LOCUS       NM_001356455            4438 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thyroid hormone receptor associated protein 3
            (Thrap3), transcript variant 2, mRNA.
ACCESSION   NM_001356455 XM_006503041
VERSION     NM_001356455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Zhang,R., Bu,F., Wang,Y., Huang,M., Lin,X., Wu,C., Chen,J.,
            Huang,Y., Wang,H., Ye,S., Hu,X., Wang,Q. and Zheng,L.
  TITLE     LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate
            atherosclerosis by regulating c-FOS in vascular smooth muscle cells
            proliferation and migration
  JOURNAL   Atherosclerosis 379, 117183 (2023)
   PUBMED   37549548
  REMARK    GeneRIF: LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate
            atherosclerosis by regulating c-FOS in vascular smooth muscle cells
            proliferation and migration.
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Jang,H.J., Lee,Y.H., Dao,T., Jo,Y., Khim,K.W., Eom,H.J., Lee,J.E.,
            Song,Y.J., Choi,S.S., Park,K., Ji,H., Chae,Y.C., Myung,K., Kim,H.,
            Ryu,D., Park,N.H., Park,S.H. and Choi,J.H.
  TITLE     Thrap3 promotes nonalcoholic fatty liver disease by suppressing
            AMPK-mediated autophagy
  JOURNAL   Exp Mol Med 55 (8), 1720-1733 (2023)
   PUBMED   37524868
  REMARK    GeneRIF: Thrap3 promotes nonalcoholic fatty liver disease by
            suppressing AMPK-mediated autophagy.
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Sono,T., Akiyama,H., Miura,S., Deng,J.M., Shukunami,C., Hiraki,Y.,
            Tsushima,Y., Azuma,Y., Behringer,R.R. and Matsuda,S.
  TITLE     THRAP3 interacts with and inhibits the transcriptional activity of
            SOX9 during chondrogenesis
  JOURNAL   J Bone Miner Metab 36 (4), 410-419 (2018)
   PUBMED   28770354
  REMARK    GeneRIF: These results indicate that THRAP3 negatively regulates
            SOX9 transcriptional activity as a cofactor of a SOX9
            transcriptional complex during chondrogenesis.
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Maga,A.M., Navarro,N., Cunningham,M.L. and Cox,T.C.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Orelio,C. and Dzierzak,E.
  TITLE     Identification of 2 novel genes developmentally regulated in the
            mouse aorta-gonad-mesonephros region
  JOURNAL   Blood 101 (6), 2246-2249 (2003)
   PUBMED   12433684
REFERENCE   9  (bases 1 to 4438)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4438)
  AUTHORS   Ito,M., Okano,H.J., Darnell,R.B. and Roeder,R.G.
  TITLE     The TRAP100 component of the TRAP/Mediator complex is essential in
            broad transcriptional events and development
  JOURNAL   EMBO J 21 (13), 3464-3475 (2002)
   PUBMED   12093747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732624.6, BB855884.1 and BC092239.1.
            
            On Oct 5, 2017 this sequence version replaced XM_006503041.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.205422.1,
                                           SRR9219382.179771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL732624.6         27636-27666         c
            32-344              BB855884.1         3-315
            345-4438            BC092239.1         173-4266
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.0 cM"
     gene            1..4438
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /note="thyroid hormone receptor associated protein 3"
                     /db_xref="GeneID:230753"
                     /db_xref="MGI:MGI:2442637"
     exon            1..141
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            142..229
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            230..383
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..3102
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /note="thyroid hormone receptor-associated protein complex
                     150 kDa component"
                     /codon_start=1
                     /product="thyroid hormone receptor-associated protein 3"
