LOCUS       NP_001343384             951 aa            linear   ROD 09-FEB-2025
DEFINITION  thyroid hormone receptor-associated protein 3 [Mus musculus].
ACCESSION   NP_001343384 XP_006503104
VERSION     NP_001343384.1
DBSOURCE    REFSEQ: accession NM_001356455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 951)
  AUTHORS   Zhang,R., Bu,F., Wang,Y., Huang,M., Lin,X., Wu,C., Chen,J.,
            Huang,Y., Wang,H., Ye,S., Hu,X., Wang,Q. and Zheng,L.
  TITLE     LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate
            atherosclerosis by regulating c-FOS in vascular smooth muscle cells
            proliferation and migration
  JOURNAL   Atherosclerosis 379, 117183 (2023)
   PUBMED   37549548
  REMARK    GeneRIF: LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate
            atherosclerosis by regulating c-FOS in vascular smooth muscle cells
            proliferation and migration.
REFERENCE   2  (residues 1 to 951)
  AUTHORS   Jang,H.J., Lee,Y.H., Dao,T., Jo,Y., Khim,K.W., Eom,H.J., Lee,J.E.,
            Song,Y.J., Choi,S.S., Park,K., Ji,H., Chae,Y.C., Myung,K., Kim,H.,
            Ryu,D., Park,N.H., Park,S.H. and Choi,J.H.
  TITLE     Thrap3 promotes nonalcoholic fatty liver disease by suppressing
            AMPK-mediated autophagy
  JOURNAL   Exp Mol Med 55 (8), 1720-1733 (2023)
   PUBMED   37524868
  REMARK    GeneRIF: Thrap3 promotes nonalcoholic fatty liver disease by
            suppressing AMPK-mediated autophagy.
REFERENCE   3  (residues 1 to 951)
  AUTHORS   Sono,T., Akiyama,H., Miura,S., Deng,J.M., Shukunami,C., Hiraki,Y.,
            Tsushima,Y., Azuma,Y., Behringer,R.R. and Matsuda,S.
  TITLE     THRAP3 interacts with and inhibits the transcriptional activity of
            SOX9 during chondrogenesis
  JOURNAL   J Bone Miner Metab 36 (4), 410-419 (2018)
   PUBMED   28770354
  REMARK    GeneRIF: These results indicate that THRAP3 negatively regulates
            SOX9 transcriptional activity as a cofactor of a SOX9
            transcriptional complex during chondrogenesis.
REFERENCE   4  (residues 1 to 951)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   5  (residues 1 to 951)
  AUTHORS   Maga,A.M., Navarro,N., Cunningham,M.L. and Cox,T.C.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 951)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   7  (residues 1 to 951)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (residues 1 to 951)
  AUTHORS   Orelio,C. and Dzierzak,E.
  TITLE     Identification of 2 novel genes developmentally regulated in the
            mouse aorta-gonad-mesonephros region
  JOURNAL   Blood 101 (6), 2246-2249 (2003)
   PUBMED   12433684
REFERENCE   9  (residues 1 to 951)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 951)
  AUTHORS   Ito,M., Okano,H.J., Darnell,R.B. and Roeder,R.G.
  TITLE     The TRAP100 component of the TRAP/Mediator complex is essential in
            broad transcriptional events and development
  JOURNAL   EMBO J 21 (13), 3464-3475 (2002)
   PUBMED   12093747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732624.6, BB855884.1 and BC092239.1.
            
            On Oct 5, 2017 this sequence version replaced XP_006503104.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.205422.1,
                                           SRR9219382.179771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.0 cM"
     Protein         1..951
                     /product="thyroid hormone receptor-associated protein 3"
                     /note="thyroid hormone receptor-associated protein complex
                     150 kDa component"
                     /calculated_mol_wt=108047
     Region          1..94
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          2..190
                     /region_name="Required for mRNA splicing activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            17
                     /site_type="methylation"
                     /note="Dimethylated arginine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            66
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            101
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            108
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          117..558
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            221
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            233
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          248..766
                     /region_name="THRAP3_BCLAF1"
                     /note="THRAP3/BCLAF1 family; pfam15440"
                     /db_xref="CDD:464718"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            252
                     /site_type="methylation"
                     /note="N6-methyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            253
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            257
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            326
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            346
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          359..951
                     /region_name="Required for mRNA decay activity.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            394
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            403
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            405
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            452
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            468
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            476
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            516
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            524
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            532
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            555
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            557
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            559
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            616
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            619
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          660..951
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            679
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18630941,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            681
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            695
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            808
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W1; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            841
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Region          <857..>923
                     /region_name="Btz"
                     /note="CASC3/Barentsz eIF4AIII binding; cl09653"
                     /db_xref="CDD:447763"
     Site            860
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M7V8; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            870
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            924
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     Site            935
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q569Z6.1)"
     CDS             1..951
                     /gene="Thrap3"
                     /gene_synonym="9330151F09Rik; B230333E16Rik; Trap150"
                     /coded_by="NM_001356455.1:247..3102"
                     /db_xref="CCDS:CCDS18645.1"
                     /db_xref="GeneID:230753"
                     /db_xref="MGI:MGI:2442637"
ORIGIN      
        1 msktnksksg srssrsrsas rsrsrsfsks rsrsrsvsrs rkrrlssrsr srsyspahnr
       61 ernhprvyqn rdfrghnrgy rrpyyfrgrn rgfypwgqyn rggygnyrsn wqnyrqaysp
      121 rrgrsrsrsp krrspsprsr shsrnsdkss sdrsrrssss rsssnhsrve sskrkstkek
      181 kssskdsrps qaagdnqgde akeqtfsggt sqdikgsess kpwpdattyg agsasrasvs
      241 dlsprerspa lksplqsvvv rrrsprpspv pkpspplsna sqmgssmsgg agyqsgahqg
      301 qfdhgsgsls pskkspvgks ppatgsaygs sqkeesaasg gaayskryle eqktengkdk
      361 eqkqtnadke klkekggfsd advkmksdpf apktdsekpf rgsqspkryk lrddfekkma
      421 dfhkeeldeh dkdkskgrke pefddepkfm skviagaskn qeeeksgkwe slhtgkekqr
      481 kaeemedepf tersrkeerg gskrsesghr gfvpeknfrv taykavqeks ssppprktse
      541 srdklgskgd fssgkssfsi treaqvnvrm dsfdedlarp sgllaqerkl crdlvhsnkk
      601 eqefrsifqh iqsaqsqrsp selfaqhivt ivhhvkehhf gssgmtlher ftkylkrgne
      661 qeaaknkksp eihrridisp stfrkhglth eelksprepg ykaegkykdd pvdlrldier
      721 rkkhkerdlk rgksresvds rdsshsrers tektekthkg skkqkkhrra rdrsrsssss
      781 sqsshsykae eypeeaeere estsgfdksr lgtkdfvgpn erggrargtf qfrargrgwg
      841 rgnysgnnnn nsnndfqkrs reeewdpeyt pkskkyylhd dregegsdkw mgrgrgrgaf
      901 prgrgrfmfr ksstspkwah dkfsgeegei eddesgtenr eekdslqpsa e
//
