LOCUS       NM_011585               4477 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytotoxic granule-associated RNA binding protein 1
            (Tia1), transcript variant 1, mRNA.
ACCESSION   NM_011585
VERSION     NM_011585.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4477)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4477)
  AUTHORS   Osma-Garcia,I.C., Mouysset,M., Capitan-Sobrino,D., Aubert,Y.,
            Turner,M. and Diaz-Munoz,M.D.
  TITLE     The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis
  JOURNAL   Cell Mol Immunol 20 (9), 1063-1076 (2023)
   PUBMED   37474714
  REMARK    GeneRIF: The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA
            translation to protect germinal center responses from apoptosis.
REFERENCE   3  (bases 1 to 4477)
  AUTHORS   Osma-Garcia,I.C., Capitan-Sobrino,D., Mouysset,M., Aubert,Y.,
            Maloudi,O., Turner,M. and Diaz-Munoz,M.D.
  TITLE     The splicing regulators TIA1 and TIAL1 are required for the
            expression of the DNA damage repair machinery during B cell
            lymphopoiesis
  JOURNAL   Cell Rep 41 (12), 111869 (2022)
   PUBMED   36543128
REFERENCE   4  (bases 1 to 4477)
  AUTHORS   Jia,X., Zhang,S., Tan,S., Du,B., He,M., Qin,H., Chen,J., Duan,X.,
            Luo,J., Chen,F., Ouyang,L., Wang,J., Chen,G., Yu,B., Zhang,G.,
            Zhang,Z., Lyu,Y., Huang,Y., Jiao,J., Chen,J.Y.H., Swoboda,K.J.,
            Agolini,E., Novelli,A., Leoni,C., Zampino,G., Cappuccio,G.,
            Brunetti-Pierri,N., Gerard,B., Ginglinger,E., Richer,J.,
            McMillan,H., White-Brown,A., Hoekzema,K., Bernier,R.A.,
            Kurtz-Nelson,E.C., Earl,R.K., Meddens,C., Alders,M., Fuchs,M.,
            Caumes,R., Brunelle,P., Smol,T., Kuehl,R., Day-Salvatore,D.L.,
            Monaghan,K.G., Morrow,M.M., Eichler,E.E., Hu,Z., Yuan,L., Tan,J.,
            Xia,K., Shen,Y. and Guo,H.
  TITLE     De novo variants in genes regulating stress granule assembly
            associate with neurodevelopmental disorders
  JOURNAL   Sci Adv 8 (33), eabo7112 (2022)
   PUBMED   35977029
REFERENCE   5  (bases 1 to 4477)
  AUTHORS   Carrascoso,I., Velasco,B.R. and Izquierdo,J.M.
  TITLE     Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic
            Fibroblasts Is Associated with Changes in Mitochondrial Morphology
            and Respiration
  JOURNAL   Int J Mol Sci 22 (23), 12775 (2021)
   PUBMED   34884582
  REMARK    GeneRIF: Deficiency of T-Cell Intracellular Antigen 1 in Murine
            Embryonic Fibroblasts Is Associated with Changes in Mitochondrial
            Morphology and Respiration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4477)
  AUTHORS   Le Guiner,C., Lejeune,F., Galiana,D., Kister,L., Breathnach,R.,
            Stevenin,J. and Del Gatto-Konczak,F.
  TITLE     TIA-1 and TIAR activate splicing of alternative exons with weak 5'
            splice sites followed by a U-rich stretch on their own pre-mRNAs
  JOURNAL   J Biol Chem 276 (44), 40638-40646 (2001)
   PUBMED   11514562
REFERENCE   7  (bases 1 to 4477)
  AUTHORS   Del Gatto-Konczak,F., Bourgeois,C.F., Le Guiner,C., Kister,L.,
            Gesnel,M.C., Stevenin,J. and Breathnach,R.
