LOCUS       NM_009382               1753 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus thymus cell antigen 1, theta (Thy1), mRNA.
ACCESSION   NM_009382
VERSION     NM_009382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   Oberholtzer,N., Chakraborty,P., Kassir,M.F., Dressman,J., Das,S.,
            Mills,S., Comte-Walters,S., Gooz,M., Choi,S., Parikh,R.Y.,
            Hedley,Z., Vaena,S., DeMass,R., Scurti,G., Romeo,M.,
            Gangaraju,V.K., Berto,S., Hill,E., Ball,L.E., Mehta,A.S.,
            Maldonado,E.N., Nishimura,M.I., Ogretmen,B. and Mehrotra,S.
  TITLE     H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T
            cell immunotherapeutic response
  JOURNAL   Sci Adv 10 (46), eadp1152 (2024)
   PUBMED   39546607
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   Messmer,J.M., Thommek,C., Piechutta,M., Venkataramani,V.,
            Wehner,R., Westphal,D., Schubert,M., Mayer,C.D., Effern,M.,
            Berghoff,A.S., Hinze,D., Helfrich,I., Schadendorf,D., Wick,W.,
            Holzel,M., Karreman,M.A. and Winkler,F.
  TITLE     T lymphocyte recruitment to melanoma brain tumors depends on
            distinct venous vessels
  JOURNAL   Immunity 57 (11), 2688-2703 (2024)
   PUBMED   39368486
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Rosenlehner,T., Pennavaria,S., Akcabozan,B., Jahani,S.,
            O'Neill,T.J., Krappmann,D., Straub,T., Kranich,J. and Obst,R.
  TITLE     Reciprocal regulation of mTORC1 signaling and ribosomal
            biosynthesis determines cell cycle progression in activated T cells
  JOURNAL   Sci Signal 17 (859), eadi8753 (2024)
   PUBMED   39436996
  REMARK    Erratum:[Sci Signal. 2024 Dec 17;17(867):eadu7437. doi:
            10.1126/scisignal.adu7437. PMID: 39689184]
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Ulibarri,M.R., Lin,Y., Ramprashad,J.C., Han,G., Hasan,M.H.,
            Mithila,F.J., Ma,C., Gopinath,S., Zhang,N., Milner,J.J. and
            Beura,L.K.
  TITLE     Epithelial organoid supports resident memory CD8 T cell
            differentiation
  JOURNAL   Cell Rep 43 (8), 114621 (2024)
   PUBMED   39153200
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1753)
  AUTHORS   Douglas,T.C. and Dawson,P.E.
  TITLE     Location of the gene for theta antigen in the mouse. III. The
            position of Thy-1 relative to Lap-1 and Mpi-1
  JOURNAL   J Hered 70 (4), 250-254 (1979)
   PUBMED   314952
REFERENCE   7  (bases 1 to 1753)
  AUTHORS   Douglas,T.C., Meo,T. and Skarvall,H.
  TITLE     Location of the gene for theta antigen in the mouse. II.
            Three-point crosses place Thy-1 in proximal region of chromosome 9
  JOURNAL   J Hered 69 (4), 224-228 (1978)
   PUBMED   310441
REFERENCE   8  (bases 1 to 1753)
  AUTHORS   Zaleski,M. and Klein,J.
  TITLE     Genetic control of the immune response to Thy-1 antigens
  JOURNAL   Immunol Rev 38, 120-162 (1978)
   PUBMED   75164
  REMARK    Review article
REFERENCE   9  (bases 1 to 1753)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
REFERENCE   10 (bases 1 to 1753)
  AUTHORS   Trowbridge,I.S. and Mazauskas,C.
  TITLE     Immunological properties of murine thymus-dependent lymphocyte
            surface glycoproteins
  JOURNAL   Eur J Immunol 6 (8), 557-562 (1976)
   PUBMED   61878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126459.3, CJ043838.1,
            AK003006.1, CD776453.1 and BF455369.1.
            
            On Mar 28, 2007 this sequence version replaced NM_009382.2.
            
            Summary: This gene encodes a glycoprotein that is anchored to the
            cell surface of thymocytes, neuronal and other cells through a
            glycosyl-phosphatidylinositol moiety. A soluble form of the encoded
            protein has also been detected in serum and cerebrospinal fluid.
