LOCUS       NP_778154                732 aa            linear   ROD 03-JUN-2025
DEFINITION  TIR domain-containing adapter molecule 1 [Mus musculus].
ACCESSION   NP_778154
VERSION     NP_778154.1
DBSOURCE    REFSEQ: accession NM_174989.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 732)
  AUTHORS   Yeap,H.W., Goh,G.R., Rosli,S.N., Pung,H.S., Giogha,C., Eng,V.V.,
            Pearson,J.S., Hartland,E.L. and Chen,K.W.
  TITLE     A bacterial network of T3SS effectors counteracts host
            pro-inflammatory responses and cell death to promote infection
  JOURNAL   EMBO J 44 (9), 2424-2445 (2025)
   PUBMED   40128366
REFERENCE   2  (residues 1 to 732)
  AUTHORS   Chan,F.H.M., Yeap,H.W., Liu,Z., Rosli,S.N., Low,K.E., Bonne,I.,
            Wu,Y., Chong,S.Z. and Chen,K.W.
  TITLE     Plasticity of cell death pathways ensures GSDMD activation during
            Yersinia pseudotuberculosis infection
  JOURNAL   Cell Rep 44 (1), 115216 (2025)
   PUBMED   39823227
REFERENCE   3  (residues 1 to 732)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 732)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 732)
  AUTHORS   Magri,Z., Jetton,D., Muendlein,H.I., Connolly,W.M., Russell,H.,
            Smirnova,I., Sharma,S., Bunnell,S. and Poltorak,A.
  TITLE     CD14 is a decision-maker between Fas-mediated death and
            inflammation
  JOURNAL   Cell Rep 43 (9), 114685 (2024)
   PUBMED   39213151
REFERENCE   6  (residues 1 to 732)
  AUTHORS   Hoebe,K., Du,X., Georgel,P., Janssen,E., Tabeta,K., Kim,S.O.,
            Goode,J., Lin,P., Mann,N., Mudd,S., Crozat,K., Sovath,S., Han,J.
            and Beutler,B.
  TITLE     Identification of Lps2 as a key transducer of MyD88-independent TIR
            signalling
  JOURNAL   Nature 424 (6950), 743-748 (2003)
   PUBMED   12872135
  REMARK    GeneRIF: Lps2 mutation is a distal frameshift error in Trif or
            Ticam-1; Trif(Lps2) homozygotes are markedly resistant to the toxic
            effects of LPS, and are hypersusceptible to mouse cytomegalovirus,
            failing to produce type I interferons when infected
REFERENCE   7  (residues 1 to 732)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Hoshino,K., Kaisho,T., Sanjo,H.,
            Takeuchi,O., Sugiyama,M., Okabe,M., Takeda,K. and Akira,S.
  TITLE     Role of adaptor TRIF in the MyD88-independent toll-like receptor
            signaling pathway
  JOURNAL   Science 301 (5633), 640-643 (2003)
   PUBMED   12855817
  REMARK    GeneRIF: findings demonstrate that TRIF is essential for TLR3- and
            TLR4-mediated signaling pathways facilitating mammalian antiviral
            host defense
REFERENCE   8  (residues 1 to 732)
  AUTHORS   Oshiumi,H., Matsumoto,M., Funami,K., Akazawa,T. and Seya,T.
  TITLE     TICAM-1, an adaptor molecule that participates in Toll-like
            receptor 3-mediated interferon-beta induction
  JOURNAL   Nat Immunol 4 (2), 161-167 (2003)
   PUBMED   12539043
  REMARK    GeneRIF: identified an alternative adaptor, designated
            Toll-interleukin 1 receptor domain (TIR)-containing adaptor
            molecule (TICAM)-1, that can physically bind the TIR domain of TLR3
REFERENCE   9  (residues 1 to 732)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
REFERENCE   10 (residues 1 to 732)
  AUTHORS   Yamamoto,M., Sato,S., Mori,K., Hoshino,K., Takeuchi,O., Takeda,K.
            and Akira,S.
  TITLE     Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter
            that preferentially activates the IFN-beta promoter in the
            Toll-like receptor signaling
  JOURNAL   J Immunol 169 (12), 6668-6672 (2002)
   PUBMED   12471095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026385.19.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037048.2, AK054219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.24 cM"
     Protein         1..732
                     /product="TIR domain-containing adapter molecule 1"
                     /note="TIR domain-containing adaptor inducing
                     interferon-beta; toll-like receptor adaptor molecule 1;
                     TIR domain-containing adapter protein inducing IFN-beta;
                     toll-interleukin-1 receptor domain-containing adapter
                     protein inducing interferon beta"
                     /calculated_mol_wt=79099
     Region          1..153
                     /region_name="TRIF-NTD.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          1..148
                     /region_name="TRIF-NTD"
                     /note="TRIF N-terminal domain; pfam17798"
                     /db_xref="CDD:436052"
     Region          84..91
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          144..191
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          206..209
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6; propagated from
                     UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          247..254
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          296..306
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          305..389
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          399..516
                     /region_name="TIR_2"
                     /note="TIR domain; pfam13676"
                     /db_xref="CDD:463954"
     Region          514..713
                     /region_name="Sufficient to induce apoptosis.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          603..679
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          678..697
                     /region_name="RHIM"
                     /note="RIP homotypic interaction motif; pfam12721"
                     /db_xref="CDD:463679"
     Region          696..732
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     CDS             1..732
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /coded_by="NM_174989.5:199..2397"
                     /db_xref="CCDS:CCDS28900.1"
                     /db_xref="GeneID:106759"
                     /db_xref="MGI:MGI:2147032"
ORIGIN      
        1 mdnpgpslrg afgilgaler drlthlkhkl gslcsgsqes kllhamvlla lgqdtearvs
       61 leslkmntva qlvahqwadm ettegpeepp dlswtvarly hllaeenlcp astrdmayqv
      121 alrdfasqgd hqlgqlqnea wdrcssdikg dpsgfqplhs hqgslqppsa spavtrsqpr
      181 pidtpdwswg htlhstnsta slashleisq sptlaflssh hgthgpsklc ntpldtqepq
      241 lvpegcqepe eiswppsvet svslglphei svpevspeea spilpdalaa pdtsvhcpie
      301 ctelstnsrs pltsttesvg kqwpitsqrs pqvpvgddsl qnttsssppa qppslqaspk
      361 lppsplssas spssypappt stspvldhse tsdqkfynfv viharadeqv alrireklet
      421 lgvpdgatfc eefqvpgrge lhclqdaidh sgftilllta sfdcslslhq inhalmnslt
      481 qsgrqdcvip llplecsqaq lspdttrllh sivwldehsp ifarkvantf ktqklqaqrv
      541 rwkkaqeart lkeqsiqlea erqnvaaisa aytayvhsyr awqaemnklg vafgknlslg
      601 tptpswpgcp qpipshpqgg tpvfpyspqp psfpqppcfp qppsfpqpps fplppvsspq
      661 sqsfpsassp apqtpgpqpl iihhaqmvql gvnnhmwght gaqssddkte csenpcmgpl
      721 tdqgepllet pe
//
