LOCUS       NM_009380               6083 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thyroid hormone receptor beta (Thrb), transcript
            variant 2, mRNA.
ACCESSION   NM_009380
VERSION     NM_009380.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6083)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   2  (bases 1 to 6083)
  AUTHORS   Hones,G.S., Geist,D., Wenzek,C., Pfluger,P.T., Muller,T.D.,
            Aguilar-Pimentel,J.A., Amarie,O.V., Becker,L., Dragano,N.,
            Garrett,L., Holter,S.M., Rathkolb,B., Rozman,J., Spielmann,N.,
            Treise,I., Wolf,E., Wurst,W., Fuchs,H., Gailus-Durner,V., Hrabe de
            Angelis,M., Fuhrer,D. and Moeller,L.C.
  TITLE     Comparative Phenotyping of Mice Reveals Canonical and Noncanonical
            Physiological Functions of TRalpha and TRbeta
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38889231
  REMARK    GeneRIF: Comparative Phenotyping of Mice Reveals Canonical and
            Noncanonical Physiological Functions of TRalpha and TRbeta.
REFERENCE   3  (bases 1 to 6083)
  AUTHORS   Geist,D., Hones,G.S., Grund,S.C., Pape,J., Siemes,D.,
            Spangenberg,P., Tolstik,E., Dorr,S., Spielmann,N., Fuchs,H.,
            Gailus-Durner,V., Hrabe de Angelis,M., Mittag,J., Engel,D.R.,
            Fuhrer,D., Lorenz,K. and Moeller,L.C.
  TITLE     Canonical and Noncanonical Contribution of Thyroid Hormone Receptor
            Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in
            Male Mice
  JOURNAL   Thyroid 34 (6), 785-795 (2024)
   PUBMED   38757582
  REMARK    GeneRIF: Canonical and Noncanonical Contribution of Thyroid Hormone
            Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart
            Rate in Male Mice.
REFERENCE   4  (bases 1 to 6083)
  AUTHORS   Ahuja,N., Gupta,S., Arora,R., Bhagyaraj,E., Tiwari,D., Kumar,S. and
            Gupta,P.
  TITLE     Nr1h4 and Thrb ameliorate ER stress and provide protection in the
            MPTP mouse model of Parkinson's
  JOURNAL   Life Sci Alliance 7 (7), e202302416 (2024)
   PUBMED   38609183
  REMARK    GeneRIF: Nr1h4 and Thrb ameliorate ER stress and provide protection
            in the MPTP mouse model of Parkinson's.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6083)
  AUTHORS   Minakhina,S., Kim,S.Y. and Wondisford,F.E.
  TITLE     Regulation of hypothalamic reactive oxygen species and feeding
            behavior by phosphorylation of the beta 2 thyroid hormone receptor
            isoform
  JOURNAL   Sci Rep 14 (1), 7200 (2024)
   PUBMED   38531895
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6083)
  AUTHORS   Horlein,A.J., Naar,A.M., Heinzel,T., Torchia,J., Gloss,B.,
            Kurokawa,R., Ryan,A., Kamei,Y., Soderstrom,M., Glass,C.K. et al.
  TITLE     Ligand-independent repression by the thyroid hormone receptor
            mediated by a nuclear receptor co-repressor
  JOURNAL   Nature 377 (6548), 397-404 (1995)
   PUBMED   7566114
REFERENCE   7  (bases 1 to 6083)
  AUTHORS   Ng,L., Forrest,D., Haugen,B.R., Wood,W.M. and Curran,T.
  TITLE     N-terminal variants of thyroid hormone receptor beta: differential
            function and potential contribution to syndrome of resistance to
            thyroid hormone
  JOURNAL   Mol Endocrinol 9 (9), 1202-1213 (1995)
   PUBMED   7491112
REFERENCE   8  (bases 1 to 6083)
  AUTHORS   Wood,W.M., Dowding,J.M., Haugen,B.R., Bright,T.M., Gordon,D.F. and
            Ridgway,E.C.
  TITLE     Structural and functional characterization of the genomic locus
            encoding the murine beta 2 thyroid hormone receptor
  JOURNAL   Mol Endocrinol 8 (12), 1605-1617 (1994)
   PUBMED   7708051
REFERENCE   9  (bases 1 to 6083)
  AUTHORS   Wood,W.M., Ocran,K.W., Gordon,D.F. and Ridgway,E.C.
