LOCUS       NM_009383               4292 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Tia1 cytotoxic granule-associated RNA binding
            protein-like 1 (Tial1), transcript variant 1, mRNA.
ACCESSION   NM_009383
VERSION     NM_009383.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4292)
  AUTHORS   Osma-Garcia,I.C., Mouysset,M., Capitan-Sobrino,D., Aubert,Y.,
            Turner,M. and Diaz-Munoz,M.D.
  TITLE     The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis
  JOURNAL   Cell Mol Immunol 20 (9), 1063-1076 (2023)
   PUBMED   37474714
  REMARK    GeneRIF: The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis.
REFERENCE   3  (bases 1 to 4292)
  AUTHORS   Vatandaslar,H., Garzia,A., Meyer,C., Godbersen,S., Brandt,L.T.L.,
            Griesbach,E., Chao,J.A., Tuschl,T. and Stoffel,M.
  TITLE     In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets
            regulating cholesterol synthesis and secretion
  JOURNAL   Nat Commun 14 (1), 3386 (2023)
   PUBMED   37296170
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4292)
  AUTHORS   Osma-Garcia,I.C., Capitan-Sobrino,D., Mouysset,M., Aubert,Y.,
            Maloudi,O., Turner,M. and Diaz-Munoz,M.D.
  TITLE     The splicing regulators TIA1 and TIAL1 are required for the
            expression of the DNA damage repair machinery during B cell
            lymphopoiesis
  JOURNAL   Cell Rep 41 (12), 111869 (2022)
   PUBMED   36543128
REFERENCE   5  (bases 1 to 4292)
  AUTHORS   Kato,Y., Iwamori,T., Ninomiya,Y., Kohda,T., Miyashita,J., Sato,M.
            and Saga,Y.
  TITLE     ELAVL2-directed RNA regulatory network drives the formation of
            quiescent primordial follicles
  JOURNAL   EMBO Rep 20 (12), e48251 (2019)
   PUBMED   31657143
REFERENCE   6  (bases 1 to 4292)
  AUTHORS   Marker,P.C., Dahiya,R. and Cunha,G.R.
  TITLE     Spontaneous mutation in mice provides new insight into the genetic
            mechanisms that pattern the seminal vesicles and prostate gland
  JOURNAL   Dev Dyn 226 (4), 643-653 (2003)
   PUBMED   12666202
REFERENCE   7  (bases 1 to 4292)
  AUTHORS   Kimball,S.R., Horetsky,R.L., Ron,D., Jefferson,L.S. and
            Harding,H.P.
  TITLE     Mammalian stress granules represent sites of accumulation of
            stalled translation initiation complexes
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C273-C284 (2003)
   PUBMED   12388085
REFERENCE   8  (bases 1 to 4292)
  AUTHORS   Piecyk,M., Wax,S., Beck,A.R., Kedersha,N., Gupta,M., Maritim,B.,
            Chen,S., Gueydan,C., Kruys,V., Streuli,M. and Anderson,P.
  TITLE     TIA-1 is a translational silencer that selectively regulates the
            expression of TNF-alpha
  JOURNAL   EMBO J 19 (15), 4154-4163 (2000)
   PUBMED   10921895
REFERENCE   9  (bases 1 to 4292)
  AUTHORS   Beck,A.R., Miller,I.J., Anderson,P. and Streuli,M.
  TITLE     RNA-binding protein TIAR is essential for primordial germ cell
            development
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2331-2336 (1998)
   PUBMED   9482885
REFERENCE   10 (bases 1 to 4292)
  AUTHORS   Beck,A.R., Medley,Q.G., O'Brien,S., Anderson,P. and Streuli,M.
  TITLE     Structure, tissue distribution and genomic organization of the
            murine RRM-type RNA binding proteins TIA-1 and TIAR
  JOURNAL   Nucleic Acids Res 24 (19), 3829-3835 (1996)
   PUBMED   8871565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130474.12 and AK012085.1.
