LOCUS       NP_082414                528 aa            linear   ROD 05-MAY-2025
DEFINITION  U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 [Mus musculus].
ACCESSION   NP_082414 XP_903963 XP_923145
VERSION     NP_082414.1
DBSOURCE    REFSEQ: accession NM_028138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 528)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY133372.1, AK012806.1 and AC165966.3.
            
            On or before Jul 23, 2009 this sequence version replaced
            XP_923145.1, XP_903963.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012806.1, SRR13422603.312334.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 51.04 cM"
     Protein         1..528
                     /product="U6 snRNA (guanine-N(2))-methyltransferase
                     THUMPD2"
                     /note="THUMP domain-containing protein 2"
                     /calculated_mol_wt=57538
     Region          18..>76
                     /region_name="THUMP_AdoMetMT"
                     /note="THUMP domain associated with
                     S-adenosylmethionine-dependent methyltransferases;
                     cd11715"
                     /db_xref="CDD:212584"
     Region          154..200
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CZB3.3)"
     Region          <203..264
                     /region_name="THUMP"
                     /note="The THUMP domain is named after after thiouridine
                     synthases, methylases and PSUSs; smart00981"
                     /db_xref="CDD:214952"
     Region          286..420
                     /region_name="Trm11"
                     /note="tRNA G10 N-methylase Trm11 [Translation, ribosomal
                     structure and biogenesis]; COG1041"
                     /db_xref="CDD:440663"
     Region          437..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CZB3.3)"
     CDS             1..528
                     /gene="Thumpd2"
                     /gene_synonym="2810025A12Rik"
                     /coded_by="NM_028138.1:26..1612"
                     /db_xref="CCDS:CCDS50190.1"
                     /db_xref="GeneID:72167"
                     /db_xref="MGI:MGI:1919417"
ORIGIN      
        1 mavaqadpgs dpaggarffc tagrglepfl mrevrarlea tqveyisgkv ffttcsdlps
       61 mkklksaerl fvlikkqlpi avsslhkgki lnemqrfvnd dpgswleais lwkkllehdp
      121 krekvsqrda nplkrkagen etiiakklkv eekqevakdh gesqedkllq gspeqgeavt
      181 rtelqdhrln sttekaadaq dqedltfrvs crctgnvrkv itgqeagrvi glalmrqfgw
      241 kadlrnpnie ifmhlsdays vvgipllrmp lasrtyiqta glrstiawam asiaeikaga
      301 lvldpmcglg tilveaaeew pdvfymgadm sdaqllgacd nlkaagltdr iellkssvtd
      361 lplpsqstdv iisdipfgkk fklgkdiksi lqemervlrv ggamvlllse dhhrhltdcg
      421 gssipltskg hiaepemktl snpdrtgapd taspsqrass vqclgrmrpc gslvpvesfk
      481 vslgktdafi ckykkaqasg lssaechepg ahtemaamqe spslqdsl
//
