LOCUS       NM_001347640            4401 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Tia1 cytotoxic granule-associated RNA binding
            protein-like 1 (Tial1), transcript variant 2, mRNA.
ACCESSION   NM_001347640 XM_006507570
VERSION     NM_001347640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4401)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4401)
  AUTHORS   Osma-Garcia,I.C., Mouysset,M., Capitan-Sobrino,D., Aubert,Y.,
            Turner,M. and Diaz-Munoz,M.D.
  TITLE     The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis
  JOURNAL   Cell Mol Immunol 20 (9), 1063-1076 (2023)
   PUBMED   37474714
  REMARK    GeneRIF: The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis.
REFERENCE   3  (bases 1 to 4401)
  AUTHORS   Vatandaslar,H., Garzia,A., Meyer,C., Godbersen,S., Brandt,L.T.L.,
            Griesbach,E., Chao,J.A., Tuschl,T. and Stoffel,M.
  TITLE     In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets
            regulating cholesterol synthesis and secretion
  JOURNAL   Nat Commun 14 (1), 3386 (2023)
   PUBMED   37296170
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4401)
  AUTHORS   Osma-Garcia,I.C., Capitan-Sobrino,D., Mouysset,M., Aubert,Y.,
            Maloudi,O., Turner,M. and Diaz-Munoz,M.D.
  TITLE     The splicing regulators TIA1 and TIAL1 are required for the
            expression of the DNA damage repair machinery during B cell
            lymphopoiesis
  JOURNAL   Cell Rep 41 (12), 111869 (2022)
   PUBMED   36543128
REFERENCE   5  (bases 1 to 4401)
  AUTHORS   Kato,Y., Iwamori,T., Ninomiya,Y., Kohda,T., Miyashita,J., Sato,M.
            and Saga,Y.
  TITLE     ELAVL2-directed RNA regulatory network drives the formation of
            quiescent primordial follicles
  JOURNAL   EMBO Rep 20 (12), e48251 (2019)
   PUBMED   31657143
REFERENCE   6  (bases 1 to 4401)
  AUTHORS   Marker,P.C., Dahiya,R. and Cunha,G.R.
  TITLE     Spontaneous mutation in mice provides new insight into the genetic
            mechanisms that pattern the seminal vesicles and prostate gland
  JOURNAL   Dev Dyn 226 (4), 643-653 (2003)
   PUBMED   12666202
REFERENCE   7  (bases 1 to 4401)
  AUTHORS   Kimball,S.R., Horetsky,R.L., Ron,D., Jefferson,L.S. and
            Harding,H.P.
  TITLE     Mammalian stress granules represent sites of accumulation of
            stalled translation initiation complexes
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C273-C284 (2003)
   PUBMED   12388085
REFERENCE   8  (bases 1 to 4401)
  AUTHORS   Piecyk,M., Wax,S., Beck,A.R., Kedersha,N., Gupta,M., Maritim,B.,
            Chen,S., Gueydan,C., Kruys,V., Streuli,M. and Anderson,P.
  TITLE     TIA-1 is a translational silencer that selectively regulates the
            expression of TNF-alpha
  JOURNAL   EMBO J 19 (15), 4154-4163 (2000)
   PUBMED   10921895
REFERENCE   9  (bases 1 to 4401)
  AUTHORS   Beck,A.R., Miller,I.J., Anderson,P. and Streuli,M.
  TITLE     RNA-binding protein TIAR is essential for primordial germ cell
            development
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2331-2336 (1998)
   PUBMED   9482885
REFERENCE   10 (bases 1 to 4401)
  AUTHORS   Beck,A.R., Medley,Q.G., O'Brien,S., Anderson,P. and Streuli,M.
  TITLE     Structure, tissue distribution and genomic organization of the
            murine RRM-type RNA binding proteins TIA-1 and TIAR
  JOURNAL   Nucleic Acids Res 24 (19), 3829-3835 (1996)
   PUBMED   8871565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130474.12.