  TITLE     The RNA-binding protein TIA-1 is a novel mammalian splicing
            regulator acting through intron sequences adjacent to a 5' splice
            site
  JOURNAL   Mol Cell Biol 20 (17), 6287-6299 (2000)
   PUBMED   10938105
REFERENCE   8  (bases 1 to 4477)
  AUTHORS   Piecyk,M., Wax,S., Beck,A.R., Kedersha,N., Gupta,M., Maritim,B.,
            Chen,S., Gueydan,C., Kruys,V., Streuli,M. and Anderson,P.
  TITLE     TIA-1 is a translational silencer that selectively regulates the
            expression of TNF-alpha
  JOURNAL   EMBO J 19 (15), 4154-4163 (2000)
   PUBMED   10921895
REFERENCE   9  (bases 1 to 4477)
  AUTHORS   Beck,A.R., Medley,Q.G., O'Brien,S., Anderson,P. and Streuli,M.
  TITLE     Structure, tissue distribution and genomic organization of the
            murine RRM-type RNA binding proteins TIA-1 and TIAR
  JOURNAL   Nucleic Acids Res 24 (19), 3829-3835 (1996)
   PUBMED   8871565
REFERENCE   10 (bases 1 to 4477)
  AUTHORS   Lowin,B., French,L., Martinou,J.C. and Tschopp,J.
  TITLE     Expression of the CTL-associated protein TIA-1 during murine
            embryogenesis
  JOURNAL   J Immunol 157 (4), 1448-1454 (1996)
   PUBMED   8759725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153374.5 and U55862.1.
            
            On Aug 12, 2009 this sequence version replaced NM_011585.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144222.1, AK088486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC153374.5         126466-126657       c
            193-1656            U55862.1           1-1464
            1657-4477           AC153374.5         97471-100291        c
FEATURES             Location/Qualifiers
     source          1..4477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.69 cM"
     gene            1..4477
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="cytotoxic granule-associated RNA binding protein 1"
                     /db_xref="GeneID:21841"
                     /db_xref="MGI:MGI:107914"
     exon            1..304
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1439
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolysin TIA-1; RNA-binding protein TIA-1;
                     T-cell-restricted intracellular antigen-1; cytotoxic
                     granule associated RNA binding protein TIA1"
                     /codon_start=1
                     /product="cytotoxic granule associated RNA binding protein
                     TIA1 isoform 1"
                     /protein_id="NP_035715.1"
                     /db_xref="CCDS:CCDS20312.1"
                     /db_xref="GeneID:21841"
                     /db_xref="MGI:MGI:107914"
                     /translation="MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAG
                     NDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRS
                     QDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDA
                     ENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPNNCTVYC
                     GGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFSSHESAAHAIVSVNGTTIEG
                     HVVKCYWGKETLDMINPVQQQNQIGYPPTYGQWGQWYGNAQQIGQYVPNGWQVPAYGV
                     YGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGSMLPSQPAGYRVAGYETQ"
     exon            305..401
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..500
