosis
            in neutrophils and macrophages
  JOURNAL   Cell Death Dis 15 (7), 479 (2024)
   PUBMED   38965211
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Hoebe,K., Du,X., Georgel,P., Janssen,E., Tabeta,K., Kim,S.O.,
            Goode,J., Lin,P., Mann,N., Mudd,S., Crozat,K., Sovath,S., Han,J.
            and Beutler,B.
  TITLE     Identification of Lps2 as a key transducer of MyD88-independent TIR
            signalling
  JOURNAL   Nature 424 (6950), 743-748 (2003)
   PUBMED   12872135
  REMARK    GeneRIF: Lps2 mutation is a distal frameshift error in Trif or
            Ticam-1; Trif(Lps2) homozygotes are markedly resistant to the toxic
            effects of LPS, and are hypersusceptible to mouse cytomegalovirus,
            failing to produce type I interferons when infected
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Hoshino,K., Kaisho,T., Sanjo,H.,
            Takeuchi,O., Sugiyama,M., Okabe,M., Takeda,K. and Akira,S.
  TITLE     Role of adaptor TRIF in the MyD88-independent toll-like receptor
            signaling pathway
  JOURNAL   Science 301 (5633), 640-643 (2003)
   PUBMED   12855817
  REMARK    GeneRIF: findings demonstrate that TRIF is essential for TLR3- and
            TLR4-mediated signaling pathways facilitating mammalian antiviral
            host defense
REFERENCE   8  (bases 1 to 2830)
  AUTHORS   Oshiumi,H., Matsumoto,M., Funami,K., Akazawa,T. and Seya,T.
  TITLE     TICAM-1, an adaptor molecule that participates in Toll-like
            receptor 3-mediated interferon-beta induction
  JOURNAL   Nat Immunol 4 (2), 161-167 (2003)
   PUBMED   12539043
  REMARK    GeneRIF: identified an alternative adaptor, designated
            Toll-interleukin 1 receptor domain (TIR)-containing adaptor
            molecule (TICAM)-1, that can physically bind the TIR domain of TLR3
REFERENCE   9  (bases 1 to 2830)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
REFERENCE   10 (bases 1 to 2830)
  AUTHORS   Yamamoto,M., Sato,S., Mori,K., Hoshino,K., Takeuchi,O., Takeda,K.
            and Akira,S.
  TITLE     Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter
            that preferentially activates the IFN-beta promoter in the
            Toll-like receptor signaling
  JOURNAL   J Immunol 169 (12), 6668-6672 (2002)
   PUBMED   12471095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026385.19.
            
            On Aug 21, 2018 this sequence version replaced NM_174989.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037048.2, AK054219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC026385.19        155929-156002       c
            75-2830             AC026385.19        148697-151452       c
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.24 cM"
     gene            1..2830
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /note="TIR domain containing adaptor molecule 1"
                     /db_xref="GeneID:106759"
                     /db_xref="MGI:MGI:2147032"
     exon            1..74
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /inference="alignment:Splign:2.1.0"
     exon            75..2830
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2397
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /note="TIR domain-containing adaptor inducing
                     interferon-beta; toll-like receptor adaptor molecule 1;
                     TIR domain-containing adapter protein inducing IFN-beta;
                     toll-interleukin-1 receptor domain-containing adapter
                     protein inducing interferon beta"
                     /codon_start=1
                     /product="TIR domain-containing adapter molecule 1"
                     /protein_id="NP_778154.1"
                     /db_xref="CCDS:CCDS28900.1"
                     /db_xref="GeneID:106759"
                     /db_xref="MGI:MGI:2147032"
                     /translation="MDNPGPSLRGAFGILGALERDRLTHLKHKLGSLCSGSQESKLLH
                     AMVLLALGQDTEARVSLESLKMNTVAQLVAHQWADMETTEGPEEPPDLSWTVARLYHL
                     LAEENLCPASTRDMAYQVALRDFASQGDHQLGQLQNEAWDRCSSDIKGDPSGFQPLHS
                     HQGSLQPPSASPAVTRSQPRPIDTPDWSWGHTLHSTNSTASLASHLEISQSPTLAFLS
                     SHHGTHGPSKLCNTPLDTQEPQLVPEGCQEPEEISWPPSVETSVSLGLPHEISVPEVS
                     PEEASPILPDALAAPDTSVHCPIECTELSTNSRSPLTSTTESVGKQWPITSQRSPQVP
