LOCUS       NM_145585               2905 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus THUMP domain containing 1 (Thumpd1), mRNA.
ACCESSION   NM_145585 XM_017322199 XM_914669 XM_923364
VERSION     NM_145585.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Zhang,X., Jiang,G., Sun,M., Zhou,H., Miao,Y., Liang,M., Wang,E. and
            Zhang,Y.
  TITLE     Cytosolic THUMPD1 promotes breast cancer cells invasion and
            metastasis via the AKT-GSK3-Snail pathway
  JOURNAL   Oncotarget 8 (8), 13357-13366 (2017)
   PUBMED   28076326
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Blackburn,A.C., Hill,L.Z., Roberts,A.L., Wang,J., Aud,D., Jung,J.,
            Nikolcheva,T., Allard,J., Peltz,G., Otis,C.N., Cao,Q.J.,
            Ricketts,R.S., Naber,S.P., Mollenhauer,J., Poustka,A., Malamud,D.
            and Jerry,D.J.
  TITLE     Genetic mapping in mice identifies DMBT1 as a candidate modifier of
            mammary tumors and breast cancer risk
  JOURNAL   Am J Pathol 170 (6), 2030-2041 (2007)
   PUBMED   17525270
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Choi,P., Xanthaki,D., Rose,S.J., Haywood,M., Reiser,H. and
            Morley,B.J.
  TITLE     Linkage analysis of the genetic determinants of T-cell IL-4
            secretion, and identification of Flj20274 as a putative candidate
            gene
  JOURNAL   Genes Immun 6 (4), 290-297 (2005)
   PUBMED   15815685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164158.3, BY031969.1, AK152912.1, CO042524.1 and AI851052.1.
            
            On or before Feb 16, 2018 this sequence version replaced
            XM_017322199.1, NM_145585.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.159694.1,
                                           SRR1660811.151798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC164158.3         123371-123468
            99-204              AC164158.3         126086-126191
            205-232             BY031969.1         2-29
            233-2351            AK152912.1         2-2120
            2352-2503           CO042524.1         406-557             c
            2504-2905           AI851052.1         3-404               c
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.13 cM"
     gene            1..2905
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /note="THUMP domain containing 1"
                     /db_xref="GeneID:233802"
                     /db_xref="MGI:MGI:2444479"
     exon            1..98
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            99..492
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1314
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /codon_start=1
                     /product="THUMP domain-containing protein 1"
                     /protein_id="NP_663560.1"
                     /db_xref="CCDS:CCDS21785.1"
                     /db_xref="GeneID:233802"
                     /db_xref="MGI:MGI:2444479"
                     /translation="MATTAQQSPQPVAGKRKGKSQFLPAKRARRGDAGGPRQLEPGLQ
                     GILITCNMNERKCVEEAYSLLNEYGDDMYGPEKFIDKDQQPSGSEGEDDDAEAALKKE
                     VGDIKASTEKRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKTRVIL
                     RMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELA
                     GIVGSLNSENKVDLTNPEYTVVVEIIKAVCCLSVVKDYVLFRKYNLQEVVKSAKDSQP
                     HPKLGNGKEAKLEPDSKLSQSDPPEGNQVAPESIEELGQTEPGSETQAGSEGDAKPEP
                     ESQVSEVPKTNENELS"
     exon            493..667
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..916
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            917..2893
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /note="hexamer: AATGAA"
     polyA_site      2893
                     /gene="Thumpd1"
