LOCUS       NM_001164805           11019 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus thrombospondin, type I, domain containing 7A (Thsd7a),
            mRNA.
ACCESSION   NM_001164805 XM_287555 XM_983072
VERSION     NM_001164805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11019)
  AUTHORS   Seifert,L., Zahner,G., Meyer-Schwesinger,C., Hickstein,N.,
            Dehde,S., Wulf,S., Kollner,S.M.S., Lucas,R., Kylies,D.,
            Froembling,S., Zielinski,S., Kretz,O., Borodovsky,A.,
            Biniaminov,S., Wang,Y., Cheng,H., Koch-Nolte,F., Zipfel,P.F.,
            Hopfer,H., Puelles,V.G., Panzer,U., Huber,T.B., Wiech,T. and
            Tomas,N.M.
  TITLE     The classical pathway triggers pathogenic complement activation in
            membranous nephropathy
  JOURNAL   Nat Commun 14 (1), 473 (2023)
   PUBMED   36709213
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11019)
  AUTHORS   Shuster,S.A., Li,J., Chon,U., Sinantha-Hu,M.C., Luginbuhl,D.J.,
            Udeshi,N.D., Carey,D.K., Takeo,Y.H., Xie,Q., Xu,C., Mani,D.R.,
            Han,S., Ting,A.Y., Carr,S.A. and Luo,L.
  TITLE     In situ cell-type-specific cell-surface proteomic profiling in mice
  JOURNAL   Neuron 110 (23), 3882-3896 (2022)
   PUBMED   36220098
REFERENCE   4  (bases 1 to 11019)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11019)
  AUTHORS   Clark,E.A., Rutlin,M., Capano,L.S., Aviles,S., Saadon,J.R.,
            Taneja,P., Zhang,Q., Bullis,J.B., Lauer,T., Myers,E., Schulmann,A.,
            Forrest,D. and Nelson,S.B.
  TITLE     Cortical RORbeta is required for layer 4 transcriptional identity
            and barrel integrity
  JOURNAL   Elife 9, e52370 (2020)
   PUBMED   32851975
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11019)
  AUTHORS   You,L., Yan,K., Zou,J., Zhao,H., Bertos,N.R., Park,M., Wang,E. and
            Yang,X.J.
  TITLE     The chromatin regulator Brpf1 regulates embryo development and cell
            proliferation
  JOURNAL   J Biol Chem 290 (18), 11349-11364 (2015)
   PUBMED   25773539
REFERENCE   7  (bases 1 to 11019)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 11019)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 11019)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 11019)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB656281.1, DV653338.1, AK136087.1, AK133324.1, AK164834.1,
            AC122394.5 and BC052230.1.
            
            On or before Sep 23, 2009 this sequence version replaced
            XM_983072.2, XM_287555.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173072.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               BB656281.1         1-620
            621-1070            DV653338.1         316-765
            1071-2089           AK136087.1         2-1020
            2090-5259           AK133324.1         170-3339
            5260-6420           AK164834.1         151-1311
            6421-8379           AC122394.5         151465-153423
            8380-11019          BC052230.1         1-2640
FEATURES             Location/Qualifiers
     source          1..11019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.31 cM"