                     /protein_id="NP_001343384.1"
                     /db_xref="CCDS:CCDS18645.1"
                     /db_xref="GeneID:230753"
                     /db_xref="MGI:MGI:2442637"
                     /translation="MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSVSRSRKRR
                     LSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRG
                     GYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSS
                     RSSSNHSRVESSKRKSTKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDIKGSE
                     SSKPWPDATTYGAGSASRASVSDLSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPP
                     LSNASQMGSSMSGGAGYQSGAHQGQFDHGSGSLSPSKKSPVGKSPPATGSAYGSSQKE
                     ESAASGGAAYSKRYLEEQKTENGKDKEQKQTNADKEKLKEKGGFSDADVKMKSDPFAP
                     KTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEELDEHDKDKSKGRKEPEFDDEPKFM
                     SKVIAGASKNQEEEKSGKWESLHTGKEKQRKAEEMEDEPFTERSRKEERGGSKRSESG
                     HRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGSKGDFSSGKSSFSITREAQV
                     NVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELF
                     AQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGNEQEAAKNKKSPEIHRRIDISPST
                     FRKHGLTHEELKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRESVDS
                     RDSSHSRERSTEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYPEEAEE
                     REESTSGFDKSRLGTKDFVGPNERGGRARGTFQFRARGRGWGRGNYSGNNNNNSNNDF
                     QKRSREEEWDPEYTPKSKKYYLHDDREGEGSDKWMGRGRGRGAFPRGRGRFMFRKSST
                     SPKWAHDKFSGEEGEIEDDESGTENREEKDSLQPSAE"
     exon            384..1286
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1982
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2155
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2267
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2352
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2540
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2736
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2880
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..4416
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4384..4389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /note="hexamer: AATAAA"
     polyA_site      4412
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /note="major polyA site"
ORIGIN      
        1 atttcccagg aggtagcgga gcgaggcggt agccgccgtc gtcggagagc ggggacgcgg
       61 ggcgcgctag cgggcggggg cgagcttcgg gccggttgtg ccgttgcgag attgcagctg
      121 tagtcgctcc ggccggtcaa gagttatacc ctgactgtaa ttgaagaagc cagtggtgct
      181 gctggtgttt ttcagaggca gttcaagttg aatcattgat tctactgagg tgtaaactct
      241 tccaagatgt caaaaacaaa caaatccaag tctgggtctc gctcttctcg ctcaagatct
      301 gcatccagat ctcggtctcg ttcgttttca aagtctcggt cccgaagccg atctgtctct
      361 cgttcaagga agcgcaggct gagttctagg tctcgttcca gatcatattc tccagctcat
      421 aacagagaaa ggaatcaccc cagagtgtat cagaatcgag atttccgagg tcataacaga
      481 ggctacagga ggccctatta cttccgtggg cgaaaccgag gcttttatcc atggggccag
      541 tataaccgag gtggctatgg aaactaccgt tccaattggc agaactaccg gcaagcatac
      601 agccctcgtc ggggccgttc tcgatcccgg tccccaaaga gaaggtcccc ttcaccacgg
      661 tccaggagcc attctaggaa ctctgacaag tcatcctctg acaggtcaag acgctcctca
      721 tcctcccggt cgtcctccaa ccacagcaga gttgagtcgt ctaagcgaaa gtctacaaaa
      781 gagaaaaagt cctcttccaa ggatagccgg ccatctcagg cagctggtga taaccaggga
      841 gatgaggcta aggagcagac attctctgga ggcacctctc aagatataaa agggtctgag
      901 agctcaaagc catggccaga tgccaccacc tatggcgccg gttctgcatc acgggcctcg
      961 gtttctgatc tgagtccccg ggagagaagc ccagctctca aaagccccct ccagtctgtg
     1021 gtggttaggc gcaggtcacc acgccctagc cctgtgccaa aacccagtcc tccactttct
     1081 aatgcgtccc agatgggctc gtctatgtca gggggtgctg ggtatcagtc tggagcacac
     1141 caaggccagt tcgaccatgg ctctgggtct ttgagtccat ccaaaaagag ccctgtgggt
     1201 aagagtccac cagctactgg ctctgcatat ggctcatctc agaaagagga gagtgctgct
