LOCUS       NM_009381               1124 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus thyroid hormone responsive (Thrsp), mRNA.
ACCESSION   NM_009381
VERSION     NM_009381.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Custodio,R.J.P., Kim,M., Sayson,L.V., Lee,H.J., Ortiz,D.M.,
            Kim,B.N., Kim,H.J. and Cheong,J.H.
  TITLE     Low striatal T3 is implicated in inattention and memory impairment
            in an ADHD mouse model overexpressing thyroid hormone-responsive
            protein
  JOURNAL   Commun Biol 4 (1), 1101 (2021)
   PUBMED   34545202
  REMARK    GeneRIF: Low striatal T3 is implicated in inattention and memory
            impairment in an ADHD mouse model overexpressing thyroid
            hormone-responsive protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   Perez-Estrada,J.R., Hernandez-Garcia,D., Leyva-Castro,F.,
            Ramos-Leon,J., Cuevas-Benitez,O., Diaz-Munoz,M., Castro-Obregon,S.,
            Ramirez-Solis,R., Garcia,C. and Covarrubias,L.
  TITLE     Reduced lifespan of mice lacking catalase correlates with altered
            lipid metabolism without oxidative damage or premature aging
  JOURNAL   Free Radic Biol Med 135, 102-115 (2019)
   PUBMED   30818059
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Zhu,Q., Anderson,G.W., Mucha,G.T., Parks,E.J., Metkowski,J.K. and
            Mariash,C.N.
  TITLE     The Spot 14 protein is required for de novo lipid synthesis in the
            lactating mammary gland
  JOURNAL   Endocrinology 146 (8), 3343-3350 (2005)
   PUBMED   15890771
  REMARK    GeneRIF: Spot 14 protein, absent in the lactating mammary gland, is
            required for maximum efficiency of de novo lipid synthesis in vivo
REFERENCE   7  (bases 1 to 1124)
  AUTHORS   Verheijen,M.H., Chrast,R., Burrola,P. and Lemke,G.
  TITLE     Local regulation of fat metabolism in peripheral nerves
  JOURNAL   Genes Dev 17 (19), 2450-2464 (2003)
   PUBMED   14522948
REFERENCE   8  (bases 1 to 1124)
  AUTHORS   Zhu,Q., Mariash,A., Margosian,M.R., Gopinath,S., Fareed,M.T.,
            Anderson,G.W. and Mariash,C.N.
  TITLE     Spot 14 gene deletion increases hepatic de novo lipogenesis
  JOURNAL   Endocrinology 142 (10), 4363-4370 (2001)
   PUBMED   11564699
REFERENCE   9  (bases 1 to 1124)
  AUTHORS   Grillasca,J.P., Gastaldi,M., Khiri,H., Dace,A., Peyrol,N.,
            Reynier,P., Torresani,J. and Planells,R.
  TITLE     Cloning and initial characterization of human and mouse Spot 14
            genes
  JOURNAL   FEBS Lett 401 (1), 38-42 (1997)
   PUBMED   9003802
REFERENCE   10 (bases 1 to 1124)
  AUTHORS   Taviaux,S., Planells,R., Gastaldi,M., Torresani,J. and
            Grillasca,J.P.
  TITLE     Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to
            human chromosome 11 bands q13.5-->q14.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 219-220 (1997)
   PUBMED   9186528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC172193.2, BY238050.1, AK077300.1 and AI117155.1.
            
            On Nov 25, 2015 this sequence version replaced NM_009381.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ266831.1, BC009165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC172193.2         147793-147795       c
            4-153               BY238050.1         4-153
            154-247             BY238050.1         155-248
            248-1080            AK077300.1         1-833
            1081-1124           AI117155.1         354-397
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.49 cM"
     gene            1..1124
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /note="thyroid hormone responsive"
                     /db_xref="GeneID:21835"
                     /db_xref="MGI:MGI:109126"
     exon            1..519
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..500
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /note="spot 14 protein; thyroid hormone responsive SPOT14
                     homolog"
                     /codon_start=1
                     /product="thyroid hormone-inducible hepatic protein"
                     /protein_id="NP_033407.1"
                     /db_xref="CCDS:CCDS21458.1"
                     /db_xref="GeneID:21835"
                     /db_xref="MGI:MGI:109126"
                     /translation="MQVLTKRYPKNCLLTVMDRYSAVVRNMEQVVMIPSLLRDVQLSG
                     PGGSVQDGAPDLYTYFTMLKSICVEVDHGLLPREEWQAKVAGNETSEAENDAAETEEA
                     EEDRISEELDLEAQFHLHFCSLHHILTHLTRKAQEVTRKYQEMTGQVL"
     exon            520..1102
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1078..1083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /note="hexamer: ATTAAA"
     polyA_site      1091
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
                     /note="major polyA site"
     polyA_site      1099
                     /gene="Thrsp"
                     /gene_synonym="S14; SPOT14"
ORIGIN      
        1 gaaatagcgc tggggcagtc tgccggactc tgaggaagga agcaaccatg caagtgctaa
       61 cgaaacgcta tcccaagaac tgcctgctga cagtcatgga tcggtactcc gcggtggtgc
      121 ggaacatgga gcaggtggtg atgatcccca gccttctgag ggatgtgcag ctgagtgggc
      181 ctgggggctc ggtccaggac ggagcccctg atctctatac ctacttcacc atgctcaaga
      241 gcatctgtgt agaagtggac cacgggctgc tgccaaggga ggaatggcag gccaaggtgg
      301 ctggcaacga aaccagcgag gctgagaacg acgctgctga aacggaggag gccgaagaag
      361 acaggatctc ggaggagctg gacctagaag cccagttcca cctgcacttc tgcagcctcc
      421 atcacatcct tacccacctg acccggaaag cacaggaggt gacgcggaaa taccaggaaa
      481 tgacagggca ggttctgtag gtctttgact cttctgaaga tcgctttaca cgagagaaga
      541 ctgatgaaga ccccgaggtg catcaacccg agacctggac agagggcctg gccccaggtg
      601 gacgcgaagg cggcttccgt ctccctctga gtgcatctgt ggacttggtt gcaggctcac
      661 ctttaagata tttgtgtgac tcccaacttc tcttccgtat cttagcagtt tgaggttcac
      721 gaggcagcaa ggatcagtag gaagcacagg tattaacaag ttggccaaag ttcacgtccc
      781 acctctggga tgtcgtttag tgcctggtgt catgtcgcag ttactctttc atgtataaag
      841 cagggatgct gtatctacct cacacggtta ctaaaagcaa acacggaatc caaagccctg
      901 ggcacatgcc gacatctgaa aagctggtgt ttctcccacc tccctccaag tgcatgctgt
      961 acgcagctct tgcttttatc cctggggaaa ggctgaggtc actgagtgtg tgggatgagc
     1021 tgctcaggct gctgggcctg atgcgctgag cacatgaacc taactattgt agtagcaatt
     1081 aaagaagaaa aggaaaacat ggaaaaaaaa aaaaaaaaaa aaaa
//
