LOCUS       NM_144543                976 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus thymocyte nuclear protein 1 (Thyn1), transcript
            variant 1, mRNA.
ACCESSION   NM_144543
VERSION     NM_144543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 976)
  AUTHORS   Kitaura,F., Yuno,M., Fujita,T., Wakana,S., Ueda,J., Yamagata,K. and
            Fujii,H.
  TITLE     Normal B cell development and Pax5 expression in
            Thy28/ThyN1-deficient mice
  JOURNAL   PLoS One 14 (7), e0220199 (2019)
   PUBMED   31329649
  REMARK    GeneRIF: Thy28-deficient mice showed normal development of B cells
            and unaltered Pax5 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 976)
  AUTHORS   Toyota,H., Sudo,K., Kojima,K., Yanase,N., Nagao,T., Takahashi,R.H.,
            Iobe,H., Kuwabara,T., Kakiuchi,T. and Mizuguchi,J.
  TITLE     Thy28 protects against anti-CD3-mediated thymic cell death in vivo
  JOURNAL   Apoptosis 20 (4), 444-454 (2015)
   PUBMED   25547913
  REMARK    GeneRIF: Modulation of Thy28 expression plays a crucial role in the
            determination of thymic cell fate.
REFERENCE   4  (bases 1 to 976)
  AUTHORS   Toyota,H., Jiang,X.Z., Asakura,H. and Mizuguchi,J.
  TITLE     Thy28 partially prevents apoptosis induction following engagement
            of membrane immunoglobulin in WEHI-231 B lymphoma cells
  JOURNAL   Cell Mol Biol Lett 17 (1), 36-48 (2012)
   PUBMED   22139584
  REMARK    GeneRIF: Thy28 regulates mIg-mediated apoptotic events through the
            JNK-H(2)O(2) activation pathway, concomitant with an accumulation
            of cells in G1 phase associated with upregulation of p27(Kip1)
REFERENCE   5  (bases 1 to 976)
  AUTHORS   Jiang,X., Toyota,H., Takada,E., Yoshimoto,T., Kitamura,T.,
            Yamada,J. and Mizuguchi,J.
  TITLE     Modulation of mThy28 nuclear protein expression during thymocyte
            development
  JOURNAL   Tissue Cell 35 (6), 471-478 (2003)
   PUBMED   14580360
REFERENCE   6  (bases 1 to 976)
  AUTHORS   Jiang,X.Z., Toyota,H., Yoshimoto,T., Takada,E., Asakura,H. and
            Mizuguchi,J.
  TITLE     Anti-IgM-induced down-regulation of nuclear Thy28 protein
            expression in Ramos B lymphoma cells
  JOURNAL   Apoptosis 8 (5), 509-519 (2003)
   PUBMED   14601557
  REMARK    GeneRIF: down-regulation of the nuclear Thy28 expression appears to
            correlate with the induction of apoptosis in Ramos B lymphoma cells
REFERENCE   7  (bases 1 to 976)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 976)
  AUTHORS   Miyaji,H., Yoshimoto,T., Asakura,H., Komachi,A., Kamiya,S.,
            Takasaki,M. and Mizuguchi,J.
  TITLE     Molecular cloning and characterization of the mouse thymocyte
            protein gene
  JOURNAL   Gene 297 (1-2), 189-196 (2002)
   PUBMED   12384300
REFERENCE   9  (bases 1 to 976)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB236103.1, AB080370.1 and BE953030.1.
            
            On Nov 15, 2007 this sequence version replaced NM_144543.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016594.1, DV062524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                CB236103.1         9-84
            77-854              AB080370.1         1-778
            855-976             BE953030.1         1-122               c
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 12.06 cM"
     gene            1..976
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /note="thymocyte nuclear protein 1"
                     /db_xref="GeneID:77862"
                     /db_xref="MGI:MGI:1925112"
     exon            1..89
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            90..195
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..833
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thymocyte protein thy28; mThy28"
                     /codon_start=1
                     /product="thymocyte nuclear protein 1 isoform 1"
                     /protein_id="NP_653126.1"
                     /db_xref="CCDS:CCDS22937.1"
                     /db_xref="GeneID:77862"
                     /db_xref="MGI:MGI:1925112"
                     /translation="MPRPRKRQTGTAGPDRKKLSGKRTKTENSESTSVKLENSSLEMT
                     TTFKNGGKNLSNYWLMKSEPESRLEKGIDMKFSIEDLKAQPKQTACWDGVRNYQARNF
                     LRAMKLEDEAFFYHSNCKQPGIVGLMKIVKEAYPDHTQFEKSNPHYDPSSKEDDPKWS
                     MVDVQFVRMMKRFIPLEELKTYHQAHKATGGPLKSMTLFTRQRLSVQPLTQEEFDFIL
                     SLEETEPS"
     exon            196..377
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            378..446
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            447..539
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            540..635
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            636..786
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     exon            787..963
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      944..949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /note="hexamer: AATAAA"
     polyA_site      963
                     /gene="Thyn1"
                     /gene_synonym="D730042P09Rik; HSPC144; MDS012; MY105;
                     Thy28"
                     /note="major polyA site"
ORIGIN      
        1 acgcgtcttc tactaagcct gtccgggcac gccagtcgcc tcaaggctcc cagaagatta
       61 gcctggcagt gcttcaaggc gtttgggtgg ttttagaaga caagagctgt ttcttacccg
      121 tccggttagc ttcagcctcc tacagagagg ccatgccgag accccgcaag aggcagactg
      181 ggactgctgg tccagacagg aagaagctat ccgggaaacg tactaaaact gaaaactcag
      241 aaagtacatc agtcaagcta gagaactcca gccttgagat gacgacaacc tttaaaaatg
      301 gtggcaagaa tttaagcaac tactggctga tgaagtcaga gccagaaagc cggctagaga
      361 aaggtataga catgaagttc agcatcgagg atctcaaagc acagcccaag cagacagctt
      421 gctgggatgg tgttcgcaac tatcaggctc ggaacttcct cagggccatg aaattggagg
      481 atgaagcctt cttctaccat agcaactgca aacagcctgg cattgttgga cttatgaaga
      541 ttgtaaagga ggcttaccca gaccacacac agtttgagaa aagtaatccc cattacgatc
      601 catccagcaa agaggacgac cctaaatggt cgatggtgga tgtacagttt gttcgaatga
      661 tgaagcgctt catccctctg gaggagctta aaacctatca ccaagcccac aaagctactg
      721 gcggcccctt aaaaagcatg actctcttca cccgccagag actttccgtt cagcctctga
      781 ctcaagaaga gtttgatttt attttgagcc tggaggaaac agaaccaagt taatcagaag
      841 gctctactga tggagtgaac aagccaagat tttataagac agaaggagaa agcttgctgt
      901 atccacctgg ggtcgtgtgc acggatggtt tgttaatttt cctaataaaa gatttaatga
      961 caaaaaaaaa aaaaaa
//
