LOCUS       NP_001035516            1018 aa            linear   ROD 30-APR-2024
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform a
            precursor [Mus musculus].
ACCESSION   NP_001035516
VERSION     NP_001035516.2
DBSOURCE    REFSEQ: accession NM_001040426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1018)
  AUTHORS   Elbitar,S., Renard,M., Arnaud,P., Hanna,N., Jacob,M.P., Guo,D.C.,
            Tsutsui,K., Gross,M.S., Kessler,K., Tosolini,L., Dattilo,V.,
            Dupont,S., Jonquet,J., Langeois,M., Benarroch,L., Aubart,M.,
            Ghaleb,Y., Abou Khalil,Y., Varret,M., El Khoury,P., Ho-Tin-Noe,B.,
            Alembik,Y., Gaertner,S., Isidor,B., Gouya,L., Milleron,O.,
            Sekiguchi,K., Milewicz,D., De Backer,J., Le Goff,C., Michel,J.B.,
            Jondeau,G., Sakai,L.Y., Boileau,C. and Abifadel,M.
  TITLE     Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein,
            predispose to inherited thoracic aortic aneurysm
  JOURNAL   Genet Med 23 (1), 111-122 (2021)
   PUBMED   32855533
  REMARK    GeneRIF: Pathogenic variants in THSD4, encoding the ADAMTS-like 6
            protein, predispose to inherited thoracic aortic aneurysm.
REFERENCE   3  (residues 1 to 1018)
  AUTHORS   Howden,R., Cho,H.Y., Miller-DeGraff,L., Walker,C., Clark,J.A.,
            Myers,P.H., Rouse,D.C. and Kleeberger,S.R.
  TITLE     Cardiac physiologic and genetic predictors of hyperoxia-induced
            acute lung injury in mice
  JOURNAL   Am J Respir Cell Mol Biol 46 (4), 470-478 (2012)
   PUBMED   22052878
REFERENCE   4  (residues 1 to 1018)
  AUTHORS   Saito,M., Kurokawa,M., Oda,M., Oshima,M., Tsutsui,K., Kosaka,K.,
            Nakao,K., Ogawa,M., Manabe,R.I., Suda,N., Ganjargal,G., Hada,Y.,
            Noguchi,T., Teranaka,T., Sekiguchi,K., Yoneda,T. and Tsuji,T.
  TITLE     ADAMTSL6beta protein rescues fibrillin-1 microfibril disorder in a
            Marfan syndrome mouse model through the promotion of fibrillin-1
            assembly
  JOURNAL   J Biol Chem 286 (44), 38602-38613 (2011)
   PUBMED   21880733
  REMARK    GeneRIF: ADAMTSL6beta has a role in fibrillin-1 microfibril
            formation
REFERENCE   5  (residues 1 to 1018)
  AUTHORS   Salbaum,J.M., Kruger,C., Zhang,X., Delahaye,N.A., Pavlinkova,G.,
            Burk,D.H. and Kappen,C.
  TITLE     Altered gene expression and spongiotrophoblast differentiation in
            placenta from a mouse model of diabetes in pregnancy
  JOURNAL   Diabetologia 54 (7), 1909-1920 (2011)
   PUBMED   21491160
REFERENCE   6  (residues 1 to 1018)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   7  (residues 1 to 1018)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   8  (residues 1 to 1018)
  AUTHORS   Tsutsui,K., Manabe,R., Yamada,T., Nakano,I., Oguri,Y., Keene,D.R.,
            Sengle,G., Sakai,L.Y. and Sekiguchi,K.
  TITLE     ADAMTSL-6 is a novel extracellular matrix protein that binds to
            fibrillin-1 and promotes fibrillin-1 fibril formation
  JOURNAL   J Biol Chem 285 (7), 4870-4882 (2010)
   PUBMED   19940141
  REMARK    GeneRIF: Results indicated that ADAMTSL-6 is a novel
            microfibril-associated protein that binds directly to fibrillin-1
            and promotes fibrillin-1 matrix assembly.