     gene            1..11019
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /note="thrombospondin, type I, domain containing 7A"
                     /db_xref="GeneID:330267"
                     /db_xref="MGI:MGI:2685683"
     exon            1..457
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..5241
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /note="thrombospondin type-1 domain-containing protein 7A"
                     /codon_start=1
                     /product="thrombospondin type-1 domain-containing protein
                     7A precursor"
                     /protein_id="NP_001158277.1"
                     /db_xref="CCDS:CCDS51721.1"
                     /db_xref="GeneID:330267"
                     /db_xref="MGI:MGI:2685683"
                     /translation="MGLRAGRLASPSRGVLQLLRLPLLLLLLLSSGARGAAAQGDTEV
                     PTLYLWKTGPWGRCMGDDCGPGGIQTRAVWCAHVEGWTTLHTNCKQAVRPSNQQNCFK
                     VCDWHKELYDWRLGTWDRCQPVISKSLEKSRECVKGEEGIQVREIMCIQKDKDIPAED
                     IICEYFEPKPLLEQACLIPCQKDCIVSEFSPWSECSRTCGSGLQHRTRHVVAPPQYGG
                     SGCPNLTEFQVCQSNPCEEDESLYSLQVGPWSACSVPHTRQARQARRRGKNKEREKER
                     GKAVKDPEARELIKKKRNRNRQNRQENRYWDIQIGYQTRDVTCLNRTGKSADLSFCQQ
                     ERLPMTFQSCVITKECQVSEWLEWSPCSKTCHDVTSPTGTRVRTRTITQFPIGSEKEC
                     PALEEKEPCVSQGDGAVLCATYGWRTTEWTECHVDPLLSQQDKRRANQTALCGGGVQT
                     REIYCIQTNDNMLSHGNTQKDKEASKPVDSKLCTGPVPNTTQLCHVPCPIECEVSPWS
                     AWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGATGNCPHLLEAIPCEEPSCYDWK
                     SVRLGDCEPDNGKSCGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDC
                     VLSAWSSWSSCSHTCSGKTTEGKQTRARSILAYAGEEGGIRCPNISALQEVRSCNEHP
                     CTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKK
                     CPESLRPETVRPCLLPCRKDCVVTPYSDWTPCPSSCREGDSGARKQSRQRVIIQLPAN
                     GGKECSDPLYEEKACEAPPTCHSYRWKTHKWRRCQLVPWSIQQDVPGAQEGCGPGRQA
                     RAITCRKQDGGQASIQECLQYAGPVPALTQACQIPCQDDCQFTSWSKFSSCNGDCGAV
                     RTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLL
                     GMKVQGDSKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEW
                     SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYIW
                     VTEPWSVCKVTFVDMRDNCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEDMPLGSRE
                     CKLPCPEDCVISEWGPWTQCALPCNPSGSRQRSADPIRQPADEGRACPDAVEKEPCSL
                     NKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEELGLEKNW
                     PMNTSCTVECPVNCQLSDWSSWSQCSQTCGLTGKMIRKRTVTQPFQGDGRPCPSLMEQ
                     SKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSAEDFSKVVDEEFCA
                     NTELIIDGNKQIVLEETCTQPCPGDCYLNDWSSWSLCQLTCVNGEDLGFGGIQVRSRA
                     VIIQELENQHLCPEQMLETKSCDDGQCYEYKWVASAWKGSSRTVWCQRSDGINVTGGC
                     LVVSQPDTDRSCNPPCSQPHSYCSEMKTCRCEEGYTEVMSSNSTLEQCTLIPVVVIPT
                     VEDKRGDVKTSRAVHPTQPSINPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLVF
                     IVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM"