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..555
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..588
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..676
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..752
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..861
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..957
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1042
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1166
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1312
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..4477
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3229..3234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="major polyA site"
     regulatory      3843..3848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3869
                     /gene="Tia1"
                     /gene_synonym="2310050N03Rik; mTIA-1; TIA-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagggtgag catgctagct ggctgtgcgc atgcgcggca cgggtcactc ggctgccggc
       61 tcctaggcgt ccggctcgcc gccatcttgg atcggggttt cattgttcgc ggtaggccgg
      121 gccttttttt gtgtaatcgc tgccaaagaa gaaagcgaag tagcctccgg tcaagcgagg
      181 aggccggctc ttccgcagcc atagcccgcc tcaaggattt gggaggtagc gaagggcagg
      241 gagctggacc ctgaggtgcc gccgcgaccg cagcagccat ggaggacgag atgcccaaga
      301 ctctatacgt cggtaacctt tctcgagatg tgacagaagc tctcatcctc cagctcttta
      361 gccagattgg accttgtaaa aactgcaaaa tgattatgga tacagcagga aatgacccat
      421 actgttttgt ggagttccat gagcaccgtc atgcagctgc agccctggct gccatgaatg
      481 ggcggaagat aatgggtaag gaagtgaaag tgaattgggc aacaacccct agcagtcaaa
      541 agaaggatac gagcagtagt accgttgtca gcacacagcg ttcacaagat catttccatg
      601 tgtttgttgg tgacctcagt ccagaaatca caaccgaaga catcaaagca gcgtttgcac
      661 catttggaag aatttcagat gcccgtgtgg taaaagacat ggctaccggg aagtctaagg
      721 gatatggctt tgtctccttt ttcaacaaat gggatgcaga aaatgccatt cagcagatgg
      781 gtggccagtg gcttggtgga agacaaatca gaactaactg ggcaacccga aagcctccag
      841 ctccaaagag tacatatgag tcgaacacca aacagctgtc atatgatgag gttgtgagtc
      901 agtctagtcc caacaactgc actgtgtact gtggaggggt gacgtcagga ctgacagaac
      961 aactaatgcg tcagactttt tctccatttg gacaaataat ggaaattcga gtcttcccag
     1021 ataaaggata ctcatttgtt cggttcagtt cccatgaaag tgcagcacat gcgattgttt
     1081 ctgttaatgg tactaccatt gaagggcatg tggtgaaatg ttattggggc aaagagactc
     1141 ttgatatgat aaaccctgtg caacagcaaa atcaaattgg atatccacca acatatggcc
     1201 agtggggcca gtggtatgga aatgcacaac agattggcca gtatgtgcct aacggttggc
     1261 aagtacctgc ctatggagtg tatggccagc catggagcca gcaggggttc aatcagaccc
     1321 agtcttctgc accgtggatg ggacccaatt acagtgtgcc accacctcaa gggcagaatg
     1381 gcagcatgtt gcctagtcag cctgctgggt atcgagtggc cgggtatgaa acccagtgaa
     1441 aacagactac agaacggaag ccagtggctt gaagccacag ggagggtagg aaaactgttg
     1501 tttacgtaaa gatttatcaa atcagtcagt acaaatgcca gatacaatgt atttatttaa
     1561 aagattcatt tttttaatca tgaaattact tttcatccac attgttttaa aaaggaacac
     1621 gatggtggat gtttgccaat ttttgccttc attatctttt ttgataaagt ttctcagatc
     1681 cttgtttcaa agacaaatgc agggattact gccacttttt taaaaataag aggcagaaaa
     1741 ttgcacaatg ttgaactttt ctccactaaa atcgtgtgca gttttagttt gcattcctga
     1801 taggatttaa aacatgtaat atagatgtaa aaaaaaaaaa aaaaagccaa acttgtgcaa