     1261 tcgggagggg cagcatattc aaaaaggtat ctggaggagc agaagactga gaatgggaag
     1321 gataaggagc agaaacaaac aaatgccgat aaggagaagc tgaaggagaa agggggcttc
     1381 tctgatgctg atgtcaaaat gaaatctgat ccatttgctc ccaagacgga ctctgagaag
     1441 cccttccgag gcagccagtc gcccaaaagg tataagcttc gggatgactt tgagaaaaag
     1501 atggctgact tccacaagga ggagctggat gagcacgata aggacaaaag taagggaagg
     1561 aaggaacccg agtttgatga tgagcccaaa tttatgtcga aagtcatagc cggtgcaagc
     1621 aaaaaccagg aggaagagaa gtcaggcaag tgggagagcc tgcacacagg gaaggaaaag
     1681 cagaggaagg cagaggaaat ggaggatgag cctttcacag agagatcccg aaaggaggag
     1741 cgtggagggt ccaagaggag tgaaagtggg cacaggggct ttgtgccaga aaagaatttc
     1801 cgggtgactg cgtacaaggc ggtccaggag aaaagttcat cgccgccccc aaggaagacc
     1861 tctgagagcc gtgacaagct gggaagcaaa ggagactttt cctcagggaa gtcttccttt
     1921 tccattaccc gggaggccca agtcaatgtc cggatggact ccttcgatga ggaccttgca
     1981 cgacctagtg gtttattggc tcaggagcga aagctctgtc gggatctagt ccatagcaac
     2041 aaaaaggagc aggagttccg ttccattttc cagcacatac agtcggctca gtctcagcgt
     2101 agcccctcag aactgtttgc tcagcacata gtgaccattg ttcatcatgt taaagagcat
     2161 cactttggat cctctggaat gacattgcat gaacgcttta ctaaatacct aaagagagga
     2221 aatgaacaag aagcagctaa aaataagaaa agcccagaga tacacaggag gatagacatt
     2281 tcccccagta cattcagaaa gcatggtttg actcatgagg aattgaaaag tccacgggaa
     2341 cctggctaca aggctgaggg aaaatacaaa gatgatcctg ttgatcttcg ccttgatatt
     2401 gaacgtcgta aaaaacataa ggagagagat cttaagcgag gtaaatcaag agagtcagtg
     2461 gattccagag actctagcca ctcaagagaa agatcaactg aaaagacaga gaaaacccac
     2521 aaaggatcaa agaagcagaa gaagcaccgc agagcaagag accggtccag gtcctcctcc
     2581 tcctcctccc agtcctccca ttcctacaaa gcagaggagt accctgagga ggcagaagag
     2641 agggaggaga gcacctcagg tttcgacaaa tccagattgg ggaccaaaga cttcgtgggt
     2701 ccgaatgaaa gaggcggcag agctcgggga acctttcaat ttcgtgcaag agggagagga
     2761 tggggcagag gaaactattc tggtaacaat aacaacaaca gcaacaatga ttttcaaaag
     2821 agaagccggg aagaagagtg ggatccagag tacacgccca agagcaagaa gtattacttg
     2881 catgacgacc gggaaggcga gggcagcgac aagtggatgg gccgaggccg aggccgagga
     2941 gcctttcccc gggggcgggg ccggttcatg ttccggaagt ccagtaccag ccccaagtgg
     3001 gcccatgaca agttcagtgg ggaggaggga gagatagaag acgacgagag tgggacagag
     3061 aacagagaag agaaggacag tttacagccc tcagctgagt aggggccgct cttgatggag
     3121 cccttgcccg gggaagaaag gcgctgggag aggctggtgg agctaaacaa ggagcctcaa
     3181 gaagatcctg aaaacgccac cccacaaccc acttgccaca cagaatccat cccacgacag
     3241 cagagtgtcc ctggtgccat ccgtctcact ggacagagga caggacgttg ccaccgagcc
     3301 tagatgagac cacacactgg gctcctgctg ctgctggtgg tgtggggggt gggcagggta
     3361 gggagaagga tgctgatgct tggactttgt tttggttttg ttgtcccacc cccactccca
     3421 ccccaattag aaaccaagtt ttcttcattg catttcattt ggaactaaat gggaatttgg
     3481 ttttcagtct cttcctgtcc tgagttttat taagaaatcc ttttttcttt ttcttctttt
     3541 taggggatat atagtaatat tagtgtaaag attttaattt gggcaacttt gactcttaag
     3601 agaaaacaaa gcatgtgaat aaaaattgaa gtgttcacct cagtttggga ccaaactgct
     3661 tggatcttgt acaaaccggt tttgtatgtt gaggaggagt ttaaggcctt tctgaccacc
     3721 tcgtgttccc ctttctacac agccatgtat cccgtggagt tgctcccagc ctccccatgc
     3781 accctgctct gtctcatttc tcctgggctg ggcttcccat tctccaccag cagctccagt
     3841 gtcccaacct ttgtagtcct gctggtcttc agcaagagga gtggaaactg gagggcagtt
     3901 tctggacggt tttctaagaa acttctgaat tctattatct ttacaaatac aagatgagaa
     3961 aataattttt tcaatatttt ttattaatct ttttataaaa tgaaaagaaa cgcctatgat
     4021 taaggatggt ggttatggct gggtggtctg tggggttgtg tgtttttggg tttttccttt
     4081 tttttttctc tttaacctta cgttttgggt tgaaacattt tcagatgttg gggggcatcc
     4141 tcattaaagg gtccttgtgc ttgccttccg gggcagcggt ccccagcagg tgaaccgctg
     4201 cctgcgcgca tctgttggac gccgactgca ccctcctccc tccccagcct tcgctcttgg
     4261 gttgttgtgc atacttccct ttactttgct aatttcaata gttatgttgg ttttacttga
     4321 atgattcatg tttaggggag aacaaaaaaa cacccttaaa tttttgtttc aactcctcct
     4381 gcaaataaaa acaataaatg aagtggcaga tgtaaaaaaa aaaaaaaaaa aaaaaaaa
//