     exon            458..1289
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1538
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1720
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1876
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2089
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2284
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2519
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2635
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2768
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2872
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3067
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3331
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3510
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3516
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3650
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3804
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3949
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4065
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4183
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4329
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4504
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4678
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4774
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4857
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5068
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5156
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..11000
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10972..10977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /note="hexamer: CATAAA"
     polyA_site      11000
                     /gene="Thsd7a"
                     /gene_synonym="Gm837"
                     /note="major polyA site"
ORIGIN      
        1 tgtcagctgg ggccccctgc ggccggctgt gtccctcgcc gctaggacct gccagtctgc
       61 gcgccatggc agcggcggca gcatccccgc cagcatcccc gccagccagc ggcggcggcg
      121 gtggcgtcca cggccgccgc tgatgctatt gttccctagt gttagttgct ctttggctgc
      181 ttttcatctg gagcgaacaa tagaagcagg gagagctttg ctttctctac tggtggagaa
      241 ggaaagaccg tcccctgcga gagtggtgcg gctccggagg ctggagcggc tgcggacagc
      301 atggggttgc gagccgggcg cctggcgtcc ccgagccggg gcgtcctgca gctgctgcgg
      361 ttgccactgc tcttgctact cctgctgagc tctggcgccc gcggggctgc ggcgcaggga
      421 gacaccgagg tgcccaccct ctatctgtgg aagaccggtc cctggggacg atgcatggga
      481 gatgactgtg gaccgggcgg catccagact cgggctgtgt ggtgtgctca cgtggaaggc
      541 tggactacgt tacatacaaa ctgcaagcag gctgtgagac ccagtaacca gcaaaactgt
      601 ttcaaggtct gtgactggca caaggaattg tacgactgga ggctgggaac ctgggatcgg
      661 tgtcagcctg tgatttcgaa aagcctcgag aaatcgcgag aatgcgtgaa gggtgaggaa
      721 ggcatccagg tgagagagat aatgtgcatc caaaaggaca aggacattcc cgccgaggac
      781 atcatctgcg agtactttga acccaagccc cttctggaac aggcctgcct catcccttgc
      841 cagaaagact gcatcgtgtc tgagttctca ccctggtctg agtgttccag gacctgtggc
      901 agtggcctgc agcaccgcac gaggcacgtg gttgcaccgc cacagtatgg aggctctggc
      961 tgtcccaacc tcaccgagtt tcaggtgtgc cagtccaacc cctgcgagga ggatgagagc