  TITLE     Isolation and characterization of mouse complementary DNAs encoding
            alpha and beta thyroid hormone receptors from thyrotrope cells: the
            mouse pituitary-specific beta 2 isoform differs at the amino
            terminus from the corresponding species from rat pituitary tumor
            cells
  JOURNAL   Mol Endocrinol 5 (8), 1049-1061 (1991)
   PUBMED   1944303
REFERENCE   10 (bases 1 to 6083)
  AUTHORS   Issemann,I. and Green,S.
  TITLE     Cloning of novel members of the steroid hormone receptor
            superfamily
  JOURNAL   J Steroid Biochem Mol Biol 40 (1-3), 263-269 (1991)
   PUBMED   1958530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089035.1, AC154681.2 and AC154626.2.
            
            On Jan 12, 2008 this sequence version replaced NM_009380.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089035.1, AK133662.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2898              BC089035.1         1-2898
            2899-3446           AC154681.2         1-548               c
            3447-6083           AC154626.2         44438-47074
FEATURES             Location/Qualifiers
     source          1..6083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..6083
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /note="thyroid hormone receptor beta"
                     /db_xref="GeneID:21834"
                     /db_xref="MGI:MGI:98743"
     exon            1..558
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1661
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     c-erbA-2; c-erbA-beta; nuclear receptor subfamily 1 group
                     A member 2; TR beta"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform 2"
                     /protein_id="NP_033406.1"
                     /db_xref="CCDS:CCDS26835.1"
                     /db_xref="GeneID:21834"
                     /db_xref="MGI:MGI:98743"
                     /translation="MNYCMPEVHEVCPAASSNCYMQVTDYLAYLEDSPALSGRDVQAV
                     PSSSIYMEQAWAVNQPYTCSYPGNLFKSKDSDLDMALSQSSQPAHLPEEKPFPQVQSP
                     PHSQKKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCK
                     YEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREEL
                     QKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGG
                     KVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVR
                     YDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLL
                     MSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHA
                     SRFLHMKVECPTELFPPLFLEVFED"
     exon            559..659
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..807
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1013
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1160
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1419
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..6083
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6064..6069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /note="hexamer: AAGAAA"
     polyA_site      6071
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /note="major polyA site"
     polyA_site      6083
                     /gene="Thrb"
                     /gene_synonym="c-erbAbeta; Nr1a2; T3Rbeta; T3R[b]; Thrb1;
                     Thrb2"
                     /note="major polyA site"
ORIGIN      
        1 caggagagct tgaagatgca gcgtcgaagc tgggtcttgg cacatcaggt gctactctga
       61 agtgaggcag gcgaggttgc tgggctggtg gtgtttattc atctcctctc ttgtttcatg
      121 tgtatgtatg tatgctctcc gagtatatgc acggctccat ggttcagggg gctggcaaat
      181 gcatgcgtag agcgtgtgta tatgtaaagt agaacctgaa cctggatagc aaaatgaact