                     /gene_synonym="6330575P11Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccttcaaaag aagcttgaca tggctccaga gaaatgctct caggatgtaa ctggtggtac
       61 tgaacttgat gcttgcatct gttaaaagat caactaaaag cccacttgga agctgttgtc
      121 actttatgcg aggactgggc ggcaccggag ccaccggaag gcggcgtgca ggaccgcttg
      181 ggcaaactgt cgcgtacgtg tgacgcaatc accccgcgtc cgcgcagacg aagacgccaa
      241 ggaacgtgga tagtaggaag catggcgacc accgcccagc agtcccctca gcctgttgcc
      301 ggaaagcgca aaggcaaatc ccagttcctg ccggccaagc gggcccgacg cggtgacgca
      361 ggcggcccgc ggcagctgga gcccggcctg cagggcatcc tcatcacctg caacatgaac
      421 gagcgcaagt gcgtggagga ggcctacagc ctgctcaacg agtacggcga cgacatgtac
      481 gggccggaaa agtttataga caaggaccag cagccctctg gaagtgaggg agaagacgat
      541 gatgcagagg ctgccttgaa gaaagaagtt ggtgacatta aggcttctac agagaagagg
      601 ctgagaagat tccagtcagt ggagagtgga gcgaataatg tagtcttcat caggacgctt
      661 gggatagaac ctgagaaatt agtgcatcat attctccagg atatgtacaa aaccaagaaa
      721 aagaagacaa gggttattct acgaatgctg cccatctcag gcacatgtaa agctttttta
      781 gaagatatga aaaaatatgc agaaacattt ctggaaccct ggtttaaagc cccaaacaaa
      841 gggacatttc agattgtata caaatctcga aacaatagcc atatgaatag agaagaagtt
      901 attaaagagt tggcaggaat agtgggcagc ctcaattcag aaaacaaagt ggatctcact
      961 aatccagaat acacggtggt agtggaaatc atcaaagctg tgtgttgcct gagtgttgtg
     1021 aaagattatg tgctgttcag aaaatacaac ctccaagaag tggtgaagag tgcaaaagac
     1081 tcgcagcctc acccaaagct gggaaatggc aaagaagcaa aattggaacc tgatagcaag
     1141 ttgagtcaga gtgatccccc agaagggaac caggtggcac cagagagtat cgaggagctc
     1201 gggcagacag agccggggtc tgaaacccag gcggggagtg aaggagacgc taaacctgaa
     1261 cctgaaagtc aagtctcaga agtacccaag acaaatgaaa atgagctctc ataggtcatt
     1321 ctgtgggaag gtggtctcag ctagggttcc atatgaaatt gtgataatat attttgactt
     1381 ttgtgtgctg ctcaatgctg atcccacagt ccccgttgtc agttttgtta gagccttcca
     1441 ggcctgtatg tcggtatgca gaagcataca ctgtttctca ggggagggtg ctaggaggat
     1501 ggtgttggct tctcctcctc tttactctct ctagtttcct tttaaacact gccaactgat
     1561 gggactggac agtctctgag tgggaaatga caggacattc ccaggagggt gtgtgctatg
     1621 gctcagctgt ccctgcttgt tctgttgtac acatagagaa gctgcattgt ggattatatg
     1681 ggaatcactt tgtgatgctt tctgctgtta gtttttcttg ggtttttgtt tgttttgttt
     1741 gcaaatctga tgtctcatca ctgcaggtgt tttgagaagg tgtgagtgag aagagaactg
     1801 ctctaggtgt agacccaggg gtgtttctga taaggttagg gatgaggaat cactgccggg
     1861 ccacatatcc tagtaccaaa accaggaaag aaagctacta tcccagggtt tcactggact
     1921 gctgtccaag ctggtctgtc agcttgtggt gctttccagt gttcgtcaca ggcagagatt
     1981 ggaagggtag aagggagcag tgaatactgt aaacccagct gtccaggtgg ggactgtaac
     2041 ataggttggg aactgggttt gtgcttaaat cttaatgcac agagctagtg acgtgagaat
     2101 atatacttcg catcacacag ctagaggctt gcttggtaag ccagaccaag aagatatggg
     2161 agaagcagag aataggcagt accttgctaa tgcagacggg gctagaccat cctcaggtgt
     2221 ttgacatgct acctcgggtc tgagattgaa accatcttga aaggataggc cttagggtca
     2281 cttaggggaa cgggaggaga ggatcttggt gccttcttgt ggcttgctcc aagatagagg
     2341 gacttttctt ttaatagtgt aggacagagg gcctgaggac cagttactct tggctcagac
     2401 aggttgttct ggagcagggc agttgctgca cttgggattt tgatctatac tttgctttta
     2461 acggcctttt tatttgtttg ttttgaacga gtccctactg gctatttgcc agttgtacag
     2521 tgctgtgtgc tcttgggatc taaattcact cacagatttt gctctgcctt cagatttgcg
     2581 gactttgtct tcactgcctt ttcagtgtgc tagcgtacag gtgatccagg gtaggaactt
     2641 agcagttagt tttaaactat agcagttagg acagaaaata aagaagcaga aaccaaatcc
     2701 ccgtgctgac gatcagcatg cctgtcctgc tctgcagaga gaggagttaa gcctgggcct
     2761 ggaggacacg tttctccaaa gctgaataca gttctcagat atttttactg cattttgttc
     2821 ttggtacagc tgaactttca agttttcaaa gttcctgata ttttaaaaaa taaaaatgaa
     2881 tttgttctgt aaaaaaaaaa aaaaa
//