                     VGDDSLQNTTSSSPPAQPPSLQASPKLPPSPLSSASSPSSYPAPPTSTSPVLDHSETS
                     DQKFYNFVVIHARADEQVALRIREKLETLGVPDGATFCEEFQVPGRGELHCLQDAIDH
                     SGFTILLLTASFDCSLSLHQINHALMNSLTQSGRQDCVIPLLPLECSQAQLSPDTTRL
                     LHSIVWLDEHSPIFARKVANTFKTQKLQAQRVRWKKAQEARTLKEQSIQLEAERQNVA
                     AISAAYTAYVHSYRAWQAEMNKLGVAFGKNLSLGTPTPSWPGCPQPIPSHPQGGTPVF
                     PYSPQPPSFPQPPCFPQPPSFPQPPSFPLPPVSSPQSQSFPSASSPAPQTPGPQPLII
                     HHAQMVQLGVNNHMWGHTGAQSSDDKTECSENPCMGPLTDQGEPLLETPE"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /note="hexamer: AATAAA"
     polyA_site      2830
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /note="major polyA site"
ORIGIN      
        1 tcccttctct ctcctcctcc tccagcagcc accagggacc gggagatcta ccagctcaag
       61 acccctacag ccaggtctgt gctgccgccc tccagcatct ttgcagcagg ggacgaggct
      121 gtgtgggagg ctgtcggttc ggaacatgtc tccacccacc ccaccctctg tggctccagg
      181 cttcattctc ccccatccat ggataaccca gggccttcgc tccgtggtgc ctttggcatt
      241 ctaggtgcct tggaaaggga caggctgacc cacctgaaac acaagctggg gagtctgtgt
      301 tcaggcagcc aggagtcaaa gcttctccat gccatggtac tcctggctct gggccaggac
      361 acggaggcca gggtctctct ggagtccttg aagatgaaca cagtagccca gctggtagcc
      421 caccagtggg cagacatgga gaccacagag ggccctgagg agcctccaga cttgtcctgg
      481 acggtggctc gcctgtacca cctgctggct gaggagaacc tgtgtccggc ctccacaagg
      541 gacatggctt accaggtggc ccttcgtgac tttgcctccc agggtgacca ccagctgggc
      601 caactccaga atgaggcctg ggatcggtgc agttcagata tcaaggggga ccccagtggt
      661 ttccagccac tccattctca tcagggttcc ctgcagccac cttcagcatc ccctgcagtg
      721 accagaagcc agcctcgtcc cattgacaca ccagactgga gttggggaca tacgttacac
      781 tccaccaaca gcactgcctc actggccagc cacctagaga tcagccagtc acccactctt
      841 gcctttctct cttcacacca tggaacccat gggcccagca agctatgtaa cacaccgctg
      901 gacactcagg agcctcagct tgtccctgaa ggctgccaag aacctgagga gataagctgg
      961 cctccatcag tggagaccag tgtctcctta gggttaccac acgaaattag cgttccagag
     1021 gtgtctccag aggaggcttc gcccatcctc cctgacgccc tggctgctcc agacacaagt
     1081 gtccactgtc ccattgaatg cacagagttg tctacaaact ccaggtctcc cctgacgtcc
     1141 accacagaaa gtgttggaaa gcagtggcct attacaagtc agaggtcacc tcaggttcct
     1201 gtaggagatg attctctgca gaacaccacg tcatccagcc ctcctgccca gccaccatcc
     1261 ctccaagcct cccctaagct gcctccttcc cctctgtcct ctgcttcctc cccgagcagc
     1321 taccctgctc ctccaacctc cacatcccct gttttggacc actcagaaac atctgatcag
     1381 aaattctata actttgtggt tatccatgcc agggctgatg aacaggtggc cctacgtatt
     1441 cgggagaagc tggagaccct cggggtacct gacggggcca ccttctgtga ggaatttcag
     1501 gtgcccgggc gtggtgagct gcactgtctc caagatgcca tcgatcactc ggggttcacg
     1561 atcctgctcc tgactgctag ctttgattgc agcctgagcc tgcatcaaat caaccatgct
     1621 ctcatgaaca gccttacaca gtctgggagg caggactgtg tgatccccct cctcccactt
     1681 gagtgttctc aggcccagct cagcccagat acaaccagac tgctccacag cattgtgtgg
     1741 ctggatgaac actccccaat cttcgccaga aaggtggcaa acaccttcaa gacacagaag
     1801 ctccaggcac agcgggtacg ctggaagaaa gcgcaggagg ccagaaccct caaggagcag
     1861 agcatacagc tggaggcaga gcggcaaaac gtggcagcca tatctgctgc ctacacagcc
     1921 tatgtccata gctatagggc ctggcaagca gagatgaaca aacttggggt ggcttttggg
     1981 aagaacttgt cactggggac tccaacaccc agctggcccg gatgtccaca gccaatacct
     2041 tctcatcctc agggtggtac tccagttttc ccctattccc cacagcctcc atccttccct
     2101 cagcctccat gcttccctca gcctccatcc ttccctcagc ctccatcctt cccactgcct
     2161 ccagtctctt ccccacagtc ccaatccttt ccatcagcct cctccccagc cccacagact
     2221 ccaggacctc agcctctcat tattcaccat gcccagatgg ttcagctggg tgtcaacaat
     2281 cacatgtggg gccacacagg ggcccagtca tctgatgaca agactgagtg ttcggagaac
     2341 ccctgtatgg gccctctgac tgatcagggc gaaccccttc ttgagactcc agagtgacca
     2401 ggttggaccc cacctagatg gctagagtga caagattgga cttcacctgg gtccttaaaa
     2461 tgatagtgga ggaagggaac ctcgcctggg tccccagagt agccagagga cttagcttgg
     2521 gctcccacag tggctattag ttggacccag cttgagaccc cagaggcagg gaagaccaca
     2581 cctataaatc aggcctggga aacatgcaga aaccccattt gaacagactg tgggactcca
     2641 atctgaatcc tctatgtgga cagaggatga tggggccaga ggcacctctg aggtgccctc
     2701 agcgcagcct cgtaaacttc attcactgtg acacatgctg ttcatagggt ctctctgggg
     2761 aggatgcggt cccggggcac atagggaggg tcctgttttt ataataaagt tattgacaac
     2821 tgagtcataa
//