            The encoded protein undergoes further processing to generate the
            mature protein which mediates cell-cell interactions to trigger
            downstream signaling pathways. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.55023.1, CB195612.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC126459.3         10290-10329         c
            41-730              CJ043838.1         2-691
            731-1089            AK003006.1         1-359               c
            1090-1158           AC126459.3         5711-5779           c
            1159-1732           CD776453.1         21-594              c
            1733-1753           BF455369.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.52 cM"
     gene            1..1753
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /note="thymus cell antigen 1, theta"
                     /db_xref="GeneID:21838"
                     /db_xref="MGI:MGI:98747"
     exon            1..93
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..155
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..607
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /EC_number="3.1.26.4"
                     /note="thy-1 membrane glycoprotein; thy-1 antigen"
                     /codon_start=1
                     /product="thy-1 membrane glycoprotein preproprotein"
                     /protein_id="NP_033408.1"
                     /db_xref="CCDS:CCDS23093.1"
                     /db_xref="GeneID:21838"
                     /db_xref="MGI:MGI:98747"
                     /translation="MNPAISVALLLSVLQVSRGQKVTSLTACLVNQNLRLDCRHENNT
                     KDNSIQHEFSLTREKRKHVLSGTLGIPEHTYRSRVTLSNQPYIKVLTLANFTTKDEGD
                     YFCELQVSGANPMSSNKSISVYRDKLVKCGGISLLVQNTSWMLLLLLSLSLLQALDFI
                     SL"
     exon            156..494
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1735
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /note="hexamer: AATAAA"
     polyA_site      1735
                     /gene="Thy1"
                     /gene_synonym="CD90; T25; Thy-1; Thy-1.2; Thy1.1; Thy1.2"
                     /note="major polyA site"
ORIGIN      
        1 cccacccctg gtgaaaactg cgggcttcag cgctgggtgc agcaactgga ggcgttggcg
       61 caccaggagg aggctgcagc taggggagtc cagaatccaa gtcggaactc ttggcaccat
      121 gaacccagcc atcagcgtcg ctctcctgct ctcagtcttg caggtgtccc gagggcagaa
      181 ggtgaccagc ctgacagcct gcctggtgaa ccaaaacctt cgcctggact gccgccatga
      241 gaataacacc aaggataact ccatccagca tgagttcagc ctgacccgag agaagaggaa
      301 gcacgtgctc tcaggcaccc ttgggatacc cgagcacacg taccgctccc gcgtcaccct
      361 ctccaaccag ccctatatca aggtccttac cctagccaac ttcaccacca aggatgaggg
      421 cgactacttt tgtgagcttc aagtctcggg cgcgaatccc atgagctcca ataaaagtat
      481 cagtgtgtat agagacaagc tggtcaagtg tggcggcata agcctgctgg ttcagaacac
      541 atcctggatg ctgctgctgc tgctttccct ctccctcctc caagccctgg acttcatttc
      601 tctgtgactg gttgggccca aggagaaaca ggagccctcg aggtccttcc tctgcagagg
      661 tcttgcttct cccggtcagc tgactccctc cccaagtcct tcaaatatct cagaacatgg
      721 ggagaaacgg ggaccttgtc cctcctaagg aaccccagtg ctgcatgcca tcatcccccc
      781 caccctcgcc cccacccccg ccacttctcc ctccatgcat accactagct gtcattttgt
      841 actctgtatt tattccaggg ctgcttctga ttatttagtt tgttctttcc ctggagacct
      901 gttagaacat aagggcgtat ggtgggtagg ggaggcagga tatcagtccc tggggcgagt
      961 tcctccctgc caaccaagcc agatgcctga aagagatatg gatgagggaa gttggactgt
     1021 gcctgtacct ggtacagtca tactctgttg aaagaatcat cggggagggg ggggggggct
     1081 caagatggga gagctctgct gagcctttgt ggaccatcca atgaggatga gggcttagat
     1141 tctaccaggt cattctcagc caccacacac aagcgctctg ccatcactga agaagccccc
     1201 tagggctctt gggccagggc acactcagta aagatgcagg ttcagtcagg gaatgatggg
     1261 gaaaggggta ggaggtgggg gagggatcac cccctcctct aaaacacgag cctgctgtct
     1321 ccaaaggcct ctgcctgtag tgagggtggc agaagaagac aaggagccag aactctgact
     1381 ccaggatcta agtccgtgca ggaaggggat cctagaacca tccggttgga cccagcttac
     1441 caagggagag cctttattct tctttccctt gcccctctgt gccagcccct cttgctgtcc
     1501 ctgatccccc agacagcgag agtcttgcaa cctgcctctt ccaagacctc ctaatctcag
     1561 gggcaggcgg tggagtgaga tccggcgtgc acactttttg gaagatagct ttcccaagga
     1621 tcctctcccc cactggcagc tctgcctgtc ccatcaccat gtataatacc accactgcta
     1681 cagcatctca ccgaggaaag aaaactgcac aataaaacca agcctctgga gtgtgaaaaa
     1741 aaaaaaaaaa aaa
//