     1021 ttgtacagct tgcaggtggg gccctggagc gcatgctcag tcccacacac aaggcaagcc
     1081 aggcaagcca ggcgtcgtgg caagaacaag gagagggaga aggagagagg aaaagccgtg
     1141 aaggacccag aggcccgtga gctcatcaag aagaagagaa acagaaacag acagaacaga
     1201 caggagaaca gatactggga catccagatt ggctatcaga cccgggacgt gacgtgctta
     1261 aacaggactg ggaaatctgc ggacctcagc ttttgccagc aagagaggct gcccatgacc
     1321 ttccagtcct gcgtgatcac caaagagtgc caggtgtctg agtggttgga atggagccca
     1381 tgttcaaaaa catgccacga tgtcacatcc cctacaggca ctcgagtaag gacaaggact
     1441 atcacacagt ttccgattgg aagtgagaag gaatgtccag ctcttgagga gaaggagccc
     1501 tgtgtgtctc agggagatgg agctgtcctc tgtgctacat atggctggag aactacagag
     1561 tggacagagt gccacgtgga ccctttgctt agtcagcagg acaagaggcg tgccaatcag
     1621 acagccctct gtggaggagg tgtccagacc cgggaaatat attgcataca aaccaacgac
     1681 aacatgctct cccatggaaa tacacagaag gacaaagaag cttcaaaacc agtggactca
     1741 aaattatgca ctggccctgt tcctaacacc acacagctgt gccacgttcc ttgtccaatt
     1801 gaatgtgagg tttcgccttg gtcagcctgg ggaccatgta cttatgaaaa ctgtaatgac
     1861 cagcaaggca aaaaaggatt caaattaagg aagcgacgca ttactaatga gcctactgga
     1921 ggttctgggg caactggaaa ctgccctcac ttattggaag ccattccctg tgaagagcca
     1981 tcctgctatg actggaaatc agtgagactc ggagactgtg aaccagataa tggaaaatcc
     2041 tgtgggcctg gcactcaagt tcaagaggtt gtatgcatca acagtgatgg agaagaagtg
     2101 gacagacagc tctgcagaga cgcaatcttt cctatccctg tggcctgtga tgctccatgc
     2161 ccgaaggact gtgtgctcag tgcgtggtcc tcgtggtcct cctgttcgca tacctgctct
     2221 gggaaaacca cagaagggaa acagacccga gcccggtcaa ttttggccta tgcaggtgaa
     2281 gaaggtggaa ttcgctgccc taacatcagt gctttgcaag aggtgcgcag ctgcaatgag
     2341 catccttgca ctgtgtacca ctggcaaact ggtccctggg gtcagtgtat agaggacaca
     2401 tcggtgtcat ccttcaatac gaccacaaca tggaatgggg aggcctcatg ttctgtgggc
     2461 atgcagacac gaaaagtcat ctgtgtgcga gtcaacgtgg gccaagtggg acctaagaag
     2521 tgtcctgaaa gccttcggcc tgaaacagtg agaccctgct tgcttccttg tcggaaggac
     2581 tgtgtcgtga ccccatacag tgactggact ccatgcccct cttcatgcag agaaggagac
     2641 tctggagcca ggaagcagtc tcgacagcga gtcatcattc agctgccagc caatggcggc
     2701 aaggaatgct cagacccact atatgaagag aaggcctgtg aagcccctcc cacatgtcac
     2761 agctacaggt ggaagacaca caaatggcgc aggtgccagt tagttccttg gagcattcaa
     2821 caggatgttc ctggagcaca ggaaggctgc ggacctgggc ggcaggcaag agccattact
     2881 tgtcgaaagc aagatggagg gcaggctagc atccaggagt gcctccagta tgcaggccct
     2941 gtgccagccc tgacccaggc ttgccagatc ccctgccaag atgactgtca atttaccagc
     3001 tggtccaagt tttcttcatg caacggagac tgcggtgcag ttaggaccag aaagcgtgct
     3061 attgttggga aaagtaaaaa gaaggaaaaa tgtaaaaact ctcatttgta ccctctgatc
     3121 gagacccagt attgtccctg tgacaaatat aacgcacagc ctgtggggaa ctggtcagac
     3181 tgtattttac cggaagggaa ggcggaggtg ctgctgggaa tgaaggtaca aggcgacagc
     3241 aaggaatgcg ggcaaggata ccgttaccaa gcgatggcgt gctatgatca aaatggcaga
     3301 cttgtggaaa catcgcgatg caacagccat ggttacatag aagaagcctg catcatcccc
     3361 tgcccctcag actgcaagct cagtgagtgg tccaactggt cccgctgcag caagtcctgt
     3421 ggcagcggcg tgaaggtccg gtccaagtgg ctgcgcgaaa agccttataa cggaggaagg
     3481 ccttgcccca aactggacca tgtcaaccag gcacaggtgt acgaggtcgt cccatgccac