      241 actgtatgcc agaggtacac gaagtgtgcc cagctgccag cagcaactgc tacatgcagg
      301 tcactgacta cctcgcatat ctggaagaca gtccggctct cagtggtcgt gatgtccaag
      361 ctgtgcccag tagcagcata tatatggaac aggcctgggc agtgaatcag ccttatacct
      421 gtagttaccc tggaaacctg tttaaaagca aggactctga cttggacatg gccctcagtc
      481 agtccagcca gcctgcacat ctccctgaag aaaagccttt tcctcaagtg cagtcgccac
      541 cgcactcaca aaaaaaaggg tatatcccca gctatttaga caaagatgag ctctgtgtag
      601 tgtgtgggga caaagccaca gggtaccact atcgctgcat cacctgtgaa ggctgcaagg
      661 gcttctttag aagaaccatt cagaaaagtc tccatccatc ttattcctgt aaatatgaag
      721 gaaagtgcat catagacaaa gtcacccgca accagtgcca ggaatgtcgc tttaagaaat
      781 gcatctatgt tggcatggca acagacttgg tgctggatga cagcaagagg ctagccaagc
      841 ggaagcttat agaggagaac cgtgagaaga ggcggcggga agagctacag aaatcaattg
      901 ggcacaagcc agaacccacg gatgaggagt gggagctcat caagacagtc actgaggccc
      961 acgtggccac caatgcccag ggcagccact ggaagcagaa gcggaaattc ctgccagaag
     1021 acattggaca agcacccatc gtgaatgccc cagaaggtgg caaggttgac ctggaagcct
     1081 tcagtcattt tacaaaaatc atcacaccag caattaccag agtggtggat tttgccaaaa
     1141 agttgcccat gttttgtgag ctgccatgtg aagaccagat catcctcctc aaaggctgct
     1201 gcatggagat catgtccctt cgagctgctg tgcgctatga cccagacagc gagactctaa
     1261 ctttgaatgg ggaaatggca gtgacacgag gccagctgaa aaatgggggc cttggggtgg
     1321 tttcagatgc catctttgac ctgggcatgt ctctgtcatc tttcaacctg gatgacactg
     1381 aagtcgccct gcttcaggcc gtcctgctaa tgtcttcaga tcgcccaggg ctagcctgtg
     1441 ttgagagaat agagaaatac caagacagtt tcctgttggc ctttgaacac tatatcaatt
     1501 accggaagca ccatgtgaca cacttttggc ccaaactcct gatgaaggtg acagacctgc
     1561 ggatgattgg agcttgccat gccagccgct tcctccacat gaaggtggag tgccccactg
     1621 agctcttccc gcctctgttc ttagaagtat ttgaggacta aatttactgg acaagttctt
     1681 gtcattcctg cagcacgact gggtgtcatt gcattccacc tgtagcattc tgttgttgtt
     1741 tcttcgtttc tctgtgtcaa gtgagatcat cgatggtcag cagatcacca atggcataga
     1801 cttggatgaa attgttcttt gaatgtgggt ctttgtaacc attgcatttt gttctccagt
     1861 ccttggtgtg aatgctttga agggcttaca gcagtgcagt ctgagtgggg tacaatcatt
     1921 atttcaccag cacgaagtca tcaccagctc ccatctgtcc ctgggcagac tcaagcaagc
     1981 caaacagcat ttcagaagac taaagaagcc ttaaaaccga gaccacagtc atcttgatcc
     2041 aacatgatcc attctgatgt gtgcaaggtg aagctgtaga gcccaggccg cctcagggtg
     2101 agcatggctt ttatcacgga aggggagaag gagcagtttc tactcaggag ctcatcattg
     2161 ccagcactcg tgttctccaa gcagcctgac ttggaatgtg caggaatatc cataccataa
     2221 caaatcaact ttcctttcca tggccttttg taaccttatg atttacttca agttgcacaa
     2281 gagtatgact tgactggttt gaggccacaa agaaagtctt tttttttttt tttttttttc
     2341 agtatgccca tagagcttgt aaatcttcat caatgttaaa gcatactttc caaaatgcgt
     2401 gtggtgttac ctcaagcagg aaggcacctt tccaccttag attcacaagc cacaaagctc
     2461 gaatctgttt acatagtgca gtcccttttc aatggcctat gaagcagtcc tctgcccagc
     2521 ttagctcaca aaggtcttat ccaggctgtg tctgttgagc tgatgatgtt cccctgtaga
     2581 ctgaatcttc caatcaggga gacacatggg gaaattccag gcttgtttgg aaaaatccct
     2641 ggaaaagatc agtacaggaa caatcagatt caaaggaaaa aaactactca tggtataggc
     2701 tgtcagatta gagggaatgc tctccctgga tcagcaagcg ctttacttat tcacaaatat
     2761 ctcccagtcc catcccatcg ctgtctccca atctcaccct tgtggctacc cacctcccta
     2821 gattctgagg cactaaatag cttctctctc tctctctctc tctctctctc tctctctctc
     2881 tctctctctc tctctctctc ctaaatcttc tgtagcttac acaccattac cctggcaaat
     2941 actcctcata aaatacagca gaccattcat acctgctacc caacttatcc ccaatgacca
     3001 agtagagtag atgtttctaa gcaacaagta gtgacaactt acccaaaaat gggcaaagac
     3061 tgtacacata caactgaatg tactgactct tcactgactt cgcagatgta aaatattctt
     3121 tgcctgcctt tcactgcctt agcctggaaa tgctgggaaa aaaaacaagc catatcagca