            
            On Sep 16, 2006 this sequence version replaced NM_009383.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U55861.1, AK012085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AC130474.12        97144-97500
            358-1787            AK012085.1         2-1431
            1788-4292           AC130474.12        116376-118880
FEATURES             Location/Qualifiers
     source          1..4292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.2 cM"
     gene            1..4292
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="Tia1 cytotoxic granule-associated RNA binding
                     protein-like 1"
                     /db_xref="GeneID:21843"
                     /db_xref="MGI:MGI:107913"
     exon            1..389
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1536
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="isoform 1 is encoded by transcript variant 1; Tial1
                     cytotoxic granule-associated RNA binding protein-like 1;
                     nucleolysin TIAR; TIA-1-related protein"
                     /codon_start=1
                     /product="nucleolysin TIAR isoform 1"
                     /protein_id="NP_033409.1"
                     /db_xref="CCDS:CCDS21897.1"
                     /db_xref="GeneID:21843"
                     /db_xref="MGI:MGI:107913"
                     /translation="MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQ
                     PDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATT
                     PSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFV
                     SFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSS
                     PKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVS
                     VNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVP
                     PYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASFPTQ
                     "
     exon            390..486
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            487..636
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            692..779
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            780..855
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            856..964
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1060
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1145
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1269
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1409
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..4292
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="hexamer: ATTAAA"
     polyA_site      2277
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="major polyA site"
ORIGIN      
        1 tgtccagtcg cagggtgtac tctttggccg ggctttctgt ctctttagct acttttgccg
       61 gacaggccgt cgcagctggc ctgagcagtg acctggcggg ccgcgcctgc gccctgccgc
      121 gtttcctgcc tggctggtgg tggcggccat tttgttcatc ctcctcctcc tcctgctcct
      181 cctggttgga gcgcagtgtc cggagcgggc tggggggagc ggacccgaga gcggggttca
      241 gtaccttttc ctctgtcccc agccggcgcc cggagccccc ctccccttcc ttcccgcccc
      301 ctcccctccc cagccctgcc ctcccccttg tcccgggatc actccgtcgc acccaccatg
      361 atggaagacg acggacagcc ccggactcta tacgtaggta acctctccag agatgtgaca
      421 gaagtcctta ttcttcagtt attcagtcag atcggaccct gtaaaagctg taaaatgata
      481 acagagcaac ccgatagcag aagggtcaac tcttctgttg gattttctgt tttgcagcat
      541 acaagcaatg acccatattg ctttgtggaa ttttatgaac acagagatgc agctgctgca
      601 ttagctgcta tgaatgggag aaaaattttg ggaaaggagg tcaaagtaaa ctgggcaaca
      661 acaccaagta gccagaaaaa agatacttcc aatcacttcc atgtgtttgt tggggatttg
      721 agtccagaaa ttacaacaga agatatcaaa tcagcatttg ccccctttgg taaaatatcg
      781 gatgcccggg tagttaaaga catggcaact ggaaagtcca aaggctatgg ttttgtatct
      841 ttttataaca aactggatgc agagaatgca attgtgcata tggggggtca gtggttggga
      901 ggtcgacaaa tcagaaccaa ttgggccaca cgtaaaccac ctgcccctaa aagtacacaa
      961 gaaactaaca ctaagcagtt gagatttgaa gatgtagtaa accagtcaag tccaaaaaac
     1021 tgtactgtgt actgtggagg aattgcttcg gggctgacag atcaacttat gagacaaaca