            
            On Dec 4, 2016 this sequence version replaced XM_006507570.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010496.1, ERR3363658.1458558.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               AC130474.12        96984-97532
            550-646             AC130474.12        103625-103721
            647-745             AC130474.12        109938-110036
            746-800             AC130474.12        110261-110315
            801-888             AC130474.12        110449-110536
            889-964             AC130474.12        112387-112462
            965-1073            AC130474.12        112898-113006
            1074-1169           AC130474.12        113750-113845
            1170-1254           AC130474.12        113960-114044
            1255-1378           AC130474.12        114253-114376
            1379-1518           AC130474.12        114711-114850
            1519-4401           AC130474.12        115998-118880
FEATURES             Location/Qualifiers
     source          1..4401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.2 cM"
     gene            1..4401
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="Tia1 cytotoxic granule-associated RNA binding
                     protein-like 1"
                     /db_xref="GeneID:21843"
                     /db_xref="MGI:MGI:107913"
     exon            1..549
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..1645
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="isoform 2 is encoded by transcript variant 2; Tial1
                     cytotoxic granule-associated RNA binding protein-like 1;
                     nucleolysin TIAR; TIA-1-related protein"
                     /codon_start=1
                     /product="nucleolysin TIAR isoform 2"
                     /protein_id="NP_001334569.1"
                     /db_xref="CCDS:CCDS85429.1"
                     /db_xref="GeneID:21843"
                     /db_xref="MGI:MGI:107913"
                     /translation="MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEH
                     TSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVG
                     DLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGG
                     QWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTD
                     QLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGK
                     ESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD
                     QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASFPTQ"
     exon            550..646
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            647..745
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            746..800
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            801..888
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            889..964
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1073
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1169
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1254
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1378
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1518
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..4401
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="hexamer: ATTAAA"
     polyA_site      2386
                     /gene="Tial1"
                     /gene_synonym="5330433G13Rik; mTIAR; TIAR"
                     /note="major polyA site"
ORIGIN      
        1 cagttcccag aaggccactg gagaagggct tcccccactt tcccgggacc gcaattcccg
       61 gagacttggt ttcgcggctt ttctctctgt gttgggtctc tcttggaccc ggataggtct
      121 tgactggcca gcaggcccac agcgacaacg tgctccgtcg tgtccagtcg cagggtgtac
      181 tctttggccg ggctttctgt ctctttagct acttttgccg gacaggccgt cgcagctggc
      241 ctgagcagtg acctggcggg ccgcgcctgc gccctgccgc gtttcctgcc tggctggtgg
      301 tggcggccat tttgttcatc ctcctcctcc tcctgctcct cctggttgga gcgcagtgtc
      361 cggagcgggc tggggggagc ggacccgaga gcggggttca gtaccttttc ctctgtcccc
      421 agccggcgcc cggagccccc ctccccttcc ttcccgcccc ctcccctccc cagccctgcc
      481 ctcccccttg tcccgggatc actccgtcgc acccaccatg atggaagacg acggacagcc
      541 ccggactcta tacgtaggta acctctccag agatgtgaca gaagtcctta ttcttcagtt
      601 attcagtcag atcggaccct gtaaaagctg taaaatgata acagagcata caagcaatga
      661 cccatattgc tttgtggaat tttatgaaca cagagatgca gctgctgcat tagctgctat
      721 gaatgggaga aaaattttgg gaaaggaggt caaagtaaac tgggcaacaa caccaagtag
      781 ccagaaaaaa gatacttcca atcacttcca tgtgtttgtt ggggatttga gtccagaaat