     3181 agaattacct aaaagcaaag gaagtcactg tgaaaagcaa ggaaactcaa ttctttccac
     3241 taggcttggt ggggcatctt tggatctttg gcctcgctgg aagtcgggct gcctgagttc
     3301 tactttgtac tctgcagcct gggtaattta ggaccttaca atttcagttt tcttacctcc
     3361 tgggaaatga gttgaactcc aaaaatcctt cttctcttcc ctattgtttg acttccagga
     3421 aagagagggg atgtctttga aagatccttt tgtattcaaa tttgtagctt caaaaaggaa
     3481 tgtatttggg caatcaattt gagtgagaat gagaatttga ttcagaggaa ggcagaatgg
     3541 ccttagaggc ataaaactta gaggcacagc actgaaagtc ccaagagact gggaataacc
     3601 aaggaagcag gaatggtttg tcactaaagg atttagcctg acttcccaga taaaacatcg
     3661 ctgaagagat taaatagaag gaagaagccc cattagattc atgttcaaac atgtcagagg
     3721 tagcctgtac ctggcctcct gcttcaggaa cttcattaaa catgtgatcc ctatgtcagc
     3781 tcttctggaa gaccttcatc caaacaataa aaactttgct gtaagaccaa ttctccttcc
     3841 aaagggagag ggggaggcag ggaggcgagt cctgcacagg catacaaact tctggaacac
     3901 cagaatttct aaggaagttt cctgattctg acagttttca aagggaatca gaaaccctgg
     3961 cactagtgca gggtttgacc cagaatcatt cagagtgctg taaggattaa gcattgggca
     4021 ctagcccagt cttcacaacc cagccagcca cagcaaagtg accctccctc tacagaggcc
     4081 cacctttcag ggacagaccc agctctggca atcatgttta gggttgaata ctccacaagc
     4141 catgcgagct tcactcttct ggtgggaagg aaccagaatg atagtaggtc aggacagcca
     4201 aagacacgct tttgagaaat tcattttatg aaactagatt gtaagggatt tcctctcaaa
     4261 tttttttctt ctcttttaaa aaatcattct cttctaatct tgtccagact ttcaaatcaa
     4321 gtgtggacat ggtggcagga acctttacac ctgctccact gtggggagat attccagtca
     4381 agaaaacaca ctcatcctgc tgggatgctc actgacaaat ggaatttatg gacaagaagg
     4441 ctgtgcacat gcagcaaaaa tgtgcatgtg tacacatgtg cgtatatctg ttcattgcct
     4501 caagtgtact tcgcacttca gtttaaatgt gcagaacttc cagaaactgg aaggaaaaaa
     4561 aaaaaaaaaa cttcttcatg attctgctga aaacaccacg tgctgcctct gagctttttc
     4621 tagtcccttg agcctcagtc ctcagtgatg cgcttatgtg atgaagcctc agcccagcgc
     4681 atcccctgcc tctttcccag ttcaatcttg gggagggtcc ttctcacagt gacctgcagg
     4741 ctggccctgc caccttggcc tcctcacact cagttctccc caagccagca tcccgacctg
     4801 ctgagcctct tcagagcatg tcattgtcag taagacctct tcattctgtg gaactcaagc
     4861 ctatccatgt catattgacc ttttgctgca tgagtcataa attatcaaat cagtcttacg
     4921 gtttttgaga tgtagccagt gttttataag gctaaacctt tctcatgaac ttaatttaag
     4981 tgaataacca aactaccggt ccttctccaa tgagagatga cagacaattg aatctctgcc
     5041 ctttgcagtg gcgatggcat caggtcctaa aataagctta taattttcct gttattttaa
     5101 taatatggaa atattaaaat aatgtttctt ttgatagtga tagactgatc catatttaaa
     5161 ttttatagag aagaaatttt attgtactgt gatatagata tttattatcc aggtaaggac
     5221 ttgcccggtg tgtatttttt acaattgaaa cattttactt taatctctaa aagaaaaaag
     5281 actataaaac atatacatat taaaaaaagg ctagggagaa aaaaggtttg gctttatcaa
     5341 agaattttta ctgtgttgta tacatgtttg caaatgaaaa atttacacat ttttagtgtt
     5401 tccacattaa ttagtgccgc cttcaagagc aatattgtgc agtaaacact gtttgtggct
     5461 ttctgttgcc cagctcaaac tgaccccatc ttatgcacaa gacaatcaga tgttacgtct
     5521 ttcctctgag gacatagaca atactcaaca gagcacaatg tgaaacaaag aacaagattg
     5581 taggcatggg ctgtgctgct gatggagatg atcagggtgc atgcgcactc acatggcctt
     5641 gtaccactgc ctccttttgg ttgttctttg tgacgttggt atctttctct tgacatcaaa
     5701 tagccaaagt agttctccat gttttcttca gaaaagacca ttctttttcc cataatgtgt
     5761 tcatgccctg agaatcagaa aaatgaaaac aaaaacaaaa aaagatacgg atggaataga
     5821 gaggtttata gtcagtggaa gattggtatt ttgcaaacag tgttaagtga tattgctatt
     5881 gctagattgg taattttttt tcagcctaaa atcgttgaaa tctgtgatca aatgttttaa
     5941 actatccaga aagaaaattt gtatatttgg gaaaatggat ttttacatag cttttgtatg
     6001 cggatattaa attgtaatta tgaatatagt ggacataggt actcataagc ttaaattcta
     6061 aaaaagaaaa agcttacaat aga
//