     3541 agtgactgta accagtacat atgggtcaca gagccatgga gtgtctgcaa ggtgaccttt
     3601 gtggacatgc gagacaactg cggagaaggt gtgcagaccc gaaaagtgag atgcatgcag
     3661 aatacagcag atggcccttc tgaacatgtg gaggattacc tgtgtgaccc agaagatatg
     3721 cccctgggct ctagagagtg taaactccca tgccctgagg actgtgtcat atctgagtgg
     3781 ggaccatgga cccagtgtgc tttgccttgc aatccaagtg gttcgaggca aaggtcagcc
     3841 gatcccatca gacagcctgc tgatgaagga agagcctgcc ctgatgctgt ggagaaagag
     3901 ccctgtagcc tgaacaaaaa ttgttaccac tatgactata atgtcacaga ctggagtacg
     3961 tgtcagctga gcgagaaggc agtttgtggg aatggcatta aaacaaggat gttggactgt
     4021 gttcgaagtg atggcaagtc cgttgaccta aagtactgtg aagagcttgg gctggaaaag
     4081 aattggccaa tgaacacatc ctgcacagtg gaatgccctg tgaactgcca gctttctgac
     4141 tggtcttctt ggtcacaatg ttctcaaaca tgtggactca caggaaaaat gatacgaaaa
     4201 cgaactgtaa cccagccctt tcaaggtgat gggaggccct gcccttctct gatggaacag
     4261 tccaagcctt gcccagtgaa gccatgttat cggtggcaat atggccagtg gtctccatgc
     4321 caagttcagg aggcccagtg tggagaagga accaggacac ggaatatttc ttgtgttgtg
     4381 agtgatggct cagctgagga tttcagcaaa gtggtggacg aagagttctg tgctaacaca
     4441 gagctcatca tagatggtaa taaacaaata gttttggagg aaacctgcac ccagccctgc
     4501 ccaggtgact gttatttgaa tgactggtct tcatggagtc tgtgtcagct gacctgtgta
     4561 aatggtgagg atcttggctt tggtggaata caagtccggt ccagagcagt gattatacaa
     4621 gaactggaga atcaacacct atgtccagag cagatgttag aaacaaaatc atgtgatgac
     4681 ggacaatgct atgagtacaa gtgggtggca agtgcttgga agggctcctc tcggacagtc
     4741 tggtgtcaaa gatcagatgg cataaacgta acagggggct gcttggtggt gagccagcct
     4801 gatactgaca ggtcttgtaa cccaccctgt agtcaaccgc actcatattg tagtgagatg
     4861 aagacctgcc gctgtgaaga agggtacact gaagtcatgt cctctaacag cacccttgag
     4921 caatgcacac ttattcccgt ggtggtgatt cccactgtgg aggataaaag aggagatgtg
     4981 aaaaccagcc gggcagttca cccaacccag ccctccatta acccagcagg acggggcagg
     5041 acatggtttc tacagccatt tgggccagat ggaagattaa agacctgggt ttatggtgtc
     5101 gcagccgggg catttgtgct gttagtcttc attgtctcca tgatttatct agcgtgcaaa
     5161 aagccaaaga aaccccaaag acggcagaac aaccgcctca aacctttaac cttagcatac
     5221 gatggagacg ctgatatgta acattgactt ttcctggaca caaccagact tggccttttc
     5281 cctttatagt agacatccag aggccagagt gccagtattc aaatgtgtga gttataatta
     5341 actttaactg ttatgaacac catcattaag aaaaaggaga aaatcctact ccctctagga
     5401 atattcaaga caatagcact gaaacgtaga gtcagctctg agaattctaa gagatgcagt
     5461 gaagtgcatg ctgtgtcctg agagttttgt ggcatctttt ctgaaatcta cccaattttt
     5521 tcaaaaagaa aaaacaaaaa cccactttga tctctaaaac atagtgagga gattggccaa
     5581 ctgggaagcc agatgcaaga ctgcttgcag cactaaccca ccgaactttt tagcatgaag
     5641 agttcatact gaaggcttta caattctaca cttaaccatg ccaacgtgta tactcgatca
     5701 aatgacttac atgatgtcac cttatatact tgttaataag caacttttaa cagtgaagaa
     5761 gatgtaaggc ctatgccaag tggaaaatcc attgaacaac ttagcgtctt catggttgat
     5821 ggtagcattg attggcctgc attttagaga caaactcttt tataagactt tacccttgtc
     5881 tctctctaat gtgtgaatgc tggacatgta ctagccttag aagaaggggt cctcaagttc
     5941 ggtattttat agtggttatt gtctgggaaa caaatatgct agtgttaata cctttctact