      841 tacaacagaa gatatcaaat cagcatttgc cccctttggt aaaatatcgg atgcccgggt
      901 agttaaagac atggcaactg gaaagtccaa aggctatggt tttgtatctt tttataacaa
      961 actggatgca gagaatgcaa ttgtgcatat ggggggtcag tggttgggag gtcgacaaat
     1021 cagaaccaat tgggccacac gtaaaccacc tgcccctaaa agtacacaag aaactaacac
     1081 taagcagttg agatttgaag atgtagtaaa ccagtcaagt ccaaaaaact gtactgtgta
     1141 ctgtggagga attgcttcgg ggctgacaga tcaacttatg agacaaacat tttcaccatt
     1201 tggacaaatt atggaaatac gagtttttcc agagaagggc tattcgtttg tcagattttc
     1261 cactcacgag agtgcggccc acgccattgt ctctgtgaac ggcactacaa tcgaaggaca
     1321 tgtggtgaaa tgctattggg gtaaagaatc tcctgatatg actaaaaact tccaacaggt
     1381 tgactacagt cagtggggcc agtggagcca agtgtatgga aacccacaac agtatggaca
     1441 gtatatggca aatgggtggc aagtaccacc ctatggagta tatgggcagc cgtggaacca
     1501 acaaggattt ggagtagatc aatccccttc tgctgcttgg atgggtggat ttggtgctca
     1561 gcctcctcaa ggacaagccc ctccccctgt aatacctcct ccaaaccaag ctgggtatgg
     1621 aatggcaagc ttcccgacac agtgagctgg gactcgaaac acgattgtaa ttcaccacag
     1681 gctgcagtct cctgtcacac tctgaagaca tgaaaagtaa acatcggaaa atgaaaatat
     1741 ttattttaaa aattgaaatg tttggaacct ttagcacagc tttgcttggt gaaggacaca
     1801 tgtcttctag ttctgccttt ttaagttttt gttcatgatg gatatgaaca tgatttttct
     1861 ttgtgtacaa aaaactaaaa taaagtcaat aaagacaatt ctgactataa attttgatat
     1921 aataggagaa atgggtaata cacttcgatc cttagacact attccatttt tatcttgctg
     1981 ttcagtattt taactcactg tgtttttaaa agagcaaaaa agggagtatc gtgaaaaact
     2041 gagaatcaca tcagttcgtc ctgaatcctg atactcccct cccgtccctg aggcggacca
     2101 catagaaggc agcaggagaa agtgtgattt cagaagaagt ccatgatgtg ggagtcgctg
     2161 tggaagaaat atgttattct cttatgttaa agaaaatgaa gccagactga aagcgtgcag
     2221 cctgaataag gaccagcatc gtagaaggtt cttgaacgat tgttggtggt ccatattaag
     2281 acatattttt aaaactttaa aagtgttggt tatcaaaaat gtatattaca tttcatttgg
     2341 gggaaaattc caagtatggt gtttatatta aagtcagacg gtcatacttg tgcttttaca
     2401 tggagtttaa atgataaaca ttgtaaatat tgaataacta cagtgtttca aaagcatgct
     2461 tcaacataga agtagcagca atgtaattat tcgaggtgac aagtaacatg ctcgctgcca
     2521 gtgcagtgct cagtagcagt gttaacactg atgtctccac gtcttcacgg ttggccatgt
     2581 aaaaggagaa ggacacaaat gactacacag aagaagcctt aatttaattt catacaaatc
     2641 tttgatgcat tagtatattc taaattgtaa gtagaagtta gatttgggct tttttcccct
     2701 ttcttccttt ctttcatttc cttttgtttt gttttatttg gtacataaat accttgatta
     2761 aaacccagtg aagtgatttc agggttgcta taagttgtat agcacaagtt ttttttttgt
     2821 ttttttttgt ttttttaaga aatcttggga tgtttttaaa aattagtcta ttttgcccaa
     2881 gaattttctt aacaagattg ctaaaacatc ttacttagac aacctgatgt atcagttata
     2941 atctgataac caatttgagt cgtacacaag ttgtgacttt ttatttctaa tttgtttttt
     3001 ctttgggagt gtgtgggtga cagatgtgaa taggcctgag ttgtatgtgt gcagttttaa
     3061 ctgaatcttt aggaagatgc gggagttcca ggcatgctcc cctgacatct ttcagtctat
     3121 gtggatacag tctgcctcat agttctatac aatgggaatg tgaaatagat aaaatcctat
     3181 gtgtttcaat tgtgacaact aggaggtgca aatgttttga tagtgtgtta aacctgttgg
     3241 cctgtgtatg cacaagagca aaaaacccta acctaacctt cttgaggtaa gatgggtaag
     3301 acacatgaag ccgttgaagt ctaaagatta agataatgtg gtttttttta tattggtgac
     3361 cacaaagatt ctggagttta ttccctcctt cacttaggaa cacagccaaa tgtattcagc
     3421 ataaaaatgt acagggtctg aagttctttt ttgagccaaa atctttatgt actttagttg
     3481 ggtttttttt tttttttttt tggtttttaa acacaactac cctgtgttaa cactcgtcag
     3541 tgactaaata gacccctgga gttttttgat ttgggtgttt tgttttgttt ttgtttttgt
     3601 ttttgtcttt ttgtcatacc tttgggggat atttttggaa aagttatttt atattttata
     3661 agaagaaaac aagctatatt ttgcccttga gttaagattt tcattaaatt ttgtgaaact
     3721 cgaacaacct aaaggctttt taagttgata aattgataaa agcttactaa attaaaattt
     3781 cagtttccct ttttttcctc tgccagtaaa ttaagtggct tactgagata actaatggct
     3841 aactctagct gtagtctttt ctcttttata tcctatgagt taataaaact atccagacta
     3901 gttacattgc catagtaagc atgtgactga catcttttgt cttaatttgg atgagaaaaa
     3961 aaaatttttt tttggtaagt cagtcacagt catttcacag caaatagttt taagatagaa
     4021 aggacatgtg caaatgaaat gcaccatttt aggaaatgag atgatcaagc taacacaggt
     4081 ccagactgtc ttacaatgca gatttgagtt tgtgccctcc gtccacttta agcctaagaa
     4141 ctgttgcctt ttctttcctg tgttcgtcaa gaacagcaga gagactcttt ggcatgcaag
     4201 gaaatgtctc ttcatagttt cttgagattt atcttggtgt gtttctgcct gccatcgtct
     4261 gtgcttgaat ccttttctac tagcatttcc tcggtgccag tccgtctgat ctttatgttt
     4321 gccgccagtg agaggccaac taaagccaaa gctgtaaacc acagttgaag taagtctttc
     4381 aataaagact agtctatgta a
//