     1861 agtctagaag ttctctatga ctttcagtat gcacacagtt gtcttaggtt taaagagtaa
     1921 tagacgtttc gtgaactata ccatctccac tattatccct ttggaatttt taaatgtaaa
     1981 ttattagttt atatcatttt atatccacat tttttcacaa atttgtcctg ccttatgaaa
     2041 tatctgtaaa atattcttaa atgaaaaaaa atgatgttca cttagattga aaacttttct
     2101 cagatggacc gataattgca ttcatcttgt ttttataaga gaaggtgcct caaggattcc
     2161 ctgttggatt tgtttaaaag gactttttat cttctgtgat aacctttgcc atgtaccagg
     2221 aactaggaaa acaagaaact tgttctaaag agatctgcaa tgtgataagt cctcgccgca
     2281 tcagtctcgt gcgtcagcat ttatgtttac acgcattgtt gtctaagata cttcagcaag
     2341 tcatgttgtg cagttagcaa actttgtatg tcatttcctc ctacaggtgt catgaagagt
     2401 tgacgtaaga cagattttac atttgcatgt gaatatcaca tacatacttt ggtagtcttt
     2461 gatacaaact catctgctct tctttttcaa gcattttgag acacaaagtt gtatgtaaag
     2521 gaatatatta attagatttt ttttagttag atttacttta aaaagtaaat ccactttaat
     2581 gtgtacaaat gatagctgtg aaactgtaga gtttttctct gtcaggcttg ggattcacta
     2641 agaactccaa aactagcctg aaggaccagc cgggcaaaac attttttaaa tattcagagg
     2701 ccaaaatatg agcaaacaaa taaaaaaact cttaaaagtc ctacctcctt aaacagcctt
     2761 caaggcaaag cccctgcgca caggcatggc tttggtcttg gtccctggtc tcttggagcc
     2821 cccatagtac tattgaggtt tactcttcac tggcgttgtt ctagccttgg ggttcctaat
     2881 atatttcaga gtctcttggt ttggtgtggt tttagtgatg accacacctt ctcctcacag
     2941 tagagaggaa ggagccctgt gcactgtggg tttgaggcct gcagagagct cccagcattt
     3001 tacttgggcc tatggaattg gaagcatttc ctggcctgta tctttcaggt aggagcacac
     3061 aactctaacc tgttttctaa gccagtcccc ttgtacaaca gagcccagga agacagtctc
     3121 aaatgtgtgc ttctctggag ctcaattcta tgcagttgtg ctaatgtttc attaagtcac
     3181 tgtgtatttt taagtactaa aacattgaaa tttgctttat ggaagatgaa taaatttttt
     3241 aaatacttgg aattttattt ctttgtaaac ttctacagat caggacagac aataaaagca
     3301 gcttaaataa aatactaaaa acaaaaagac aaaacccaca caccaggatg ctatctttaa
     3361 gtttttctgg atttgtctct attttagcat ccttagtata tgtctttgtt taagaatttt
     3421 acttcctttg taactttagg ctgcaggatc ttttgggcac aagtaattta ttgtgtgcaa
     3481 aagtgtagtt tctctcttct tttgactctt tcaagtacta aggactttta ttagtagcat
     3541 attcttattg cacagatctt aaaattcatg ttgatttgct gttaagaagg tggtggtgct
     3601 gtgttcctga tgaaagactg acatatcagg aacatagctg ttgttagttt aaataaatca
     3661 tttaagtcat ttctcaacct aaaaaacttc atcctggtat aagtatcagg taaggaaatg
     3721 aaggttttta aagtgaactt ccttgcaata tgcattcagg ttttattctc tggtactgta
     3781 aagaacctga gtgactctca gtgggtcatg gagccagtat tctttatcct gactgtttgg
     3841 atattaaaat tcctttatgt tttatatgac ctgtggggtc ttcttgcagt gattattgtg
     3901 tgtgagattt ttcccccggc gctggcgtat tcatattata ttgttaacac tcaggttcac
     3961 cttatcccag aagccatggt ctgcatgggt tccagaggat ctgcactctg cagacttagc
     4021 caactgtgaa gtcagagttt ggtcttcctg gtgtaaagga gactccccgt ctagattgtc
     4081 cttctcttgc ttttccctgt gctcatcttc cttttagatt tgtgctagag gtccctttca
     4141 ttgtcagggg actagattac atctacagaa ggagtagaca gacttaataa gggctatcca
     4201 tgctactgag atgatagttt agttagacaa acaaaatata ttcataggaa aatttcaaaa
     4261 gcaaaacttt ttaatgagtg atgatttcta aaaactaatt tttattggtc tagtgacctg
     4321 gtttagcagg taaggtgatt gttgccaagc ctgatgccct gagtttgaac atactaggga
     4381 gaagtagaga attaattctc acaagttatc ctcgtccctc cacatgtgta caccctccca
     4441 ccatggccac gtatatcaat aaatctttaa aactgcc
//