     6001 ttccctaatt tcacactggt tgcctacatc ttttttgcta tatggaaggc acattttgca
     6061 ctatattagt gcagcaagat aggcacttaa ccagtgttgc catagaaact gcctcttttc
     6121 atatgggatg atgaagacat ctgtgccaag agtgctgtgg agacatttgc aagcttttgt
     6181 ccactgaaga gaattagttc agtcttgatg gtaacaggat caaatctact attacacctg
     6241 ctgtctacac tcttccttct tgctatagtc atcatgaaat tgacgatatg gcaataattc
     6301 aagtgttgaa gtccctaaac ccaacccaaa cctccaaaat gtagaacccc ttggttgggt
     6361 tgcagttgct cttggaaggc tgtttatgac aagatttata tatttgttat ctttgttttt
     6421 aaaaaaagaa gaagaagaag aaaagcaaag aaaaaaggac tggttgtctt cataattttg
     6481 agtagataga gaaaatagtg tatcaatgat ttttctaaca aaaagaaatc aaaattattt
     6541 gttagctttc ctgtcttcct gatttgtttt tcagtcttac aggctgtatt tcatagtcat
     6601 ggtcttttgc ccttttcatg gttgaaatct gaattagcgt gatttattaa gatataaaat
     6661 ttaagaagag aaggataaat aatcttgtcc agggcttgct taaacatcta gagcaagggg
     6721 cataagcctt taaagcaaaa gagcaaacag gaaatgtttt cagtcaggtc tttagttcag
     6781 ctcagaacac tggcactgtg tggtgcttcc ggagaagtca gctgggtgac accattttct
     6841 gacagaactt tcctcccacg agaagccagc cagccacatt tgcgtgtctc agtttcctga
     6901 gctgccttct atggctttat gccttatgtg gctttagagc tagccctaca ttatattatc
     6961 attagcttcc agtcaattac tctctgtcta tcaagtgtgc ttaatttcac aggtgtcaat
     7021 tcatagtcat taacttatga ttgttgggaa atcaactctg tgttcactgg tgaaacacag
     7081 gaaatgccac cacggaatat agctcacctc tttcttgtga aaaagaaagc taacctgtgt
     7141 catgaaaaag cactcacata cttctgtcac taacagaaat gctacagtta gcctctgata
     7201 gaatggggac ccttttgctt ttcagttttt taaacacggt aaacacatga cttttattta
     7261 tttcatttta ttgttttatt ttttatctga aacatgtctg tatggctgga actgtggttt
     7321 tgttgatgag gtgttttgcc tttaccagct gtgtttgagc tccctctgct gtccattaga
     7381 acagcttttt ctgcccagat tagaaacgaa ttctgaataa gaggatgttg tcatctccca
     7441 actgaaaaat ctttatatat aattcaatat gaacacaatg tggtgaatgc ttcttactca
     7501 tgccagatat aatgcactaa atgattacgt catttcaaag agagtggata gccaagaatt
     7561 taactaaggg aaagcattaa agaggaagga aaaataatat tgatattctg aaactgtaat
     7621 agtacacaca cacacacaca cacacacaca cacacacaat cactcttcca aataatcttt
     7681 gagttgagct ctttgaataa aataagctca gtctgtccaa aatagttaaa tcacaatctc
     7741 tgtgggtagc tgaaaaattt taacaatctg atgaagtgtg ggcaaaactt agcaatcttg
     7801 agataggaaa taaaatagga tattttttct taccccaaac tacacttaag gtatttgata
     7861 aaatgtgatt aattataaaa aaaattaatg ttctcctact taggatatgg taaccaaatc
     7921 aattaaaaat caaaaattaa aaaatgttgt gaaggtggaa aatgtttatg aaaaactaat
     7981 tatatttaaa tactatattc atgttggata aacacttttg atattcatca ttaggataaa
     8041 ttaatactgt gtggcctatt gttagaaagg tggggaaaag aatgtattca tttggataat
     8101 taggacaaat gggaggttat tgttttcacg tacagattcc tttattgatt tccccagaac
     8161 tttattctca gaagggaaat gctggaaacc tgtttgatgt cccttttcct ttccaaatct
     8221 gtgtgtgagc aggaagaaaa gaaggaggca gggagtgagg gaaaggagag agacaaggaa
     8281 caaatggatg aaggaaggaa gaaaggaagg aagaaagaaa ggaaggaagg aagatgtcct
     8341 acttgatttg aaaaagaatg aatgaaagca gacgtttata gaattttgtt ggattgtccc
     8401 aggaaaagta gcatggctga tctccctgga aagcaaccga tttgcctgta catcagtgtc
     8461 catccaatat gctgactata agaagctcta tttcgaaacc tacattcttt tgaatgtagc