     1081 ttttcaccat ttggacaaat tatggaaata cgagtttttc cagagaaggg ctattcgttt
     1141 gtcagatttt ccactcacga gagtgcggcc cacgccattg tctctgtgaa cggcactaca
     1201 atcgaaggac atgtggtgaa atgctattgg ggtaaagaat ctcctgatat gactaaaaac
     1261 ttccaacagg ttgactacag tcagtggggc cagtggagcc aagtgtatgg aaacccacaa
     1321 cagtatggac agtatatggc aaatgggtgg caagtaccac cctatggagt atatgggcag
     1381 ccgtggaacc aacaaggatt tggagtagat caatcccctt ctgctgcttg gatgggtgga
     1441 tttggtgctc agcctcctca aggacaagcc cctccccctg taatacctcc tccaaaccaa
     1501 gctgggtatg gaatggcaag cttcccgaca cagtgagctg ggactcgaaa cacgattgta
     1561 attcaccaca ggctgcagtc tcctgtcaca ctctgaagac atgaaaagta aacatcggaa
     1621 aatgaaaata tttattttaa aaattgaaat gtttggaacc tttagcacag ctttgcttgg
     1681 tgaaggacac atgtcttcta gttctgcctt tttaagtttt tgttcatgat ggatatgaac
     1741 atgatttttc tttgtgtaca aaaaactaaa ataaagtcaa taaagacaat tctgactata
     1801 aattttgata taataggaga aatgggtaat acacttcgat ccttagacac tattccattt
     1861 ttatcttgct gttcagtatt ttaactcact gtgtttttaa aagagcaaaa aagggagtat
     1921 cgtgaaaaac tgagaatcac atcagttcgt cctgaatcct gatactcccc tcccgtccct
     1981 gaggcggacc acatagaagg cagcaggaga aagtgtgatt tcagaagaag tccatgatgt
     2041 gggagtcgct gtggaagaaa tatgttattc tcttatgtta aagaaaatga agccagactg
     2101 aaagcgtgca gcctgaataa ggaccagcat cgtagaaggt tcttgaacga ttgttggtgg
     2161 tccatattaa gacatatttt taaaacttta aaagtgttgg ttatcaaaaa tgtatattac
     2221 atttcatttg ggggaaaatt ccaagtatgg tgtttatatt aaagtcagac ggtcatactt
     2281 gtgcttttac atggagttta aatgataaac attgtaaata ttgaataact acagtgtttc
     2341 aaaagcatgc ttcaacatag aagtagcagc aatgtaatta ttcgaggtga caagtaacat
     2401 gctcgctgcc agtgcagtgc tcagtagcag tgttaacact gatgtctcca cgtcttcacg
     2461 gttggccatg taaaaggaga aggacacaaa tgactacaca gaagaagcct taatttaatt
     2521 tcatacaaat ctttgatgca ttagtatatt ctaaattgta agtagaagtt agatttgggc
     2581 ttttttcccc tttcttcctt tctttcattt ccttttgttt tgttttattt ggtacataaa
     2641 taccttgatt aaaacccagt gaagtgattt cagggttgct ataagttgta tagcacaagt
     2701 tttttttttg tttttttttg tttttttaag aaatcttggg atgtttttaa aaattagtct
     2761 attttgccca agaattttct taacaagatt gctaaaacat cttacttaga caacctgatg
     2821 tatcagttat aatctgataa ccaatttgag tcgtacacaa gttgtgactt tttatttcta
     2881 atttgttttt tctttgggag tgtgtgggtg acagatgtga ataggcctga gttgtatgtg
     2941 tgcagtttta actgaatctt taggaagatg cgggagttcc aggcatgctc ccctgacatc
     3001 tttcagtcta tgtggataca gtctgcctca tagttctata caatgggaat gtgaaataga
     3061 taaaatccta tgtgtttcaa ttgtgacaac taggaggtgc aaatgttttg atagtgtgtt
     3121 aaacctgttg gcctgtgtat gcacaagagc aaaaaaccct aacctaacct tcttgaggta
     3181 agatgggtaa gacacatgaa gccgttgaag tctaaagatt aagataatgt ggtttttttt
     3241 atattggtga ccacaaagat tctggagttt attccctcct tcacttagga acacagccaa
     3301 atgtattcag cataaaaatg tacagggtct gaagttcttt tttgagccaa aatctttatg
     3361 tactttagtt gggttttttt tttttttttt ttggttttta aacacaacta ccctgtgtta
     3421 acactcgtca gtgactaaat agacccctgg agttttttga tttgggtgtt ttgttttgtt
     3481 tttgtttttg tttttgtctt tttgtcatac ctttggggga tatttttgga aaagttattt
     3541 tatattttat aagaagaaaa caagctatat tttgcccttg agttaagatt ttcattaaat
     3601 tttgtgaaac tcgaacaacc taaaggcttt ttaagttgat aaattgataa aagcttacta
     3661 aattaaaatt tcagtttccc tttttttcct ctgccagtaa attaagtggc ttactgagat
     3721 aactaatggc taactctagc tgtagtcttt tctcttttat atcctatgag ttaataaaac
     3781 tatccagact agttacattg ccatagtaag catgtgactg acatcttttg tcttaatttg
     3841 gatgagaaaa aaaaattttt ttttggtaag tcagtcacag tcatttcaca gcaaatagtt
     3901 ttaagataga aaggacatgt gcaaatgaaa tgcaccattt taggaaatga gatgatcaag
     3961 ctaacacagg tccagactgt cttacaatgc agatttgagt ttgtgccctc cgtccacttt
     4021 aagcctaaga actgttgcct tttctttcct gtgttcgtca agaacagcag agagactctt
     4081 tggcatgcaa ggaaatgtct cttcatagtt tcttgagatt tatcttggtg tgtttctgcc
     4141 tgccatcgtc tgtgcttgaa tccttttcta ctagcatttc ctcggtgcca gtccgtctga
     4201 tctttatgtt tgccgccagt gagaggccaa ctaaagccaa agctgtaaac cacagttgaa
     4261 gtaagtcttt caataaagac tagtctatgt aa
//