REFERENCE   9  (residues 1 to 1018)
  AUTHORS   McDaniel,A.H., Li,X., Tordoff,M.G., Bachmanov,A.A. and Reed,D.R.
  TITLE     A locus on mouse Chromosome 9 (Adip5) affects the relative weight
            of the gonadal but not retroperitoneal adipose depot
  JOURNAL   Mamm Genome 17 (11), 1078-1092 (2006)
   PUBMED   17103052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138976.1 and AC131749.2.
            
            On Jan 6, 2010 this sequence version replaced NP_001035516.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.38 cM"
     Protein         1..1018
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform a precursor"
                     /note="thrombospondin type-1 domain-containing protein 4;
                     ADAMTSL-4; ADAMTS-like protein 4; ADAMTS-like protein 6; A
                     disintegrin and metalloproteinase with thrombospondin
                     motifs-like protein 6"
                     /calculated_mol_wt=110535
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2726
     mat_peptide     27..1018
                     /product="Thrombospondin type-1 domain-containing protein
                     4. /id=PRO_0000313584"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UTY6.2)"
                     /calculated_mol_wt=110535
     Region          34..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UTY6.2)"
     Region          57..>81
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          116..240
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UTY6.2)"
     Region          317..411
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          413..528
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          534..623
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UTY6.2)"
     Region          627..676
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          680..736
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          739..793
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          797..850
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          856..912
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          916..967
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          975..1005
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1018
                     /gene="Thsd4"
                     /gene_synonym="ADAMTSL-6; Adamtsl4; ADAMTSL6;
                     B230114P05Rik"
                     /coded_by="NM_001040426.3:275..3331"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS40661.1"
                     /db_xref="GeneID:207596"
                     /db_xref="MGI:MGI:2672033"
ORIGIN      
        1 mvsyltscls alstlllllg sqlvcpqpst ehrkvpqrma vtegtpedsg sgspgvwgsw
       61 gpwsacsrsc sggvmeqtrp clpssyrarg gsrpngrals itghvvsavr tsvplhrsqe
      121 dqralagsna srqgpavvrg srhpqargre pserrsrtrg pigpgkygyg kapyilplqt
      181 dtthtpqrlr rqrpssrhsr sqeasaskqg yrppthqfsh sqplyqsdsg prsglppsea
      241 siyqlplthd qsypaasslf hrpelsshhg arphgaaqaf pqhlrstais cigayrqykl
      301 cntnacpesg rsirevqcas ynnkpfmgrf yewepfaevk gnrkcelncq atgyrfyvrq
      361 aekvidgtpc dqngtaicvs gqcksigcdd flgsdkvldk cgvcggdntg cqvvsgvfkh
      421 altslgyhrv veipqgatki nitemhksnn ylalrsrsgr siingnwaid rpgkyegggt
      481 mftykrpnev sstagesfla egptneildv ymihqqpnpg vhyeyvimrn naispqvpph
      541 rrpgepfngq leeedrgqed reereknqek edsqveapev ftsestqtfp vrhperfpsh
      601 rpdnlvppap qpprrsrdhn wkqlgttecs ttcgkgsqyp ifrcvhrnth eevpesycds
      661 smkptpeeep cnlfpcpafw digewsecsk tcglgmqhrq vlcrqvyanr sltvqpyrcq
      721 hlekpettst cqlkicsewq irtdwtscsv pcgvgqrtrd vkcvsnigdm vhdeecnmkl
      781 rpndiencdm gpcakswflt ewsercsaec gagvrtrsvv cmtnhvsslp legcgnnrpv
      841 eatpcdngpc tgkvewftgs wsqcsiecgs gtqqrevicv rknadtfevl dpyecsflek
      901 ppsqqachlk pcgakwfste wsmcskscqg gfrvrevrcl sddmtpsslc dpqlkpeere
      961 scntqdcvpe vdenckdkyy ncnvvvqarl cvynyyktac casctrvanr hvgflgsr
//