     8521 ttaagctaat tgaaaaagga gtatgttaaa gcatgtcttt taactatgta ataaagcaca
     8581 gatcacttat aaaaaggcat atttattaca ttttacatgt aagacacttt tcagggcact
     8641 taaaatagta acggcttttg tatacacagg tcactaagac atccaaaaga aaagaagcat
     8701 gcttcatgag agctcctcgc actggtacac atcactatag attctttata agtgtgctta
     8761 gaacttttcc acagggactc taagtgtcag gatatgctat gaagagtagc aatgcttact
     8821 gtggcttaat aagaactgtt aggttcctga atatttcaag ataaagccat tgcttataaa
     8881 ggaagagagc agcttttccc acacattggt tcacctcctc cagcttactg tatccttggt
     8941 cctgggtgac acttttctct gcctagcctc tcaaattcta ttctgattgt ttatagcctt
     9001 gtctgccttg ctccaaacca cctttctcta aacatgctca aaaatttaga aggcaaagtg
     9061 cagtataatt attaactcat aatattatgt tattatggtc tagtcagaca ataaacctga
     9121 aaatatctaa atcaagcaac cttgccaatg gcaaaaccct actttaacta ctgtaactgg
     9181 ctataagtct tatcgttctg ttttgtagtt gtttagctgg cttttctttc tatgggtaat
     9241 aatttgtgtt ttatcaaatt ctgagcctca gtaagcttgc tggctacttt tctatcattt
     9301 gtttgtgttt atttttaaaa gtaaacattt tgactctctt tctggtactt tttcctaccc
     9361 atttttcttc acagatttga ggaaatcagg ttctatcact gtaaactata attattccta
     9421 ttgaaataaa actatcagtt ataatgtaac tatttttatt taaatgggat acacttgtca
     9481 aagtaatgac taaagaataa aaaaagtcat gcacatgaca tgtcaaagga agactaaaac
     9541 taaaatcctt gctatgaaaa tgtcaaatct taaacttaca ttgttaatag ccaatatcct
     9601 cttattcccc tactttcttt cttttttgtt ttttcttctt ttactatttt ttctcttttt
     9661 ttaaactcca gagtttattc ccctccgggt ccaccctcca actgttccac gtcccatgcc
     9721 tcctccccgc cctcctgtgc cccctccctg cccctgctta catatcagca caaaagcctg
     9781 tatctatcac tagtgagcag aaaggagaat ctatttctag ggagacttag agtcagaata
     9841 gatttgcaaa atcatgcatg ccaaatgtcc tggaatcttg ttgtttgtaa gtgtctccta
     9901 gttcaaatgt cctttgtcca gttccccttg taggactaag gaggaggcag accaggagcc
     9961 cctcaacaag tctgtaagaa ctcctgcaga acatacctga gccctctgag tctctttggg
    10021 cttgagaacg gaatctccct gttccttatg tgataatccc ccaccccacc cccggtcctt
    10081 ccttaagatg ttctggctaa tgtacacaag gaggtgtgga tccagcaagt ggtttcttct
    10141 ttgttttatt attgtttgct tgcttgcttg ggtatttttt ttaatcaaca agatattttg
    10201 cagtgtgatg aaaatcgttc tttttaagag agacagtggg aagtggttat ctacaagatt
    10261 aaatgaaaaa aatgttaaat aatgttaaat ttgcattttt ttttattctg ctctgtcaag
    10321 aaagatcata aacctggaaa tgtctgaagc aagcaacctt gcctgtcggc aaaaacctac
    10381 tttccttaca ctgtaaatgg ctataagttt tattgttttg ttttgtagtt gttttgggtt
    10441 ccttttcttt ctataggtaa taatttatat tttatctaaa tttaagcctc aataaggtct
    10501 ctggatattt tttttttaca atctgtttgt gtttattttt tttaattaaa cacttcgatt
    10561 tgctttctgg tactttttcc tcccattttt attcacagaa atttgaagat atcagtatgt
    10621 acaattgtaa aatttaattt tatcaaattt ataatctatt attctttaca ttatattgct
    10681 ctaagtgagt acttttatta atttatcttc ctgaatattt attttgttgg agtaaggagc
    10741 tagctatctg tgaatctttt gttaatatta ctttgtaaat tgtgtaatgt aatttatttt
    10801 aaattatgca tacttctttt ttaatgcaca aaatatctat gtacgaggga ctgcagattg
    10861 gcaaatactg tcactaagct tatgcagcta atgtggatgg cgtgtggaga tgtaatgtgc
    10921 ttttctacat tttcatatgg gttatttgta aatatctata ttgctgacag acataaatcc
    10981 agaagtcatt ttcattctaa aaaaaaaaaa aaaaaaaaa
//
